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Gallbladder adenocarcinoma

MedGen UID:
76009
•Concept ID:
C0279651
•
Neoplastic Process
Synonyms: Adenocarcinoma of Gallbladder; adenocarcinoma of gallbladder; Adenocarcinoma of the Gallbladder; adenocarcinoma of the gallbladder; gall bladder adenocarcinoma; Gallbladder Adenocarcinoma; gallbladder adenocarcinoma
 
Monarch Initiative: MONDO:0006215

Definition

An adenocarcinoma arising from the gallbladder. It is the most common malignant tumor of the gallbladder and it is usually well to moderately differentiated. The incidence is higher in patients with gallstones than in patients without gallstones. Signs and symptoms usually present late in the course of the disease and are reminiscent of those of chronic cholecystitis including right upper quadrant pain. Histologic variants include adenocarcinoma of the intestinal type, clear cell adenocarcinoma, mucinous adenocarcinoma, papillary adenocarcinoma, and signet ring adenocarcinoma. [from NCI]

Professional guidelines

PubMed

Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article
AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With Primary Sclerosing Cholangitis: Expert Review.
Bowlus CL, Lim JK, Lindor KD
Clin Gastroenterol Hepatol 2019 Nov;17(12):2416-2422. Epub 2019 Jul 12 doi: 10.1016/j.cgh.2019.07.011. PMID: 31306801
Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
Eltawil KM, Gustafsson BI, Kidd M, Modlin IM
J Clin Gastroenterol 2010 Nov-Dec;44(10):687-95. doi: 10.1097/MCG.0b013e3181d7a6d4. PMID: 20375728

Recent clinical studies

Etiology

A prospective study on the prevalence of NAFLD, advanced fibrosis, cirrhosis and hepatocellular carcinoma in people with type 2 diabetes.
Ajmera V, Cepin S, Tesfai K, Hofflich H, Cadman K, Lopez S, Madamba E, Bettencourt R, Richards L, Behling C, Sirlin CB, Loomba R
J Hepatol 2023 Mar;78(3):471-478. Epub 2022 Nov 19 doi: 10.1016/j.jhep.2022.11.010. PMID: 36410554Free PMC Article
Comparison of clinicopathological characteristics of mucinous adenocarcinoma and conventional adenocarcinoma of gallbladder.
Zou RQ, Hu HJ, Liu F, Lv TR, Wang JK, Regmi P, Li FY
Asian J Surg 2023 Jan;46(1):283-290. Epub 2022 Apr 11 doi: 10.1016/j.asjsur.2022.03.094. PMID: 35422386
Lymphadenectomy in gallbladder adenocarcinoma: Are we doing enough?
Papageorge MV, de Geus SWL, Woods AP, Ng SC, Drake FT, Merrill A, Cassidy MR, McAneny D, Tseng JF, Sachs TE
Am J Surg 2022 Jul;224(1 Pt B):423-428. Epub 2021 Dec 24 doi: 10.1016/j.amjsurg.2021.12.028. PMID: 34972539
Staging of Biliary and Primary Liver Tumors: Current Recommendations and Workup.
Krampitz GW, Aloia TA
Surg Oncol Clin N Am 2019 Oct;28(4):663-683. doi: 10.1016/j.soc.2019.06.007. PMID: 31472912
Mesohepatectomy.
Scudamore CH, Buczkowski AK, Shayan H, Ho SG, Legiehn GM, Chung SW, Owen DA
Am J Surg 2000 May;179(5):356-60. doi: 10.1016/s0002-9610(00)00374-3. PMID: 10930479

Diagnosis

A prospective study on the prevalence of NAFLD, advanced fibrosis, cirrhosis and hepatocellular carcinoma in people with type 2 diabetes.
Ajmera V, Cepin S, Tesfai K, Hofflich H, Cadman K, Lopez S, Madamba E, Bettencourt R, Richards L, Behling C, Sirlin CB, Loomba R
J Hepatol 2023 Mar;78(3):471-478. Epub 2022 Nov 19 doi: 10.1016/j.jhep.2022.11.010. PMID: 36410554Free PMC Article
Can patients with gallbladder adenocarcinoma and liver metastases obtain survival benefit from surgery? A population-based study.
Gao T, Tang H, Zhou B, Bai D, Jin S, Zhang C, Jiang G
Updates Surg 2022 Aug;74(4):1353-1366. Epub 2022 Jun 4 doi: 10.1007/s13304-022-01302-9. PMID: 35661322
Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.
Zhao L, Xu L, Hemmerich A, Ferguson NL, Guy CD, McCall SJ, Cardona DM, Westerhoff M, Pai RK, Xiao SY, Liu B, Green CL, Hart J, Zhang X
Virchows Arch 2021 Mar;478(3):427-434. Epub 2020 Sep 7 doi: 10.1007/s00428-020-02925-2. PMID: 32895766
Staging of Biliary and Primary Liver Tumors: Current Recommendations and Workup.
Krampitz GW, Aloia TA
Surg Oncol Clin N Am 2019 Oct;28(4):663-683. doi: 10.1016/j.soc.2019.06.007. PMID: 31472912
Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
Eltawil KM, Gustafsson BI, Kidd M, Modlin IM
J Clin Gastroenterol 2010 Nov-Dec;44(10):687-95. doi: 10.1097/MCG.0b013e3181d7a6d4. PMID: 20375728

Therapy

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer.
Engstrom LD, Aranda R, Waters L, Moya K, Bowcut V, Vegar L, Trinh D, Hebbert A, Smith CR, Kulyk S, Lawson JD, He L, Hover LD, Fernandez-Banet J, Hallin J, Vanderpool D, Briere DM, Blaj A, Marx MA, Rodon J, Offin M, Arbour KC, Johnson ML, Kwiatkowski DJ, Jänne PA, Haddox CL, Papadopoulos KP, Henry JT, Leventakos K, Christensen JG, Shazer R, Olson P
Cancer Discov 2023 Nov 1;13(11):2412-2431. doi: 10.1158/2159-8290.CD-23-0669. PMID: 37552839Free PMC Article
Can patients with gallbladder adenocarcinoma and liver metastases obtain survival benefit from surgery? A population-based study.
Gao T, Tang H, Zhou B, Bai D, Jin S, Zhang C, Jiang G
Updates Surg 2022 Aug;74(4):1353-1366. Epub 2022 Jun 4 doi: 10.1007/s13304-022-01302-9. PMID: 35661322
A predictive model for survival of gallbladder adenocarcinoma.
Yifan T, Zheyong L, Miaoqin C, Liang S, Xiujun C
Surg Oncol 2018 Sep;27(3):365-372. Epub 2018 May 23 doi: 10.1016/j.suronc.2018.05.007. PMID: 30217289
Clinical outcomes of small cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder.
Yun SP, Shin N, Seo HI
World J Gastroenterol 2015 Jan 7;21(1):269-75. doi: 10.3748/wjg.v21.i1.269. PMID: 25574101Free PMC Article
Mesohepatectomy.
Scudamore CH, Buczkowski AK, Shayan H, Ho SG, Legiehn GM, Chung SW, Owen DA
Am J Surg 2000 May;179(5):356-60. doi: 10.1016/s0002-9610(00)00374-3. PMID: 10930479

Prognosis

Comparison of clinicopathological characteristics of mucinous adenocarcinoma and conventional adenocarcinoma of gallbladder.
Zou RQ, Hu HJ, Liu F, Lv TR, Wang JK, Regmi P, Li FY
Asian J Surg 2023 Jan;46(1):283-290. Epub 2022 Apr 11 doi: 10.1016/j.asjsur.2022.03.094. PMID: 35422386
Low expression of DUSP4 expression predicts unfavorable prognosis in gallbladder adenocarcinoma.
Jee S, Sim J, Bang S, Park H, Myung J, Paik SS, Choi D, Kim Y, Kim H
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):809-813. doi: 10.4103/ijpm.ijpm_352_21. PMID: 36308185
Lymphadenectomy in gallbladder adenocarcinoma: Are we doing enough?
Papageorge MV, de Geus SWL, Woods AP, Ng SC, Drake FT, Merrill A, Cassidy MR, McAneny D, Tseng JF, Sachs TE
Am J Surg 2022 Jul;224(1 Pt B):423-428. Epub 2021 Dec 24 doi: 10.1016/j.amjsurg.2021.12.028. PMID: 34972539
Site-specific metastases of gallbladder adenocarcinoma and their prognostic value for survival: a SEER-based study.
Yang Y, Tu Z, Ye C, Cai H, Yang S, Chen X, Tu J
BMC Surg 2021 Jan 23;21(1):59. doi: 10.1186/s12893-021-01068-8. PMID: 33485332Free PMC Article
Staging of Biliary and Primary Liver Tumors: Current Recommendations and Workup.
Krampitz GW, Aloia TA
Surg Oncol Clin N Am 2019 Oct;28(4):663-683. doi: 10.1016/j.soc.2019.06.007. PMID: 31472912

Clinical prediction guides

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer.
Engstrom LD, Aranda R, Waters L, Moya K, Bowcut V, Vegar L, Trinh D, Hebbert A, Smith CR, Kulyk S, Lawson JD, He L, Hover LD, Fernandez-Banet J, Hallin J, Vanderpool D, Briere DM, Blaj A, Marx MA, Rodon J, Offin M, Arbour KC, Johnson ML, Kwiatkowski DJ, Jänne PA, Haddox CL, Papadopoulos KP, Henry JT, Leventakos K, Christensen JG, Shazer R, Olson P
Cancer Discov 2023 Nov 1;13(11):2412-2431. doi: 10.1158/2159-8290.CD-23-0669. PMID: 37552839Free PMC Article
Lymphadenectomy in gallbladder adenocarcinoma: Are we doing enough?
Papageorge MV, de Geus SWL, Woods AP, Ng SC, Drake FT, Merrill A, Cassidy MR, McAneny D, Tseng JF, Sachs TE
Am J Surg 2022 Jul;224(1 Pt B):423-428. Epub 2021 Dec 24 doi: 10.1016/j.amjsurg.2021.12.028. PMID: 34972539
Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article
Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.
Zhao L, Xu L, Hemmerich A, Ferguson NL, Guy CD, McCall SJ, Cardona DM, Westerhoff M, Pai RK, Xiao SY, Liu B, Green CL, Hart J, Zhang X
Virchows Arch 2021 Mar;478(3):427-434. Epub 2020 Sep 7 doi: 10.1007/s00428-020-02925-2. PMID: 32895766
AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With Primary Sclerosing Cholangitis: Expert Review.
Bowlus CL, Lim JK, Lindor KD
Clin Gastroenterol Hepatol 2019 Nov;17(12):2416-2422. Epub 2019 Jul 12 doi: 10.1016/j.cgh.2019.07.011. PMID: 31306801

Recent systematic reviews

Indocyanine green (ICG) fluorescence in robotic hepatobiliary surgery: A systematic review.
Potharazu AV, Gangemi A
Int J Med Robot 2023 Feb;19(1):e2485. Epub 2022 Dec 2 doi: 10.1002/rcs.2485. PMID: 36417426Free PMC Article
Systematic review of squamous cell carcinoma of the gallbladder.
Takahashi H, Irri A, Fenig Y, Byale A, Thung S, Gunasekaran G
Am J Surg 2022 Sep;224(3):863-868. Epub 2022 Apr 23 doi: 10.1016/j.amjsurg.2022.04.024. PMID: 35483997
Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article

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