Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

In situ carcinoma

MedGen UID:: 763
•Concept ID:: C0007099
•: Neoplastic Process

Synonyms:	Carcinoma in Situ; Carcinoma, Intraepithelial; Carcinoma, Preinvasive; Intraepithelial Carcinoma; Preinvasive Carcinoma
SNOMED CT:	Carcinoma in situ (109355002); Cancer in situ (109355002); Non-invasive carcinoma (1187138006); Intraepithelial carcinoma (1187138006); Carcinoma in situ (1187138006)

Monarch Initiative:	MONDO:0004647

Definition

A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIn situ carcinoma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Epithelial neoplasm
        Carcinoma
        In situ carcinoma
        Adenocarcinoma in situ
        Adenocarcinoma In Situ in a Polyp
        Adenocarcinoma In Situ in Adenomatous Polyp
        High grade glandular intraepithelial neoplasia
        Ampullary Flat Intraepithelial Neoplasia, High Grade
        Appendix High Grade Intraepithelial Neoplasia
        Cervical Adenocarcinoma In Situ
        Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8
        Clinical Stage 0 Gastroesophageal Junction Adenocarcinoma AJCC v8
        Colorectal High Grade Intraepithelial Neoplasia
        Ductal breast carcinoma in situ and lobular carcinoma in situ
        Ductal carcinoma in situ
        Grade II Glandular Intraepithelial Neoplasia
        Grade III prostatic intraepithelial neoplasia
        High Grade Cervical Glandular Intraepithelial Neoplasia
        High Grade Esophageal Glandular Intraepithelial Neoplasia
        High Grade Gastric Intraepithelial Neoplasia
        High Grade Pancreatic Intraepithelial Neoplasia
        High Grade Prostatic Intraepithelial Neoplasia
        High-Grade Biliary Intraepithelial Neoplasia
        Lobular carcinoma in situ
        Pathologic Stage 0 Esophageal Adenocarcinoma AJCC v8
        Pathologic Stage 0 Gastroesophageal Junction Adenocarcinoma AJCC v8
        Small Intestinal High Grade Intraepithelial Neoplasia
        Stage 0 Esophageal Adenocarcinoma AJCC v7
        Stage 0 Fallopian Tube Cancer AJCC v7
        Lung adenocarcinoma in situ
        Lung Mucinous Adenocarcinoma In Situ
        Lung Non-Mucinous Adenocarcinoma In Situ
        Stage 0 Bladder Adenocarcinoma AJCC v6 and v7
        Stage 0 Lung Adenocarcinoma AJCC v6 and v7
        Stage 0 Pancreatic Cancer AJCC v6 and v7
        Stage 0 Pancreatic Cancer AJCC v8
        Stage 0 Small Intestinal Adenocarcinoma AJCC v8
        Anatomic Stage 0 Breast Cancer AJCC v8
        Bladder flat intraepithelial lesion
        Stage 0is Bladder Cancer AJCC v8
        Stage 0is Bladder Urothelial Carcinoma AJCC v6 and v7
        Breast carcinoma in situ
        Mammary Paget disease
        Breast Paget Disease with Invasive Ductal Carcinoma
        Breast Paget Disease without Invasive Carcinoma
        Paget disease of the nipple
        Recurrent Breast Paget Disease
        Carcinoma In Situ in a Polyp
        Cervical intraepithelial neoplasia
        Cervical Glandular Intraepithelial Neoplasia
        Low Grade Cervical Glandular Intraepithelial Neoplasia
        Cervical squamous intraepithelial neoplasia
        High Grade Cervical Squamous Intraepithelial Neoplasia
        Low Grade Cervical Squamous Intraepithelial Neoplasia
        High Grade Cervical Intraepithelial Neoplasia
        Cervical intraepithelial neoplasia grade 2/3
        Stage 0 Cervical Cancer AJCC v6
        Stage 0 Cervical Cancer AJCC v7
        Low Grade Cervical Intraepithelial Neoplasia
        Digestive System Carcinoma In Situ
        Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8
        Clinical Stage 0 Gastric Cancer AJCC v8
        Pathologic Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8
        Pathologic Stage 0 Gastric Cancer AJCC v8
        Stage 0 Ampulla of Vater Cancer AJCC v7
        Stage 0 Ampulla of Vater Cancer AJCC v8
        Stage 0 Anal Canal Cancer AJCC v6 and v7
        Stage 0 AIDS-Related Anal Canal Cancer AJCC v6 and v7
        Stage 0 Anal Cancer AJCC v8
        Anal Intraepithelial Neoplasia 3
        Stage 0 Appendix Carcinoma AJCC v7
        Stage 0 Appendix Carcinoma AJCC v8
        Stage 0 Colorectal Cancer AJCC v6 and v7
        Stage 0 Colon Cancer AJCC v6 and v7
        Stage 0 Rectal Cancer AJCC v6 and v7
        Stage 0 Rectosigmoid Cancer AJCC v6 and v7
        Stage 0 Colorectal Cancer AJCC v8
        Stage 0 Colon Cancer AJCC v8
        Stage 0 Rectal Cancer AJCC v8
        Stage 0 Esophageal Cancer AJCC v6
        Stage 0 Esophageal Cancer AJCC v7
        Stage 0 Esophageal Squamous Cell Carcinoma AJCC v7
        Stage 0 Gallbladder Cancer AJCC v6 and v7
        Stage 0 Gallbladder Cancer AJCC v8
        Stage 0 Gastric Cancer AJCC v6 and v7
        Gastric Body Carcinoma In Situ AJCC v6 and v7
        Gastric Cardia Carcinoma In Situ AJCC v6 and v7
        Gastric Fundus Carcinoma In Situ AJCC v6 and v7
        Gastric Pylorus Carcinoma In Situ AJCC v6 and v7
        Stage 0 Small Intestinal Cancer AJCC v7
        Middle Ear Carcinoma In Situ
        Papillary Carcinoma In Situ
        Breast Papillary Ductal Carcinoma In Situ
        Breast Micropapillary Ductal Carcinoma In Situ
        Breast Solid Papillary Carcinoma In Situ
        Stage 0 Laryngeal Verrucous Carcinoma AJCC v6, v7, and v8
        Pharynx carcinoma in situ
        Carcinoma in situ of oropharynx
        Stage 0 Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7
        Stage 0 Hypopharyngeal Carcinoma AJCC v6, v7, and v8
        Stage 0 Hypopharyngeal Squamous Cell Carcinoma AJCC v6, v7, and v8
        Stage 0 Nasopharyngeal Carcinoma AJCC v6, v7, and v8
        Stage 0 Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v6, v7, and v8
        Stage 0 Nasopharyngeal Undifferentiated Carcinoma AJCC v6, v7, and v8
        Stage 0 Oropharyngeal (p16-Negative) Carcinoma AJCC v8
        Prognostic Stage 0 Breast Cancer AJCC v8
        Prostate intraepithelial neoplasia
        Low Grade Prostatic Intraepithelial Neoplasia
        Skin carcinoma in situ
        Skin squamous cell carcinoma in situ
        Bowen disease of the skin
        Stage 0 Lip Basal Cell Carcinoma AJCC v6 and v7
        Squamous carcinoma in situ
        Cervical Squamous Cell Carcinoma In Situ
        Lung Squamous Cell Carcinoma In Situ
        Stage 0 Lung Squamous Cell Carcinoma AJCC v6 and v7
        Penis carcinoma in situ
        Squamous Cell Carcinoma In Situ of the Nipple
        Stage 0 Bladder Squamous Cell Carcinoma AJCC v6 and v7
        Stage 0 Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
        Stage 0 Laryngeal Squamous Cell Carcinoma AJCC v6, v7, and v8
        Stage 0 Epiglottic Carcinoma AJCC v6, v7, and v8
        Stage 0 Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7
        Trachea carcinoma in situ
        Stage 0 Breast Cancer AJCC v6 and v7
        Female Breast Carcinoma In Situ
        Male Breast Carcinoma In Situ
        Stage 0 Laryngeal Cancer AJCC v6, v7, and V8
        Stage 0 Lip and Oral Cavity Cancer AJCC v6 and v7
        Stage 0 Lip Cancer AJCC v6 and v7
        Stage 0 Oral Cavity Cancer AJCC v6 and v7
        Stage 0 Lung Cancer AJCC v6 and v7
        Stage 0 Lung Non-Small Cell Cancer AJCC v6 and v7
        Stage 0 Lung Adenosquamous Carcinoma AJCC v6 and v7
        Stage 0 Lung Large Cell Carcinoma AJCC v6 and v7
        Stage 0 Major Salivary Gland Cancer AJCC v8
        Stage 0 Vaginal Cancer AJCC v6
        Stage 0 Vaginal Cancer AJCC v7
        Stage 0 Vulvar Cancer AJCC v6
        Stage 0 Vulvar Cancer AJCC v7
        Stage 0is Renal Pelvis and Ureter Cancer AJCC v7
        Carcinoma in situ of renal pelvis
        Stage 0is Ureter Cancer AJCC v7
        Stage 0is Renal Pelvis and Ureter Cancer AJCC v8
        Stage 0is Renal Pelvis Cancer AJCC v8
        Stage 0is Ureter Cancer AJCC v8
        Stage 0is Urethral Cancer AJCC v7
        Stage 0is Urethral Cancer AJCC v8

Professional guidelines

PubMed

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.

Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026 Free PMC Article

Breast Cancer Treatment.

Trayes KP, Cokenakes SEH
Am Fam Physician 2021 Aug 1;104(2):171-178. PMID: 34383430

Treatment of breast cancer.

Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754

See all (1279)

Recent clinical studies

Etiology

Are we overtreating intraductal papillomas?

Kiran S, Jeong YJ, Nelson ME, Ring A, Johnson MB, Sheth PA, Ma Y, Sener SF, Lang JE
J Surg Res 2018 Nov;231:387-394. Epub 2018 Jun 29 doi: 10.1016/j.jss.2018.06.008. PMID: 30278958 Free PMC Article

Breast Carcinoma: Updates in Molecular Profiling 2018.

Bandyopadhyay S, Bluth MH, Ali-Fehmi R
Clin Lab Med 2018 Jun;38(2):401-420. doi: 10.1016/j.cll.2018.02.006. PMID: 29776638

Diagnostic challenges in papillary lesions of the breast.

Rakha EA, Ellis IO
Pathology 2018 Jan;50(1):100-110. Epub 2017 Nov 26 doi: 10.1016/j.pathol.2017.10.005. PMID: 29179906

Whence High-Grade Serous Ovarian Cancer.

Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656

Opinion: Comment on Evaluation and Treatment of Cryptorchidism: AUA/AAP and Nordic Consensus Guidelines.

Hadziselimovic F
Urol Int 2016;96(3):249-54. Epub 2016 Jan 30 doi: 10.1159/000443741. PMID: 26824668

See all (437)

Diagnosis

Avoiding "False Positive" and "False Negative" Immunohistochemical Results in Breast Pathology.

Li Z, Dabbs DJ
Pathobiology 2022;89(5):309-323. Epub 2022 Mar 4 doi: 10.1159/000521682. PMID: 35249034

Apocrine lesions of the breast.

Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861 Free PMC Article

Primary squamous cell carcinoma of the ovary. Review of the literature.

Koufopoulos N, Nasi D, Goudeli C, Antoniadou F, Kokkali S, Pigadioti E, Provatas I, Maggo E, Ardavanis A, Terzakis E, Arkoumani E, J Agnantis N, Apostolikas N, Khaldi L
J BUON 2019 Sep-Oct;24(5):1776-1784. PMID: 31786837

Breast Carcinoma: Updates in Molecular Profiling 2018.

Bandyopadhyay S, Bluth MH, Ali-Fehmi R
Clin Lab Med 2018 Jun;38(2):401-420. doi: 10.1016/j.cll.2018.02.006. PMID: 29776638

Diagnostic challenges in papillary lesions of the breast.

Rakha EA, Ellis IO
Pathology 2018 Jan;50(1):100-110. Epub 2017 Nov 26 doi: 10.1016/j.pathol.2017.10.005. PMID: 29179906

See all (433)

Therapy

Actinic keratosis: where do we stand and where is the future going to take us?

Cramer P, Stockfleth E
Expert Opin Emerg Drugs 2020 Mar;25(1):49-58. Epub 2020 Feb 20 doi: 10.1080/14728214.2020.1730810. PMID: 32067498

Opinion: Comment on Evaluation and Treatment of Cryptorchidism: AUA/AAP and Nordic Consensus Guidelines.

Hadziselimovic F
Urol Int 2016;96(3):249-54. Epub 2016 Jan 30 doi: 10.1159/000443741. PMID: 26824668

Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance.

Ahmed N, Abubaker K, Findlay J, Quinn M
J Cell Biochem 2013 Jan;114(1):21-34. doi: 10.1002/jcb.24317. PMID: 22887554

The treatment of in situ breast cancer.

Fentiman IS
Acta Oncol 1989;28(6):923-6. doi: 10.3109/02841868909092333. PMID: 2558695

Vulvovaginal reconstruction following radical surgery.

Stern JL, Lacey CG
Baillieres Clin Obstet Gynaecol 1987 Jun;1(2):277-92. doi: 10.1016/s0950-3552(87)80055-x. PMID: 3319336

See all (125)

Prognosis

Avoiding "False Positive" and "False Negative" Immunohistochemical Results in Breast Pathology.

Li Z, Dabbs DJ
Pathobiology 2022;89(5):309-323. Epub 2022 Mar 4 doi: 10.1159/000521682. PMID: 35249034

The Many Faces of Serous Neoplasms and Related Lesions of the Female Pelvis: A Review.

Rashid S, Arafah MA, Akhtar M
Adv Anat Pathol 2022 May 1;29(3):154-167. doi: 10.1097/PAP.0000000000000334. PMID: 35180738 Free PMC Article

Primary squamous cell carcinoma of the ovary. Review of the literature.

Diagnostic challenges in papillary lesions of the breast.

Rakha EA, Ellis IO
Pathology 2018 Jan;50(1):100-110. Epub 2017 Nov 26 doi: 10.1016/j.pathol.2017.10.005. PMID: 29179906

Whence High-Grade Serous Ovarian Cancer.

Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656

See all (322)

Clinical prediction guides

Avoiding "False Positive" and "False Negative" Immunohistochemical Results in Breast Pathology.

Li Z, Dabbs DJ
Pathobiology 2022;89(5):309-323. Epub 2022 Mar 4 doi: 10.1159/000521682. PMID: 35249034

Are we overtreating intraductal papillomas?

Kiran S, Jeong YJ, Nelson ME, Ring A, Johnson MB, Sheth PA, Ma Y, Sener SF, Lang JE
J Surg Res 2018 Nov;231:387-394. Epub 2018 Jun 29 doi: 10.1016/j.jss.2018.06.008. PMID: 30278958 Free PMC Article

Diagnostic challenges in papillary lesions of the breast.

Rakha EA, Ellis IO
Pathology 2018 Jan;50(1):100-110. Epub 2017 Nov 26 doi: 10.1016/j.pathol.2017.10.005. PMID: 29179906

Whence High-Grade Serous Ovarian Cancer.

Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656

Breast carcinoma: molecular profiling and updates.

Bandyopadhyay S, Ali-Fehmi R
Clin Lab Med 2013 Dec;33(4):891-909. doi: 10.1016/j.cll.2013.08.009. PMID: 24267194

See all (276)

Recent systematic reviews

Risk-reducing medications for primary breast cancer: a network meta-analysis.

Mocellin S, Goodwin A, Pasquali S
Cochrane Database Syst Rev 2019 Apr 29;4(4):CD012191. doi: 10.1002/14651858.CD012191.pub2. PMID: 31032883 Free PMC Article

Columnar cell lesions on breast needle biopsies: is surgical excision necessary? A systematic review.

Verschuur-Maes AH, van Deurzen CH, Monninkhof EM, van Diest PJ
Ann Surg 2012 Feb;255(2):259-65. doi: 10.1097/SLA.0b013e318233523f. PMID: 21989373

See all (2)

MedGen

National Center for Biotechnology Information

Send to:

In situ carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity