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Bolivian hemorrhagic fever

MedGen UID:
76386
•Concept ID:
C0282192
•
Disease or Syndrome
Synonyms: Bolivian Hemorrhagic Fever; Bolivian Hemorrhagic Fevers; Fever, Bolivian Hemorrhagic; Hemorrhagic Fever, Bolivian; Infection, Machupo virus; Machupo virus Infection; Machupo virus Infections
SNOMED CT: Bolivian hemorrhagic fever (67247008); Hemorrhagic fever due to Machupo virus (67247008); Black typhus (67247008); BHF - Bolivian hemorrhagic fever (67247008); Machupo hemorrhagic fever (67247008)
 
Monarch Initiative: MONDO:0017875
Orphanet: ORPHA319229

Definition

Bolivian hemorrhagic fever (BHF), caused by the Machupo virus (MACV), is a severe acute viral hemorrhagic fever characterized by fever, myalgia, and arthralgia followed by hemorrhagic and neurological manifestations. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBolivian hemorrhagic fever
Follow this link to review classifications for Bolivian hemorrhagic fever in Orphanet.

Professional guidelines

PubMed

Molecular approaches for the treatment of hemorrhagic fever virus infections.
Andrei G, De Clercq E
Antiviral Res 1993 Sep;22(1):45-75. doi: 10.1016/0166-3542(93)90085-w. PMID: 8250543

Recent clinical studies

Etiology

Bolivian hemorrhagic fever: A narrative review.
Silva-Ramos CR, Faccini-Martínez ÁA, Calixto OJ, Hidalgo M
Travel Med Infect Dis 2021 Mar-Apr;40:102001. Epub 2021 Feb 25 doi: 10.1016/j.tmaid.2021.102001. PMID: 33640478
South American Hemorrhagic Fevers: A summary for clinicians.
Frank MG, Beitscher A, Webb CM, Raabe V; members of the Medical Countermeasures Working Group of the National Emerging Special Pathogens Training and Education Center’s (NETEC’s) Special Pathogens Research Network (SPRN)
Int J Infect Dis 2021 Apr;105:505-515. Epub 2021 Feb 18 doi: 10.1016/j.ijid.2021.02.046. PMID: 33610781
Risks and prevention of nosocomial transmission of rare zoonotic diseases.
Weber DJ, Rutala WA
Clin Infect Dis 2001 Feb 1;32(3):446-56. Epub 2001 Jan 24 doi: 10.1086/318509. PMID: 11170953
Molecular approaches for the treatment of hemorrhagic fever virus infections.
Andrei G, De Clercq E
Antiviral Res 1993 Sep;22(1):45-75. doi: 10.1016/0166-3542(93)90085-w. PMID: 8250543

Diagnosis

Bolivian hemorrhagic fever: A narrative review.
Silva-Ramos CR, Faccini-Martínez ÁA, Calixto OJ, Hidalgo M
Travel Med Infect Dis 2021 Mar-Apr;40:102001. Epub 2021 Feb 25 doi: 10.1016/j.tmaid.2021.102001. PMID: 33640478
Research efforts to control highly pathogenic arenaviruses: a summary of the progress and gaps.
Kerber R, Reindl S, Romanowski V, Gómez RM, Ogbaini-Emovon E, Günther S, ter Meulen J
J Clin Virol 2015 Mar;64:120-7. Epub 2014 Dec 18 doi: 10.1016/j.jcv.2014.12.004. PMID: 25549822
Bolivian hemorrhagic fever. A pathologic description.
Child PL, MacKenzie RB, Valverde LR, Johnson KM
Arch Pathol 1967 May;83(5):434-45. PMID: 6023050

Therapy

Research efforts to control highly pathogenic arenaviruses: a summary of the progress and gaps.
Kerber R, Reindl S, Romanowski V, Gómez RM, Ogbaini-Emovon E, Günther S, ter Meulen J
J Clin Virol 2015 Mar;64:120-7. Epub 2014 Dec 18 doi: 10.1016/j.jcv.2014.12.004. PMID: 25549822
Pathology of experimental Machupo virus infection, Chicava strain, in cynomolgus macaques (Macaca fascicularis) by intramuscular and aerosol exposure.
Bell TM, Shaia CI, Bunton TE, Robinson CG, Wilkinson ER, Hensley LE, Cashman KA
Vet Pathol 2015 Jan;52(1):26-37. Epub 2014 Jul 2 doi: 10.1177/0300985814540544. PMID: 24990481
Treatment of Bolivian hemorrhagic fever with intravenous ribavirin.
Kilgore PE, Ksiazek TG, Rollin PE, Mills JN, Villagra MR, Montenegro MJ, Costales MA, Paredes LC, Peters CJ
Clin Infect Dis 1997 Apr;24(4):718-22. doi: 10.1093/clind/24.4.718. PMID: 9145749
Prospects for the control of Bolivian hemorrhagic fever.
Kilgore PE, Peters CJ, Mills JN, Rollin PE, Armstrong L, Khan AS, Ksiazek TG
Emerg Infect Dis 1995 Jul-Sep;1(3):97-100. doi: 10.3201/eid0103.950308. PMID: 8903174Free PMC Article
Molecular approaches for the treatment of hemorrhagic fever virus infections.
Andrei G, De Clercq E
Antiviral Res 1993 Sep;22(1):45-75. doi: 10.1016/0166-3542(93)90085-w. PMID: 8250543

Prognosis

Description and characterization of a novel live-attenuated tri-segmented Machupo virus in Guinea pigs.
Zaza AD, Herbreteau CH, Peyrefitte CN
Virol J 2018 Jun 7;15(1):99. doi: 10.1186/s12985-018-1009-4. PMID: 29879985Free PMC Article
Pathogenesis of Bolivian Hemorrhagic Fever in Guinea Pigs.
Bell TM, Bunton TE, Shaia CI, Raymond JW, Honnold SP, Donnelly GC, Shamblin JD, Wilkinson ER, Cashman KA
Vet Pathol 2016 Jan;53(1):190-9. Epub 2015 Jul 2 doi: 10.1177/0300985815588609. PMID: 26139838
Pathology of experimental Machupo virus infection, Chicava strain, in cynomolgus macaques (Macaca fascicularis) by intramuscular and aerosol exposure.
Bell TM, Shaia CI, Bunton TE, Robinson CG, Wilkinson ER, Hensley LE, Cashman KA
Vet Pathol 2015 Jan;52(1):26-37. Epub 2014 Jul 2 doi: 10.1177/0300985814540544. PMID: 24990481
Genetic diversity among Bolivian arenaviruses.
Cajimat MN, Milazzo ML, Rollin PE, Nichol ST, Bowen MD, Ksiazek TG, Fulhorst CF
Virus Res 2009 Mar;140(1-2):24-31. Epub 2008 Dec 19 doi: 10.1016/j.virusres.2008.10.016. PMID: 19041349Free PMC Article
Treatment of Bolivian hemorrhagic fever with intravenous ribavirin.
Kilgore PE, Ksiazek TG, Rollin PE, Mills JN, Villagra MR, Montenegro MJ, Costales MA, Paredes LC, Peters CJ
Clin Infect Dis 1997 Apr;24(4):718-22. doi: 10.1093/clind/24.4.718. PMID: 9145749

Clinical prediction guides

Genetic diversity among Bolivian arenaviruses.
Cajimat MN, Milazzo ML, Rollin PE, Nichol ST, Bowen MD, Ksiazek TG, Fulhorst CF
Virus Res 2009 Mar;140(1-2):24-31. Epub 2008 Dec 19 doi: 10.1016/j.virusres.2008.10.016. PMID: 19041349Free PMC Article
Pathology of Bolivian hemorrhagic fever in the rhesus monkey.
Terrell TG, Stookey JL, Eddy GA, Kastello MD
Am J Pathol 1973 Nov;73(2):477-94. PMID: 4202335Free PMC Article

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