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Dysbiosis

MedGen UID:
772407
•Concept ID:
C3658208
•
Pathologic Function
Synonyms: Disbioses; Disbiosis; Dys symbiosis; Dys-symbioses; Dys-symbiosis; Dysbioses

Definition

Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDysbiosis

Professional guidelines

PubMed

Gut microbiota and hypertension: association, mechanisms and treatment.
Yang Z, Wang Q, Liu Y, Wang L, Ge Z, Li Z, Feng S, Wu C
Clin Exp Hypertens 2023 Dec 31;45(1):2195135. doi: 10.1080/10641963.2023.2195135. PMID: 36994745
Gut microbiota and its metabolites in depression: from pathogenesis to treatment.
Liu L, Wang H, Chen X, Zhang Y, Zhang H, Xie P
EBioMedicine 2023 Apr;90:104527. Epub 2023 Mar 22 doi: 10.1016/j.ebiom.2023.104527. PMID: 36963238Free PMC Article
Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment.
Bisgaard TH, Allin KH, Keefer L, Ananthakrishnan AN, Jess T
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):717-726. Epub 2022 Jun 22 doi: 10.1038/s41575-022-00634-6. PMID: 35732730

Recent clinical studies

Etiology

Schizophrenia: The new etiological synthesis.
Rantala MJ, Luoto S, Borráz-León JI, Krams I
Neurosci Biobehav Rev 2022 Nov;142:104894. Epub 2022 Sep 28 doi: 10.1016/j.neubiorev.2022.104894. PMID: 36181926
Gut microbiota, inflammatory bowel disease and colorectal cancer.
Quaglio AEV, Grillo TG, De Oliveira ECS, Di Stasi LC, Sassaki LY
World J Gastroenterol 2022 Aug 14;28(30):4053-4060. doi: 10.3748/wjg.v28.i30.4053. PMID: 36157114Free PMC Article
Gut microbiota and allergic diseases in children.
Akagawa S, Kaneko K
Allergol Int 2022 Jul;71(3):301-309. Epub 2022 Mar 18 doi: 10.1016/j.alit.2022.02.004. PMID: 35314107
Intricate Connections between the Microbiota and Endometriosis.
Jiang I, Yong PJ, Allaire C, Bedaiwy MA
Int J Mol Sci 2021 May 26;22(11) doi: 10.3390/ijms22115644. PMID: 34073257Free PMC Article
Mechanisms and consequences of intestinal dysbiosis.
Weiss GA, Hennet T
Cell Mol Life Sci 2017 Aug;74(16):2959-2977. Epub 2017 Mar 28 doi: 10.1007/s00018-017-2509-x. PMID: 28352996

Diagnosis

Gut dysbiosis in nonalcoholic fatty liver disease: pathogenesis, diagnosis, and therapeutic implications.
Fang J, Yu CH, Li XJ, Yao JM, Fang ZY, Yoon SH, Yu WY
Front Cell Infect Microbiol 2022;12:997018. Epub 2022 Nov 8 doi: 10.3389/fcimb.2022.997018. PMID: 36425787Free PMC Article
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders.
Sorboni SG, Moghaddam HS, Jafarzadeh-Esfehani R, Soleimanpour S
Clin Microbiol Rev 2022 Jan 19;35(1):e0033820. Epub 2022 Jan 5 doi: 10.1128/CMR.00338-20. PMID: 34985325Free PMC Article
Bacterial Vaginosis: What Do We Currently Know?
Abou Chacra L, Fenollar F, Diop K
Front Cell Infect Microbiol 2021;11:672429. Epub 2022 Jan 18 doi: 10.3389/fcimb.2021.672429. PMID: 35118003Free PMC Article
Intestinal Barrier in Human Health and Disease.
Di Tommaso N, Gasbarrini A, Ponziani FR
Int J Environ Res Public Health 2021 Dec 6;18(23) doi: 10.3390/ijerph182312836. PMID: 34886561Free PMC Article
The role of the microbiota in periodontal disease.
Curtis MA, Diaz PI, Van Dyke TE
Periodontol 2000 2020 Jun;83(1):14-25. doi: 10.1111/prd.12296. PMID: 32385883

Therapy

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression.
Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, Xie Z, Chu X, Yang J, Wang H, Chang S, Gong Y, Ruan L, Zhang G, Yan S, Lian W, Du C, Yang D, Zhang Q, Lin F, Liu J, Zhang H, Ge C, Xiao S, Ding J, Geng M
Cell Res 2019 Oct;29(10):787-803. Epub 2019 Sep 6 doi: 10.1038/s41422-019-0216-x. PMID: 31488882Free PMC Article
Role of Probiotics in Human Gut Microbiome-Associated Diseases.
Kim SK, Guevarra RB, Kim YT, Kwon J, Kim H, Cho JH, Kim HB, Lee JH
J Microbiol Biotechnol 2019 Sep 28;29(9):1335-1340. doi: 10.4014/jmb.1906.06064. PMID: 31434172
Airway inflammation in COPD: progress to precision medicine.
Brightling C, Greening N
Eur Respir J 2019 Aug;54(2) Epub 2019 Aug 1 doi: 10.1183/13993003.00651-2019. PMID: 31073084
The gut microbiome in food allergy.
Zhao W, Ho HE, Bunyavanich S
Ann Allergy Asthma Immunol 2019 Mar;122(3):276-282. Epub 2018 Dec 20 doi: 10.1016/j.anai.2018.12.012. PMID: 30578857Free PMC Article
Probiotics, gut microbiota and health.
Butel MJ
Med Mal Infect 2014 Jan;44(1):1-8. Epub 2013 Nov 28 doi: 10.1016/j.medmal.2013.10.002. PMID: 24290962

Prognosis

Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors.
Huang DQ, Mathurin P, Cortez-Pinto H, Loomba R
Nat Rev Gastroenterol Hepatol 2023 Jan;20(1):37-49. Epub 2022 Oct 18 doi: 10.1038/s41575-022-00688-6. PMID: 36258033Free PMC Article
Gut microbiota, inflammatory bowel disease and colorectal cancer.
Quaglio AEV, Grillo TG, De Oliveira ECS, Di Stasi LC, Sassaki LY
World J Gastroenterol 2022 Aug 14;28(30):4053-4060. doi: 10.3748/wjg.v28.i30.4053. PMID: 36157114Free PMC Article
Intricate Connections between the Microbiota and Endometriosis.
Jiang I, Yong PJ, Allaire C, Bedaiwy MA
Int J Mol Sci 2021 May 26;22(11) doi: 10.3390/ijms22115644. PMID: 34073257Free PMC Article
Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention.
Huang DQ, El-Serag HB, Loomba R
Nat Rev Gastroenterol Hepatol 2021 Apr;18(4):223-238. Epub 2020 Dec 21 doi: 10.1038/s41575-020-00381-6. PMID: 33349658Free PMC Article
The Healthy Microbiome-What Is the Definition of a Healthy Gut Microbiome?
Shanahan F, Ghosh TS, O'Toole PW
Gastroenterology 2021 Jan;160(2):483-494. Epub 2020 Nov 27 doi: 10.1053/j.gastro.2020.09.057. PMID: 33253682

Clinical prediction guides

Schizophrenia: The new etiological synthesis.
Rantala MJ, Luoto S, Borráz-León JI, Krams I
Neurosci Biobehav Rev 2022 Nov;142:104894. Epub 2022 Sep 28 doi: 10.1016/j.neubiorev.2022.104894. PMID: 36181926
Bacterial Vaginosis: What Do We Currently Know?
Abou Chacra L, Fenollar F, Diop K
Front Cell Infect Microbiol 2021;11:672429. Epub 2022 Jan 18 doi: 10.3389/fcimb.2021.672429. PMID: 35118003Free PMC Article
Intricate Connections between the Microbiota and Endometriosis.
Jiang I, Yong PJ, Allaire C, Bedaiwy MA
Int J Mol Sci 2021 May 26;22(11) doi: 10.3390/ijms22115644. PMID: 34073257Free PMC Article
Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity.
Kinashi Y, Hase K
Front Immunol 2021;12:673708. Epub 2021 Apr 22 doi: 10.3389/fimmu.2021.673708. PMID: 33968085Free PMC Article
Estrogen-gut microbiome axis: Physiological and clinical implications.
Baker JM, Al-Nakkash L, Herbst-Kralovetz MM
Maturitas 2017 Sep;103:45-53. Epub 2017 Jun 23 doi: 10.1016/j.maturitas.2017.06.025. PMID: 28778332

Recent systematic reviews

High-Fiber Diet and Crohn's Disease: Systematic Review and Meta-Analysis.
Serrano Fernandez V, Seldas Palomino M, Laredo-Aguilera JA, Pozuelo-Carrascosa DP, Carmona-Torres JM
Nutrients 2023 Jul 12;15(14) doi: 10.3390/nu15143114. PMID: 37513532Free PMC Article
The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: A systematic review.
Barrio C, Arias-Sánchez S, Martín-Monzón I
Psychoneuroendocrinology 2022 Mar;137:105640. Epub 2021 Dec 17 doi: 10.1016/j.psyneuen.2021.105640. PMID: 34942539
Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis.
Nikolova VL, Smith MRB, Hall LJ, Cleare AJ, Stone JM, Young AH
JAMA Psychiatry 2021 Dec 1;78(12):1343-1354. doi: 10.1001/jamapsychiatry.2021.2573. PMID: 34524405Free PMC Article
Understanding the gut microbiota and sarcopenia: a systematic review.
Liu C, Cheung WH, Li J, Chow SK, Yu J, Wong SH, Ip M, Sung JJY, Wong RMY
J Cachexia Sarcopenia Muscle 2021 Dec;12(6):1393-1407. Epub 2021 Sep 14 doi: 10.1002/jcsm.12784. PMID: 34523250Free PMC Article
Association between antibiotics and gut microbiome dysbiosis in children: systematic review and meta-analysis.
McDonnell L, Gilkes A, Ashworth M, Rowland V, Harries TH, Armstrong D, White P
Gut Microbes 2021 Jan-Dec;13(1):1-18. doi: 10.1080/19490976.2020.1870402. PMID: 33651651Free PMC Article

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