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Orthostatic syncope

MedGen UID:
776676
•Concept ID:
C0749201
•
Disease or Syndrome; Sign or Symptom
HPO: HP:0012670

Definition

Syncope following a quick change in position from lying down to standing. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrthostatic syncope

Professional guidelines

PubMed

Salt supplementation in the management of orthostatic intolerance: Vasovagal syncope and postural orthostatic tachycardia syndrome.
Williams EL, Raj SR, Schondorf R, Shen WK, Wieling W, Claydon VE
Auton Neurosci 2022 Jan;237:102906. Epub 2021 Nov 11 doi: 10.1016/j.autneu.2021.102906. PMID: 34823150
Syncope: Approaches to Diagnosis and Management.
Palaniswamy C, Aronow WS, Agrawal N, Balasubramaniyam N, Lakshmanadoss U
Am J Ther 2016 Jan-Feb;23(1):e208-17. doi: 10.1097/MJT.0b013e318256ed0f. PMID: 22960849
Evaluation and management of syncope.
Veltmann C, Borggrefe M, Wolpert C, Schimpf R
Minerva Cardioangiol 2010 Dec;58(6):701-15. PMID: 21135810

Recent clinical studies

Etiology

Etiology of Syncope and Unexplained Falls in Elderly Adults with Dementia: Syncope and Dementia (SYD) Study.
Ungar A, Mussi C, Ceccofiglio A, Bellelli G, Nicosia F, Bo M, Riccio D, Martone AM, Guadagno L, Noro G, Ghidoni G, Rafanelli M, Marchionni N, Abete P
J Am Geriatr Soc 2016 Aug;64(8):1567-73. Epub 2016 Jun 28 doi: 10.1111/jgs.14225. PMID: 27351866
An approach to the clinical assessment and management of syncope in adults.
Ntusi NA, Coccia CB, Cupido BJ, Chin A
S Afr Med J 2015 Aug;105(8):690-3. doi: 10.7196/samjnew.8065. PMID: 26543940
Evaluation of syncope.
Gauer RL
Am Fam Physician 2011 Sep 15;84(6):640-50. PMID: 21916389
Heart rate and blood pressure variability in orthostatic syncope.
Lagi A, Cipriani M, Buccheri AM, Tamburini C
Clin Sci (Lond) 1996;91 Suppl:62-4. doi: 10.1042/cs0910062supp. PMID: 8813829
Mitral valve prolapse.
Devereux RB
J Am Med Womens Assoc (1972) 1994 Nov-Dec;49(6):192-7. PMID: 7829819

Diagnosis

Faintly tired: a systematic review of fatigue in patients with orthostatic syncope.
Wu REY, Khan FM, Hockin BCD, Lobban TCA, Sanatani S, Claydon VE
Clin Auton Res 2022 Jun;32(3):185-203. Epub 2022 Jun 10 doi: 10.1007/s10286-022-00868-z. PMID: 35689118Free PMC Article
Do Orthostatic Vital Signs Have Utility in the Evaluation of Syncope?
Schaffer JT, Keim SM, Hunter BR, Kirschner JM, De Lorenzo RA
J Emerg Med 2018 Dec;55(6):780-787. Epub 2018 Oct 10 doi: 10.1016/j.jemermed.2018.09.011. PMID: 30316621
Postural tachycardia syndrome: a heterogeneous and multifactorial disorder.
Benarroch EE
Mayo Clin Proc 2012 Dec;87(12):1214-25. Epub 2012 Nov 1 doi: 10.1016/j.mayocp.2012.08.013. PMID: 23122672Free PMC Article
Evaluation of syncope.
Gauer RL
Am Fam Physician 2011 Sep 15;84(6):640-50. PMID: 21916389
Mitral valve prolapse.
Devereux RB
J Am Med Womens Assoc (1972) 1994 Nov-Dec;49(6):192-7. PMID: 7829819

Therapy

Postural tachycardia syndrome: a heterogeneous and multifactorial disorder.
Benarroch EE
Mayo Clin Proc 2012 Dec;87(12):1214-25. Epub 2012 Nov 1 doi: 10.1016/j.mayocp.2012.08.013. PMID: 23122672Free PMC Article
Use of octreotide in the treatment of refractory orthostatic intolerance.
Kanjwal K, Saeed B, Karabin B, Kanjwal Y, Grubb BP
Am J Ther 2012 Jan;19(1):7-10. doi: 10.1097/MJT.0b013e3181e28156. PMID: 20535001
Current management of syncope : focus on drug therapy.
Venugopal D, Jhanjee R, Benditt DG
Am J Cardiovasc Drugs 2007;7(6):399-411. doi: 10.2165/00129784-200707060-00003. PMID: 18076207
Treatment of autonomic neuropathy, postural tachycardia and orthostatic syncope with octreotide LAR.
Hoeldtke RD, Bryner KD, Hoeldtke ME, Hobbs G
Clin Auton Res 2007 Dec;17(6):334-40. Epub 2007 Aug 31 doi: 10.1007/s10286-007-0436-x. PMID: 17767379
Cardiac factors in orthostatic hypotension.
Lollgen H, Dirschedl P, Koppenhagen K, Klein KE
Acta Astronaut 1992 Jul;27:93-5. doi: 10.1016/0094-5765(92)90183-j. PMID: 11537605

Prognosis

An approach to the clinical assessment and management of syncope in adults.
Ntusi NA, Coccia CB, Cupido BJ, Chin A
S Afr Med J 2015 Aug;105(8):690-3. doi: 10.7196/samjnew.8065. PMID: 26543940
The prevalence and prognostic significance of near syncope and syncope: a prospective study of 395 cases in an emergency department (the SPEED study).
Greve Y, Geier F, Popp S, Bertsch T, Singler K, Meier F, Smolarsky A, Mang H, Müller C, Christ M
Dtsch Arztebl Int 2014 Mar 21;111(12):197-204. doi: 10.3238/arztebl.2014.0197. PMID: 24717304Free PMC Article
NT-pro-BNP for differential diagnosis in patients with syncope.
Pfister R, Diedrichs H, Larbig R, Erdmann E, Schneider CA
Int J Cardiol 2009 Mar 20;133(1):51-4. Epub 2008 Jan 30 doi: 10.1016/j.ijcard.2007.11.082. PMID: 18237792
Current management of syncope : focus on drug therapy.
Venugopal D, Jhanjee R, Benditt DG
Am J Cardiovasc Drugs 2007;7(6):399-411. doi: 10.2165/00129784-200707060-00003. PMID: 18076207
Mitral valve prolapse.
Devereux RB
J Am Med Womens Assoc (1972) 1994 Nov-Dec;49(6):192-7. PMID: 7829819

Clinical prediction guides

Faintly tired: a systematic review of fatigue in patients with orthostatic syncope.
Wu REY, Khan FM, Hockin BCD, Lobban TCA, Sanatani S, Claydon VE
Clin Auton Res 2022 Jun;32(3):185-203. Epub 2022 Jun 10 doi: 10.1007/s10286-022-00868-z. PMID: 35689118Free PMC Article
Etiology of Syncope and Unexplained Falls in Elderly Adults with Dementia: Syncope and Dementia (SYD) Study.
Ungar A, Mussi C, Ceccofiglio A, Bellelli G, Nicosia F, Bo M, Riccio D, Martone AM, Guadagno L, Noro G, Ghidoni G, Rafanelli M, Marchionni N, Abete P
J Am Geriatr Soc 2016 Aug;64(8):1567-73. Epub 2016 Jun 28 doi: 10.1111/jgs.14225. PMID: 27351866
The prevalence and prognostic significance of near syncope and syncope: a prospective study of 395 cases in an emergency department (the SPEED study).
Greve Y, Geier F, Popp S, Bertsch T, Singler K, Meier F, Smolarsky A, Mang H, Müller C, Christ M
Dtsch Arztebl Int 2014 Mar 21;111(12):197-204. doi: 10.3238/arztebl.2014.0197. PMID: 24717304Free PMC Article
Current management of syncope : focus on drug therapy.
Venugopal D, Jhanjee R, Benditt DG
Am J Cardiovasc Drugs 2007;7(6):399-411. doi: 10.2165/00129784-200707060-00003. PMID: 18076207
Heart rate and blood pressure variability in orthostatic syncope.
Lagi A, Cipriani M, Buccheri AM, Tamburini C
Clin Sci (Lond) 1996;91 Suppl:62-4. doi: 10.1042/cs0910062supp. PMID: 8813829

Recent systematic reviews

Faintly tired: a systematic review of fatigue in patients with orthostatic syncope.
Wu REY, Khan FM, Hockin BCD, Lobban TCA, Sanatani S, Claydon VE
Clin Auton Res 2022 Jun;32(3):185-203. Epub 2022 Jun 10 doi: 10.1007/s10286-022-00868-z. PMID: 35689118Free PMC Article

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