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Luminal B breast carcinoma

MedGen UID:
770986
Concept ID:
C3642346
Neoplastic Process
Synonyms: Luminal B; Luminal B Breast Cancer; Luminal B breast cancer; Luminal B Breast Carcinoma; luminal B breast carcinoma; Luminal B Estrogen Receptor Positive Subtype of Breast Carcinoma; Luminal B estrogen receptor positive subtype of breast carcinoma; Luminal B oestrogen receptor positive subtype of breast carcinoma; Luminal B Subtype of Breast Carcinoma; Luminal B subtype of breast carcinoma
 
Monarch Initiative: MONDO:0021115

Definition

A biologic subset of breast carcinoma defined by low to moderate expression of genes characteristic of luminal epithelial cells including estrogen receptor (ER), and high expression of GGH, LAPTM4B, and CCNE1. This subtype of breast cancer is associated with a good prognosis, although not as favorable as the luminal A subtype. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLuminal B breast carcinoma

Professional guidelines

PubMed

Kawaji H, Kubo M, Yamashita N, Yamamoto H, Kai M, Kajihara A, Yamada M, Kurata K, Kaneshiro K, Harada Y, Hayashi S, Shimazaki A, Mori H, Akiyoshi S, Oki E, Oda Y, Baba E, Mori M, Nakamura M
Cancer Med 2021 Jan;10(2):529-539. Epub 2020 Dec 4 doi: 10.1002/cam4.3619. PMID: 33274848Free PMC Article
McGuire A, Brown JA, Kerin MJ
Cancer Metastasis Rev 2015 Mar;34(1):145-55. doi: 10.1007/s10555-015-9551-7. PMID: 25721950Free PMC Article
Ades F, Zardavas D, Bozovic-Spasojevic I, Pugliano L, Fumagalli D, de Azambuja E, Viale G, Sotiriou C, Piccart M
J Clin Oncol 2014 Sep 1;32(25):2794-803. Epub 2014 Jul 21 doi: 10.1200/JCO.2013.54.1870. PMID: 25049332

Recent clinical studies

Diagnosis

Arihiro K, Oda M, Ohara M, Kadoya T, Osaki A, Nishisaka T, Shiroma N, Kobayashi Y
Jpn J Clin Oncol 2016 Dec;46(12):1081-1087. Epub 2016 Aug 10 doi: 10.1093/jjco/hyw107. PMID: 27511992

Prognosis

Arihiro K, Oda M, Ohara M, Kadoya T, Osaki A, Nishisaka T, Shiroma N, Kobayashi Y
Jpn J Clin Oncol 2016 Dec;46(12):1081-1087. Epub 2016 Aug 10 doi: 10.1093/jjco/hyw107. PMID: 27511992

Clinical prediction guides

Arihiro K, Oda M, Ohara M, Kadoya T, Osaki A, Nishisaka T, Shiroma N, Kobayashi Y
Jpn J Clin Oncol 2016 Dec;46(12):1081-1087. Epub 2016 Aug 10 doi: 10.1093/jjco/hyw107. PMID: 27511992

Supplemental Content

Table of contents

    Clinical resources

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