U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Parotid salivary glands, polycystic dysgenetic disease of(PDDP)

MedGen UID:
764047
Concept ID:
C3551133
Disease or Syndrome
Synonym: PDDP
 
Monarch Initiative: MONDO:0010872
OMIM®: 600343

Definition

Polycystic dysgenetic disease of the parotid gland (PDDP) is a rare benign condition of the parotid gland. The disorder presents often in childhood or young adulthood, but may occur later in life. It occurs most commonly in females. Features include fluctuating and nontender swelling of the parotid gland bilaterally, without defects in salivary function. Histology shows replacement of the lobular portion of the parotid gland by multiple epithelial-lined cysts arising from the intercalated ducts. The cysts often contain altered salivary secretions, including spheroliths or microliths; eosinophilic congophilic deposits have also been described. Chronic inflammation is not present. The condition is thought to result from a developmental defect of the intercalated duct system. Surgery may be indicated for diagnosis or for cosmetic reasons (summary by Smyth et al., 1993; Layfield and Gopez, 2002; Eley et al., 2011). [from OMIM]

Clinical features

From HPO
Enlargement of parotid gland
MedGen UID:
488850
Concept ID:
C0341047
Disease or Syndrome
Increased size of the parotid gland.

Recent clinical studies

Diagnosis

Rashad R, Barakat A
J Histotechnol 2024 Jun;47(2):87-91. Epub 2024 Jan 15 doi: 10.1080/01478885.2023.2299911. PMID: 38224047
Kahraman D, Yalavac P, Akar E, Özen Ö, Günhan Ö
Indian J Pathol Microbiol 2020 Jan-Mar;63(1):109-111. doi: 10.4103/IJPM.IJPM_502_18. PMID: 32031136
Wiedemann HR
Am J Med Genet 1997 Jan 20;68(2):222-4. doi: 10.1002/(sici)1096-8628(19970120)68:2<222::aid-ajmg20>3.0.co;2-v. PMID: 9028463
Seifert G
Pathol Res Pract 1992 Oct;188(7):836-46. PMID: 1448373
Seifert G, Thomsen S, Donath K
Virchows Arch A Pathol Anat Histol 1981;390(3):273-88. doi: 10.1007/BF00496559. PMID: 7281479

Clinical prediction guides

Wiedemann HR
Am J Med Genet 1997 Jan 20;68(2):222-4. doi: 10.1002/(sici)1096-8628(19970120)68:2<222::aid-ajmg20>3.0.co;2-v. PMID: 9028463

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...