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Ovarian teratoma

MedGen UID:
76072
•Concept ID:
C0280131
•
Neoplastic Process
Synonym: TERATOMA, OVARIAN
SNOMED CT: Teratoma of ovary (716077006); Ovarian teratoma (716077006)
 
HPO: HP:0012226
Monarch Initiative: MONDO:0005602
OMIM®: 166950

Definition

The presence of a teratoma in the ovary. [from HPO]

Conditions with this feature

Ovarian dermoid cyst
MedGen UID:
68637
•Concept ID:
C0237020
•
Neoplastic Process
An cystic ovarian teratoma composed of dermal and epidermal elements and containing tissue components including hair, teeth, bone, thyroid, and others.
See: Condition Record
Ovarian dermoid cyst

Professional guidelines

PubMed

Ovarian teratomas: clinical features, imaging findings and management.
Saleh M, Bhosale P, Menias CO, Ramalingam P, Jensen C, Iyer R, Ganeshan D
Abdom Radiol (NY) 2021 Jun;46(6):2293-2307. Epub 2021 Jan 4 doi: 10.1007/s00261-020-02873-0. PMID: 33394097
Characteristics, treatment and outcomes of women with immature ovarian teratoma, 1998-2012.
Jorge S, Jones NL, Chen L, Hou JY, Tergas AI, Burke WM, Ananth CV, Neugut AI, Herhshman DL, Wright JD
Gynecol Oncol 2016 Aug;142(2):261-6. Epub 2016 Jun 1 doi: 10.1016/j.ygyno.2016.05.024. PMID: 27222024Free PMC Article
Treatment principles of ovarian teratoma with anti-N-methyl-D-aspartate receptor encephalitis.
Bai Y, Guan Q, Jiang J, Zhang Z
Arch Gynecol Obstet 2016 Sep;294(3):623-9. Epub 2016 Apr 7 doi: 10.1007/s00404-016-4050-9. PMID: 27056053

Recent clinical studies

Etiology

Paraneoplastic encephalitis.
Casagrande S, Zuliani L, Grisold W
Handb Clin Neurol 2024;200:131-149. doi: 10.1016/B978-0-12-823912-4.00019-0. PMID: 38494274
Fast-growing immature ovarian teratoma during pregnancy: a case report and a review of the literature.
He Z, Lu Y, Xie C
BMC Pregnancy Childbirth 2022 Jun 27;22(1):519. doi: 10.1186/s12884-022-04857-y. PMID: 35761185Free PMC Article
Research progress in teratoma-associated anti-N-methyl-D-aspartate receptor encephalitis: The gynecological perspective.
Gu J, Chen Q, Gu H, Duan R
J Obstet Gynaecol Res 2021 Nov;47(11):3749-3757. Epub 2021 Aug 15 doi: 10.1111/jog.14984. PMID: 34396640
Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.
Kiely D, Lewis C, Gray J, Hall N
Pediatr Blood Cancer 2021 Nov;68(11):e29237. Epub 2021 Jul 31 doi: 10.1002/pbc.29237. PMID: 34331503
Extragonadal teratomas in women and adolescent girls: A systematic review.
Kanneganti A, Bhadiraju P, Tong PSY
Eur J Obstet Gynecol Reprod Biol 2021 Jul;262:134-141. Epub 2021 May 7 doi: 10.1016/j.ejogrb.2021.05.005. PMID: 34022590

Diagnosis

Ovarian teratomas: clinical features, imaging findings and management.
Saleh M, Bhosale P, Menias CO, Ramalingam P, Jensen C, Iyer R, Ganeshan D
Abdom Radiol (NY) 2021 Jun;46(6):2293-2307. Epub 2021 Jan 4 doi: 10.1007/s00261-020-02873-0. PMID: 33394097
An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models.
Dalmau J, Armangué T, Planagumà J, Radosevic M, Mannara F, Leypoldt F, Geis C, Lancaster E, Titulaer MJ, Rosenfeld MR, Graus F
Lancet Neurol 2019 Nov;18(11):1045-1057. Epub 2019 Jul 17 doi: 10.1016/S1474-4422(19)30244-3. PMID: 31326280
Encephalitis associated with antibodies against the NMDA receptor.
Guasp M, Dalmau J
Med Clin (Barc) 2018 Jul 23;151(2):71-79. Epub 2017 Nov 26 doi: 10.1016/j.medcli.2017.10.015. PMID: 29183618
Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis.
Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R
Lancet Neurol 2011 Jan;10(1):63-74. doi: 10.1016/S1474-4422(10)70253-2. PMID: 21163445Free PMC Article
Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies.
Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, Dessain SK, Rosenfeld MR, Balice-Gordon R, Lynch DR
Lancet Neurol 2008 Dec;7(12):1091-8. Epub 2008 Oct 11 doi: 10.1016/S1474-4422(08)70224-2. PMID: 18851928Free PMC Article

Therapy

Effect and timing of operative treatment for teratoma associated N-Methyl-d-Aspartate receptor-antibody encephalitis: A systematic review with meta-analysis.
Erlebach R, Brandi G
J Neuroimmunol 2023 Sep 15;382:578153. Epub 2023 Jul 22 doi: 10.1016/j.jneuroim.2023.578153. PMID: 37499300
An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models.
Dalmau J, Armangué T, Planagumà J, Radosevic M, Mannara F, Leypoldt F, Geis C, Lancaster E, Titulaer MJ, Rosenfeld MR, Graus F
Lancet Neurol 2019 Nov;18(11):1045-1057. Epub 2019 Jul 17 doi: 10.1016/S1474-4422(19)30244-3. PMID: 31326280
Immature Ovarian Teratoma: When to Give Adjuvant Therapy?
Faure-Conter C, Pashankar F
J Pediatr Hematol Oncol 2017 Oct;39(7):487-489. doi: 10.1097/MPH.0000000000000950. PMID: 28859031
Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis.
Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R
Lancet Neurol 2011 Jan;10(1):63-74. doi: 10.1016/S1474-4422(10)70253-2. PMID: 21163445Free PMC Article
Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.
Dalmau J, Tüzün E, Wu HY, Masjuan J, Rossi JE, Voloschin A, Baehring JM, Shimazaki H, Koide R, King D, Mason W, Sansing LH, Dichter MA, Rosenfeld MR, Lynch DR
Ann Neurol 2007 Jan;61(1):25-36. doi: 10.1002/ana.21050. PMID: 17262855Free PMC Article

Prognosis

Paraneoplastic encephalitis.
Casagrande S, Zuliani L, Grisold W
Handb Clin Neurol 2024;200:131-149. doi: 10.1016/B978-0-12-823912-4.00019-0. PMID: 38494274
An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models.
Dalmau J, Armangué T, Planagumà J, Radosevic M, Mannara F, Leypoldt F, Geis C, Lancaster E, Titulaer MJ, Rosenfeld MR, Graus F
Lancet Neurol 2019 Nov;18(11):1045-1057. Epub 2019 Jul 17 doi: 10.1016/S1474-4422(19)30244-3. PMID: 31326280
Encephalitis associated with antibodies against the NMDA receptor.
Guasp M, Dalmau J
Med Clin (Barc) 2018 Jul 23;151(2):71-79. Epub 2017 Nov 26 doi: 10.1016/j.medcli.2017.10.015. PMID: 29183618
Glial fibrillary acidic protein immunoglobulin G as biomarker of autoimmune astrocytopathy: Analysis of 102 patients.
Flanagan EP, Hinson SR, Lennon VA, Fang B, Aksamit AJ, Morris PP, Basal E, Honorat JA, Alfugham NB, Linnoila JJ, Weinshenker BG, Pittock SJ, McKeon A
Ann Neurol 2017 Feb;81(2):298-309. doi: 10.1002/ana.24881. PMID: 28120349
Paraneoplastic neurological syndromes.
Graus F, Dalmau J
Curr Opin Neurol 2012 Dec;25(6):795-801. doi: 10.1097/WCO.0b013e328359da15. PMID: 23041955Free PMC Article

Clinical prediction guides

Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis.
Al-Diwani A, Theorell J, Damato V, Bull J, McGlashan N, Green E, Kienzler AK, Harrison R, Hassanali T, Campo L, Browne M, Easton A, Soleymani Majd H, Tenaka K, Iorio R, Dale RC, Harrison P, Geddes J, Quested D, Sharp D, Lee ST, Nauen DW, Makuch M, Lennox B, Fowler D, Sheerin F, Waters P, Leite MI, Handel AE, Irani SR
Brain 2022 Aug 27;145(8):2742-2754. doi: 10.1093/brain/awac088. PMID: 35680425Free PMC Article
Encephalitis associated with antibodies against the NMDA receptor.
Guasp M, Dalmau J
Med Clin (Barc) 2018 Jul 23;151(2):71-79. Epub 2017 Nov 26 doi: 10.1016/j.medcli.2017.10.015. PMID: 29183618
On human parthenogenesis.
Jose de Carli G, Campos Pereira T
Med Hypotheses 2017 Sep;106:57-60. Epub 2017 Jul 11 doi: 10.1016/j.mehy.2017.07.008. PMID: 28818272
Glial fibrillary acidic protein immunoglobulin G as biomarker of autoimmune astrocytopathy: Analysis of 102 patients.
Flanagan EP, Hinson SR, Lennon VA, Fang B, Aksamit AJ, Morris PP, Basal E, Honorat JA, Alfugham NB, Linnoila JJ, Weinshenker BG, Pittock SJ, McKeon A
Ann Neurol 2017 Feb;81(2):298-309. doi: 10.1002/ana.24881. PMID: 28120349
Paraneoplastic neurological syndromes.
Graus F, Dalmau J
Curr Opin Neurol 2012 Dec;25(6):795-801. doi: 10.1097/WCO.0b013e328359da15. PMID: 23041955Free PMC Article

Recent systematic reviews

Effect and timing of operative treatment for teratoma associated N-Methyl-d-Aspartate receptor-antibody encephalitis: A systematic review with meta-analysis.
Erlebach R, Brandi G
J Neuroimmunol 2023 Sep 15;382:578153. Epub 2023 Jul 22 doi: 10.1016/j.jneuroim.2023.578153. PMID: 37499300
Clinical Characteristics of Anti-N-Methyl-d-Aspartate Receptor Encephalitis Overlapping with Demyelinating Diseases: A Review.
Zhang S, Yang Y, Liu W, Li Z, Li J, Zhou D
Front Immunol 2022;13:857443. Epub 2022 Jun 28 doi: 10.3389/fimmu.2022.857443. PMID: 35837405Free PMC Article
Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.
Kiely D, Lewis C, Gray J, Hall N
Pediatr Blood Cancer 2021 Nov;68(11):e29237. Epub 2021 Jul 31 doi: 10.1002/pbc.29237. PMID: 34331503
Extragonadal teratomas in women and adolescent girls: A systematic review.
Kanneganti A, Bhadiraju P, Tong PSY
Eur J Obstet Gynecol Reprod Biol 2021 Jul;262:134-141. Epub 2021 May 7 doi: 10.1016/j.ejogrb.2021.05.005. PMID: 34022590
Ovarian teratoma-associated anti-NMDAR encephalitis: a systematic review of reported cases.
Acién P, Acién M, Ruiz-Maciá E, Martín-Estefanía C
Orphanet J Rare Dis 2014 Oct 14;9:157. doi: 10.1186/s13023-014-0157-x. PMID: 25312434Free PMC Article

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