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Thin toenail

MedGen UID:: 767027
•Concept ID:: C3554113
•: Anatomical Abnormality; Finding

Synonym:	Thin toenails

HPO:	HP:0012746

Definition

Toenail that appears thin when viewed on end. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVThin toenail

Phenotypic abnormality
- Abnormality of the integument
  - Abnormal skin adnexa morphology
    - Abnormal nail morphology
      - Abnormal toenail morphology
        Thin toenail

Conditions with this feature

Ectodermal dysplasia 6, hair/nail type

MedGen UID:: 767025
•Concept ID:: C3554111
•: Disease or Syndrome

Some ectodermal dysplasias are here classified as congenital disorders characterized by abnormal development in 2 or more ectodermal structures (hair, nails, teeth, and sweat glands) without other systemic findings. Ectodermal dysplasia of the hair/nail type is a rare congenital condition characterized by hypotrichosis and nail dystrophy without nonectodermal or other ectodermal manifestations.

See: Condition Record

Ectodermal dysplasia 6, hair/nail type

Professional guidelines

PubMed

Fetal alcohol spectrum disorders - diagnostic difficulties in the neonatal period and new diagnostic approaches.

Jańczewska I, Wierzba J, Cichoń-Kotek M, Jańczewska A
Dev Period Med 2019;23(1):60-66. doi: 10.34763/devperiodmed.20192301.6066. PMID: 30954983 Free PMC Article

Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).

Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501

Phenotype and genotype in 103 patients with tricho-rhino-phalangeal syndrome.

Maas SM, Shaw AC, Bikker H, Lüdecke HJ, van der Tuin K, Badura-Stronka M, Belligni E, Biamino E, Bonati MT, Carvalho DR, Cobben J, de Man SA, Den Hollander NS, Di Donato N, Garavelli L, Grønborg S, Herkert JC, Hoogeboom AJ, Jamsheer A, Latos-Bielenska A, Maat-Kievit A, Magnani C, Marcelis C, Mathijssen IB, Nielsen M, Otten E, Ousager LB, Pilch J, Plomp A, Poke G, Poluha A, Posmyk R, Rieubland C, Silengo M, Simon M, Steichen E, Stumpel C, Szakszon K, Polonkai E, van den Ende J, van der Steen A, van Essen T, van Haeringen A, van Hagen JM, Verheij JB, Mannens MM, Hennekam RC
Eur J Med Genet 2015 May;58(5):279-92. Epub 2015 Mar 16 doi: 10.1016/j.ejmg.2015.03.002. PMID: 25792522

See all (6)

Recent clinical studies

Etiology

Clinical and Molecular Genetic Analysis of Cases with Ectodermal Dysplasia.

Yapijakis C, Douka A, Gintoni I, Agiannitopoulos K, Vlachakis D, Chrousos GP
Adv Exp Med Biol 2023;1423:181-186. doi: 10.1007/978-3-031-31978-5_15. PMID: 37525042

Fosravuconazole to treat severe onychomycosis in the elderly.

Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Kubo M, Fukushima S, Ihn H
J Dermatol 2021 Feb;48(2):228-231. Epub 2020 Oct 25 doi: 10.1111/1346-8138.15651. PMID: 33099769

Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).

Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501

Silicon: the health benefits of a metalloid.

Martin KR
Met Ions Life Sci 2013;13:451-73. doi: 10.1007/978-94-007-7500-8_14. PMID: 24470100

Internal fixation of nonunions.

Rodriguez-Merchan EC, Gomez-Castresana F
Clin Orthop Relat Res 2004 Feb;(419):13-20. doi: 10.1097/00003086-200402000-00004. PMID: 15021126

See all (53)

Diagnosis

Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).

Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501

Oculodentodigital dysplasia.

Doshi DC, Limdi PK, Parekh NV, Gohil NR
Indian J Ophthalmol 2016 Mar;64(3):227-30. doi: 10.4103/0301-4738.180191. PMID: 27146935 Free PMC Article

Trachyonychia: a comprehensive review.

Gordon KA, Vega JM, Tosti A
Indian J Dermatol Venereol Leprol 2011 Nov-Dec;77(6):640-5. doi: 10.4103/0378-6323.86470. PMID: 22016269

Rapp-Hodgkin syndrome.

Kim G, Shin H
Dermatol Online J 2004 Nov 30;10(3):23. PMID: 15748593

Familial koilonychia.

Gao XH, Li X, Zhao Y, Wang Y, Chen HD
Int J Dermatol 2001 Apr;40(4):290-1. doi: 10.1046/j.1365-4362.2001.01212-5.x. PMID: 11454091

See all (47)

Therapy

Fosravuconazole to treat severe onychomycosis in the elderly.

Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Kubo M, Fukushima S, Ihn H
J Dermatol 2021 Feb;48(2):228-231. Epub 2020 Oct 25 doi: 10.1111/1346-8138.15651. PMID: 33099769

Comparison of pigmentary side effects of taxanes and anthracyclines: an onychoscopic evaluation.

Yorulmaz A, Dogan M, Artuz F, Zengin N
Cutan Ocul Toxicol 2017 Jun;36(2):135-139. Epub 2016 May 10 doi: 10.3109/15569527.2016.1173698. PMID: 27086693

Urea: A Clinically Oriented Overview from Bench to Bedside.

Friedman AJ, von Grote EC, Meckfessel MH
J Drugs Dermatol 2016 May 1;15(5):633-9. PMID: 27168272

Internal fixation of nonunions.

Rodriguez-Merchan EC, Gomez-Castresana F
Clin Orthop Relat Res 2004 Feb;(419):13-20. doi: 10.1097/00003086-200402000-00004. PMID: 15021126

Slipped capital femoral epiphysis associated with radiation therapy.

Loder RT, Hensinger RN, Alburger PD, Aronsson DD, Beaty JH, Roy DR, Stanton RP, Turker R
J Pediatr Orthop 1998 Sep-Oct;18(5):630-6. doi: 10.1097/00004694-199809000-00015. PMID: 9746415

See all (31)

Prognosis

Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).

Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501

Dermatologic findings of focal dermal hypoplasia (Goltz syndrome).

Bree AF, Grange DK, Hicks MJ, Goltz RW
Am J Med Genet C Semin Med Genet 2016 Mar;172C(1):44-51. Epub 2016 Feb 9 doi: 10.1002/ajmg.c.31472. PMID: 26858134

Revision with plates of humeral nonunions secondary to failed intramedullary nailing.

Allende C, Paz A, Altube G, Boccolini H, Malvarez A, Allende B
Int Orthop 2014 Apr;38(4):899-903. Epub 2013 Nov 21 doi: 10.1007/s00264-013-2180-2. PMID: 24258153 Free PMC Article

Laurin-Sandrow syndrome: review and redefinition.

Mariño-Enríquez A, Lapunzina P, Omeñaca F, Morales C, Rodríguez JI
Am J Med Genet A 2008 Oct 1;146A(19):2557-65. doi: 10.1002/ajmg.a.32393. PMID: 18792985

The treatment of fractures of the proximal humerus.

Lentz W, Meuser P
Arch Orthop Trauma Surg (1978) 1980;96(4):283-5. doi: 10.1007/BF00432866. PMID: 7396673

See all (25)

Clinical prediction guides

Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).

Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501

Revision with plates of humeral nonunions secondary to failed intramedullary nailing.

Allende C, Paz A, Altube G, Boccolini H, Malvarez A, Allende B
Int Orthop 2014 Apr;38(4):899-903. Epub 2013 Nov 21 doi: 10.1007/s00264-013-2180-2. PMID: 24258153 Free PMC Article

Late-onset Rothmund-Thomson syndrome.

Kumar P, Sharma PK, Gautam RK, Jain RK, Kar HK
Int J Dermatol 2007 May;46(5):492-3. doi: 10.1111/j.1365-4632.2007.03248.x. PMID: 17472679

Use and abuse of flexible intramedullary nailing in children and adolescents.

Lascombes P, Haumont T, Journeau P
J Pediatr Orthop 2006 Nov-Dec;26(6):827-34. doi: 10.1097/01.bpo.0000235397.64783.d6. PMID: 17065959

Olmsted syndrome.

Perry HO, Su WP
Semin Dermatol 1995 Jun;14(2):145-51. doi: 10.1016/s1085-5629(05)80011-2. PMID: 7640195

See all (40)