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Spindle cell intraocular melanoma

MedGen UID:
76015
Concept ID:
C0279687
Neoplastic Process
Synonyms: Spindle Cell Intraocular Melanoma; spindle cell intraocular melanoma; Spindle Cell Melanoma of the Uvea; spindle cell melanoma of the uvea; Spindle Cell Melanoma of Uvea; spindle cell melanoma of uvea; Spindle Cell Uveal Melanoma; spindle cell uveal melanoma; Uveal Spindle Cell Melanoma; uveal spindle cell melanoma
 
Monarch Initiative: MONDO:0003744

Definition

A melanoma arising from the choroid, ciliary body, or the iris. It is characterized by the presence of spindle-shaped melanocytes. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748

Recent clinical studies

Etiology

Hamal D, Limbu B, Sthapit PR, Pradhan E, Shrestha R, Saiju R
Nepal J Ophthalmol 2019 Jan;11(21):64-73. doi: 10.3126/nepjoph.v11i1.25422. PMID: 31523069
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Baderca F, Solovan C, Boghian L
Rom J Morphol Embryol 2013;54(1):77-83. PMID: 23529312
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar S
Am J Ophthalmol 2001 Sep;132(3):336-42. doi: 10.1016/s0002-9394(01)01051-0. PMID: 11530045

Diagnosis

Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Hamal D, Limbu B, Sthapit PR, Pradhan E, Shrestha R, Saiju R
Nepal J Ophthalmol 2019 Jan;11(21):64-73. doi: 10.3126/nepjoph.v11i1.25422. PMID: 31523069
Richards NQ, Kofler JK, Chu CT, Stefko ST
Retin Cases Brief Rep 2017 Fall;11(4):302-305. doi: 10.1097/ICB.0000000000000348. PMID: 27315324
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810

Therapy

Ambrosini G, Natale CA, Musi E, Garyantes T, Schwartz GK
Cancer Res Commun 2023 Apr;3(4):540-547. Epub 2023 Apr 5 doi: 10.1158/2767-9764.CRC-22-0399. PMID: 37035582Free PMC Article
Hussain RN, Heimann H, Damato B
Melanoma Res 2020 Feb;30(1):102-106. doi: 10.1097/CMR.0000000000000635. PMID: 31425478
Harley MR, Rao R, Lally SE, Shields CL
J AAPOS 2017 Aug;21(4):340-342. Epub 2017 Jun 16 doi: 10.1016/j.jaapos.2017.06.007. PMID: 28630029
Kreissig I, Jost B
Eur J Ophthalmol 1992 Jan-Mar;2(1):30-2. doi: 10.1177/112067219200200107. PMID: 1638163

Prognosis

Bălăşoiu AT, Ştefănescu-Dima AŞ, Bălăşoiu M, Ciurea RN, Muraru A, Dan AO, Simionescu CE
Rom J Morphol Embryol 2022 Oct-Dec;63(4):645-652. doi: 10.47162/RJME.63.4.07. PMID: 36808200Free PMC Article
Longhitano L, Giallongo S, Orlando L, Broggi G, Longo A, Russo A, Caltabiano R, Giallongo C, Barbagallo I, Di Rosa M, Giuffrida R, Parenti R, Li Volti G, Vicario N, Tibullo D
Int J Mol Sci 2022 Dec 20;24(1) doi: 10.3390/ijms24010024. PMID: 36613471Free PMC Article
Hamal D, Limbu B, Sthapit PR, Pradhan E, Shrestha R, Saiju R
Nepal J Ophthalmol 2019 Jan;11(21):64-73. doi: 10.3126/nepjoph.v11i1.25422. PMID: 31523069
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810
Kuo PK, Puliafito CA, Wang KM, Liu HS, Wu BF
Int Ophthalmol Clin 1982 Fall;22(3):57-71. doi: 10.1097/00004397-198202230-00007. PMID: 7107133

Clinical prediction guides

Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Abbott DW, Simons K, Giorgadze T
Ann Diagn Pathol 2019 Oct;42:39-41. Epub 2019 Jun 22 doi: 10.1016/j.anndiagpath.2019.06.010. PMID: 31306857
Baderca F, Solovan C, Boghian L
Rom J Morphol Embryol 2013;54(1):77-83. PMID: 23529312
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810
Kuo PK, Puliafito CA, Wang KM, Liu HS, Wu BF
Int Ophthalmol Clin 1982 Fall;22(3):57-71. doi: 10.1097/00004397-198202230-00007. PMID: 7107133

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