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Increased risk of medulloblastoma

MedGen UID:
764446
•Concept ID:
C3551532
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk of medulloblastoma

Professional guidelines

PubMed

Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Medulloblastoma: Tumor Biology and Relevance to Treatment and Prognosis Paradigm.
Coluccia D, Figuereido C, Isik S, Smith C, Rutka JT
Curr Neurol Neurosci Rep 2016 May;16(5):43. doi: 10.1007/s11910-016-0644-7. PMID: 27021772
Management of children with primitive neuroectodermal tumors of the posterior fossa/medulloblastoma.
Packer RJ, Sutton LN, D'Angio G, Evans AE, Schut L
Pediatr Neurosci 1985-1986;12(4-5):272-82. doi: 10.1159/000120264. PMID: 3039477

Recent clinical studies

Etiology

Childhood Medulloblastoma: An Overview.
Suk Y, Gwynne WD, Burns I, Venugopal C, Singh SK
Methods Mol Biol 2022;2423:1-12. doi: 10.1007/978-1-0716-1952-0_1. PMID: 34978683
Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Leary SES, Packer RJ, Li Y, Billups CA, Smith KS, Jaju A, Heier L, Burger P, Walsh K, Han Y, Embry L, Hadley J, Kumar R, Michalski J, Hwang E, Gajjar A, Pollack IF, Fouladi M, Northcott PA, Olson JM
JAMA Oncol 2021 Sep 1;7(9):1313-1321. doi: 10.1001/jamaoncol.2021.2224. PMID: 34292305Free PMC Article
How we treat medulloblastoma in adults.
Franceschi E, Seidel C, Sahm F, Pajtler KW, Hau P
ESMO Open 2021 Aug;6(4):100173. Epub 2021 Jun 9 doi: 10.1016/j.esmoop.2021.100173. PMID: 34118771Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Cerebellar mutism.
Pitsika M, Tsitouras V
J Neurosurg Pediatr 2013 Dec;12(6):604-14. Epub 2013 Sep 27 doi: 10.3171/2013.8.PEDS13168. PMID: 24073751

Diagnosis

Childhood Medulloblastoma: An Overview.
Suk Y, Gwynne WD, Burns I, Venugopal C, Singh SK
Methods Mol Biol 2022;2423:1-12. doi: 10.1007/978-1-0716-1952-0_1. PMID: 34978683
Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Leary SES, Packer RJ, Li Y, Billups CA, Smith KS, Jaju A, Heier L, Burger P, Walsh K, Han Y, Embry L, Hadley J, Kumar R, Michalski J, Hwang E, Gajjar A, Pollack IF, Fouladi M, Northcott PA, Olson JM
JAMA Oncol 2021 Sep 1;7(9):1313-1321. doi: 10.1001/jamaoncol.2021.2224. PMID: 34292305Free PMC Article
How we treat medulloblastoma in adults.
Franceschi E, Seidel C, Sahm F, Pajtler KW, Hau P
ESMO Open 2021 Aug;6(4):100173. Epub 2021 Jun 9 doi: 10.1016/j.esmoop.2021.100173. PMID: 34118771Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Embryonal brain tumors.
McGovern SL, Grosshans D, Mahajan A
Cancer J 2014 Nov-Dec;20(6):397-402. doi: 10.1097/PPO.0000000000000081. PMID: 25415685

Therapy

Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Leary SES, Packer RJ, Li Y, Billups CA, Smith KS, Jaju A, Heier L, Burger P, Walsh K, Han Y, Embry L, Hadley J, Kumar R, Michalski J, Hwang E, Gajjar A, Pollack IF, Fouladi M, Northcott PA, Olson JM
JAMA Oncol 2021 Sep 1;7(9):1313-1321. doi: 10.1001/jamaoncol.2021.2224. PMID: 34292305Free PMC Article
How we treat medulloblastoma in adults.
Franceschi E, Seidel C, Sahm F, Pajtler KW, Hau P
ESMO Open 2021 Aug;6(4):100173. Epub 2021 Jun 9 doi: 10.1016/j.esmoop.2021.100173. PMID: 34118771Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Embryonal brain tumors.
McGovern SL, Grosshans D, Mahajan A
Cancer J 2014 Nov-Dec;20(6):397-402. doi: 10.1097/PPO.0000000000000081. PMID: 25415685
Cerebellar mutism.
Pitsika M, Tsitouras V
J Neurosurg Pediatr 2013 Dec;12(6):604-14. Epub 2013 Sep 27 doi: 10.3171/2013.8.PEDS13168. PMID: 24073751

Prognosis

Childhood Medulloblastoma: An Overview.
Suk Y, Gwynne WD, Burns I, Venugopal C, Singh SK
Methods Mol Biol 2022;2423:1-12. doi: 10.1007/978-1-0716-1952-0_1. PMID: 34978683
How we treat medulloblastoma in adults.
Franceschi E, Seidel C, Sahm F, Pajtler KW, Hau P
ESMO Open 2021 Aug;6(4):100173. Epub 2021 Jun 9 doi: 10.1016/j.esmoop.2021.100173. PMID: 34118771Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
p53 and Meduloblastoma.
Ramaswamy V, Nör C, Taylor MD
Cold Spring Harb Perspect Med 2015 Dec 18;6(2):a026278. doi: 10.1101/cshperspect.a026278. PMID: 26684332Free PMC Article
Embryonal brain tumors.
McGovern SL, Grosshans D, Mahajan A
Cancer J 2014 Nov-Dec;20(6):397-402. doi: 10.1097/PPO.0000000000000081. PMID: 25415685

Clinical prediction guides

Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Leary SES, Packer RJ, Li Y, Billups CA, Smith KS, Jaju A, Heier L, Burger P, Walsh K, Han Y, Embry L, Hadley J, Kumar R, Michalski J, Hwang E, Gajjar A, Pollack IF, Fouladi M, Northcott PA, Olson JM
JAMA Oncol 2021 Sep 1;7(9):1313-1321. doi: 10.1001/jamaoncol.2021.2224. PMID: 34292305Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
A review of dosimetric and toxicity modeling of proton versus photon craniospinal irradiation for pediatrics medulloblastoma.
Ho ESQ, Barrett SA, Mullaney LM
Acta Oncol 2017 Aug;56(8):1031-1042. Epub 2017 May 16 doi: 10.1080/0284186X.2017.1324207. PMID: 28509599
Medulloblastoma: Tumor Biology and Relevance to Treatment and Prognosis Paradigm.
Coluccia D, Figuereido C, Isik S, Smith C, Rutka JT
Curr Neurol Neurosci Rep 2016 May;16(5):43. doi: 10.1007/s11910-016-0644-7. PMID: 27021772
Childhood brain tumors.
Sklar CA
J Pediatr Endocrinol Metab 2002 May;15 Suppl 2:669-73. doi: 10.1515/jpem.2002.15.s2.669. PMID: 12092679

Recent systematic reviews

Cancer risk in children and young adults born preterm: A systematic review and meta-analysis.
Paquette K, Coltin H, Boivin A, Amre D, Nuyt AM, Luu TM
PLoS One 2019;14(1):e0210366. Epub 2019 Jan 4 doi: 10.1371/journal.pone.0210366. PMID: 30608983Free PMC Article
The clinical importance of medulloblastoma extent of resection: a systematic review.
Thompson EM, Bramall A, Herndon JE 2nd, Taylor MD, Ramaswamy V
J Neurooncol 2018 Sep;139(3):523-539. Epub 2018 May 23 doi: 10.1007/s11060-018-2906-5. PMID: 29796724

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