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Prostate intraepithelial neoplasia

MedGen UID:
76480
Concept ID:
C0282612
Neoplastic Process
Synonyms: Intraepithelial Neoplasia, Prostatic; Intraepithelial Neoplasm, Prostatic; Intraepithelial Neoplasms, Prostatic; Intraepithelial Prostatic Neoplasia; Intraepithelial Prostatic Neoplasias; Neoplasia, Intraepithelial Prostatic; Neoplasia, Prostatic Intraepithelial; Neoplasm, Prostatic Intraepithelial; Neoplasms, Prostatic Intraepithelial; Prostatic Intraepithelial Neoplasia; Prostatic Intraepithelial Neoplasias; Prostatic Intraepithelial Neoplasm; Prostatic Intraepithelial Neoplasms; Prostatic Neoplasia, Intraepithelial
SNOMED CT: PIN - Prostatic intraepithelial neoplasia (254901000); Prostatic intraepithelial neoplasia (254901000)
 
Monarch Initiative: MONDO:0005193

Definition

A neoplastic proliferation of the epithelial cells that line the acini and the ducts of the prostate gland. The neoplastic epithelial cells are confined within the acini and the ducts and they do not invade the surrounding prostatic stroma. Morphologically, it is classified as low or high grade. [from NCI]

Professional guidelines

PubMed

Cheetham PJ, Katz AE
Arch Esp Urol 2011 Oct;64(8):720-34. PMID: 22052755
Mohanty NK, Saxena S, Singh UP, Goyal NK, Arora RP
Urol Oncol 2005 Nov-Dec;23(6):383-5. doi: 10.1016/j.urolonc.2005.05.012. PMID: 16301113
McNaughton-Collins M, Barry MJ, Caubet JF, Bates DW, Lee JM, Hauser A, Fowler FJ Jr
J Urol 2004 Dec;172(6 Pt 1):2366-8. doi: 10.1097/01.ju.0000145178.29852.7b. PMID: 15538269

Recent clinical studies

Etiology

Melnychuk MP
Wiad Lek 2023;76(2):420-426. doi: 10.36740/WLek202302125. PMID: 37010182
Мelnychuk MP
Wiad Lek 2021;74(1):35-38. PMID: 33851583
Thomas MU, Messex JK, Dang T, Abdulkadir SA, Jorcyk CL, Liou GY
FEBS J 2021 Mar;288(6):1871-1886. Epub 2020 Sep 25 doi: 10.1111/febs.15541. PMID: 32865335Free PMC Article
Jacob SA, Khan TM, Lee LH
Nutr Cancer 2017 Apr;69(3):353-364. Epub 2017 Feb 17 doi: 10.1080/01635581.2017.1285037. PMID: 28287319
Palapattu GS, Sutcliffe S, Bastian PJ, Platz EA, De Marzo AM, Isaacs WB, Nelson WG
Carcinogenesis 2005 Jul;26(7):1170-81. Epub 2004 Oct 21 doi: 10.1093/carcin/bgh317. PMID: 15498784

Diagnosis

Melnychuk MP
Wiad Lek 2023;76(2):420-426. doi: 10.36740/WLek202302125. PMID: 37010182
Khamis ZI, Iczkowski KA, Sang QX
Med Res Rev 2012 Sep;32(5):1026-77. Epub 2011 Jan 16 doi: 10.1002/med.20232. PMID: 22886631
Resnick MJ, Lee DJ, Magerfleisch L, Vanarsdalen KN, Tomaszewski JE, Wein AJ, Malkowicz SB, Guzzo TJ
Urology 2011 Mar;77(3):548-52. Epub 2011 Jan 7 doi: 10.1016/j.urology.2010.08.063. PMID: 21215436
Palapattu GS, Sutcliffe S, Bastian PJ, Platz EA, De Marzo AM, Isaacs WB, Nelson WG
Carcinogenesis 2005 Jul;26(7):1170-81. Epub 2004 Oct 21 doi: 10.1093/carcin/bgh317. PMID: 15498784
el-Shirbiny AM
Adv Clin Chem 1994;31:99-133. doi: 10.1016/s0065-2423(08)60334-0. PMID: 7533474

Therapy

Jacob SA, Khan TM, Lee LH
Nutr Cancer 2017 Apr;69(3):353-364. Epub 2017 Feb 17 doi: 10.1080/01635581.2017.1285037. PMID: 28287319
Holder SL, Abdulkadir SA
Curr Cancer Drug Targets 2014;14(2):105-14. doi: 10.2174/1568009613666131126113854. PMID: 24274399
Cheetham PJ, Katz AE
Arch Esp Urol 2011 Oct;64(8):720-34. PMID: 22052755
Taneja SS, Smith MR, Dalton JT, Raghow S, Barnette G, Steiner M, Veverka KA
Expert Opin Investig Drugs 2006 Mar;15(3):293-305. doi: 10.1517/13543784.15.3.293. PMID: 16503765
Nelson PS, Gleason TP, Brawer MK
Eur Urol 1996;30(2):269-78. doi: 10.1159/000474180. PMID: 8875211

Prognosis

Мelnychuk MP
Wiad Lek 2021;74(1):35-38. PMID: 33851583
Raspollini MR, Montagnani I, Cirri P, Baroni G, Cimadamore A, Scarpelli M, Cheng L, Lopez-Beltran A, Montironi R, Barnea ER
Int J Biol Markers 2020 Jun;35(2):82-90. Epub 2020 May 11 doi: 10.1177/1724600820919969. PMID: 32389051
Leite KR, Mitteldorf CA, Camara-Lopes LH
Int Braz J Urol 2005 Mar-Apr;31(2):131-6. doi: 10.1590/s1677-55382005000200007. PMID: 15877832
Alcaraz A, Barranco MA, Corral JM, Ribal MJ, Carrió A, Mallofré C, Llopis J, Cetina A, Alvarez-Vijande R
Prostate 2001 Apr;47(1):29-35. doi: 10.1002/pros.1044. PMID: 11304727
el-Shirbiny AM
Adv Clin Chem 1994;31:99-133. doi: 10.1016/s0065-2423(08)60334-0. PMID: 7533474

Clinical prediction guides

Melnychuk MP
Wiad Lek 2023;76(2):420-426. doi: 10.36740/WLek202302125. PMID: 37010182
Sigorski D, Wesołowski W, Gruszecka A, Gulczyński J, Zieliński P, Misiukiewicz S, Kitlińska J, Iżycka-Świeszewska E
J Cancer Res Clin Oncol 2023 Aug;149(9):5803-5822. Epub 2022 Dec 30 doi: 10.1007/s00432-022-04540-x. PMID: 36583743Free PMC Article
Pascal LE, Masoodi KZ, Liu J, Qiu X, Song Q, Wang Y, Zang Y, Yang T, Wang Y, Rigatti LH, Chandran U, Colli LM, Vencio RZN, Lu Y, Zhang J, Wang Z
J Endocrinol 2017 Nov;235(2):123-136. doi: 10.1530/JOE-17-0112. PMID: 28870994Free PMC Article
Jacob SA, Khan TM, Lee LH
Nutr Cancer 2017 Apr;69(3):353-364. Epub 2017 Feb 17 doi: 10.1080/01635581.2017.1285037. PMID: 28287319
el-Shirbiny AM
Adv Clin Chem 1994;31:99-133. doi: 10.1016/s0065-2423(08)60334-0. PMID: 7533474

Recent systematic reviews

Jacob SA, Khan TM, Lee LH
Nutr Cancer 2017 Apr;69(3):353-364. Epub 2017 Feb 17 doi: 10.1080/01635581.2017.1285037. PMID: 28287319

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