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Fetal Neurodevelopmental Disorder

MedGen UID:
769787
•Concept ID:
C3641147
•
Disease or Syndrome

Definition

A fetal affliction that has a neurological basis and manifests as a developmental disability. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal Neurodevelopmental Disorder

Professional guidelines

PubMed

Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.
Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, Daly K, Doutré S, Gibson L, Giles ML, Greenlee J, Hamilton ST, Harrison GJ, Hui L, Jones CA, Palasanthiran P, Schleiss MR, Shand AW, van Zuylen WJ
Lancet Infect Dis 2017 Jun;17(6):e177-e188. Epub 2017 Mar 11 doi: 10.1016/S1473-3099(17)30143-3. PMID: 28291720
Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders.
Hoyme HE, Kalberg WO, Elliott AJ, Blankenship J, Buckley D, Marais AS, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Jewett T, Coles CD, Chambers C, Jones KL, Adnams CM, Shah PE, Riley EP, Charness ME, Warren KR, May PA
Pediatrics 2016 Aug;138(2) Epub 2016 Jul 27 doi: 10.1542/peds.2015-4256. PMID: 27464676Free PMC Article
Diagnosis, treatment, and prevention of cerebral palsy.
O'Shea TM
Clin Obstet Gynecol 2008 Dec;51(4):816-28. doi: 10.1097/GRF.0b013e3181870ba7. PMID: 18981805Free PMC Article

Recent clinical studies

Etiology

Maternal immune activation and neuroinflammation in human neurodevelopmental disorders.
Han VX, Patel S, Jones HF, Dale RC
Nat Rev Neurol 2021 Sep;17(9):564-579. Epub 2021 Aug 2 doi: 10.1038/s41582-021-00530-8. PMID: 34341569
Autism Spectrum Disorder Genetics and the Search for Pathological Mechanisms.
Manoli DS, State MW
Am J Psychiatry 2021 Jan 1;178(1):30-38. doi: 10.1176/appi.ajp.2020.20111608. PMID: 33384012Free PMC Article
Prenatal stress: Effects on fetal and child brain development.
Lautarescu A, Craig MC, Glover V
Int Rev Neurobiol 2020;150:17-40. Epub 2019 Dec 14 doi: 10.1016/bs.irn.2019.11.002. PMID: 32204831
Iron deficiency in pregnancy.
Georgieff MK
Am J Obstet Gynecol 2020 Oct;223(4):516-524. Epub 2020 Mar 14 doi: 10.1016/j.ajog.2020.03.006. PMID: 32184147Free PMC Article
Autism Spectrum Disorder: Classification, diagnosis and therapy.
Sharma SR, Gonda X, Tarazi FI
Pharmacol Ther 2018 Oct;190:91-104. Epub 2018 May 12 doi: 10.1016/j.pharmthera.2018.05.007. PMID: 29763648

Diagnosis

The placenta-brain-axis.
Rosenfeld CS
J Neurosci Res 2021 Jan;99(1):271-283. Epub 2020 Feb 27 doi: 10.1002/jnr.24603. PMID: 32108381Free PMC Article
Iron deficiency in pregnancy.
Georgieff MK
Am J Obstet Gynecol 2020 Oct;223(4):516-524. Epub 2020 Mar 14 doi: 10.1016/j.ajog.2020.03.006. PMID: 32184147Free PMC Article
Autism Spectrum Disorder: Classification, diagnosis and therapy.
Sharma SR, Gonda X, Tarazi FI
Pharmacol Ther 2018 Oct;190:91-104. Epub 2018 May 12 doi: 10.1016/j.pharmthera.2018.05.007. PMID: 29763648
Early-life exposure to EDCs: role in childhood obesity and neurodevelopment.
Braun JM
Nat Rev Endocrinol 2017 Mar;13(3):161-173. Epub 2016 Nov 18 doi: 10.1038/nrendo.2016.186. PMID: 27857130Free PMC Article
How nutritional status, diet and dietary supplements can affect autism. A review.
Kawicka A, Regulska-Ilow B
Rocz Panstw Zakl Hig 2013;64(1):1-12. PMID: 23789306

Therapy

Iron deficiency in pregnancy.
Georgieff MK
Am J Obstet Gynecol 2020 Oct;223(4):516-524. Epub 2020 Mar 14 doi: 10.1016/j.ajog.2020.03.006. PMID: 32184147Free PMC Article
Cannabis use during pregnancy and postpartum.
Badowski S, Smith G
Can Fam Physician 2020 Feb;66(2):98-103. PMID: 32060189Free PMC Article
Preconception and Prenatal Nutrition and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis.
Li M, Francis E, Hinkle SN, Ajjarapu AS, Zhang C
Nutrients 2019 Jul 17;11(7) doi: 10.3390/nu11071628. PMID: 31319515Free PMC Article
Autism Spectrum Disorder: Classification, diagnosis and therapy.
Sharma SR, Gonda X, Tarazi FI
Pharmacol Ther 2018 Oct;190:91-104. Epub 2018 May 12 doi: 10.1016/j.pharmthera.2018.05.007. PMID: 29763648
Pesticide exposure in children.
Roberts JR, Karr CJ; Council On Environmental Health
Pediatrics 2012 Dec;130(6):e1765-88. Epub 2012 Nov 26 doi: 10.1542/peds.2012-2758. PMID: 23184105Free PMC Article

Prognosis

Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review.
Ornoy A, Becker M, Weinstein-Fudim L, Ergaz Z
Int J Mol Sci 2021 Mar 15;22(6) doi: 10.3390/ijms22062965. PMID: 33803995Free PMC Article
Nutritional influences on brain development.
Georgieff MK, Ramel SE, Cusick SE
Acta Paediatr 2018 Aug;107(8):1310-1321. Epub 2018 Mar 22 doi: 10.1111/apa.14287. PMID: 29468731Free PMC Article
Folic acid and autism: What do we know?
Castro K, Klein Lda S, Baronio D, Gottfried C, Riesgo R, Perry IS
Nutr Neurosci 2016 Sep;19(7):310-7. Epub 2016 Mar 1 doi: 10.1179/1476830514Y.0000000142. PMID: 25087906
Effects of perinatal mental disorders on the fetus and child.
Stein A, Pearson RM, Goodman SH, Rapa E, Rahman A, McCallum M, Howard LM, Pariante CM
Lancet 2014 Nov 15;384(9956):1800-19. Epub 2014 Nov 14 doi: 10.1016/S0140-6736(14)61277-0. PMID: 25455250
How nutritional status, diet and dietary supplements can affect autism. A review.
Kawicka A, Regulska-Ilow B
Rocz Panstw Zakl Hig 2013;64(1):1-12. PMID: 23789306

Clinical prediction guides

Association of Antipsychotic Drug Exposure in Pregnancy With Risk of Neurodevelopmental Disorders: A National Birth Cohort Study.
Straub L, Hernández-Díaz S, Bateman BT, Wisner KL, Gray KJ, Pennell PB, Lester B, McDougle CJ, Suarez EA, Zhu Y, Zakoul H, Mogun H, Huybrechts KF
JAMA Intern Med 2022 May 1;182(5):522-533. doi: 10.1001/jamainternmed.2022.0375. PMID: 35343998Free PMC Article
Prenatal stress: Effects on fetal and child brain development.
Lautarescu A, Craig MC, Glover V
Int Rev Neurobiol 2020;150:17-40. Epub 2019 Dec 14 doi: 10.1016/bs.irn.2019.11.002. PMID: 32204831
Autism Spectrum Disorder: Classification, diagnosis and therapy.
Sharma SR, Gonda X, Tarazi FI
Pharmacol Ther 2018 Oct;190:91-104. Epub 2018 May 12 doi: 10.1016/j.pharmthera.2018.05.007. PMID: 29763648
Nutritional influences on brain development.
Georgieff MK, Ramel SE, Cusick SE
Acta Paediatr 2018 Aug;107(8):1310-1321. Epub 2018 Mar 22 doi: 10.1111/apa.14287. PMID: 29468731Free PMC Article
The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes.
Farmer DL, Thom EA, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Gupta N, Adzick NS; Management of Myelomeningocele Study Investigators
Am J Obstet Gynecol 2018 Feb;218(2):256.e1-256.e13. Epub 2017 Dec 12 doi: 10.1016/j.ajog.2017.12.001. PMID: 29246577Free PMC Article

Recent systematic reviews

Evaluation of Long-term Outcomes Associated With Preterm Exposure to Antenatal Corticosteroids: A Systematic Review and Meta-analysis.
Ninan K, Liyanage SK, Murphy KE, Asztalos EV, McDonald SD
JAMA Pediatr 2022 Jun 1;176(6):e220483. Epub 2022 Jun 6 doi: 10.1001/jamapediatrics.2022.0483. PMID: 35404395Free PMC Article
Lead (Pb) and neurodevelopment: A review on exposure and biomarkers of effect (BDNF, HDL) and susceptibility.
Gundacker C, Forsthuber M, Szigeti T, Kakucs R, Mustieles V, Fernandez MF, Bengtsen E, Vogel U, Hougaard KS, Saber AT
Int J Hyg Environ Health 2021 Sep;238:113855. Epub 2021 Oct 13 doi: 10.1016/j.ijheh.2021.113855. PMID: 34655857
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
McGoldrick E, Stewart F, Parker R, Dalziel SR
Cochrane Database Syst Rev 2020 Dec 25;12(12):CD004454. doi: 10.1002/14651858.CD004454.pub4. PMID: 33368142Free PMC Article
Preconception and Prenatal Nutrition and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis.
Li M, Francis E, Hinkle SN, Ajjarapu AS, Zhang C
Nutrients 2019 Jul 17;11(7) doi: 10.3390/nu11071628. PMID: 31319515Free PMC Article
Interventions to improve gross motor performance in children with neurodevelopmental disorders: a meta-analysis.
Lucas BR, Elliott EJ, Coggan S, Pinto RZ, Jirikowic T, McCoy SW, Latimer J
BMC Pediatr 2016 Nov 29;16(1):193. doi: 10.1186/s12887-016-0731-6. PMID: 27899082Free PMC Article

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