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In Utero Drug Withdrawal

MedGen UID:
769756
Concept ID:
C3641116
Mental or Behavioral Dysfunction

Definition

Drug withdrawal symptoms in a fetus following maternal discontinuation or reduction of use of one or more addictive substance(s) that have caused fetal physiological dependence. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIn Utero Drug Withdrawal

Professional guidelines

PubMed

McPhail BT, Emoto C, Butler D, Fukuda T, Akinbi H, Vinks AA
J Clin Pharmacol 2021 Jul;61(7):857-870. Epub 2021 Feb 1 doi: 10.1002/jcph.1811. PMID: 33382111
Cook CE, Fantasia HC
Nurs Womens Health 2019 Aug;23(4):357-365. Epub 2019 Jun 25 doi: 10.1016/j.nwh.2019.05.006. PMID: 31251931
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184

Recent clinical studies

Etiology

Wang Y, Berger L, Durrance C, Kirby RS, Kuo D, Pac J, Ehrenthal DB
Obstet Gynecol 2023 Sep 1;142(3):603-611. doi: 10.1097/AOG.0000000000005289. PMID: 37548391Free PMC Article
Krysko KM, Dobson R, Alroughani R, Amato MP, Bove R, Ciplea AI, Fragoso Y, Houtchens M, Jokubaitis VG, Magyari M, Abdelnasser A, Padma V, Thiel S, Tintore M, Vukusic S, Hellwig K
Lancet Neurol 2023 Apr;22(4):350-366. doi: 10.1016/S1474-4422(22)00426-4. PMID: 36931808
Lee JJ, Saraiya N, Kuzniewicz MW
J Neurosurg Anesthesiol 2023 Jan 1;35(1):142-146. Epub 2022 Dec 6 doi: 10.1097/ANA.0000000000000876. PMID: 36745179
Paradise SL, Landis CA, Klein DA
Am Fam Physician 2022 Sep;106(3):251-259. PMID: 36126006
Rosenfeld CS
Biol Reprod 2022 Apr 26;106(4):676-686. doi: 10.1093/biolre/ioac003. PMID: 35024817Free PMC Article

Diagnosis

Wang Y, Berger L, Durrance C, Kirby RS, Kuo D, Pac J, Ehrenthal DB
Obstet Gynecol 2023 Sep 1;142(3):603-611. doi: 10.1097/AOG.0000000000005289. PMID: 37548391Free PMC Article
Krysko KM, Dobson R, Alroughani R, Amato MP, Bove R, Ciplea AI, Fragoso Y, Houtchens M, Jokubaitis VG, Magyari M, Abdelnasser A, Padma V, Thiel S, Tintore M, Vukusic S, Hellwig K
Lancet Neurol 2023 Apr;22(4):350-366. doi: 10.1016/S1474-4422(22)00426-4. PMID: 36931808
Rosenfeld CS
Biol Reprod 2022 Apr 26;106(4):676-686. doi: 10.1093/biolre/ioac003. PMID: 35024817Free PMC Article
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
Abel EL
Drug Alcohol Depend 1984 Sep;14(1):1-10. doi: 10.1016/0376-8716(84)90012-7. PMID: 6386408

Therapy

Paradise SL, Landis CA, Klein DA
Am Fam Physician 2022 Sep;106(3):251-259. PMID: 36126006
Tobon AL, Habecker E, Forray A
Curr Psychiatry Rep 2019 Nov 16;21(12):118. doi: 10.1007/s11920-019-1110-4. PMID: 31734808Free PMC Article
Cook CE, Fantasia HC
Nurs Womens Health 2019 Aug;23(4):357-365. Epub 2019 Jun 25 doi: 10.1016/j.nwh.2019.05.006. PMID: 31251931
Mangat AK, Schmölzer GM, Kraft WK
Semin Fetal Neonatal Med 2019 Apr;24(2):133-141. Epub 2019 Feb 5 doi: 10.1016/j.siny.2019.01.009. PMID: 30745219Free PMC Article
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184

Prognosis

Wang Y, Berger L, Durrance C, Kirby RS, Kuo D, Pac J, Ehrenthal DB
Obstet Gynecol 2023 Sep 1;142(3):603-611. doi: 10.1097/AOG.0000000000005289. PMID: 37548391Free PMC Article
van Hoogdalem MW, Wexelblatt SL, Akinbi HT, Vinks AA, Mizuno T
Pharmacol Ther 2022 Jun;234:108045. Epub 2021 Nov 20 doi: 10.1016/j.pharmthera.2021.108045. PMID: 34813863
McPhail BT, Emoto C, Butler D, Fukuda T, Akinbi H, Vinks AA
J Clin Pharmacol 2021 Jul;61(7):857-870. Epub 2021 Feb 1 doi: 10.1002/jcph.1811. PMID: 33382111
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
Cohen-Israel M, Berger I, Martonovich EY, Klinger G, Stahl B, Linder N
Br J Clin Pharmacol 2018 Jan;84(1):189-194. Epub 2017 Oct 22 doi: 10.1111/bcp.13437. PMID: 29044597Free PMC Article

Clinical prediction guides

Wang Y, Berger L, Durrance C, Kirby RS, Kuo D, Pac J, Ehrenthal DB
Obstet Gynecol 2023 Sep 1;142(3):603-611. doi: 10.1097/AOG.0000000000005289. PMID: 37548391Free PMC Article
Mangat AK, Schmölzer GM, Kraft WK
Semin Fetal Neonatal Med 2019 Apr;24(2):133-141. Epub 2019 Feb 5 doi: 10.1016/j.siny.2019.01.009. PMID: 30745219Free PMC Article
Wachman EM, Schiff DM, Silverstein M
JAMA 2018 Apr 3;319(13):1362-1374. doi: 10.1001/jama.2018.2640. PMID: 29614184
Whitehead MI, Hillard TC, Crook D
Obstet Gynecol 1990 Apr;75(4 Suppl):59S-76S; discussion 81S-83S. PMID: 2179792
Abel EL
Drug Alcohol Depend 1984 Sep;14(1):1-10. doi: 10.1016/0376-8716(84)90012-7. PMID: 6386408

Recent systematic reviews

Wang J, Cosci F
Psychother Psychosom 2021;90(5):299-307. Epub 2021 May 10 doi: 10.1159/000516031. PMID: 33971648
Shan F, MacVicar S, Allegaert K, Offringa M, Jansson LM, Simpson S, Moulsdale W, Kelly LE
Trials 2020 Mar 12;21(1):262. doi: 10.1186/s13063-020-4183-9. PMID: 32164782Free PMC Article
Furness S, Roberts H, Marjoribanks J, Lethaby A
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD000402. doi: 10.1002/14651858.CD000402.pub4. PMID: 22895916Free PMC Article
Furness S, Roberts H, Marjoribanks J, Lethaby A, Hickey M, Farquhar C
Cochrane Database Syst Rev 2009 Apr 15;(2):CD000402. doi: 10.1002/14651858.CD000402.pub3. PMID: 19370558
Beaumont H, Augood C, Duckitt K, Lethaby A
Cochrane Database Syst Rev 2007 Jul 18;2007(3):CD001017. doi: 10.1002/14651858.CD001017.pub2. PMID: 17636649Free PMC Article

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