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Fluoropyrimidine response

MedGen UID:
776457
•Concept ID:
CN184090
•
Sign or Symptom
Drug:
Fluoropyrimidine
MedGen UID:
452644
•Concept ID:
C0596581
•
Pharmacologic Substance
Any fluoropyrimidine-based agent with potential antineoplastic activity. As an antimetabolite, a fluoropyrimidine interferes with pyrimidine utilization and incorporation into DNA and RNA. [from NCI]
Fluoropyrimidine
 
Gene (location): DPYD (1p21.3)

Professional guidelines

PubMed

2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS).
Lyon AR, López-Fernández T, Couch LS, Asteggiano R, Aznar MC, Bergler-Klein J, Boriani G, Cardinale D, Cordoba R, Cosyns B, Cutter DJ, de Azambuja E, de Boer RA, Dent SF, Farmakis D, Gevaert SA, Gorog DA, Herrmann J, Lenihan D, Moslehi J, Moura B, Salinger SS, Stephens R, Suter TM, Szmit S, Tamargo J, Thavendiranathan P, Tocchetti CG, van der Meer P, van der Pal HJH; ESC Scientific Document Group
Eur Heart J 2022 Nov 1;43(41):4229-4361. doi: 10.1093/eurheartj/ehac244. PMID: 36017568
Adjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update.
Baxter NN, Kennedy EB, Bergsland E, Berlin J, George TJ, Gill S, Gold PJ, Hantel A, Jones L, Lieu C, Mahmoud N, Morris AM, Ruiz-Garcia E, You YN, Meyerhardt JA
J Clin Oncol 2022 Mar 10;40(8):892-910. Epub 2021 Dec 22 doi: 10.1200/JCO.21.02538. PMID: 34936379
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update.
Amstutz U, Henricks LM, Offer SM, Barbarino J, Schellens JHM, Swen JJ, Klein TE, McLeod HL, Caudle KE, Diasio RB, Schwab M
Clin Pharmacol Ther 2018 Feb;103(2):210-216. Epub 2017 Nov 20 doi: 10.1002/cpt.911. PMID: 29152729Free PMC Article

Recent clinical studies

Etiology

MIR27A rs895819 TC genotype increases risk of fluoropyrimidine-induced severe toxicity independently of DPYD variations.
Ragia G, Biziota E, Koukaki T, Amarantidis K, Manolopoulos VG
Pharmacogenomics 2024 Jan;25(2):59-67. Epub 2024 Feb 14 doi: 10.2217/pgs-2023-0223. PMID: 38353109
MTHFR c.665C>T guided fluoropyrimidine therapy in cancer: gender-dependent effect on dose requirements.
Ioannou C, Ragia G, Balgkouranidou I, Xenidis N, Amarantidis K, Koukaki T, Biziota E, Kakolyris S, Manolopoulos VG
Drug Metab Pers Ther 2022 Sep 1;37(3):323-327. Epub 2022 Mar 11 doi: 10.1515/dmpt-2021-0219. PMID: 35272420
Assessment of infusional 5-fluorouracil schedule and dose intensity: a Southwest Oncology Group and Eastern Cooperative Oncology Group study.
Leichman CG, Benedetti JK, Zalupski MM, Hochster H, Shields AF, Lenz HJ, Wade Iii JL, Bearden Iii JD, Macdonald JS
Clin Colorectal Cancer 2005 Jul;5(2):119-23. doi: 10.3816/ccc.2005.n.024. PMID: 16098253

Diagnosis

MIR27A rs895819 TC genotype increases risk of fluoropyrimidine-induced severe toxicity independently of DPYD variations.
Ragia G, Biziota E, Koukaki T, Amarantidis K, Manolopoulos VG
Pharmacogenomics 2024 Jan;25(2):59-67. Epub 2024 Feb 14 doi: 10.2217/pgs-2023-0223. PMID: 38353109
Assessment of infusional 5-fluorouracil schedule and dose intensity: a Southwest Oncology Group and Eastern Cooperative Oncology Group study.
Leichman CG, Benedetti JK, Zalupski MM, Hochster H, Shields AF, Lenz HJ, Wade Iii JL, Bearden Iii JD, Macdonald JS
Clin Colorectal Cancer 2005 Jul;5(2):119-23. doi: 10.3816/ccc.2005.n.024. PMID: 16098253

Therapy

MIR27A rs895819 TC genotype increases risk of fluoropyrimidine-induced severe toxicity independently of DPYD variations.
Ragia G, Biziota E, Koukaki T, Amarantidis K, Manolopoulos VG
Pharmacogenomics 2024 Jan;25(2):59-67. Epub 2024 Feb 14 doi: 10.2217/pgs-2023-0223. PMID: 38353109
MTHFR c.665C>T guided fluoropyrimidine therapy in cancer: gender-dependent effect on dose requirements.
Ioannou C, Ragia G, Balgkouranidou I, Xenidis N, Amarantidis K, Koukaki T, Biziota E, Kakolyris S, Manolopoulos VG
Drug Metab Pers Ther 2022 Sep 1;37(3):323-327. Epub 2022 Mar 11 doi: 10.1515/dmpt-2021-0219. PMID: 35272420
Assessment of infusional 5-fluorouracil schedule and dose intensity: a Southwest Oncology Group and Eastern Cooperative Oncology Group study.
Leichman CG, Benedetti JK, Zalupski MM, Hochster H, Shields AF, Lenz HJ, Wade Iii JL, Bearden Iii JD, Macdonald JS
Clin Colorectal Cancer 2005 Jul;5(2):119-23. doi: 10.3816/ccc.2005.n.024. PMID: 16098253

Prognosis

MIR27A rs895819 TC genotype increases risk of fluoropyrimidine-induced severe toxicity independently of DPYD variations.
Ragia G, Biziota E, Koukaki T, Amarantidis K, Manolopoulos VG
Pharmacogenomics 2024 Jan;25(2):59-67. Epub 2024 Feb 14 doi: 10.2217/pgs-2023-0223. PMID: 38353109
miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation.
Boni V, Bitarte N, Cristobal I, Zarate R, Rodriguez J, Maiello E, Garcia-Foncillas J, Bandres E
Mol Cancer Ther 2010 Aug;9(8):2265-75. Epub 2010 Jul 20 doi: 10.1158/1535-7163.MCT-10-0061. PMID: 20647341
Assessment of infusional 5-fluorouracil schedule and dose intensity: a Southwest Oncology Group and Eastern Cooperative Oncology Group study.
Leichman CG, Benedetti JK, Zalupski MM, Hochster H, Shields AF, Lenz HJ, Wade Iii JL, Bearden Iii JD, Macdonald JS
Clin Colorectal Cancer 2005 Jul;5(2):119-23. doi: 10.3816/ccc.2005.n.024. PMID: 16098253

Clinical prediction guides

MIR27A rs895819 TC genotype increases risk of fluoropyrimidine-induced severe toxicity independently of DPYD variations.
Ragia G, Biziota E, Koukaki T, Amarantidis K, Manolopoulos VG
Pharmacogenomics 2024 Jan;25(2):59-67. Epub 2024 Feb 14 doi: 10.2217/pgs-2023-0223. PMID: 38353109
miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation.
Boni V, Bitarte N, Cristobal I, Zarate R, Rodriguez J, Maiello E, Garcia-Foncillas J, Bandres E
Mol Cancer Ther 2010 Aug;9(8):2265-75. Epub 2010 Jul 20 doi: 10.1158/1535-7163.MCT-10-0061. PMID: 20647341
Assessment of infusional 5-fluorouracil schedule and dose intensity: a Southwest Oncology Group and Eastern Cooperative Oncology Group study.
Leichman CG, Benedetti JK, Zalupski MM, Hochster H, Shields AF, Lenz HJ, Wade Iii JL, Bearden Iii JD, Macdonald JS
Clin Colorectal Cancer 2005 Jul;5(2):119-23. doi: 10.3816/ccc.2005.n.024. PMID: 16098253

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