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Lower Gingival Squamous Cell Carcinoma

MedGen UID:
76090
•Concept ID:
C0280303
•
Neoplastic Process
Synonyms: Lower Gingival SCC; Lower Gum SCC; Lower Gum Squamous Cell Carcinoma; SCC of Lower Gingiva; SCC of Lower Gum; SCC of the Lower Gingiva; SCC of the Lower Gum; Squamous Cell Carcinoma of Lower Gingiva; Squamous Cell Carcinoma of Lower Gum; Squamous Cell Carcinoma of the Lower Gingiva; Squamous Cell Carcinoma of the Lower Gum

Definition

A squamous cell carcinoma of the oral cavity that arises from the lower gingiva. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLower Gingival Squamous Cell Carcinoma

Professional guidelines

PubMed

Outcome and treatment toxicity in east-indian versus white-canadian patients with oral cavity cancer following postoperative (chemo-)radiotherapy delivered under similar multidisciplinary care: A propensity-matched cohort study.
Gudi S, O'Sullivan B, Hosni A, Su J, Hope A, Ringash J, Hueniken K, Liu G, Tong L, Goldstein D, de Almeida J, Hansen AR, Bratman SV, Cho J, Giuliani M, Hahn E, Kim J, Xu W, Waldron J, Huang SH
Oral Oncol 2021 Sep;120:105419. Epub 2021 Jun 25 doi: 10.1016/j.oraloncology.2021.105419. PMID: 34175612
Oral cancer: The first symptoms and reasons for delaying correct diagnosis and appropriate treatment.
Rutkowska M, Hnitecka S, Nahajowski M, Dominiak M, Gerber H
Adv Clin Exp Med 2020 Jun;29(6):735-743. doi: 10.17219/acem/116753. PMID: 32598579
Management of gingivobuccal complex cancer.
Misra S, Chaturvedi A, Misra NC
Ann R Coll Surg Engl 2008 Oct;90(7):546-53. Epub 2008 Aug 12 doi: 10.1308/003588408X301136. PMID: 18701010Free PMC Article

Recent clinical studies

Etiology

Prognostic value of a mandibular canal staging system for primary lesions in patients with lower gingival squamous cell carcinoma: a multicenter, retrospective study.
Yamakawa N, Okura M, Hasegawa T, Otsuru M, Sakai H, Hirai E, Rin S, Yamada SI, Yanamoto S, Yokota Y, Umeda M, Kurita H, Ueda M, Akashi M, Kirita T; Japan Oral Oncology Group (JOOG)
Int J Clin Oncol 2024 Aug;29(8):1122-1132. Epub 2024 May 2 doi: 10.1007/s10147-024-02542-y. PMID: 38696052
Evaluation of bone marrow invasion on the machine learning of 18 F-FDG PET texture analysis in lower gingival squamous cell carcinoma.
Fukushima Y, Suzuki K, Kim M, Gu W, Yokoo S, Tsushima Y
Nucl Med Commun 2024 May 1;45(5):406-411. Epub 2024 Feb 19 doi: 10.1097/MNM.0000000000001826. PMID: 38372047
Determination of diagnostic and predictive parameters for vertical mandibular invasion in patients with lower gingival squamous cell carcinoma: A retrospective study.
Shimizu T, Kim M, Palangka CRAP, Seki-Soda M, Ogawa M, Takayama Y, Yokoo S
Medicine (Baltimore) 2022 Dec 9;101(49):e32206. doi: 10.1097/MD.0000000000032206. PMID: 36626519Free PMC Article
Prognostic and staging implications of mandibular canal invasion in lower gingival squamous cell carcinoma.
Okura M, Yanamoto S, Umeda M, Otsuru M, Ota Y, Kurita H, Kamata T, Kirita T, Yamakawa N, Yamashita T, Ueda M, Komori T, Hasegawa T, Aikawa T; Japan Oral Oncology Group
Cancer Med 2016 Dec;5(12):3378-3385. Epub 2016 Oct 19 doi: 10.1002/cam4.899. PMID: 27758080Free PMC Article
Lower gingival carcinoma. Clinical and pathologic determinants of regional metastases.
Eicher SA, Overholt SM, el-Naggar AK, Byers RM, Weber RS
Arch Otolaryngol Head Neck Surg 1996 Jun;122(6):634-8. doi: 10.1001/archotol.1996.01890180042011. PMID: 8639295

Diagnosis

Evaluation of bone marrow invasion on the machine learning of 18 F-FDG PET texture analysis in lower gingival squamous cell carcinoma.
Fukushima Y, Suzuki K, Kim M, Gu W, Yokoo S, Tsushima Y
Nucl Med Commun 2024 May 1;45(5):406-411. Epub 2024 Feb 19 doi: 10.1097/MNM.0000000000001826. PMID: 38372047
Determination of diagnostic and predictive parameters for vertical mandibular invasion in patients with lower gingival squamous cell carcinoma: A retrospective study.
Shimizu T, Kim M, Palangka CRAP, Seki-Soda M, Ogawa M, Takayama Y, Yokoo S
Medicine (Baltimore) 2022 Dec 9;101(49):e32206. doi: 10.1097/MD.0000000000032206. PMID: 36626519Free PMC Article
Prognostic and staging implications of mandibular canal invasion in lower gingival squamous cell carcinoma.
Okura M, Yanamoto S, Umeda M, Otsuru M, Ota Y, Kurita H, Kamata T, Kirita T, Yamakawa N, Yamashita T, Ueda M, Komori T, Hasegawa T, Aikawa T; Japan Oral Oncology Group
Cancer Med 2016 Dec;5(12):3378-3385. Epub 2016 Oct 19 doi: 10.1002/cam4.899. PMID: 27758080Free PMC Article

Therapy

Selective apoptotic effect of Zelkova serrata twig extract on mouth epidermoid carcinoma through p53 activation.
Kang HJ, Jang YJ
Int J Oral Sci 2012 Jun;4(2):78-84. Epub 2012 Apr 13 doi: 10.1038/ijos.2012.14. PMID: 22498930Free PMC Article

Prognosis

Prognostic value of a mandibular canal staging system for primary lesions in patients with lower gingival squamous cell carcinoma: a multicenter, retrospective study.
Yamakawa N, Okura M, Hasegawa T, Otsuru M, Sakai H, Hirai E, Rin S, Yamada SI, Yanamoto S, Yokota Y, Umeda M, Kurita H, Ueda M, Akashi M, Kirita T; Japan Oral Oncology Group (JOOG)
Int J Clin Oncol 2024 Aug;29(8):1122-1132. Epub 2024 May 2 doi: 10.1007/s10147-024-02542-y. PMID: 38696052
Determination of diagnostic and predictive parameters for vertical mandibular invasion in patients with lower gingival squamous cell carcinoma: A retrospective study.
Shimizu T, Kim M, Palangka CRAP, Seki-Soda M, Ogawa M, Takayama Y, Yokoo S
Medicine (Baltimore) 2022 Dec 9;101(49):e32206. doi: 10.1097/MD.0000000000032206. PMID: 36626519Free PMC Article
Metastasis of lower gingival squamous cell carcinoma to buccinator lymph node: case report and review of the literature.
Takada K, Kuroshima T, Shimamoto H, Ohsako T, Kayamori K, Ikeda T, Harada H
World J Surg Oncol 2019 Jan 10;17(1):13. doi: 10.1186/s12957-019-1559-y. PMID: 30630467Free PMC Article
Prognostic and staging implications of mandibular canal invasion in lower gingival squamous cell carcinoma.
Okura M, Yanamoto S, Umeda M, Otsuru M, Ota Y, Kurita H, Kamata T, Kirita T, Yamakawa N, Yamashita T, Ueda M, Komori T, Hasegawa T, Aikawa T; Japan Oral Oncology Group
Cancer Med 2016 Dec;5(12):3378-3385. Epub 2016 Oct 19 doi: 10.1002/cam4.899. PMID: 27758080Free PMC Article
Lower gingival carcinoma. Clinical and pathologic determinants of regional metastases.
Eicher SA, Overholt SM, el-Naggar AK, Byers RM, Weber RS
Arch Otolaryngol Head Neck Surg 1996 Jun;122(6):634-8. doi: 10.1001/archotol.1996.01890180042011. PMID: 8639295

Clinical prediction guides

Evaluation of bone marrow invasion on the machine learning of 18 F-FDG PET texture analysis in lower gingival squamous cell carcinoma.
Fukushima Y, Suzuki K, Kim M, Gu W, Yokoo S, Tsushima Y
Nucl Med Commun 2024 May 1;45(5):406-411. Epub 2024 Feb 19 doi: 10.1097/MNM.0000000000001826. PMID: 38372047
Determination of diagnostic and predictive parameters for vertical mandibular invasion in patients with lower gingival squamous cell carcinoma: A retrospective study.
Shimizu T, Kim M, Palangka CRAP, Seki-Soda M, Ogawa M, Takayama Y, Yokoo S
Medicine (Baltimore) 2022 Dec 9;101(49):e32206. doi: 10.1097/MD.0000000000032206. PMID: 36626519Free PMC Article
What Is a Safe Distance for Preservation of the Inferior Alveolar Nerve in Lower Gingival Squamous Cell Carcinoma? A Radiographic and Histopathological Study.
Tabrizi R, Farahani Z, Barouj MD, Kheirkhahi M, Jafari M, Sadeghi HM
J Craniofac Surg 2019 Jun;30(4):e327-e330. doi: 10.1097/SCS.0000000000005280. PMID: 31166277
Prognostic and staging implications of mandibular canal invasion in lower gingival squamous cell carcinoma.
Okura M, Yanamoto S, Umeda M, Otsuru M, Ota Y, Kurita H, Kamata T, Kirita T, Yamakawa N, Yamashita T, Ueda M, Komori T, Hasegawa T, Aikawa T; Japan Oral Oncology Group
Cancer Med 2016 Dec;5(12):3378-3385. Epub 2016 Oct 19 doi: 10.1002/cam4.899. PMID: 27758080Free PMC Article
Selective apoptotic effect of Zelkova serrata twig extract on mouth epidermoid carcinoma through p53 activation.
Kang HJ, Jang YJ
Int J Oral Sci 2012 Jun;4(2):78-84. Epub 2012 Apr 13 doi: 10.1038/ijos.2012.14. PMID: 22498930Free PMC Article

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