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Central nervous system nongerminomatous germ cell tumor

MedGen UID:
760465
Concept ID:
C1696109
Neoplastic Process
Synonyms: Central Nervous System Nongerminomatous Germ Cell Tumor; central nervous system nongerminomatous germ cell tumor; nongerminomatous GCT - CNS; Nongerminomatous germ cell tumor of central nervous system; nongerminomatous germ cell tumor of the CNS; nongerminomatous germ cell tumour of the CNS
SNOMED CT: Nongerminomatous germ cell tumor of central nervous system (878808006)
 
Monarch Initiative: MONDO:0020574

Definition

Germ cell tumors of the central nervous system other than germinoma. This category includes teratoma, choriocarcinoma, embryonal carcinoma, and yolk sac tumor. [from NCI]

Professional guidelines

PubMed

Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415
Thakkar JP, Chew L, Villano JL
Med Oncol 2013 Jun;30(2):496. Epub 2013 Feb 24 doi: 10.1007/s12032-013-0496-9. PMID: 23436013
Jubran RF, Finlay J
Oncology (Williston Park) 2005 May;19(6):705-11; discussion 711-2, 715-7, 721. PMID: 15971448

Recent clinical studies

Etiology

Harris MK, Graham RT, Cappellano AM, Margol AS, Michaiel G, Crawford JR, Ioakeim-Ioannidou M, Stanek JR, Liu KX, MacDonald SM, Abdelbaki MS
Pediatr Blood Cancer 2022 Oct;69(10):e29830. Epub 2022 Jun 10 doi: 10.1002/pbc.29830. PMID: 35686831
Murphy ES, Dhall G, Fangusaro J, Bartels U, Fouladi M, Shaw D, Khatua S, Hughes CW, Panigraphy A, Ioakeim-Ioannidou M, Souweidane M, Morris D, Gajjar A, Wu S, Onar-Thomas A, Haas-Kogan DA, MacDonald SM
Int J Radiat Oncol Biol Phys 2022 May 1;113(1):143-151. Epub 2022 Jan 4 doi: 10.1016/j.ijrobp.2021.12.166. PMID: 34990779Free PMC Article
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415
Echevarría ME, Fangusaro J, Goldman S
Oncologist 2008 Jun;13(6):690-9. doi: 10.1634/theoncologist.2008-0037. PMID: 18586924

Diagnosis

Abu-Arja MH, Osorio DS, Lassaletta A, Graham RT, Coven SL, Stanek JR, Bouffet E, Finlay JL, Abdelbaki MS
Pediatr Blood Cancer 2022 Jan;69(1):e29365. Epub 2021 Sep 24 doi: 10.1002/pbc.29365. PMID: 34558189
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y
J Child Neurol 2018 Aug;33(9):610-620. Epub 2018 May 30 doi: 10.1177/0883073818772470. PMID: 29848146
Echevarría ME, Fangusaro J, Goldman S
Oncologist 2008 Jun;13(6):690-9. doi: 10.1634/theoncologist.2008-0037. PMID: 18586924
Jubran RF, Finlay J
Oncology (Williston Park) 2005 May;19(6):705-11; discussion 711-2, 715-7, 721. PMID: 15971448

Therapy

Takami H
Curr Oncol Rep 2022 Jan;24(1):105-112. Epub 2022 Jan 20 doi: 10.1007/s11912-022-01195-2. PMID: 35059994
Murphy ES, Dhall G, Fangusaro J, Bartels U, Fouladi M, Shaw D, Khatua S, Hughes CW, Panigraphy A, Ioakeim-Ioannidou M, Souweidane M, Morris D, Gajjar A, Wu S, Onar-Thomas A, Haas-Kogan DA, MacDonald SM
Int J Radiat Oncol Biol Phys 2022 May 1;113(1):143-151. Epub 2022 Jan 4 doi: 10.1016/j.ijrobp.2021.12.166. PMID: 34990779Free PMC Article
Jubran RF, Finlay J
Oncology (Williston Park) 2005 May;19(6):705-11; discussion 711-2, 715-7, 721. PMID: 15971448
Matsutani M
Semin Oncol 2004 Oct;31(5):676-83. doi: 10.1053/j.seminoncol.2004.07.010. PMID: 15497121
Knappe UJ, Bentele K, Horstmann M, Herrmann HD
Pediatr Neurosurg 1998 May;28(5):241-5. doi: 10.1159/000028658. PMID: 9732256

Prognosis

Wong TT, Tsai ML, Chang H, Hsieh KL, Ho DM, Lin SC, Yen HJ, Chen YW, Lee HL, Yang TF
Adv Exp Med Biol 2023;1405:421-455. doi: 10.1007/978-3-031-23705-8_16. PMID: 37452948
Abu-Arja MH, Osorio DS, Lassaletta A, Graham RT, Coven SL, Stanek JR, Bouffet E, Finlay JL, Abdelbaki MS
Pediatr Blood Cancer 2022 Jan;69(1):e29365. Epub 2021 Sep 24 doi: 10.1002/pbc.29365. PMID: 34558189
Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415
Thakkar JP, Chew L, Villano JL
Med Oncol 2013 Jun;30(2):496. Epub 2013 Feb 24 doi: 10.1007/s12032-013-0496-9. PMID: 23436013
Echevarría ME, Fangusaro J, Goldman S
Oncologist 2008 Jun;13(6):690-9. doi: 10.1634/theoncologist.2008-0037. PMID: 18586924

Clinical prediction guides

Zhang Y, Zhong C, Ke X, Liu J, Ye Z, Lu L, Deng K, Zhu H, Yao Y
Acta Neuropathol Commun 2023 Nov 27;11(1):188. doi: 10.1186/s40478-023-01682-y. PMID: 38012690Free PMC Article
Kumar N, Madan R, Dracham CB, Khosla D, Das N, Dey T, Elangovan A, Tripathi M, Gupta K, Ahuja CK, Kapoor R
Clin Neurol Neurosurg 2021 Mar;202:106481. Epub 2021 Jan 13 doi: 10.1016/j.clineuro.2021.106481. PMID: 33508649
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Wu CC, Guo WY, Chang FC, Luo CB, Lee HJ, Chen YW, Lee YY, Wong TT
J Neurooncol 2017 Aug;134(1):221-230. Epub 2017 May 27 doi: 10.1007/s11060-017-2513-x. PMID: 28551848
Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571

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