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Dysbiosis

MedGen UID:
772407
•Concept ID:
C3658208
•
Pathologic Function
Synonyms: Disbioses; Disbiosis; Dys symbiosis; Dys-symbioses; Dys-symbiosis; Dysbioses

Definition

Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDysbiosis

Professional guidelines

PubMed

Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment.
Bisgaard TH, Allin KH, Keefer L, Ananthakrishnan AN, Jess T
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):717-726. Epub 2022 Jun 22 doi: 10.1038/s41575-022-00634-6. PMID: 35732730
Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment.
Liu S, Gao J, Zhu M, Liu K, Zhang HL
Mol Neurobiol 2020 Dec;57(12):5026-5043. Epub 2020 Aug 23 doi: 10.1007/s12035-020-02073-3. PMID: 32829453Free PMC Article
The importance of nutritional factors and dietary management of Hashimoto's thyroiditis.
Ihnatowicz P, Drywień M, Wątor P, Wojsiat J
Ann Agric Environ Med 2020 Jun 19;27(2):184-193. Epub 2019 Oct 2 doi: 10.26444/aaem/112331. PMID: 32588591

Recent clinical studies

Etiology

Bacterial Vaginosis: What Do We Currently Know?
Abou Chacra L, Fenollar F, Diop K
Front Cell Infect Microbiol 2021;11:672429. Epub 2022 Jan 18 doi: 10.3389/fcimb.2021.672429. PMID: 35118003Free PMC Article
Intricate Connections between the Microbiota and Endometriosis.
Jiang I, Yong PJ, Allaire C, Bedaiwy MA
Int J Mol Sci 2021 May 26;22(11) doi: 10.3390/ijms22115644. PMID: 34073257Free PMC Article
The Gut Microbiota and Healthy Aging: A Mini-Review.
Kim S, Jazwinski SM
Gerontology 2018;64(6):513-520. Epub 2018 Jul 19 doi: 10.1159/000490615. PMID: 30025401Free PMC Article
Mechanisms and consequences of intestinal dysbiosis.
Weiss GA, Hennet T
Cell Mol Life Sci 2017 Aug;74(16):2959-2977. Epub 2017 Mar 28 doi: 10.1007/s00018-017-2509-x. PMID: 28352996
Proteobacteria: microbial signature of dysbiosis in gut microbiota.
Shin NR, Whon TW, Bae JW
Trends Biotechnol 2015 Sep;33(9):496-503. Epub 2015 Jul 22 doi: 10.1016/j.tibtech.2015.06.011. PMID: 26210164

Diagnosis

A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders.
Sorboni SG, Moghaddam HS, Jafarzadeh-Esfehani R, Soleimanpour S
Clin Microbiol Rev 2022 Jan 19;35(1):e0033820. Epub 2022 Jan 5 doi: 10.1128/CMR.00338-20. PMID: 34985325Free PMC Article
Bacterial Vaginosis: What Do We Currently Know?
Abou Chacra L, Fenollar F, Diop K
Front Cell Infect Microbiol 2021;11:672429. Epub 2022 Jan 18 doi: 10.3389/fcimb.2021.672429. PMID: 35118003Free PMC Article
Intestinal Barrier in Human Health and Disease.
Di Tommaso N, Gasbarrini A, Ponziani FR
Int J Environ Res Public Health 2021 Dec 6;18(23) doi: 10.3390/ijerph182312836. PMID: 34886561Free PMC Article
The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?
Magne F, Gotteland M, Gauthier L, Zazueta A, Pesoa S, Navarrete P, Balamurugan R
Nutrients 2020 May 19;12(5) doi: 10.3390/nu12051474. PMID: 32438689Free PMC Article
The role of the microbiota in periodontal disease.
Curtis MA, Diaz PI, Van Dyke TE
Periodontol 2000 2020 Jun;83(1):14-25. doi: 10.1111/prd.12296. PMID: 32385883

Therapy

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression.
Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, Xie Z, Chu X, Yang J, Wang H, Chang S, Gong Y, Ruan L, Zhang G, Yan S, Lian W, Du C, Yang D, Zhang Q, Lin F, Liu J, Zhang H, Ge C, Xiao S, Ding J, Geng M
Cell Res 2019 Oct;29(10):787-803. Epub 2019 Sep 6 doi: 10.1038/s41422-019-0216-x. PMID: 31488882Free PMC Article
Role of Probiotics in Human Gut Microbiome-Associated Diseases.
Kim SK, Guevarra RB, Kim YT, Kwon J, Kim H, Cho JH, Kim HB, Lee JH
J Microbiol Biotechnol 2019 Sep 28;29(9):1335-1340. doi: 10.4014/jmb.1906.06064. PMID: 31434172
Airway inflammation in COPD: progress to precision medicine.
Brightling C, Greening N
Eur Respir J 2019 Aug;54(2) Epub 2019 Aug 1 doi: 10.1183/13993003.00651-2019. PMID: 31073084
Autism Spectrum Disorders and the Gut Microbiota.
Fattorusso A, Di Genova L, Dell'Isola GB, Mencaroni E, Esposito S
Nutrients 2019 Feb 28;11(3) doi: 10.3390/nu11030521. PMID: 30823414Free PMC Article
Probiotics, gut microbiota and health.
Butel MJ
Med Mal Infect 2014 Jan;44(1):1-8. Epub 2013 Nov 28 doi: 10.1016/j.medmal.2013.10.002. PMID: 24290962

Prognosis

Intricate Connections between the Microbiota and Endometriosis.
Jiang I, Yong PJ, Allaire C, Bedaiwy MA
Int J Mol Sci 2021 May 26;22(11) doi: 10.3390/ijms22115644. PMID: 34073257Free PMC Article
Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention.
Huang DQ, El-Serag HB, Loomba R
Nat Rev Gastroenterol Hepatol 2021 Apr;18(4):223-238. Epub 2020 Dec 21 doi: 10.1038/s41575-020-00381-6. PMID: 33349658Free PMC Article
Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues.
Lee M, Chang EB
Gastroenterology 2021 Jan;160(2):524-537. Epub 2020 Nov 27 doi: 10.1053/j.gastro.2020.09.056. PMID: 33253681Free PMC Article
Gut-liver crosstalk in sepsis-induced liver injury.
Sun J, Zhang J, Wang X, Ji F, Ronco C, Tian J, Yin Y
Crit Care 2020 Oct 19;24(1):614. doi: 10.1186/s13054-020-03327-1. PMID: 33076940Free PMC Article
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer.
Song M, Chan AT, Sun J
Gastroenterology 2020 Jan;158(2):322-340. Epub 2019 Oct 3 doi: 10.1053/j.gastro.2019.06.048. PMID: 31586566Free PMC Article

Clinical prediction guides

Bacterial Vaginosis: What Do We Currently Know?
Abou Chacra L, Fenollar F, Diop K
Front Cell Infect Microbiol 2021;11:672429. Epub 2022 Jan 18 doi: 10.3389/fcimb.2021.672429. PMID: 35118003Free PMC Article
Intricate Connections between the Microbiota and Endometriosis.
Jiang I, Yong PJ, Allaire C, Bedaiwy MA
Int J Mol Sci 2021 May 26;22(11) doi: 10.3390/ijms22115644. PMID: 34073257Free PMC Article
Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity.
Kinashi Y, Hase K
Front Immunol 2021;12:673708. Epub 2021 Apr 22 doi: 10.3389/fimmu.2021.673708. PMID: 33968085Free PMC Article
Estrogen-gut microbiome axis: Physiological and clinical implications.
Baker JM, Al-Nakkash L, Herbst-Kralovetz MM
Maturitas 2017 Sep;103:45-53. Epub 2017 Jun 23 doi: 10.1016/j.maturitas.2017.06.025. PMID: 28778332
The role of the gut microbiota in NAFLD.
Leung C, Rivera L, Furness JB, Angus PW
Nat Rev Gastroenterol Hepatol 2016 Jul;13(7):412-25. Epub 2016 Jun 8 doi: 10.1038/nrgastro.2016.85. PMID: 27273168

Recent systematic reviews

The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: A systematic review.
Barrio C, Arias-Sánchez S, Martín-Monzón I
Psychoneuroendocrinology 2022 Mar;137:105640. Epub 2021 Dec 17 doi: 10.1016/j.psyneuen.2021.105640. PMID: 34942539
Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis.
Nikolova VL, Smith MRB, Hall LJ, Cleare AJ, Stone JM, Young AH
JAMA Psychiatry 2021 Dec 1;78(12):1343-1354. doi: 10.1001/jamapsychiatry.2021.2573. PMID: 34524405Free PMC Article
Understanding the gut microbiota and sarcopenia: a systematic review.
Liu C, Cheung WH, Li J, Chow SK, Yu J, Wong SH, Ip M, Sung JJY, Wong RMY
J Cachexia Sarcopenia Muscle 2021 Dec;12(6):1393-1407. Epub 2021 Sep 14 doi: 10.1002/jcsm.12784. PMID: 34523250Free PMC Article
Association between antibiotics and gut microbiome dysbiosis in children: systematic review and meta-analysis.
McDonnell L, Gilkes A, Ashworth M, Rowland V, Harries TH, Armstrong D, White P
Gut Microbes 2021 Jan-Dec;13(1):1-18. doi: 10.1080/19490976.2020.1870402. PMID: 33651651Free PMC Article
Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Huang R, Wang K, Hu J
Nutrients 2016 Aug 6;8(8) doi: 10.3390/nu8080483. PMID: 27509521Free PMC Article

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