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Nocturnal hypoxemia

MedGen UID:
758908
•Concept ID:
C3531793
•
Finding
Synonyms: Sleep hypoxemia; Sleep related hypoxemia; Sleep-related hypoxemia
SNOMED CT: Sleep related hypoxemia (288581000119102)
 
HPO: HP:0034312

Definition

Abnormally reduced oxyhemoglobin saturation during sleep (nocturnal). Different thresholds are used in the literature, including more than 10 percent of total sleep time below a SpO2 of 90 percent. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNocturnal hypoxemia

Professional guidelines

PubMed

Sleep disorders in chronic obstructive pulmonary disease: etiology, impact, and management.
Budhiraja R, Siddiqi TA, Quan SF
J Clin Sleep Med 2015 Mar 15;11(3):259-70. doi: 10.5664/jcsm.4540. PMID: 25700872Free PMC Article
The pathophysiology, prevention, and treatment of stroke in sickle cell disease.
Wang WC
Curr Opin Hematol 2007 May;14(3):191-7. doi: 10.1097/MOH.0b013e3280ec5243. PMID: 17414206
Multimodal postoperative pain management.
Hartrick CT
Am J Health Syst Pharm 2004 Apr;61 Suppl 1:S4-10. doi: 10.1093/ajhp/61.suppl_1.S4. PMID: 15119755

Recent clinical studies

Etiology

Hypoxic Burden in Obstructive Sleep Apnea: Present and Future.
Martinez-Garcia MA, Sánchez-de-la-Torre M, White DP, Azarbarzin A
Arch Bronconeumol 2023 Jan;59(1):36-43. Epub 2022 Sep 5 doi: 10.1016/j.arbres.2022.08.005. PMID: 36115739
Opioids and obstructive sleep apnea.
Freire C, Sennes LU, Polotsky VY
J Clin Sleep Med 2022 Feb 1;18(2):647-652. doi: 10.5664/jcsm.9730. PMID: 34672945Free PMC Article
Sleep Apnea-Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality.
Trzepizur W, Blanchard M, Ganem T, Balusson F, Feuilloy M, Girault JM, Meslier N, Oger E, Paris A, Pigeanne T, Racineux JL, Sabil A, Gervès-Pinquié C, Gagnadoux F
Am J Respir Crit Care Med 2022 Jan 1;205(1):108-117. doi: 10.1164/rccm.202105-1274OC. PMID: 34648724
Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review.
Cowie MR, Linz D, Redline S, Somers VK, Simonds AK
J Am Coll Cardiol 2021 Aug 10;78(6):608-624. doi: 10.1016/j.jacc.2021.05.048. PMID: 34353537
Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease.
Mesarwi OA, Loomba R, Malhotra A
Am J Respir Crit Care Med 2019 Apr 1;199(7):830-841. doi: 10.1164/rccm.201806-1109TR. PMID: 30422676Free PMC Article

Diagnosis

Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.
Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE
J Alzheimers Dis 2022;88(4):1411-1421. doi: 10.3233/JAD-215707. PMID: 35811518Free PMC Article
Sleep Apnea-Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality.
Trzepizur W, Blanchard M, Ganem T, Balusson F, Feuilloy M, Girault JM, Meslier N, Oger E, Paris A, Pigeanne T, Racineux JL, Sabil A, Gervès-Pinquié C, Gagnadoux F
Am J Respir Crit Care Med 2022 Jan 1;205(1):108-117. doi: 10.1164/rccm.202105-1274OC. PMID: 34648724
Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review.
Cowie MR, Linz D, Redline S, Somers VK, Simonds AK
J Am Coll Cardiol 2021 Aug 10;78(6):608-624. doi: 10.1016/j.jacc.2021.05.048. PMID: 34353537
Sleep-disordered breathing in cystic fibrosis.
Jagpal SK, Jobanputra AM, Ahmed OH, Santiago TV, Ramagopal M
Pediatr Pulmonol 2021 Feb;56 Suppl 1:S23-S31. doi: 10.1002/ppul.25028. PMID: 33263201
Sleep in Neuromuscular Diseases.
Fermin AM, Afzal U, Culebras A
Sleep Med Clin 2016 Mar;11(1):53-64. Epub 2016 Jan 9 doi: 10.1016/j.jsmc.2015.10.005. PMID: 26972033

Therapy

Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.
Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE
J Alzheimers Dis 2022;88(4):1411-1421. doi: 10.3233/JAD-215707. PMID: 35811518Free PMC Article
Opioids and obstructive sleep apnea.
Freire C, Sennes LU, Polotsky VY
J Clin Sleep Med 2022 Feb 1;18(2):647-652. doi: 10.5664/jcsm.9730. PMID: 34672945Free PMC Article
Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review.
Cowie MR, Linz D, Redline S, Somers VK, Simonds AK
J Am Coll Cardiol 2021 Aug 10;78(6):608-624. doi: 10.1016/j.jacc.2021.05.048. PMID: 34353537
Opioids, sleep, and sleep-disordered breathing.
Zutler M, Holty JE
Curr Pharm Des 2011;17(15):1443-9. doi: 10.2174/138161211796197070. PMID: 21476955
Long-term oxygen therapy.
Anthonisen NR
Ann Intern Med 1983 Oct;99(4):519-27. doi: 10.7326/0003-4819-99-4-519. PMID: 6354031

Prognosis

Nocturnal hypoxemia and prognosis in patients with acute symptomatic pulmonary embolism.
Barbero E, Rodríguez C, Mañas E, Retegui A, García-Ortega A, García-Sánchez A, Cano-Pumarega I, Martinez-Garcia MÁ, Jimenez D
Int J Cardiol 2023 Oct 15;389:131148. Epub 2023 Jul 7 doi: 10.1016/j.ijcard.2023.131148. PMID: 37423569
Sleep Apnea-Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality.
Trzepizur W, Blanchard M, Ganem T, Balusson F, Feuilloy M, Girault JM, Meslier N, Oger E, Paris A, Pigeanne T, Racineux JL, Sabil A, Gervès-Pinquié C, Gagnadoux F
Am J Respir Crit Care Med 2022 Jan 1;205(1):108-117. doi: 10.1164/rccm.202105-1274OC. PMID: 34648724
Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review.
Cowie MR, Linz D, Redline S, Somers VK, Simonds AK
J Am Coll Cardiol 2021 Aug 10;78(6):608-624. doi: 10.1016/j.jacc.2021.05.048. PMID: 34353537
Nocturnal Hypoxemia and High Circulating TNF-α Levels in Chronic Thromboembolic Pulmonary Hypertension.
Naito A, Sakao S, Terada J, Iwasawa S, Jujo Sanada T, Suda R, Kasai H, Sekine A, Nishimura R, Sugiura T, Shigeta A, Tanabe N, Tatsumi K
Intern Med 2020;59(15):1819-1826. Epub 2020 Aug 1 doi: 10.2169/internalmedicine.4458-20. PMID: 32741891Free PMC Article
Sleep-disordered breathing and COPD: the overlap syndrome.
Owens RL, Malhotra A
Respir Care 2010 Oct;55(10):1333-44; discussion 1344-6. PMID: 20875160Free PMC Article

Clinical prediction guides

Nocturnal Hypoxemia Associates With Symptom Progression and Mortality in Patients With Progressive Fibrotic Interstitial Lung Disease.
Myall KJ, West AG, Martinovic JL, Lam JL, Roque D, Wu Z, Maher TM, Molyneaux PL, Suh ES, Kent BD
Chest 2023 Nov;164(5):1232-1242. Epub 2023 May 13 doi: 10.1016/j.chest.2023.05.013. PMID: 37187434
Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.
Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE
J Alzheimers Dis 2022;88(4):1411-1421. doi: 10.3233/JAD-215707. PMID: 35811518Free PMC Article
Sleep Apnea-Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality.
Trzepizur W, Blanchard M, Ganem T, Balusson F, Feuilloy M, Girault JM, Meslier N, Oger E, Paris A, Pigeanne T, Racineux JL, Sabil A, Gervès-Pinquié C, Gagnadoux F
Am J Respir Crit Care Med 2022 Jan 1;205(1):108-117. doi: 10.1164/rccm.202105-1274OC. PMID: 34648724
Nocturnal Hypoxemia and High Circulating TNF-α Levels in Chronic Thromboembolic Pulmonary Hypertension.
Naito A, Sakao S, Terada J, Iwasawa S, Jujo Sanada T, Suda R, Kasai H, Sekine A, Nishimura R, Sugiura T, Shigeta A, Tanabe N, Tatsumi K
Intern Med 2020;59(15):1819-1826. Epub 2020 Aug 1 doi: 10.2169/internalmedicine.4458-20. PMID: 32741891Free PMC Article
Almitrine bismesylate.
Smith PD, Gotz VP, Ryerson GG
Drug Intell Clin Pharm 1987 May;21(5):417-21. doi: 10.1177/106002808702100503. PMID: 3556128

Recent systematic reviews

Association of obstructive sleep apnea and nocturnal hypoxemia with all-cancer incidence and mortality: a systematic review and meta-analysis.
Tan BKJ, Teo YH, Tan NKW, Yap DWT, Sundar R, Lee CH, See A, Toh ST
J Clin Sleep Med 2022 May 1;18(5):1427-1440. doi: 10.5664/jcsm.9772. PMID: 34755597Free PMC Article
Cognitive impairment in obstructive sleep apnea syndrome: a descriptive review.
Caporale M, Palmeri R, Corallo F, Muscarà N, Romeo L, Bramanti A, Marino S, Lo Buono V
Sleep Breath 2021 Mar;25(1):29-40. Epub 2020 May 23 doi: 10.1007/s11325-020-02084-3. PMID: 32447633
Improvement in Nocturnal Hypoxemia in Obese Patients with Obstructive Sleep Apnea after Bariatric Surgery: a Meta-Analysis.
Zhang Y, Wang W, Yang C, Shen J, Shi M, Wang B
Obes Surg 2019 Feb;29(2):601-608. doi: 10.1007/s11695-018-3573-5. PMID: 30411226
The Association of Obstructive Sleep Apnea and Pain Outcomes in Adults: A Systematic Review.
Charokopos A, Card ME, Gunderson C, Steffens C, Bastian LA
Pain Med 2018 Sep 1;19(suppl_1):S69-S75. doi: 10.1093/pm/pny140. PMID: 30203008
Obstructive sleep apnea and oxygen therapy: a systematic review of the literature and meta-analysis.
Mehta V, Vasu TS, Phillips B, Chung F
J Clin Sleep Med 2013 Mar 15;9(3):271-9. doi: 10.5664/jcsm.2500. PMID: 23493498Free PMC Article

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