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Spindle cell intraocular melanoma

MedGen UID:
76015
•Concept ID:
C0279687
•
Neoplastic Process
Synonyms: Spindle Cell Intraocular Melanoma; spindle cell intraocular melanoma; Spindle Cell Melanoma of the Uvea; spindle cell melanoma of the uvea; Spindle Cell Melanoma of Uvea; spindle cell melanoma of uvea; Spindle Cell Uveal Melanoma; spindle cell uveal melanoma; Uveal Spindle Cell Melanoma; uveal spindle cell melanoma
 
Monarch Initiative: MONDO:0003744

Definition

A melanoma arising from the choroid, ciliary body, or the iris. It is characterized by the presence of spindle-shaped melanocytes. [from NCI]

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748

Recent clinical studies

Etiology

Neoadjuvant intravitreal ranibizumab treatment in high-risk ocular melanoma patients: a two-stage single-centre phase II single-arm study.
Hussain RN, Heimann H, Damato B
Melanoma Res 2020 Feb;30(1):102-106. doi: 10.1097/CMR.0000000000000635. PMID: 31425478
Choroidal Melanoma: Our Experience.
Hamal D, Limbu B, Sthapit PR, Pradhan E, Shrestha R, Saiju R
Nepal J Ophthalmol 2019 Jan;11(21):64-73. doi: 10.3126/nepjoph.v11i1.25422. PMID: 31523069
Epidemiological and morphological data of ocular melanocytic lesions.
Baderca F, Solovan C, Boghian L
Rom J Morphol Embryol 2013;54(1):77-83. PMID: 23529312
Diffuse iris melanoma: a report of 25 cases.
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810
Ring melanoma of the anterior chamber angle: a report of fourteen cases.
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar S
Am J Ophthalmol 2001 Sep;132(3):336-42. doi: 10.1016/s0002-9394(01)01051-0. PMID: 11530045

Diagnosis

Intraocular schwannoma with extrascleral extension.
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Choroidal Melanoma: Our Experience.
Hamal D, Limbu B, Sthapit PR, Pradhan E, Shrestha R, Saiju R
Nepal J Ophthalmol 2019 Jan;11(21):64-73. doi: 10.3126/nepjoph.v11i1.25422. PMID: 31523069
INTRAOCULAR SYNOVIAL SARCOMA.
Richards NQ, Kofler JK, Chu CT, Stefko ST
Retin Cases Brief Rep 2017 Fall;11(4):302-305. doi: 10.1097/ICB.0000000000000348. PMID: 27315324
Cavitary choroidal melanoma.
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628
Diffuse iris melanoma: a report of 25 cases.
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810

Therapy

The GPER Agonist LNS8801 Induces Mitotic Arrest and Apoptosis in Uveal Melanoma Cells.
Ambrosini G, Natale CA, Musi E, Garyantes T, Schwartz GK
Cancer Res Commun 2023 Apr;3(4):540-547. Epub 2023 Apr 5 doi: 10.1158/2767-9764.CRC-22-0399. PMID: 37035582Free PMC Article
Neoadjuvant intravitreal ranibizumab treatment in high-risk ocular melanoma patients: a two-stage single-centre phase II single-arm study.
Hussain RN, Heimann H, Damato B
Melanoma Res 2020 Feb;30(1):102-106. doi: 10.1097/CMR.0000000000000635. PMID: 31425478
Malignant transformation of multifocal tapioca iris nevus in a child.
Harley MR, Rao R, Lally SE, Shields CL
J AAPOS 2017 Aug;21(4):340-342. Epub 2017 Jun 16 doi: 10.1016/j.jaapos.2017.06.007. PMID: 28630029
Hypertensive gas technique for enucleation of choroidal melanomas: a preliminary report.
Kreissig I, Jost B
Eur J Ophthalmol 1992 Jan-Mar;2(1):30-2. doi: 10.1177/112067219200200107. PMID: 1638163

Prognosis

Locally advanced choroidal melanoma with favorable molecular prognosis - case report.
Bălăşoiu AT, Ştefănescu-Dima AŞ, Bălăşoiu M, Ciurea RN, Muraru A, Dan AO, Simionescu CE
Rom J Morphol Embryol 2022 Oct-Dec;63(4):645-652. doi: 10.47162/RJME.63.4.07. PMID: 36808200Free PMC Article
Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype.
Longhitano L, Giallongo S, Orlando L, Broggi G, Longo A, Russo A, Caltabiano R, Giallongo C, Barbagallo I, Di Rosa M, Giuffrida R, Parenti R, Li Volti G, Vicario N, Tibullo D
Int J Mol Sci 2022 Dec 20;24(1) doi: 10.3390/ijms24010024. PMID: 36613471Free PMC Article
Choroidal Melanoma: Our Experience.
Hamal D, Limbu B, Sthapit PR, Pradhan E, Shrestha R, Saiju R
Nepal J Ophthalmol 2019 Jan;11(21):64-73. doi: 10.3126/nepjoph.v11i1.25422. PMID: 31523069
Diffuse iris melanoma: a report of 25 cases.
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810
Uveal melanoma in China.
Kuo PK, Puliafito CA, Wang KM, Liu HS, Wu BF
Int Ophthalmol Clin 1982 Fall;22(3):57-71. doi: 10.1097/00004397-198202230-00007. PMID: 7107133

Clinical prediction guides

Intraocular schwannoma with extrascleral extension.
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Choroidal melanoma diagnosed by aspiration cytology: A case report with cyto-histologic correlation and review of the literature.
Abbott DW, Simons K, Giorgadze T
Ann Diagn Pathol 2019 Oct;42:39-41. Epub 2019 Jun 22 doi: 10.1016/j.anndiagpath.2019.06.010. PMID: 31306857
Diffuse iris melanoma: a report of 25 cases.
Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG
Ophthalmology 2002 Aug;109(8):1553-60. doi: 10.1016/s0161-6420(02)01104-1. PMID: 12153810
A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of alpha1beta1, alpha4beta1 and alpha6beta1 integrins.
Elshaw SR, Sisley K, Cross N, Murray AK, MacNeil SM, Wagner M, Nichols CE, Rennie IG
Br J Ophthalmol 2001 Jun;85(6):732-8. doi: 10.1136/bjo.85.6.732. PMID: 11371496Free PMC Article
Uveal melanoma in China.
Kuo PK, Puliafito CA, Wang KM, Liu HS, Wu BF
Int Ophthalmol Clin 1982 Fall;22(3):57-71. doi: 10.1097/00004397-198202230-00007. PMID: 7107133

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