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Cervical Low Grade Endometrioid Stromal Sarcoma

MedGen UID:
770967
•Concept ID:
C3642327
•
Neoplastic Process
Synonyms: Cervical Endometrioid Stromal Sarcoma; Endometrioid Stromal Sarcoma of the Cervix; Low Grade Endometrioid Stromal Sarcoma of the Cervix

Definition

A very rare sarcoma that arises from the cervix and is characterized by the presence of cells that resemble endometrial stromal cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Low Grade Endometrioid Stromal Sarcoma

Professional guidelines

PubMed

Clinicopathological characteristics and treatment of patients with high-grade endometrial stromal sarcoma: A retrospective study of 40 cases.
Bai H, Yuan F, Liang B, Sun H, Gao Y, Jin M, Xing X
Medicine (Baltimore) 2022 Jan 14;101(2):e28490. doi: 10.1097/MD.0000000000028490. PMID: 35029198Free PMC Article
The management of uterine sarcomas.
Reed NS
Clin Oncol (R Coll Radiol) 2008 Aug;20(6):470-8. Epub 2008 Jun 24 doi: 10.1016/j.clon.2008.04.002. PMID: 18572394
Fertility after the treatment of gynecologic tumors.
Kesic V
Recent Results Cancer Res 2008;178:79-95. doi: 10.1007/978-3-540-71274-9_9. PMID: 18080446

Recent clinical studies

Etiology

Ovarian preservation in gynecologic oncology: current indications and techniques.
Bizzarri N, Pavone M, Loverro M, Querleu D, Fagotti A, Scambia G
Curr Opin Oncol 2023 Sep 1;35(5):401-411. Epub 2023 Jul 13 doi: 10.1097/CCO.0000000000000969. PMID: 37498120
Clinicopathological characteristics and treatment of patients with high-grade endometrial stromal sarcoma: A retrospective study of 40 cases.
Bai H, Yuan F, Liang B, Sun H, Gao Y, Jin M, Xing X
Medicine (Baltimore) 2022 Jan 14;101(2):e28490. doi: 10.1097/MD.0000000000028490. PMID: 35029198Free PMC Article
Mesonephric-like Carcinoma of the Endometrium: A Subset of Endometrial Carcinoma With an Aggressive Behavior.
Euscher ED, Bassett R, Duose DY, Lan C, Wistuba I, Ramondetta L, Ramalingam P, Malpica A
Am J Surg Pathol 2020 Apr;44(4):429-443. doi: 10.1097/PAS.0000000000001401. PMID: 31725471
Prognostic factors of synchronous endometrial and ovarian endometrioid carcinoma.
Yoneoka Y, Yoshida H, Ishikawa M, Shimizu H, Uehara T, Murakami T, Kato T
J Gynecol Oncol 2019 Jan;30(1):e7. Epub 2018 Sep 17 doi: 10.3802/jgo.2019.30.e7. PMID: 30479091Free PMC Article
Ovary and uterus-sparing procedures for low-grade endometrial stromal sarcoma: a retrospective study of 153 cases.
Bai H, Yang J, Cao D, Huang H, Xiang Y, Wu M, Cui Q, Chen J, Lang J, Shen K
Gynecol Oncol 2014 Mar;132(3):654-60. Epub 2014 Jan 9 doi: 10.1016/j.ygyno.2013.12.032. PMID: 24412112

Diagnosis

Benign Biphasic Tumors of the Mullerian Tract - a Mimic of Phyllodes Tumor. A Clinical-Pathologic Description of 21 Cases.
Wawire J, Sung CJ, Quddus MR
Ann Clin Lab Sci 2023 Jul;53(4):641-646. PMID: 37625832
Ovarian preservation in gynecologic oncology: current indications and techniques.
Bizzarri N, Pavone M, Loverro M, Querleu D, Fagotti A, Scambia G
Curr Opin Oncol 2023 Sep 1;35(5):401-411. Epub 2023 Jul 13 doi: 10.1097/CCO.0000000000000969. PMID: 37498120
Identifying SOX17 as a Sensitive and Specific Marker for Ovarian and Endometrial Carcinomas.
Shaker N, Chen W, Sinclair W, Parwani AV, Li Z
Mod Pathol 2023 Jan;36(1):100038. doi: 10.1016/j.modpat.2022.100038. PMID: 36788073
Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements.
Tsai JW, Lee JC, Hsieh TH, Huang SC, Lee PH, Liu TT, Kao YC, Chang CD, Weng TF, Li CF, Lin JC, Liang CW, Su YL, Chang IY, Wang YT, Chang NY, Yu SC, Wang JC, Huang HY
Mod Pathol 2022 Jul;35(7):911-921. Epub 2022 Feb 11 doi: 10.1038/s41379-021-01005-3. PMID: 35149769
Recently described entities in the gynaecological tract.
Reyes MC, Cooper K
Pathology 2015 Aug;47(5):414-22. doi: 10.1097/PAT.0000000000000277. PMID: 26126047

Therapy

Estrogen therapy in gynecological cancer survivors.
Guidozzi F
Climacteric 2013 Dec;16(6):611-7. Epub 2013 Aug 16 doi: 10.3109/13697137.2013.806471. PMID: 23952524
Menopause, hormone replacement and gynaecological cancers.
Hinds L, Price J
Menopause Int 2010 Jun;16(2):89-93. doi: 10.1258/mi.2010.010018. PMID: 20729501
Pitfalls in staging uterine neoplasm with imaging: a review.
Kinkel K
Abdom Imaging 2006 Mar-Apr;31(2):164-73. doi: 10.1007/s00261-005-0383-8. PMID: 16333697
Fertility-sparing surgery for malignancies in women.
Gershenson DM
J Natl Cancer Inst Monogr 2005;(34):43-7. doi: 10.1093/jncimonographs/lgi011. PMID: 15784822
Findings to date from the ASCUS-LSIL Triage Study (ALTS).
Schiffman M, Solomon D
Arch Pathol Lab Med 2003 Aug;127(8):946-9. doi: 10.5858/2003-127-946-FTDFTA. PMID: 12873166

Prognosis

Multi-institutional study on the role of post-operative radiotherapy in elderly patients with endometrial cancer.
Yavas G, Guler OC, Gultekin M, Oymak E, Yuce Sari S, Yildiz F, Onal C
Int J Gynecol Cancer 2023 May 1;33(5):719-726. doi: 10.1136/ijgc-2022-004034. PMID: 36635049
Clinicopathological characteristics and treatment of patients with high-grade endometrial stromal sarcoma: A retrospective study of 40 cases.
Bai H, Yuan F, Liang B, Sun H, Gao Y, Jin M, Xing X
Medicine (Baltimore) 2022 Jan 14;101(2):e28490. doi: 10.1097/MD.0000000000028490. PMID: 35029198Free PMC Article
Prognostic factors of synchronous endometrial and ovarian endometrioid carcinoma.
Yoneoka Y, Yoshida H, Ishikawa M, Shimizu H, Uehara T, Murakami T, Kato T
J Gynecol Oncol 2019 Jan;30(1):e7. Epub 2018 Sep 17 doi: 10.3802/jgo.2019.30.e7. PMID: 30479091Free PMC Article
Ovary and uterus-sparing procedures for low-grade endometrial stromal sarcoma: a retrospective study of 153 cases.
Bai H, Yang J, Cao D, Huang H, Xiang Y, Wu M, Cui Q, Chen J, Lang J, Shen K
Gynecol Oncol 2014 Mar;132(3):654-60. Epub 2014 Jan 9 doi: 10.1016/j.ygyno.2013.12.032. PMID: 24412112
Non-primary cervical adenocarcinomas.
Mulvany NJ, Nirenberg A, Oster AG
Pathology 1996 Nov;28(4):293-7. doi: 10.1080/00313029600169214. PMID: 9007944

Clinical prediction guides

Multi-institutional study on the role of post-operative radiotherapy in elderly patients with endometrial cancer.
Yavas G, Guler OC, Gultekin M, Oymak E, Yuce Sari S, Yildiz F, Onal C
Int J Gynecol Cancer 2023 May 1;33(5):719-726. doi: 10.1136/ijgc-2022-004034. PMID: 36635049
Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements.
Tsai JW, Lee JC, Hsieh TH, Huang SC, Lee PH, Liu TT, Kao YC, Chang CD, Weng TF, Li CF, Lin JC, Liang CW, Su YL, Chang IY, Wang YT, Chang NY, Yu SC, Wang JC, Huang HY
Mod Pathol 2022 Jul;35(7):911-921. Epub 2022 Feb 11 doi: 10.1038/s41379-021-01005-3. PMID: 35149769
Clinicopathological characteristics and treatment of patients with high-grade endometrial stromal sarcoma: A retrospective study of 40 cases.
Bai H, Yuan F, Liang B, Sun H, Gao Y, Jin M, Xing X
Medicine (Baltimore) 2022 Jan 14;101(2):e28490. doi: 10.1097/MD.0000000000028490. PMID: 35029198Free PMC Article
Prognostic factors of synchronous endometrial and ovarian endometrioid carcinoma.
Yoneoka Y, Yoshida H, Ishikawa M, Shimizu H, Uehara T, Murakami T, Kato T
J Gynecol Oncol 2019 Jan;30(1):e7. Epub 2018 Sep 17 doi: 10.3802/jgo.2019.30.e7. PMID: 30479091Free PMC Article
Endometrial stromal sarcoma arising from endometriosis: a clinicopathological study and literature review.
Lan C, Huang X, Lin S, Cai M, Liu J
Gynecol Obstet Invest 2012;74(4):288-97. Epub 2012 Sep 19 doi: 10.1159/000341706. PMID: 22986788

Recent systematic reviews

Uterine lesions with sex cord-like architectures: a systematic review.
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article
Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients.
Elsebaie MA, Elsayed Z
Arch Gynecol Obstet 2018 Mar;297(3):559-572. Epub 2017 Nov 20 doi: 10.1007/s00404-017-4591-6. PMID: 29159540
Clinical characteristics and outcomes of uterine tumors resembling ovarian sex-cord tumors (UTROSCT): a systematic review of literature.
Blake EA, Sheridan TB, Wang KL, Takiuchi T, Kodama M, Sawada K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Oct;181:163-70. Epub 2014 Aug 8 doi: 10.1016/j.ejogrb.2014.07.050. PMID: 25150955

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