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Retinopathy of Prematurity with Plus Disease

MedGen UID:
768598
Concept ID:
C3639958
Disease or Syndrome

Definition

A stage of retinopathy of prematurity characterized by the presence of the following in at least two quadrants around the optic nerve: dilation and tortuosity of major retinal vasculature as a result of increased blood flow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinopathy of Prematurity with Plus Disease

Professional guidelines

PubMed

Seery CW, Betesh S, Guo S, Zarbin MA, Bhagat N, Wagner RS
J Pediatr Ophthalmol Strabismus 2020 Nov 1;57(6):351-362. doi: 10.3928/01913913-20200824-02. PMID: 33211892
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Hartnett ME
Curr Opin Ophthalmol 2017 May;28(3):282-288. doi: 10.1097/ICU.0000000000000360. PMID: 28141765Free PMC Article

Recent clinical studies

Etiology

Schmitz T, Doret-Dion M, Sentilhes L, Parant O, Claris O, Renesme L, Abbal J, Girault A, Torchin H, Houllier M, Le Saché N, Vivanti AJ, De Luca D, Winer N, Flamant C, Thuillier C, Boileau P, Blanc J, Brevaut V, Bouet PE, Gascoin G, Beucher G, Datin-Dorriere V, Bounan S, Bolot P, Poncelet C, Alberti C, Ursino M, Aupiais C, Baud O; BETADOSE trial study group; Groupe de Recherche en Obstétrique et Gynécologie
Lancet 2022 Aug 20;400(10352):592-604. doi: 10.1016/S0140-6736(22)01535-5. PMID: 35988568
Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Ghergherehchi L, Kim SJ, Campbell JP, Ostmo S, Chan RVP, Chiang MF
Asia Pac J Ophthalmol (Phila) 2018 May-Jun;7(3):152-155. Epub 2018 May 24 doi: 10.22608/APO.201863. PMID: 29797825Free PMC Article
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Diagnosis

Young BK, Cole ED, Shah PK, Ostmo S, Subramaniam P, Venkatapathy N, Tsai ASH, Coyner AS, Gupta A, Singh P, Chiang MF, Kalpathy-Cramer J, Chan RVP, Campbell JP
JAMA Ophthalmol 2023 Jun 1;141(6):582-588. doi: 10.1001/jamaophthalmol.2023.1466. PMID: 37166816Free PMC Article
Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, Binenbaum G, Blair M, Peter Campbell J, Capone A Jr, Chen Y, Dai S, Ells A, Fleck BW, Good WV, Elizabeth Hartnett M, Holmstrom G, Kusaka S, Kychenthal A, Lepore D, Lorenz B, Martinez-Castellanos MA, Özdek Ş, Ademola-Popoola D, Reynolds JD, Shah PK, Shapiro M, Stahl A, Toth C, Vinekar A, Visser L, Wallace DK, Wu WC, Zhao P, Zin A
Ophthalmology 2021 Oct;128(10):e51-e68. Epub 2021 Jul 8 doi: 10.1016/j.ophtha.2021.05.031. PMID: 34247850Free PMC Article
Scruggs BA, Chan RVP, Kalpathy-Cramer J, Chiang MF, Campbell JP
Transl Vis Sci Technol 2020 Feb 10;9(2):5. doi: 10.1167/tvst.9.2.5. PMID: 32704411Free PMC Article
Ghergherehchi L, Kim SJ, Campbell JP, Ostmo S, Chan RVP, Chiang MF
Asia Pac J Ophthalmol (Phila) 2018 May-Jun;7(3):152-155. Epub 2018 May 24 doi: 10.22608/APO.201863. PMID: 29797825Free PMC Article
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Therapy

Schmitz T, Doret-Dion M, Sentilhes L, Parant O, Claris O, Renesme L, Abbal J, Girault A, Torchin H, Houllier M, Le Saché N, Vivanti AJ, De Luca D, Winer N, Flamant C, Thuillier C, Boileau P, Blanc J, Brevaut V, Bouet PE, Gascoin G, Beucher G, Datin-Dorriere V, Bounan S, Bolot P, Poncelet C, Alberti C, Ursino M, Aupiais C, Baud O; BETADOSE trial study group; Groupe de Recherche en Obstétrique et Gynécologie
Lancet 2022 Aug 20;400(10352):592-604. doi: 10.1016/S0140-6736(22)01535-5. PMID: 35988568
Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Hartnett ME
Curr Opin Ophthalmol 2017 May;28(3):282-288. doi: 10.1097/ICU.0000000000000360. PMID: 28141765Free PMC Article
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article
Davitt BV, Wallace DK
Surv Ophthalmol 2009 Nov-Dec;54(6):663-70. Epub 2009 Aug 8 doi: 10.1016/j.survophthal.2009.02.021. PMID: 19665743

Prognosis

Young BK, Cole ED, Shah PK, Ostmo S, Subramaniam P, Venkatapathy N, Tsai ASH, Coyner AS, Gupta A, Singh P, Chiang MF, Kalpathy-Cramer J, Chan RVP, Campbell JP
JAMA Ophthalmol 2023 Jun 1;141(6):582-588. doi: 10.1001/jamaophthalmol.2023.1466. PMID: 37166816Free PMC Article
Wang J, Ying GS, Yu Y, Tomlinson L, Binenbaum G
Ophthalmic Epidemiol 2023 Oct;30(5):523-531. Epub 2023 Jan 16 doi: 10.1080/09286586.2023.2168014. PMID: 36647265Free PMC Article
Trzcionkowska K, Termote JU, Böhringer S, van Sorge AJ, Schalij-Delfos N
Br J Ophthalmol 2023 May;107(5):712-716. Epub 2021 Dec 10 doi: 10.1136/bjophthalmol-2021-319929. PMID: 34893474Free PMC Article
Kumawat D, Sachan A, Shah P, Chawla R, Chandra P
Eye (Lond) 2021 Apr;35(4):1140-1158. Epub 2021 Jan 29 doi: 10.1038/s41433-021-01392-6. PMID: 33514899Free PMC Article
Ahmad M, Patnaik J, Thevarajah T, Cathcart J, Jung J, Singh J, Braverman R, Lynch A, McCourt E
J AAPOS 2019 Apr;23(2):90.e1-90.e6. Epub 2019 Feb 14 doi: 10.1016/j.jaapos.2018.10.012. PMID: 30772472

Clinical prediction guides

Nakayama LF, Mitchell WG, Ribeiro LZ, Dychiao RG, Phanphruk W, Celi LA, Kalua K, Santiago APD, Regatieri CVS, Moraes NSB
BMJ Open Ophthalmol 2023 Aug;8(1) doi: 10.1136/bmjophth-2022-001216. PMID: 37558406Free PMC Article
Young BK, Cole ED, Shah PK, Ostmo S, Subramaniam P, Venkatapathy N, Tsai ASH, Coyner AS, Gupta A, Singh P, Chiang MF, Kalpathy-Cramer J, Chan RVP, Campbell JP
JAMA Ophthalmol 2023 Jun 1;141(6):582-588. doi: 10.1001/jamaophthalmol.2023.1466. PMID: 37166816Free PMC Article
Cole ED, Park SH, Kim SJ, Kang KB, Valikodath NG, Al-Khaled T, Patel SN, Jonas KE, Ostmo S, Coyner A, Berrocal A, Drenser KA, Nagiel A, Horowitz JD, Lee TC, Kalpathy-Cramer J, Chiang MF, Campbell JP, Chan RVP; Imaging and Informatics in Retinopathy of Prematurity (i-ROP) Research Consortium
Ophthalmol Retina 2022 Dec;6(12):1122-1129. Epub 2022 May 31 doi: 10.1016/j.oret.2022.05.024. PMID: 35659941Free PMC Article
Hartnett ME, Toth CA
Ophthalmic Surg Lasers Imaging Retina 2019 Apr 1;50(4):228-234. doi: 10.3928/23258160-20190401-05. PMID: 30998244
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Recent systematic reviews

Shafique MA, Haseeb A, Uddin MMN, Asghar B, Chaudhry ER, Raqib MA, Ali SMS, Mustafa MS
Am J Ophthalmol 2024 Mar;259:141-150. Epub 2023 Nov 17 doi: 10.1016/j.ajo.2023.11.012. PMID: 37979602
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Sankar MJ, Sankar J, Chandra P
Cochrane Database Syst Rev 2018 Jan 8;1(1):CD009734. doi: 10.1002/14651858.CD009734.pub3. PMID: 29308602Free PMC Article
Sankar MJ, Sankar J, Mehta M, Bhat V, Srinivasan R
Cochrane Database Syst Rev 2016;2:CD009734. Epub 2016 Feb 27 doi: 10.1002/14651858.CD009734.pub2. PMID: 26932750
Kemper AR, Wallace DK, Quinn GE
Pediatrics 2008 Oct;122(4):825-30. doi: 10.1542/peds.2007-3667. PMID: 18829807Free PMC Article

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