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Invasive lobular breast carcinoma

MedGen UID:
75994
•Concept ID:
C0279565
•
Neoplastic Process
Synonyms: breast invasive lobular carcinoma; Classic Invasive Lobular Carcinoma; classic invasive lobular carcinoma; Infiltrating Lobular Adenocarcinoma; infiltrating lobular adenocarcinoma; Infiltrating Lobular Breast Carcinoma; infiltrating lobular breast carcinoma; Infiltrating Lobular Carcinoma of Breast; infiltrating lobular carcinoma of breast; Infiltrating Lobular Carcinoma of the Breast; infiltrating lobular carcinoma of the breast; Invasive Breast Lobular Carcinoma; Invasive Lobular Adenocarcinoma; invasive lobular adenocarcinoma; Invasive Lobular Breast Carcinoma; invasive lobular breast carcinoma; Invasive Lobular Carcinoma; invasive lobular carcinoma; Invasive Lobular Carcinoma of Breast; invasive lobular carcinoma of breast; Invasive Lobular Carcinoma of the Breast; invasive lobular carcinoma of the breast; Invasive Lobular Carcinoma, Classic Type; invasive lobular carcinoma, classic type
 
Monarch Initiative: MONDO:0005051

Definition

An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma. The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures. [from NCI]

Professional guidelines

PubMed

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review.
Birla R, Dinu D, Iosif C, Constantinoiu S
Chirurgia (Bucur) 2019 Sept-Oct;114(5):571-578. doi: 10.21614/chirurgia.114.5.571. PMID: 31670632
21-gene recurrence score and adjuvant chemotherapy decisions in patients with invasive lobular breast cancer.
Chen XH, Zhang WW, Wang J, Sun JY, Li FY, He ZY, Wu SG
Biomark Med 2019 Feb;13(2):83-93. Epub 2018 Dec 19 doi: 10.2217/bmm-2018-0396. PMID: 30565472
Distant metastases from invasive lobular breast carcinoma classic type - treatment and prognosis.
Skotnicki P, Sas-Korczynska B, Wohadlo L, Jakubowicz J, Blecharz P, Reinfuss M, Walasek T
Eur J Gynaecol Oncol 2016;37(5):666-670. PMID: 29787007

Recent clinical studies

Etiology

Tumor-infiltrating lymphocytes are associated with poor prognosis in invasive lobular breast carcinoma.
Tille JC, Vieira AF, Saint-Martin C, Djerroudi L, Furhmann L, Bidard FC, Kirova Y, Tardivon A, Reyal F, Carton M, Vincent-Salomon A
Mod Pathol 2020 Nov;33(11):2198-2207. Epub 2020 May 13 doi: 10.1038/s41379-020-0561-9. PMID: 32404955
Characterizing Response to Neoadjuvant Chemotherapy in Invasive Lobular Breast Carcinoma.
Riba LA, Russell T, Alapati A, Davis RB, James TA
J Surg Res 2019 Jan;233:436-443. Epub 2018 Sep 21 doi: 10.1016/j.jss.2018.08.011. PMID: 30502283
Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis.
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418
Optimal surgical treatment of invasive lobular carcinoma of the breast.
Chung MA, Cole B, Wanebo HJ, Bland KI, Chang HR
Ann Surg Oncol 1997 Oct-Nov;4(7):545-50. doi: 10.1007/BF02305534. PMID: 9367019
Conservation therapy for invasive lobular carcinoma of the breast.
Poen JC, Tran L, Juillard G, Selch MT, Giuliano A, Silverstein M, Fingerhut A, Lewinsky B, Parker RG
Cancer 1992 Jun 1;69(11):2789-95. doi: 10.1002/1097-0142(19920601)69:11<2789::aid-cncr2820691126>3.0.co;2-j. PMID: 1571910

Diagnosis

Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma.
Christgen M, Kandt LD, Antonopoulos W, Bartels S, Van Bockstal MR, Bredt M, Brito MJ, Christgen H, Colpaert C, Cserni B, Cserni G, Daemmrich ME, Danebrock R, Dedeurwaerdere F, van Deurzen CH, Erber R, Fathke C, Feist H, Fiche M, Gonzalez CA, Ter Hoeve ND, Kooreman L, Krech T, Kristiansen G, Kulka J, Laenger F, Lafos M, Lehmann U, Martin-Martinez MD, Mueller S, Pelz E, Raap M, Ravarino A, Reineke-Plaass T, Schaumann N, Schelfhout AM, De Schepper M, Schlue J, Van de Vijver K, Waelput W, Wellmann A, Graeser M, Gluz O, Kuemmel S, Nitz U, Harbeck N, Desmedt C, Floris G, Derksen PW, van Diest PJ, Vincent-Salomon A, Kreipe H
J Pathol Clin Res 2022 Mar;8(2):191-205. Epub 2021 Dec 10 doi: 10.1002/cjp2.253. PMID: 34889530Free PMC Article
Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells.
Chen F, Ding K, Priedigkeit N, Elangovan A, Levine KM, Carleton N, Savariau L, Atkinson JM, Oesterreich S, Lee AV
Cancer Res 2021 Jan 15;81(2):268-281. Epub 2020 Nov 4 doi: 10.1158/0008-5472.CAN-20-0696. PMID: 33148662Free PMC Article
Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review.
Birla R, Dinu D, Iosif C, Constantinoiu S
Chirurgia (Bucur) 2019 Sept-Oct;114(5):571-578. doi: 10.21614/chirurgia.114.5.571. PMID: 31670632
Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis.
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418
Optimal surgical treatment of invasive lobular carcinoma of the breast.
Chung MA, Cole B, Wanebo HJ, Bland KI, Chang HR
Ann Surg Oncol 1997 Oct-Nov;4(7):545-50. doi: 10.1007/BF02305534. PMID: 9367019

Therapy

Characterizing Response to Neoadjuvant Chemotherapy in Invasive Lobular Breast Carcinoma.
Riba LA, Russell T, Alapati A, Davis RB, James TA
J Surg Res 2019 Jan;233:436-443. Epub 2018 Sep 21 doi: 10.1016/j.jss.2018.08.011. PMID: 30502283
Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer.
Du T, Sikora MJ, Levine KM, Tasdemir N, Riggins RB, Wendell SG, Van Houten B, Oesterreich S
Breast Cancer Res 2018 Sep 4;20(1):106. doi: 10.1186/s13058-018-1041-8. PMID: 30180878Free PMC Article
Neoadjuvant systemic therapy in invasive lobular breast cancer: Is it indicated?
Tsung K, Grobmyer SR, Tu C, Abraham J, Budd GT, Valente SA
Am J Surg 2018 Mar;215(3):509-512. Epub 2017 Nov 14 doi: 10.1016/j.amjsurg.2017.11.011. PMID: 29197477
Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis.
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418
Magnitude of trastuzumab benefit in patients with HER2-positive, invasive lobular breast carcinoma: results from the HERA trial.
Metzger-Filho O, Procter M, de Azambuja E, Leyland-Jones B, Gelber RD, Dowsett M, Loi S, Saini KS, Cameron D, Untch M, Smith I, Gianni L, Baselga J, Jackisch C, Bell R, Sotiriou C, Viale G, Piccart-Gebhart M
J Clin Oncol 2013 Jun 1;31(16):1954-60. Epub 2013 Apr 15 doi: 10.1200/JCO.2012.46.2440. PMID: 23589556

Prognosis

Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells.
Chen F, Ding K, Priedigkeit N, Elangovan A, Levine KM, Carleton N, Savariau L, Atkinson JM, Oesterreich S, Lee AV
Cancer Res 2021 Jan 15;81(2):268-281. Epub 2020 Nov 4 doi: 10.1158/0008-5472.CAN-20-0696. PMID: 33148662Free PMC Article
Tumor-infiltrating lymphocytes are associated with poor prognosis in invasive lobular breast carcinoma.
Tille JC, Vieira AF, Saint-Martin C, Djerroudi L, Furhmann L, Bidard FC, Kirova Y, Tardivon A, Reyal F, Carton M, Vincent-Salomon A
Mod Pathol 2020 Nov;33(11):2198-2207. Epub 2020 May 13 doi: 10.1038/s41379-020-0561-9. PMID: 32404955
Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis.
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418
Optimal surgical treatment of invasive lobular carcinoma of the breast.
Chung MA, Cole B, Wanebo HJ, Bland KI, Chang HR
Ann Surg Oncol 1997 Oct-Nov;4(7):545-50. doi: 10.1007/BF02305534. PMID: 9367019
Conservation therapy for invasive lobular carcinoma of the breast.
Poen JC, Tran L, Juillard G, Selch MT, Giuliano A, Silverstein M, Fingerhut A, Lewinsky B, Parker RG
Cancer 1992 Jun 1;69(11):2789-95. doi: 10.1002/1097-0142(19920601)69:11<2789::aid-cncr2820691126>3.0.co;2-j. PMID: 1571910

Clinical prediction guides

Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma.
Christgen M, Kandt LD, Antonopoulos W, Bartels S, Van Bockstal MR, Bredt M, Brito MJ, Christgen H, Colpaert C, Cserni B, Cserni G, Daemmrich ME, Danebrock R, Dedeurwaerdere F, van Deurzen CH, Erber R, Fathke C, Feist H, Fiche M, Gonzalez CA, Ter Hoeve ND, Kooreman L, Krech T, Kristiansen G, Kulka J, Laenger F, Lafos M, Lehmann U, Martin-Martinez MD, Mueller S, Pelz E, Raap M, Ravarino A, Reineke-Plaass T, Schaumann N, Schelfhout AM, De Schepper M, Schlue J, Van de Vijver K, Waelput W, Wellmann A, Graeser M, Gluz O, Kuemmel S, Nitz U, Harbeck N, Desmedt C, Floris G, Derksen PW, van Diest PJ, Vincent-Salomon A, Kreipe H
J Pathol Clin Res 2022 Mar;8(2):191-205. Epub 2021 Dec 10 doi: 10.1002/cjp2.253. PMID: 34889530Free PMC Article
Tumor-infiltrating lymphocytes are associated with poor prognosis in invasive lobular breast carcinoma.
Tille JC, Vieira AF, Saint-Martin C, Djerroudi L, Furhmann L, Bidard FC, Kirova Y, Tardivon A, Reyal F, Carton M, Vincent-Salomon A
Mod Pathol 2020 Nov;33(11):2198-2207. Epub 2020 May 13 doi: 10.1038/s41379-020-0561-9. PMID: 32404955
Characterizing Response to Neoadjuvant Chemotherapy in Invasive Lobular Breast Carcinoma.
Riba LA, Russell T, Alapati A, Davis RB, James TA
J Surg Res 2019 Jan;233:436-443. Epub 2018 Sep 21 doi: 10.1016/j.jss.2018.08.011. PMID: 30502283
Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis.
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418
Periocular breast carcinoma metastases: correlation of clinical, radiologic and histopathologic features.
Homer N, Jakobiec FA, Stagner A, Cunnane ME, Freitag SK, Fay A, Yoon MK
Clin Exp Ophthalmol 2017 Aug;45(6):606-612. Epub 2017 Mar 3 doi: 10.1111/ceo.12926. PMID: 28181367

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