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Central nervous system nongerminomatous germ cell tumor

MedGen UID:
760465
•Concept ID:
C1696109
•
Neoplastic Process
Synonyms: Central Nervous System Nongerminomatous Germ Cell Tumor; central nervous system nongerminomatous germ cell tumor; nongerminomatous GCT - CNS; Nongerminomatous germ cell tumor of central nervous system; nongerminomatous germ cell tumor of the CNS; nongerminomatous germ cell tumour of the CNS
SNOMED CT: Nongerminomatous germ cell tumor of central nervous system (878808006)
 
Monarch Initiative: MONDO:0020574

Definition

Germ cell tumors of the central nervous system other than germinoma. This category includes teratoma, choriocarcinoma, embryonal carcinoma, and yolk sac tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system nongerminomatous germ cell tumor

Professional guidelines

PubMed

Critical review of the management of primary central nervous nongerminomatous germ cell tumors.
Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415
Primary CNS germ cell tumors: current epidemiology and update on treatment.
Thakkar JP, Chew L, Villano JL
Med Oncol 2013 Jun;30(2):496. Epub 2013 Feb 24 doi: 10.1007/s12032-013-0496-9. PMID: 23436013
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Recent clinical studies

Etiology

Multi-institutional analysis of central nervous system germ cell tumors in patients with Down syndrome.
Harris MK, Graham RT, Cappellano AM, Margol AS, Michaiel G, Crawford JR, Ioakeim-Ioannidou M, Stanek JR, Liu KX, MacDonald SM, Abdelbaki MS
Pediatr Blood Cancer 2022 Oct;69(10):e29830. Epub 2022 Jun 10 doi: 10.1002/pbc.29830. PMID: 35686831
A Phase 2 Trial of Response-Based Radiation Therapy for Localized Central Nervous System Germ Cell Tumors: Patterns of Failure and Radiation Dosimetry for Nongerminomatous Germ Cell Tumors.
Murphy ES, Dhall G, Fangusaro J, Bartels U, Fouladi M, Shaw D, Khatua S, Hughes CW, Panigraphy A, Ioakeim-Ioannidou M, Souweidane M, Morris D, Gajjar A, Wu S, Onar-Thomas A, Haas-Kogan DA, MacDonald SM
Int J Radiat Oncol Biol Phys 2022 May 1;113(1):143-151. Epub 2022 Jan 4 doi: 10.1016/j.ijrobp.2021.12.166. PMID: 34990779Free PMC Article
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Critical review of the management of primary central nervous nongerminomatous germ cell tumors.
Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415
Pediatric central nervous system germ cell tumors: a review.
Echevarría ME, Fangusaro J, Goldman S
Oncologist 2008 Jun;13(6):690-9. doi: 10.1634/theoncologist.2008-0037. PMID: 18586924

Diagnosis

Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors.
Abu-Arja MH, Osorio DS, Lassaletta A, Graham RT, Coven SL, Stanek JR, Bouffet E, Finlay JL, Abdelbaki MS
Pediatr Blood Cancer 2022 Jan;69(1):e29365. Epub 2021 Sep 24 doi: 10.1002/pbc.29365. PMID: 34558189
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Central Nervous System Germ Cell Tumors: A Review of the Literature.
Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y
J Child Neurol 2018 Aug;33(9):610-620. Epub 2018 May 30 doi: 10.1177/0883073818772470. PMID: 29848146
Extraneural metastasis of a nongerminomatous germ cell tumor of the central nervous system in a pediatric patient with a ventriculoperitoneal shunt: a case report and review of the literature.
Belongia M, Jogal S
J Pediatr Hematol Oncol 2012 Jan;34(1):e12-6. doi: 10.1097/MPH.0b013e31823dd370. PMID: 22215101
Central nervous system germ cell tumors: controversies in diagnosis and treatment.
Jubran RF, Finlay J
Oncology (Williston Park) 2005 May;19(6):705-11; discussion 711-2, 715-7, 721. PMID: 15971448

Therapy

Advances in Molecular Profiling and Developing Clinical Trials of CNS Germ Cell Tumors: Present and Future Directions.
Takami H
Curr Oncol Rep 2022 Jan;24(1):105-112. Epub 2022 Jan 20 doi: 10.1007/s11912-022-01195-2. PMID: 35059994
A Phase 2 Trial of Response-Based Radiation Therapy for Localized Central Nervous System Germ Cell Tumors: Patterns of Failure and Radiation Dosimetry for Nongerminomatous Germ Cell Tumors.
Murphy ES, Dhall G, Fangusaro J, Bartels U, Fouladi M, Shaw D, Khatua S, Hughes CW, Panigraphy A, Ioakeim-Ioannidou M, Souweidane M, Morris D, Gajjar A, Wu S, Onar-Thomas A, Haas-Kogan DA, MacDonald SM
Int J Radiat Oncol Biol Phys 2022 May 1;113(1):143-151. Epub 2022 Jan 4 doi: 10.1016/j.ijrobp.2021.12.166. PMID: 34990779Free PMC Article
Pineal germ cell tumors.
Matsutani M
Prog Neurol Surg 2009;23:76-85. Epub 2009 Mar 23 doi: 10.1159/000210054. PMID: 19329862
Central nervous system germ cell tumors: controversies in diagnosis and treatment.
Jubran RF, Finlay J
Oncology (Williston Park) 2005 May;19(6):705-11; discussion 711-2, 715-7, 721. PMID: 15971448
Clinical management of primary central nervous system germ cell tumors.
Matsutani M
Semin Oncol 2004 Oct;31(5):676-83. doi: 10.1053/j.seminoncol.2004.07.010. PMID: 15497121

Prognosis

Advances in Molecular Profiling and Developing Clinical Trials of CNS Germ Cell Tumors: Present and Future Directions.
Takami H
Curr Oncol Rep 2022 Jan;24(1):105-112. Epub 2022 Jan 20 doi: 10.1007/s11912-022-01195-2. PMID: 35059994
Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors.
Abu-Arja MH, Osorio DS, Lassaletta A, Graham RT, Coven SL, Stanek JR, Bouffet E, Finlay JL, Abdelbaki MS
Pediatr Blood Cancer 2022 Jan;69(1):e29365. Epub 2021 Sep 24 doi: 10.1002/pbc.29365. PMID: 34558189
Critical review of the management of primary central nervous nongerminomatous germ cell tumors.
Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415
Update on current standard treatments in central nervous system germ cell tumors.
Kamoshima Y, Sawamura Y
Curr Opin Neurol 2010 Dec;23(6):571-5. doi: 10.1097/WCO.0b013e32833ff522. PMID: 20885323
Pediatric central nervous system germ cell tumors: a review.
Echevarría ME, Fangusaro J, Goldman S
Oncologist 2008 Jun;13(6):690-9. doi: 10.1634/theoncologist.2008-0037. PMID: 18586924

Clinical prediction guides

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Multimodality treatment for Central Nervous System Germ Cell Tumors: Disease spectrum and management strategies - A tertiary care center experience from India.
Kumar N, Madan R, Dracham CB, Khosla D, Das N, Dey T, Elangovan A, Tripathi M, Gupta K, Ahuja CK, Kapoor R
Clin Neurol Neurosurg 2021 Mar;202:106481. Epub 2021 Jan 13 doi: 10.1016/j.clineuro.2021.106481. PMID: 33508649
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
MRI features of pediatric intracranial germ cell tumor subtypes.
Wu CC, Guo WY, Chang FC, Luo CB, Lee HJ, Chen YW, Lee YY, Wong TT
J Neurooncol 2017 Aug;134(1):221-230. Epub 2017 May 27 doi: 10.1007/s11060-017-2513-x. PMID: 28551848
Clinical and Radiologic Features of Pediatric Basal Ganglia Germ Cell Tumors.
Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571

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