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Poor Prognosis Metastatic Gestational Trophoblastic Tumor

MedGen UID:
76117
•Concept ID:
C0280481
•
Neoplastic Process

Definition

Metastatic gestational trophoblastic tumor in which risk factors are present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoor Prognosis Metastatic Gestational Trophoblastic Tumor

Professional guidelines

PubMed

Surgical treatment of lung metastasis in patients with refractory gestational trophoblastic neoplasia: A retrospective study.
Zhao L, Qin Y, Ma D, Liu H
Gynecol Oncol 2022 Oct;167(1):37-41. Epub 2022 Aug 3 doi: 10.1016/j.ygyno.2022.07.030. PMID: 35931469
A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor.
Burkett WC, Soper JT
Obstet Gynecol Surv 2022 Feb;77(2):101-110. doi: 10.1097/OGX.0000000000000978. PMID: 35201361
Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2019 Jun;153(3):684-693. Epub 2019 Apr 30 doi: 10.1016/j.ygyno.2019.03.011. PMID: 31047719

Recent clinical studies

Etiology

Morbidity, mortality, and prognostic factors in gestational trophoblastic neoplasia with liver metastasis.
Raffin D, Descargues P, Hajri T, Massardier J, You B, Lotz JP, Rousset P, Tordo J, Devouassoux-Shisheboran M, Golfier F, Bolze PA
J Gynecol Obstet Hum Reprod 2023 Oct;52(8):102636. Epub 2023 Jul 25 doi: 10.1016/j.jogoh.2023.102636. PMID: 37500013
Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor.
Burkett WC, Soper JT
Obstet Gynecol Surv 2022 Feb;77(2):101-110. doi: 10.1097/OGX.0000000000000978. PMID: 35201361
Effectiveness of craniotomy and long-term survival in 35 patients with gestational trophoblastic neoplasia with brain metastases: a clinical retrospective analysis.
Li Y, Wang W, Wan X, Feng F, He YL, Yang J, Xiang Y
J Gynecol Oncol 2022 May;33(3):e33. Epub 2022 Jan 21 doi: 10.3802/jgo.2022.33.e33. PMID: 35128861Free PMC Article
Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2019 Jun;153(3):684-693. Epub 2019 Apr 30 doi: 10.1016/j.ygyno.2019.03.011. PMID: 31047719

Diagnosis

Intestinal metastasis from choriocarcinoma: a case series and literature review.
Wang Y, Wang Z, Zhu X, Wan Q, Han P, Ying J, Qian J
World J Surg Oncol 2022 Jun 1;20(1):173. doi: 10.1186/s12957-022-02623-0. PMID: 35650620Free PMC Article
Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor.
Burkett WC, Soper JT
Obstet Gynecol Surv 2022 Feb;77(2):101-110. doi: 10.1097/OGX.0000000000000978. PMID: 35201361
Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2019 Jun;153(3):684-693. Epub 2019 Apr 30 doi: 10.1016/j.ygyno.2019.03.011. PMID: 31047719
Poor-prognosis metastatic gestational trophoblastic neoplasia.
Hammond CB, Soper JT
Clin Obstet Gynecol 1984 Mar;27(1):228-39. doi: 10.1097/00003081-198403000-00030. PMID: 6323081

Therapy

Surgical treatment of lung metastasis in patients with refractory gestational trophoblastic neoplasia: A retrospective study.
Zhao L, Qin Y, Ma D, Liu H
Gynecol Oncol 2022 Oct;167(1):37-41. Epub 2022 Aug 3 doi: 10.1016/j.ygyno.2022.07.030. PMID: 35931469
Effectiveness of craniotomy and long-term survival in 35 patients with gestational trophoblastic neoplasia with brain metastases: a clinical retrospective analysis.
Li Y, Wang W, Wan X, Feng F, He YL, Yang J, Xiang Y
J Gynecol Oncol 2022 May;33(3):e33. Epub 2022 Jan 21 doi: 10.3802/jgo.2022.33.e33. PMID: 35128861Free PMC Article
Primary colon adenocarcinoma with choriocarcinoma differentiation: a case report and review of the literature.
Boyce J, Tawagi K, Cole JT
J Med Case Rep 2020 Nov 16;14(1):220. doi: 10.1186/s13256-020-02544-0. PMID: 33190644Free PMC Article
Placental site trophoblastic tumor presenting as subaponeurotic metastasis.
Aoki Y, Kase H, Kashima K, Yahata T, Tanaka K
Int J Gynecol Cancer 2005 Mar-Apr;15(2):385-8. doi: 10.1111/j.1525-1438.2005.15235.x. PMID: 15823131
Poor-prognosis metastatic gestational trophoblastic neoplasia.
Hammond CB, Soper JT
Clin Obstet Gynecol 1984 Mar;27(1):228-39. doi: 10.1097/00003081-198403000-00030. PMID: 6323081

Prognosis

Morbidity, mortality, and prognostic factors in gestational trophoblastic neoplasia with liver metastasis.
Raffin D, Descargues P, Hajri T, Massardier J, You B, Lotz JP, Rousset P, Tordo J, Devouassoux-Shisheboran M, Golfier F, Bolze PA
J Gynecol Obstet Hum Reprod 2023 Oct;52(8):102636. Epub 2023 Jul 25 doi: 10.1016/j.jogoh.2023.102636. PMID: 37500013
Intestinal metastasis from choriocarcinoma: a case series and literature review.
Wang Y, Wang Z, Zhu X, Wan Q, Han P, Ying J, Qian J
World J Surg Oncol 2022 Jun 1;20(1):173. doi: 10.1186/s12957-022-02623-0. PMID: 35650620Free PMC Article
Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor.
Burkett WC, Soper JT
Obstet Gynecol Surv 2022 Feb;77(2):101-110. doi: 10.1097/OGX.0000000000000978. PMID: 35201361
Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2019 Jun;153(3):684-693. Epub 2019 Apr 30 doi: 10.1016/j.ygyno.2019.03.011. PMID: 31047719

Clinical prediction guides

Surgical treatment of lung metastasis in patients with refractory gestational trophoblastic neoplasia: A retrospective study.
Zhao L, Qin Y, Ma D, Liu H
Gynecol Oncol 2022 Oct;167(1):37-41. Epub 2022 Aug 3 doi: 10.1016/j.ygyno.2022.07.030. PMID: 35931469
Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor.
Burkett WC, Soper JT
Obstet Gynecol Surv 2022 Feb;77(2):101-110. doi: 10.1097/OGX.0000000000000978. PMID: 35201361
Placental Site Trophoblastic Tumor: A Distinct Entity of Gestational Trophoblastic Disease Experience from a Tertiary Referral Center in Hong Kong.
Chu MMY, Tse KY, Chan KKL, Cheung ANY, Ngan HYS
J Reprod Med 2016 Aug;61(7-8):351-356. PMID: 30408381
Gestational trophoblastic disease metastatic to the central nervous system.
Evans AC Jr, Soper JT, Clarke-Pearson DL, Berchuck A, Rodriguez GC, Hammond CB
Gynecol Oncol 1995 Nov;59(2):226-30. doi: 10.1006/gyno.1995.0013. PMID: 7590478

Recent systematic reviews

Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2019 Jun;153(3):684-693. Epub 2019 Apr 30 doi: 10.1016/j.ygyno.2019.03.011. PMID: 31047719

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