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T-cell childhood acute lymphocytic leukemia

MedGen UID:
75996
•Concept ID:
C0279583
•
Neoplastic Process
Synonyms: Childhood Precursor T-Lymphoblastic Leukemia; childhood precursor T-lymphoblastic leukemia; Childhood T Acute Lymphoblastic Leukemia; childhood T acute lymphoblastic leukemia; Childhood T-Acute Lymphoblastic Leukemia; childhood T-ALL; Childhood T-Cell Acute Lymphoblastic Leukemia; childhood T-cell acute lymphoblastic leukemia; T-Cell Childhood Acute Lymphoblastic Leukemia; T-cell childhood acute lymphoblastic leukemia; T-Cell Childhood ALL; T-cell childhood ALL; T-Cell Pediatric Acute Lymphoblastic Leukemia; T-cell pediatric acute lymphoblastic leukemia; T-cell pediatric acute lymphocytic leukemia; T-Cell Pediatric ALL; T-cell pediatric ALL
 
Monarch Initiative: MONDO:0000871

Definition

An acute lymphoblastic leukemia of T-cell origin occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-cell childhood acute lymphocytic leukemia

Professional guidelines

PubMed

Neurotoxicity Associated with Treatment of Acute Lymphoblastic Leukemia Chemotherapy and Immunotherapy.
Śliwa-Tytko P, Kaczmarska A, Lejman M, Zawitkowska J
Int J Mol Sci 2022 May 15;23(10) doi: 10.3390/ijms23105515. PMID: 35628334Free PMC Article
Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions.
Samra B, Jabbour E, Ravandi F, Kantarjian H, Short NJ
J Hematol Oncol 2020 Jun 5;13(1):70. doi: 10.1186/s13045-020-00905-2. PMID: 32503572Free PMC Article
Adult Acute Lymphoblastic Leukemia: Treatment and Management Updates.
Gregory S
Semin Oncol Nurs 2019 Dec;35(6):150951. Epub 2019 Nov 20 doi: 10.1016/j.soncn.2019.150951. PMID: 31759820

Recent clinical studies

Etiology

International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706
MRD in ALL: Optimization and Innovations.
Pierce E, Mautner B, Mort J, Blewett A, Morris A, Keng M, El Chaer F
Curr Hematol Malig Rep 2022 Aug;17(4):69-81. Epub 2022 May 26 doi: 10.1007/s11899-022-00664-6. PMID: 35616771
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Precision medicine in acute lymphoblastic leukemia.
Pui CH
Front Med 2020 Dec;14(6):689-700. Epub 2020 Oct 19 doi: 10.1007/s11684-020-0759-8. PMID: 33074527Free PMC Article
Pediatric acute lymphoblastic leukemia.
Inaba H, Mullighan CG
Haematologica 2020 Nov 1;105(11):2524-2539. doi: 10.3324/haematol.2020.247031. [Epub ahead of print] PMID: 33054110Free PMC Article

Diagnosis

International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia.
Hu Y, Zhou Y, Zhang M, Ge W, Li Y, Yang L, Wei G, Han L, Wang H, Yu S, Chen Y, Wang Y, He X, Zhang X, Gao M, Yang J, Li X, Ren J, Huang H
Clin Cancer Res 2021 May 15;27(10):2764-2772. Epub 2021 Feb 24 doi: 10.1158/1078-0432.CCR-20-3863. PMID: 33627493
Pediatric acute lymphoblastic leukemia.
Inaba H, Mullighan CG
Haematologica 2020 Nov 1;105(11):2524-2539. doi: 10.3324/haematol.2020.247031. [Epub ahead of print] PMID: 33054110Free PMC Article
Acute lymphoblastic leukemia.
Onciu M
Hematol Oncol Clin North Am 2009 Aug;23(4):655-74. doi: 10.1016/j.hoc.2009.04.009. PMID: 19577163

Therapy

Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion.
Amini L, Silbert SK, Maude SL, Nastoupil LJ, Ramos CA, Brentjens RJ, Sauter CS, Shah NN, Abou-El-Enein M
Nat Rev Clin Oncol 2022 May;19(5):342-355. Epub 2022 Mar 22 doi: 10.1038/s41571-022-00607-3. PMID: 35318469
The New Therapeutic Strategies in Pediatric T-Cell Acute Lymphoblastic Leukemia.
Lato MW, Przysucha A, Grosman S, Zawitkowska J, Lejman M
Int J Mol Sci 2021 Apr 26;22(9) doi: 10.3390/ijms22094502. PMID: 33925883Free PMC Article
T cell-engaging therapies - BiTEs and beyond.
Goebeler ME, Bargou RC
Nat Rev Clin Oncol 2020 Jul;17(7):418-434. Epub 2020 Apr 2 doi: 10.1038/s41571-020-0347-5. PMID: 32242094
Immunotherapy in pediatric acute lymphoblastic leukemia.
Inaba H, Pui CH
Cancer Metastasis Rev 2019 Dec;38(4):595-610. doi: 10.1007/s10555-019-09834-0. PMID: 31811553Free PMC Article
Mechanisms of resistance to CAR T cell therapy.
Shah NN, Fry TJ
Nat Rev Clin Oncol 2019 Jun;16(6):372-385. doi: 10.1038/s41571-019-0184-6. PMID: 30837712Free PMC Article

Prognosis

Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion.
Amini L, Silbert SK, Maude SL, Nastoupil LJ, Ramos CA, Brentjens RJ, Sauter CS, Shah NN, Abou-El-Enein M
Nat Rev Clin Oncol 2022 May;19(5):342-355. Epub 2022 Mar 22 doi: 10.1038/s41571-022-00607-3. PMID: 35318469
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
The New Therapeutic Strategies in Pediatric T-Cell Acute Lymphoblastic Leukemia.
Lato MW, Przysucha A, Grosman S, Zawitkowska J, Lejman M
Int J Mol Sci 2021 Apr 26;22(9) doi: 10.3390/ijms22094502. PMID: 33925883Free PMC Article
Acute lymphoblastic leukemia.
Onciu M
Hematol Oncol Clin North Am 2009 Aug;23(4):655-74. doi: 10.1016/j.hoc.2009.04.009. PMID: 19577163

Clinical prediction guides

MRD in ALL: Optimization and Innovations.
Pierce E, Mautner B, Mort J, Blewett A, Morris A, Keng M, El Chaer F
Curr Hematol Malig Rep 2022 Aug;17(4):69-81. Epub 2022 May 26 doi: 10.1007/s11899-022-00664-6. PMID: 35616771
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia.
Hu Y, Zhou Y, Zhang M, Ge W, Li Y, Yang L, Wei G, Han L, Wang H, Yu S, Chen Y, Wang Y, He X, Zhang X, Gao M, Yang J, Li X, Ren J, Huang H
Clin Cancer Res 2021 May 15;27(10):2764-2772. Epub 2021 Feb 24 doi: 10.1158/1078-0432.CCR-20-3863. PMID: 33627493
Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia.
Kruse A, Abdel-Azim N, Kim HN, Ruan Y, Phan V, Ogana H, Wang W, Lee R, Gang EJ, Khazal S, Kim YM
Int J Mol Sci 2020 Feb 5;21(3) doi: 10.3390/ijms21031054. PMID: 32033444Free PMC Article
Acute Lymphoblastic Leukemia in the Older Adult.
Aldoss I, Forman SJ, Pullarkat V
J Oncol Pract 2019 Feb;15(2):67-75. doi: 10.1200/JOP.18.00271. PMID: 30763199

Recent systematic reviews

Efficacy and safety of nelarabine in patients with relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis.
Kathpalia M, Mishra P, Bajpai R, Bhurani D, Agarwal N
Ann Hematol 2022 Aug;101(8):1655-1666. Epub 2022 Jun 21 doi: 10.1007/s00277-022-04880-1. PMID: 35727338
Chimeric antigen receptor T-cell therapy in adults with B-cell acute lymphoblastic leukemia.
Grover P, Veilleux O, Tian L, Sun R, Previtera M, Curran E, Muffly L
Blood Adv 2022 Mar 8;6(5):1608-1618. doi: 10.1182/bloodadvances.2020003482. PMID: 34610109Free PMC Article
Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Anti-CD19 chimeric antigen receptor T-cell therapy in acute lymphocytic leukaemia: a systematic review and meta-analysis.
Anagnostou T, Riaz IB, Hashmi SK, Murad MH, Kenderian SS
Lancet Haematol 2020 Nov;7(11):e816-e826. doi: 10.1016/S2352-3026(20)30277-5. PMID: 33091355
Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292

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