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Drug rash with eosinophilia and systemic symptoms

MedGen UID:
762193
Concept ID:
C3541994
Disease or Syndrome
Synonyms: DRESS Syndrome; DRESS Syndromes; Drug Hypersensitivity Syndrome; Drug Hypersensitivity Syndromes; Drug Reaction With Eosinophilia And Systemic Symptom; Drug Reaction with Eosinophilia and Systemic Symptoms; Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome; Hypersensitivity Syndrome, Drug; Hypersensitivity Syndromes, Drug; Syndrome, Drug Hypersensitivity; Syndromes, Drug Hypersensitivity
SNOMED CT: DRESS syndrome (702809001); Drug reaction with eosinophilia and systemic symptoms (702809001); Drug rash with eosinophilia and systemic symptoms (702809001); Drug-induced hypersensitivity syndrome (702809001); Anticonvulsant hypersensitivity syndrome (702809001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0015340; MONDO:0044876
Orphanet: ORPHA139402

Definition

A drug hypersensitivity reaction with a relatively long latency period after exposure characterised by rash, fever, lymphadenopathy, haematologic abnormalities including eosinophilia and atypical lymphocytosis and internal organ involvement. Clinical presentation is highly variable. Eosinophilia is present in 50-90% of cases. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDrug rash with eosinophilia and systemic symptoms

Professional guidelines

PubMed

Kozubek P, Wołoszczak J, Gomułka K
Int J Mol Sci 2023 Jul 9;24(14) doi: 10.3390/ijms241411257. PMID: 37511017Free PMC Article
Nadelmann ER, Yeh JE, Chen ST
JAMA Oncol 2022 Jan 1;8(1):130-138. doi: 10.1001/jamaoncol.2021.4318. PMID: 34709352
Strzelczyk A, Mann C, Willems LM, Rosenow F, Bauer S
Expert Opin Pharmacother 2020 Dec;21(18):2215-2223. Epub 2020 Aug 19 doi: 10.1080/14656566.2020.1803830. PMID: 32812825

Recent clinical studies

Etiology

Sandhu S, Neema S, Vashisht D, Venugopal R, Sengupta P, Radhakrishnan S
Dermatol Ther 2021 Jan;34(1):e14670. Epub 2020 Dec 23 doi: 10.1111/dth.14670. PMID: 33314590
Strzelczyk A, Mann C, Willems LM, Rosenow F, Bauer S
Expert Opin Pharmacother 2020 Dec;21(18):2215-2223. Epub 2020 Aug 19 doi: 10.1080/14656566.2020.1803830. PMID: 32812825
Pichler WJ, Srinoulprasert Y, Yun J, Hausmann O
Int Arch Allergy Immunol 2017;172(3):129-138. Epub 2017 Mar 18 doi: 10.1159/000458725. PMID: 28315874Free PMC Article
Cacoub P, Descamps V, Meyer O, Speirs C, Belissa-Mathiot P, Musette P
Osteoporos Int 2013 May;24(5):1751-7. Epub 2013 Jan 30 doi: 10.1007/s00198-013-2265-1. PMID: 23361875
Markel A
Isr Med Assoc J 2005 Oct;7(10):656-60. PMID: 16259349

Diagnosis

Barbaud A, Romano A
Immunol Allergy Clin North Am 2022 May;42(2):307-322. Epub 2022 Mar 31 doi: 10.1016/j.iac.2022.01.003. PMID: 35469620
Dilley M, Geng B
Clin Rev Allergy Immunol 2022 Jun;62(3):463-475. Epub 2021 Dec 15 doi: 10.1007/s12016-021-08878-x. PMID: 34910281Free PMC Article
Isaacs M, Cardones AR, Rahnama-Moghadam S
Cutis 2018 Nov;102(5):322-326. PMID: 30566546
Min Z, Garcia RR, Murillo M, Uchin JM, Bhanot N
J Infect Chemother 2017 Mar;23(3):180-184. Epub 2016 Sep 25 doi: 10.1016/j.jiac.2016.08.012. PMID: 27681233
Markel A
Isr Med Assoc J 2005 Oct;7(10):656-60. PMID: 16259349

Therapy

Dilley M, Geng B
Clin Rev Allergy Immunol 2022 Jun;62(3):463-475. Epub 2021 Dec 15 doi: 10.1007/s12016-021-08878-x. PMID: 34910281Free PMC Article
Nadelmann ER, Yeh JE, Chen ST
JAMA Oncol 2022 Jan 1;8(1):130-138. doi: 10.1001/jamaoncol.2021.4318. PMID: 34709352
Strzelczyk A, Mann C, Willems LM, Rosenow F, Bauer S
Expert Opin Pharmacother 2020 Dec;21(18):2215-2223. Epub 2020 Aug 19 doi: 10.1080/14656566.2020.1803830. PMID: 32812825
Min Z, Garcia RR, Murillo M, Uchin JM, Bhanot N
J Infect Chemother 2017 Mar;23(3):180-184. Epub 2016 Sep 25 doi: 10.1016/j.jiac.2016.08.012. PMID: 27681233
Markel A
Isr Med Assoc J 2005 Oct;7(10):656-60. PMID: 16259349

Prognosis

Aihara M
J Dermatol 2011 Mar;38(3):246-54. doi: 10.1111/j.1346-8138.2010.01196.x. PMID: 21342226
Musette P, Brandi ML, Cacoub P, Kaufman JM, Rizzoli R, Reginster JY
Osteoporos Int 2010 May;21(5):723-32. Epub 2009 Nov 17 doi: 10.1007/s00198-009-1097-5. PMID: 19921087
Chiou CC, Yang LC, Hung SI, Chang YC, Kuo TT, Ho HC, Hu S, Hong HS, Chung WH
J Eur Acad Dermatol Venereol 2008 Sep;22(9):1044-9. Epub 2008 Jul 4 doi: 10.1111/j.1468-3083.2008.02585.x. PMID: 18627428
Tas S, Simonart T
Dermatology 2003;206(4):353-6. doi: 10.1159/000069956. PMID: 12771485
Bocquet H, Bagot M, Roujeau JC
Semin Cutan Med Surg 1996 Dec;15(4):250-7. doi: 10.1016/s1085-5629(96)80038-1. PMID: 9069593

Clinical prediction guides

Mitamura Y, Schulz D, Oro S, Li N, Kolm I, Lang C, Ziadlou R, Tan G, Bodenmiller B, Steiger P, Marzano A, de Prost N, Caudin O, Levesque M, Stoffel C, Schmid-Grendelmeier P, Maverakis E, Akdis CA, Brüggen MC
Allergy 2022 Feb;77(2):595-608. Epub 2021 Jul 19 doi: 10.1111/all.14983. PMID: 34157151Free PMC Article
Sandhu S, Neema S, Vashisht D, Venugopal R, Sengupta P, Radhakrishnan S
Dermatol Ther 2021 Jan;34(1):e14670. Epub 2020 Dec 23 doi: 10.1111/dth.14670. PMID: 33314590
Strzelczyk A, Mann C, Willems LM, Rosenow F, Bauer S
Expert Opin Pharmacother 2020 Dec;21(18):2215-2223. Epub 2020 Aug 19 doi: 10.1080/14656566.2020.1803830. PMID: 32812825
Cacoub P, Descamps V, Meyer O, Speirs C, Belissa-Mathiot P, Musette P
Osteoporos Int 2013 May;24(5):1751-7. Epub 2013 Jan 30 doi: 10.1007/s00198-013-2265-1. PMID: 23361875
Musette P, Brandi ML, Cacoub P, Kaufman JM, Rizzoli R, Reginster JY
Osteoporos Int 2010 May;21(5):723-32. Epub 2009 Nov 17 doi: 10.1007/s00198-009-1097-5. PMID: 19921087

Recent systematic reviews

Zhu H, Ren V
J Cutan Med Surg 2023 Jul-Aug;27(4):388-398. Epub 2023 May 25 doi: 10.1177/12034754231177590. PMID: 37231539Free PMC Article
Nadelmann ER, Yeh JE, Chen ST
JAMA Oncol 2022 Jan 1;8(1):130-138. doi: 10.1001/jamaoncol.2021.4318. PMID: 34709352
Zuber M, Harikrishna, Vidhyashree, Chhabra M, Venkataraman R, Kumar S, Rashid M
J Basic Clin Physiol Pharmacol 2022 Sep 1;33(5):549-565. Epub 2021 Oct 27 doi: 10.1515/jbcpp-2021-0165. PMID: 34706401
Kashyap A, Sreenivasan S, Rajan AK, Rashid M, Chhabra M
J Basic Clin Physiol Pharmacol 2021 Mar 16;33(3):327-346. doi: 10.1515/jbcpp-2020-0115. PMID: 33725760
Bommersbach TJ, Lapid MI, Leung JG, Cunningham JL, Rummans TA, Kung S
Mayo Clin Proc 2016 Jun;91(6):787-801. Epub 2016 Apr 25 doi: 10.1016/j.mayocp.2016.03.006. PMID: 27126302

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