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Perinatal Central Nervous System Depression

MedGen UID:
768709
•Concept ID:
C3640069
•
Finding

Definition

Generalized depression of the central nervous system of an infant during the perinatal period. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPerinatal Central Nervous System Depression

Professional guidelines

PubMed

Repetitive transcranial magnetic stimulation for the treatment of postpartum depression.
Cox EQ, Killenberg S, Frische R, McClure R, Hill M, Jenson J, Pearson B, Meltzer-Brody SE
J Affect Disord 2020 Mar 1;264:193-200. Epub 2019 Nov 13 doi: 10.1016/j.jad.2019.11.069. PMID: 32056750
New insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum.
Meltzer-Brody S
Dialogues Clin Neurosci 2011;13(1):89-100. doi: 10.31887/DCNS.2011.13.1/smbrody. PMID: 21485749Free PMC Article
Antidepressants during pregnancy and lactation: defining exposure and treatment issues.
Newport DJ, Wilcox MM, Stowe ZN
Semin Perinatol 2001 Jun;25(3):177-90. doi: 10.1053/sper.2001.24901. PMID: 11453615

Recent clinical studies

Etiology

Perinatal depression: Heterogeneity of disease and in animal models.
Qiu W, Hodges TE, Clark EL, Blankers SA, Galea LAM
Front Neuroendocrinol 2020 Oct;59:100854. Epub 2020 Aug 1 doi: 10.1016/j.yfrne.2020.100854. PMID: 32750403
Prenatal stress: Effects on fetal and child brain development.
Lautarescu A, Craig MC, Glover V
Int Rev Neurobiol 2020;150:17-40. Epub 2019 Dec 14 doi: 10.1016/bs.irn.2019.11.002. PMID: 32204831
Perinatal programming by inflammation.
Spencer SJ, Meyer U
Brain Behav Immun 2017 Jul;63:1-7. Epub 2017 Feb 11 doi: 10.1016/j.bbi.2017.02.007. PMID: 28196717
Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health.
Babenko O, Kovalchuk I, Metz GA
Neurosci Biobehav Rev 2015 Jan;48:70-91. Epub 2014 Nov 24 doi: 10.1016/j.neubiorev.2014.11.013. PMID: 25464029
Nutritional interventions in depression and perinatal depression.
Rechenberg K, Humphries D
Yale J Biol Med 2013 Jun;86(2):127-37. Epub 2013 Jun 13 PMID: 23766734Free PMC Article

Diagnosis

Perinatal exposure to bisphenol A at the intersection of stress, anxiety, and depression.
Wiersielis KR, Samuels BA, Roepke TA
Neurotoxicol Teratol 2020 May-Jun;79:106884. Epub 2020 Apr 11 doi: 10.1016/j.ntt.2020.106884. PMID: 32289443Free PMC Article
The Relationship Between Perinatal Mental Health and Stress: a Review of the Microbiome.
Redpath N, Rackers HS, Kimmel MC
Curr Psychiatry Rep 2019 Mar 2;21(3):18. doi: 10.1007/s11920-019-0998-z. PMID: 30826885
Perinatal SSRI medications and offspring hippocampal plasticity: interaction with maternal stress and sex.
Pawluski JL, Gemmel M
Hormones (Athens) 2018 Mar;17(1):15-24. doi: 10.1007/s42000-018-0011-y. PMID: 29858853
Fetal programming of neuropsychiatric disorders.
Faa G, Manchia M, Pintus R, Gerosa C, Marcialis MA, Fanos V
Birth Defects Res C Embryo Today 2016 Sep;108(3):207-223. Epub 2016 Oct 24 doi: 10.1002/bdrc.21139. PMID: 27774781
Perinatal maternal stress and serotonin signaling: effects on pain sensitivity in offspring.
Knaepen L, Pawluski JL, Patijn J, van Kleef M, Tibboel D, Joosten EA
Dev Psychobiol 2014 Jul;56(5):885-96. Epub 2013 Dec 6 doi: 10.1002/dev.21184. PMID: 24311362

Therapy

Brain-derived neurotrophic factor (BDNF) in perinatal depression: Side show or pivotal factor?
Singh S, Fereshetyan K, Shorter S, Paliokha R, Dremencov E, Yenkoyan K, Ovsepian SV
Drug Discov Today 2023 Feb;28(2):103467. Epub 2022 Dec 14 doi: 10.1016/j.drudis.2022.103467. PMID: 36528281
Maternal diet disrupts the placenta-brain axis in a sex-specific manner.
Ceasrine AM, Devlin BA, Bolton JL, Green LA, Jo YC, Huynh C, Patrick B, Washington K, Sanchez CL, Joo F, Campos-Salazar AB, Lockshin ER, Kuhn C, Murphy SK, Simmons LA, Bilbo SD
Nat Metab 2022 Dec;4(12):1732-1745. Epub 2022 Nov 28 doi: 10.1038/s42255-022-00693-8. PMID: 36443520Free PMC Article
The effects of perinatal SSRI exposure on anxious behavior and neurobiology in rodent and human offspring.
Grieb ZA, Ragan CM
Eur Neuropsychopharmacol 2019 Nov;29(11):1169-1184. Epub 2019 Aug 16 doi: 10.1016/j.euroneuro.2019.07.239. PMID: 31427116
Perinatal SSRI medications and offspring hippocampal plasticity: interaction with maternal stress and sex.
Pawluski JL, Gemmel M
Hormones (Athens) 2018 Mar;17(1):15-24. doi: 10.1007/s42000-018-0011-y. PMID: 29858853
Nutritional interventions in depression and perinatal depression.
Rechenberg K, Humphries D
Yale J Biol Med 2013 Jun;86(2):127-37. Epub 2013 Jun 13 PMID: 23766734Free PMC Article

Prognosis

Maternal depressive symptoms, neonatal white matter, and toddler social-emotional development.
Lautarescu A, Bonthrone AF, Pietsch M, Batalle D, Cordero-Grande L, Tournier JD, Christiaens D, Hajnal JV, Chew A, Falconer S, Nosarti C, Victor S, Craig MC, Edwards AD, Counsell SJ
Transl Psychiatry 2022 Aug 9;12(1):323. doi: 10.1038/s41398-022-02073-y. PMID: 35945202Free PMC Article
Perinatal depression: Heterogeneity of disease and in animal models.
Qiu W, Hodges TE, Clark EL, Blankers SA, Galea LAM
Front Neuroendocrinol 2020 Oct;59:100854. Epub 2020 Aug 1 doi: 10.1016/j.yfrne.2020.100854. PMID: 32750403
Precision medicine in perinatal depression in light of the human microbiome.
Peñalver Bernabé B, Maki PM, Dowty SM, Salas M, Cralle L, Shah Z, Gilbert JA
Psychopharmacology (Berl) 2020 Apr;237(4):915-941. Epub 2020 Feb 17 doi: 10.1007/s00213-019-05436-4. PMID: 32065252
Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events.
Mattina GF, Van Lieshout RJ, Steiner M
Ther Adv Cardiovasc Dis 2019 Jan-Dec;13:1753944719851950. doi: 10.1177/1753944719851950. PMID: 31144599Free PMC Article
The HPA Axis During the Perinatal Period: Implications for Perinatal Depression.
Dickens MJ, Pawluski JL
Endocrinology 2018 Nov 1;159(11):3737-3746. doi: 10.1210/en.2018-00677. PMID: 30256957

Clinical prediction guides

Questionnaires and salivary cortisol to measure stress and depression in mid-pregnancy.
Vlenterie R, Geuijen PM, van Gelder MMHJ, Roeleveld N
PLoS One 2021;16(4):e0250459. Epub 2021 Apr 23 doi: 10.1371/journal.pone.0250459. PMID: 33891645Free PMC Article
Perinatal exposure to bisphenol A at the intersection of stress, anxiety, and depression.
Wiersielis KR, Samuels BA, Roepke TA
Neurotoxicol Teratol 2020 May-Jun;79:106884. Epub 2020 Apr 11 doi: 10.1016/j.ntt.2020.106884. PMID: 32289443Free PMC Article
Prenatal stress: Effects on fetal and child brain development.
Lautarescu A, Craig MC, Glover V
Int Rev Neurobiol 2020;150:17-40. Epub 2019 Dec 14 doi: 10.1016/bs.irn.2019.11.002. PMID: 32204831
Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events.
Mattina GF, Van Lieshout RJ, Steiner M
Ther Adv Cardiovasc Dis 2019 Jan-Dec;13:1753944719851950. doi: 10.1177/1753944719851950. PMID: 31144599Free PMC Article
The HPA Axis During the Perinatal Period: Implications for Perinatal Depression.
Dickens MJ, Pawluski JL
Endocrinology 2018 Nov 1;159(11):3737-3746. doi: 10.1210/en.2018-00677. PMID: 30256957

Recent systematic reviews

Effect of parental depressive symptoms on offspring's brain structure and function: A systematic review of neuroimaging studies.
Cattarinussi G, Aarabi MH, Sanjari Moghaddam H, Homayoun M, Ashrafi M, Soltanian-Zadeh H, Sambataro F
Neurosci Biobehav Rev 2021 Dec;131:451-465. Epub 2021 Sep 27 doi: 10.1016/j.neubiorev.2021.09.046. PMID: 34592256
Efficacy of non-invasive brain stimulation in decreasing depression symptoms during the peripartum period: A systematic review.
Pacheco F, Guiomar R, Brunoni AR, Buhagiar R, Evagorou O, Roca-Lecumberri A, Poleszczyk A, Lambregtse-van den Berg M, Caparros-Gonzalez RA, Fonseca A, Osório A, Soliman M, Ganho-Ávila A
J Psychiatr Res 2021 Aug;140:443-460. Epub 2021 Jun 8 doi: 10.1016/j.jpsychires.2021.06.005. PMID: 34147932

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