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Oropharyngeal squamous cell carcinoma

MedGen UID:
76094
Concept ID:
C0280313
Neoplastic Process
Synonym: Oropharynx squamous cell carcinoma
SNOMED CT: Squamous cell carcinoma of oropharynx (423464009); Primary squamous cell carcinoma of oropharynx (707585008); Cancer of oropharynx, squamous cell (423464009)
 
HPO: HP:0012182
Monarch Initiative: MONDO:0044704
Orphanet: ORPHA500478

Definition

A squamous cell carcinoma that originates in the oropharnyx. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOropharyngeal squamous cell carcinoma

Conditions with this feature

Dyskeratosis congenita, X-linked
MedGen UID:
216941
Concept ID:
C1148551
Disease or Syndrome
Dyskeratosis congenita and related telomere biology disorders (DC/TBD) are caused by impaired telomere maintenance resulting in short or very short telomeres. The phenotypic spectrum of telomere biology disorders is broad and includes individuals with classic dyskeratosis congenita (DC) as well as those with very short telomeres and an isolated physical finding. Classic DC is characterized by a triad of dysplastic nails, lacy reticular pigmentation of the upper chest and/or neck, and oral leukoplakia, although this may not be present in all individuals. People with DC/TBD are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome or acute myelogenous leukemia, solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis. Other findings can include eye abnormalities (epiphora, blepharitis, sparse eyelashes, ectropion, entropion, trichiasis), taurodontism, liver disease, gastrointestinal telangiectasias, and avascular necrosis of the hips or shoulders. Although most persons with DC/TBD have normal psychomotor development and normal neurologic function, significant developmental delay is present in both forms; additional findings include cerebellar hypoplasia (Hoyeraal Hreidarsson syndrome) and bilateral exudative retinopathy and intracranial calcifications (Revesz syndrome and Coats plus syndrome). Onset and progression of manifestations of DC/TBD vary: at the mild end of the spectrum are those who have only minimal physical findings with normal bone marrow function, and at the severe end are those who have the diagnostic triad and early-onset BMF.
Melanoma-pancreatic cancer syndrome
MedGen UID:
325450
Concept ID:
C1838547
Disease or Syndrome
Melanoma-pancreatic cancer syndrome is an inherited cancer predisposition syndrome in which mutation carriers have an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer (summary by Harinck et al., 2012). For background and phenotypic information on malignant melanoma and pancreatic cancer, see 155600 and 260350, respectively.
Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome
MedGen UID:
482833
Concept ID:
C3281203
Neoplastic Process
Patients with this syndrome develop cutaneous telangiectases in infancy with patchy alopecia over areas of affected skin, thinning of the lateral eyebrows, and mild dental and nail anomalies. Affected individuals are at increased risk of developing oropharyngeal cancer, and other malignancies have been reported as well (Tanaka et al., 2012).

Professional guidelines

PubMed

Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Grégoire V, Giraud P, Vieillevigne L, Maingon P
Cancer Radiother 2022 Feb-Apr;26(1-2):174-188. Epub 2021 Dec 22 doi: 10.1016/j.canrad.2021.10.002. PMID: 34953693
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article

Curated

NCCN, Head and Neck, 2.2022

Recent clinical studies

Etiology

Cleary RK, Cmelak AJ
J Glob Oncol 2018 Sep;4:1-9. Epub 2016 Nov 9 doi: 10.1200/JGO.2016.006304. PMID: 30241193Free PMC Article
Clump DA, Bauman JE, Ferris RL
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Hübbers CU, Akgül B
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Marur S, Burtness B
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Genden EM, Sambur IM, de Almeida JR, Posner M, Rinaldo A, Rodrigo JP, Strojan P, Takes RP, Ferlito A
Eur Arch Otorhinolaryngol 2013 Feb;270(2):405-16. Epub 2012 Jun 30 doi: 10.1007/s00405-012-2086-4. PMID: 22752642

Diagnosis

Ferris RL, Westra W
Annu Rev Pathol 2023 Jan 24;18:515-535. doi: 10.1146/annurev-pathmechdis-031521-041424. PMID: 36693202
Li R, Xiao L, Gong T, Liu J, Li Y, Zhou X, Li Y, Zheng X
Mol Oral Microbiol 2023 Feb;38(1):9-22. Epub 2022 Dec 10 doi: 10.1111/omi.12403. PMID: 36420924
Ilhan B, Lin K, Guneri P, Wilder-Smith P
J Dent Res 2020 Mar;99(3):241-248. doi: 10.1177/0022034520902128. PMID: 32077795Free PMC Article
Parvathaneni U, Lavertu P, Gibson MK, Glastonbury CM
Radiographics 2019 Nov-Dec;39(7):2055-2068. Epub 2019 Oct 11 doi: 10.1148/rg.2019190007. PMID: 31603733
Psyrri A, Prezas L, Burtness B
Clin Adv Hematol Oncol 2008 Aug;6(8):604-12. PMID: 18820604

Therapy

Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC
JAMA Oncol 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. PMID: 35482348Free PMC Article
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT
J Clin Oncol 2021 Mar 20;39(9):956-965. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03128. PMID: 33507809Free PMC Article
Nichols AC, Theurer J, Prisman E, Read N, Berthelet E, Tran E, Fung K, de Almeida JR, Bayley A, Goldstein DP, Hier M, Sultanem K, Richardson K, Mlynarek A, Krishnan S, Le H, Yoo J, MacNeil SD, Winquist E, Hammond JA, Venkatesan V, Kuruvilla S, Warner A, Mitchell S, Chen J, Corsten M, Johnson-Obaseki S, Eapen L, Odell M, Parker C, Wehrli B, Kwan K, Palma DA
Lancet Oncol 2019 Oct;20(10):1349-1359. Epub 2019 Aug 12 doi: 10.1016/S1470-2045(19)30410-3. PMID: 31416685
Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, Westra WH, Chung CH, Jordan RC, Lu C, Kim H, Axelrod R, Silverman CC, Redmond KP, Gillison ML
N Engl J Med 2010 Jul 1;363(1):24-35. Epub 2010 Jun 7 doi: 10.1056/NEJMoa0912217. PMID: 20530316Free PMC Article

Prognosis

Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT
J Clin Oncol 2021 Mar 20;39(9):956-965. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03128. PMID: 33507809Free PMC Article
Panarese I, Aquino G, Ronchi A, Longo F, Montella M, Cozzolino I, Roccuzzo G, Colella G, Caraglia M, Franco R
Expert Rev Anticancer Ther 2019 Feb;19(2):105-119. Epub 2019 Jan 15 doi: 10.1080/14737140.2019.1561288. PMID: 30582397
Duprez F, Berwouts D, De Neve W, Bonte K, Boterberg T, Deron P, Huvenne W, Rottey S, Mareel M
Head Neck 2017 Sep;39(9):1733-1743. Epub 2017 Jun 26 doi: 10.1002/hed.24687. PMID: 28650113
Chi AC, Day TA, Neville BW
CA Cancer J Clin 2015 Sep-Oct;65(5):401-21. Epub 2015 Jul 27 doi: 10.3322/caac.21293. PMID: 26215712
Clump DA, Bauman JE, Ferris RL
Surg Oncol Clin N Am 2015 Jul;24(3):509-20. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.014. PMID: 25979397

Clinical prediction guides

Woods RSR, Callanan D, Jawad H, Molony P, Werner R, Heffron C, Feeley L, Sheahan P
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1435-1443. Epub 2021 May 27 doi: 10.1007/s00405-021-06894-3. PMID: 34046748
Berdugo J, Rooper LM, Chiosea SI
Head Neck Pathol 2021 Dec;15(4):1109-1118. Epub 2021 Apr 8 doi: 10.1007/s12105-021-01317-5. PMID: 33830464Free PMC Article
Nichols AC, Theurer J, Prisman E, Read N, Berthelet E, Tran E, Fung K, de Almeida JR, Bayley A, Goldstein DP, Hier M, Sultanem K, Richardson K, Mlynarek A, Krishnan S, Le H, Yoo J, MacNeil SD, Winquist E, Hammond JA, Venkatesan V, Kuruvilla S, Warner A, Mitchell S, Chen J, Corsten M, Johnson-Obaseki S, Eapen L, Odell M, Parker C, Wehrli B, Kwan K, Palma DA
Lancet Oncol 2019 Oct;20(10):1349-1359. Epub 2019 Aug 12 doi: 10.1016/S1470-2045(19)30410-3. PMID: 31416685
Panarese I, Aquino G, Ronchi A, Longo F, Montella M, Cozzolino I, Roccuzzo G, Colella G, Caraglia M, Franco R
Expert Rev Anticancer Ther 2019 Feb;19(2):105-119. Epub 2019 Jan 15 doi: 10.1080/14737140.2019.1561288. PMID: 30582397
Dalianis T
Presse Med 2014 Dec;43(12 Pt 2):e429-34. Epub 2014 Nov 11 doi: 10.1016/j.lpm.2014.08.010. PMID: 25455638

Recent systematic reviews

Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Maria de França G, Andrade ACM, Felix FA, da Silva WR, Almeida DRMF, Leite RB, Galvão HC, Miguel MCDC
Arch Oral Biol 2021 Nov;131:105267. Epub 2021 Sep 20 doi: 10.1016/j.archoralbio.2021.105267. PMID: 34592489
Kao SS, Ooi EH
J Laryngol Otol 2018 Apr;132(4):299-313. Epub 2017 May 15 doi: 10.1017/S0022215117000998. PMID: 28502256
De Santis S, Spinosi MC, Cambi J, Bengala C, Boccuzzi S
J Stomatol Oral Maxillofac Surg 2017 Apr;118(2):103-108. Epub 2017 Feb 24 doi: 10.1016/j.jormas.2017.02.004. PMID: 28345518
Sedghizadeh PP, Billington WD, Paxton D, Ebeed R, Mahabady S, Clark GT, Enciso R
Oral Oncol 2016 Mar;54:15-27. Epub 2016 Jan 18 doi: 10.1016/j.oraloncology.2016.01.002. PMID: 26794879

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