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Stage IV Adult Diffuse Mixed Cell Lymphoma

MedGen UID:
76081
Concept ID:
C0280174
Neoplastic Process

Definition

Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IV Adult Diffuse Mixed Cell Lymphoma

Professional guidelines

PubMed

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040
Breen CT, Chao J, Mehra S, Kohli N
Ann Otol Rhinol Laryngol 2022 Apr;131(4):412-419. Epub 2021 Jun 17 doi: 10.1177/00034894211025171. PMID: 34137303
Ishida F, Kwong YL
Expert Rev Hematol 2010 Oct;3(5):593-602. doi: 10.1586/ehm.10.51. PMID: 21083476

Recent clinical studies

Etiology

Vargas JC, Marques MO, Pereira J, Braga WMT, Hamerschlak N, Tabacof J, Ferreira PRA, Colleoni GWB, Baiocchi OCG
AIDS 2023 Jul 1;37(8):1217-1226. Epub 2023 Mar 17 doi: 10.1097/QAD.0000000000003549. PMID: 36939075
Mezger NCS, Feuchtner J, Griesel M, Hämmerl L, Seraphin TP, Zietsman A, Péko JF, Tadesse F, Buziba NG, Wabinga H, Nyanchama M, Borok MZ, Kéita M, N'da G, Lorenzoni CF, Akele-Akpo MT, Gottschick C, Binder M, Mezger J, Jemal A, Parkin DM, Wickenhauser C, Kantelhardt EJ
Br J Haematol 2020 Jul;190(2):209-221. Epub 2020 Mar 17 doi: 10.1111/bjh.16575. PMID: 32181503
Zouhair A, Herrmann E, Ugurluer G, Gaye PM, Mirimanoff RO, Ozsahin M
Swiss Med Wkly 2010;140:w13076. Epub 2010 Sep 24 doi: 10.4414/smw.2010.13076. PMID: 20872294
Vural F, Cagirgan S, Saydam G, Hekimgil M, Soyer NA, Tombuloglu M
J Natl Med Assoc 2007 Nov;99(11):1277-82. PMID: 18020104Free PMC Article
Pfreundschuh M, Trümper L, Osterborg A, Pettengell R, Trneny M, Imrie K, Ma D, Gill D, Walewski J, Zinzani PL, Stahel R, Kvaloy S, Shpilberg O, Jaeger U, Hansen M, Lehtinen T, López-Guillermo A, Corrado C, Scheliga A, Milpied N, Mendila M, Rashford M, Kuhnt E, Loeffler M; MabThera International Trial Group
Lancet Oncol 2006 May;7(5):379-91. doi: 10.1016/S1470-2045(06)70664-7. PMID: 16648042

Diagnosis

Vargas JC, Marques MO, Pereira J, Braga WMT, Hamerschlak N, Tabacof J, Ferreira PRA, Colleoni GWB, Baiocchi OCG
AIDS 2023 Jul 1;37(8):1217-1226. Epub 2023 Mar 17 doi: 10.1097/QAD.0000000000003549. PMID: 36939075
Mezger NCS, Feuchtner J, Griesel M, Hämmerl L, Seraphin TP, Zietsman A, Péko JF, Tadesse F, Buziba NG, Wabinga H, Nyanchama M, Borok MZ, Kéita M, N'da G, Lorenzoni CF, Akele-Akpo MT, Gottschick C, Binder M, Mezger J, Jemal A, Parkin DM, Wickenhauser C, Kantelhardt EJ
Br J Haematol 2020 Jul;190(2):209-221. Epub 2020 Mar 17 doi: 10.1111/bjh.16575. PMID: 32181503
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393
Pfreundschuh M, Trümper L, Osterborg A, Pettengell R, Trneny M, Imrie K, Ma D, Gill D, Walewski J, Zinzani PL, Stahel R, Kvaloy S, Shpilberg O, Jaeger U, Hansen M, Lehtinen T, López-Guillermo A, Corrado C, Scheliga A, Milpied N, Mendila M, Rashford M, Kuhnt E, Loeffler M; MabThera International Trial Group
Lancet Oncol 2006 May;7(5):379-91. doi: 10.1016/S1470-2045(06)70664-7. PMID: 16648042
Ansell SM, Armitage J
Mayo Clin Proc 2005 Aug;80(8):1087-97. doi: 10.4065/80.8.1087. PMID: 16092591

Therapy

Vargas JC, Marques MO, Pereira J, Braga WMT, Hamerschlak N, Tabacof J, Ferreira PRA, Colleoni GWB, Baiocchi OCG
AIDS 2023 Jul 1;37(8):1217-1226. Epub 2023 Mar 17 doi: 10.1097/QAD.0000000000003549. PMID: 36939075
Mezger NCS, Feuchtner J, Griesel M, Hämmerl L, Seraphin TP, Zietsman A, Péko JF, Tadesse F, Buziba NG, Wabinga H, Nyanchama M, Borok MZ, Kéita M, N'da G, Lorenzoni CF, Akele-Akpo MT, Gottschick C, Binder M, Mezger J, Jemal A, Parkin DM, Wickenhauser C, Kantelhardt EJ
Br J Haematol 2020 Jul;190(2):209-221. Epub 2020 Mar 17 doi: 10.1111/bjh.16575. PMID: 32181503
Kim YH, Bagot M, Pinter-Brown L, Rook AH, Porcu P, Horwitz SM, Whittaker S, Tokura Y, Vermeer M, Zinzani PL, Sokol L, Morris S, Kim EJ, Ortiz-Romero PL, Eradat H, Scarisbrick J, Tsianakas A, Elmets C, Dalle S, Fisher DC, Halwani A, Poligone B, Greer J, Fierro MT, Khot A, Moskowitz AJ, Musiek A, Shustov A, Pro B, Geskin LJ, Dwyer K, Moriya J, Leoni M, Humphrey JS, Hudgens S, Grebennik DO, Tobinai K, Duvic M; MAVORIC Investigators
Lancet Oncol 2018 Sep;19(9):1192-1204. Epub 2018 Aug 9 doi: 10.1016/S1470-2045(18)30379-6. PMID: 30100375
Zouhair A, Herrmann E, Ugurluer G, Gaye PM, Mirimanoff RO, Ozsahin M
Swiss Med Wkly 2010;140:w13076. Epub 2010 Sep 24 doi: 10.4414/smw.2010.13076. PMID: 20872294
Pfreundschuh M, Trümper L, Osterborg A, Pettengell R, Trneny M, Imrie K, Ma D, Gill D, Walewski J, Zinzani PL, Stahel R, Kvaloy S, Shpilberg O, Jaeger U, Hansen M, Lehtinen T, López-Guillermo A, Corrado C, Scheliga A, Milpied N, Mendila M, Rashford M, Kuhnt E, Loeffler M; MabThera International Trial Group
Lancet Oncol 2006 May;7(5):379-91. doi: 10.1016/S1470-2045(06)70664-7. PMID: 16648042

Prognosis

Varanese M, Lauro A, Lattina I, Tripodi D, Daralioti T, Khouzam S, Marino IR, Stigliano V, D'Andrea V, Frattaroli S, Sorrenti S
Dig Dis Sci 2022 May;67(5):1733-1738. Epub 2022 Apr 8 doi: 10.1007/s10620-022-07498-5. PMID: 35394594
Breen CT, Chao J, Mehra S, Kohli N
Ann Otol Rhinol Laryngol 2022 Apr;131(4):412-419. Epub 2021 Jun 17 doi: 10.1177/00034894211025171. PMID: 34137303
Zouhair A, Herrmann E, Ugurluer G, Gaye PM, Mirimanoff RO, Ozsahin M
Swiss Med Wkly 2010;140:w13076. Epub 2010 Sep 24 doi: 10.4414/smw.2010.13076. PMID: 20872294
Vural F, Cagirgan S, Saydam G, Hekimgil M, Soyer NA, Tombuloglu M
J Natl Med Assoc 2007 Nov;99(11):1277-82. PMID: 18020104Free PMC Article
Pfreundschuh M, Trümper L, Osterborg A, Pettengell R, Trneny M, Imrie K, Ma D, Gill D, Walewski J, Zinzani PL, Stahel R, Kvaloy S, Shpilberg O, Jaeger U, Hansen M, Lehtinen T, López-Guillermo A, Corrado C, Scheliga A, Milpied N, Mendila M, Rashford M, Kuhnt E, Loeffler M; MabThera International Trial Group
Lancet Oncol 2006 May;7(5):379-91. doi: 10.1016/S1470-2045(06)70664-7. PMID: 16648042

Clinical prediction guides

Vargas JC, Marques MO, Pereira J, Braga WMT, Hamerschlak N, Tabacof J, Ferreira PRA, Colleoni GWB, Baiocchi OCG
AIDS 2023 Jul 1;37(8):1217-1226. Epub 2023 Mar 17 doi: 10.1097/QAD.0000000000003549. PMID: 36939075
Mezger NCS, Feuchtner J, Griesel M, Hämmerl L, Seraphin TP, Zietsman A, Péko JF, Tadesse F, Buziba NG, Wabinga H, Nyanchama M, Borok MZ, Kéita M, N'da G, Lorenzoni CF, Akele-Akpo MT, Gottschick C, Binder M, Mezger J, Jemal A, Parkin DM, Wickenhauser C, Kantelhardt EJ
Br J Haematol 2020 Jul;190(2):209-221. Epub 2020 Mar 17 doi: 10.1111/bjh.16575. PMID: 32181503
Kim YH, Bagot M, Pinter-Brown L, Rook AH, Porcu P, Horwitz SM, Whittaker S, Tokura Y, Vermeer M, Zinzani PL, Sokol L, Morris S, Kim EJ, Ortiz-Romero PL, Eradat H, Scarisbrick J, Tsianakas A, Elmets C, Dalle S, Fisher DC, Halwani A, Poligone B, Greer J, Fierro MT, Khot A, Moskowitz AJ, Musiek A, Shustov A, Pro B, Geskin LJ, Dwyer K, Moriya J, Leoni M, Humphrey JS, Hudgens S, Grebennik DO, Tobinai K, Duvic M; MAVORIC Investigators
Lancet Oncol 2018 Sep;19(9):1192-1204. Epub 2018 Aug 9 doi: 10.1016/S1470-2045(18)30379-6. PMID: 30100375
Ferreri AJ, Govi S, Pileri SA, Savage KJ
Crit Rev Oncol Hematol 2013 Feb;85(2):206-15. Epub 2012 Jul 11 doi: 10.1016/j.critrevonc.2012.06.004. PMID: 22789917
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393

Recent systematic reviews

Miller SD, Lozano-Ortega G, Mutebi A, Briggs O, Sail K, Elliott B, Kalsekar A
J Comp Eff Res 2023 Jan;12(1):e220146. Epub 2022 Nov 23 doi: 10.2217/cer-2022-0146. PMID: 36417238Free PMC Article
Monga N, Garside J, Quigley J, Hudson M, O'Donovan P, O'Rourke J, Tapprich C, Parisi L, Davids MS, Tam C
Curr Med Res Opin 2020 May;36(5):843-852. Epub 2020 Mar 31 doi: 10.1080/03007995.2020.1742101. PMID: 32162977
Brown DN, Wieser I, Wang C, Dabaja BS, Duvic M
J Am Acad Dermatol 2015 Dec;73(6):976-86. Epub 2015 Oct 21 doi: 10.1016/j.jaad.2015.09.017. PMID: 26476898
Arden-Close E, Pacey A, Eiser C
Leuk Lymphoma 2010 Apr;51(4):628-40. doi: 10.3109/10428191003587263. PMID: 20218810
Zullo A, Hassan C, Andriani A, Cristofari F, Cardinale V, Spinelli GP, Tomao S, Morini S
J Clin Gastroenterol 2010 May-Jun;44(5):340-4. doi: 10.1097/MCG.0b013e3181b4b1ab. PMID: 19745757

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