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Abulia

MedGen UID:
776735
Concept ID:
C0919974
Mental or Behavioral Dysfunction
Synonym: Aboulia
SNOMED CT: Abulia (737585009); Aboulia (737585009)
 
HPO: HP:0012671

Definition

Abulia is a severe form of apathy, characterized by difficulty in initiating and sustaining spontaneous movements, as well as reductions in emotional responsiveness, spontaneous speech, and social interaction. [from HPO]

Term Hierarchy

Conditions with this feature

Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
MedGen UID:
1634330
Concept ID:
C4551768
Disease or Syndrome
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is characterized by mid-adult onset of recurrent ischemic stroke, cognitive decline progressing to dementia, a history of migraine with aura, mood disturbance, apathy, and diffuse white matter lesions and subcortical infarcts on neuroimaging.

Professional guidelines

PubMed

Marin RS
Am J Psychiatry 1990 Jan;147(1):22-30. doi: 10.1176/ajp.147.1.22. PMID: 2403472
Rosenthal TL, Meyer V
Cond Reflex 1971 Jan-Mar;6(1):22-9. doi: 10.1007/BF03000263. PMID: 5095172

Recent clinical studies

Etiology

Baller EB, Hogan CS, Fusunyan MA, Ivkovic A, Luccarelli JW, Madva E, Nisavic M, Praschan N, Quijije NV, Beach SR, Smith FA
Psychosomatics 2020 Nov-Dec;61(6):585-596. Epub 2020 May 21 doi: 10.1016/j.psym.2020.05.013. PMID: 32828569Free PMC Article
Ferro JM, Canhâo P
Front Neurol Neurosci 2008;23:161-71. doi: 10.1159/000111377. PMID: 18004061
Moretti R, Torre P, Antonello RM, Cazzato G
Neurologist 2006 Jan;12(1):43-7. doi: 10.1097/01.nrl.0000186806.54314.e8. PMID: 16547446
Vijayaraghavan L, Krishnamoorthy ES, Brown RG, Trimble MR
Mov Disord 2002 Sep;17(5):1052-7. doi: 10.1002/mds.10194. PMID: 12360558
Caplan LR, Schmahmann JD, Kase CS, Feldmann E, Baquis G, Greenberg JP, Gorelick PB, Helgason C, Hier DB
Arch Neurol 1990 Feb;47(2):133-43. doi: 10.1001/archneur.1990.00530020029011. PMID: 2405818

Diagnosis

Thompson AE, Thompson PD
Handb Clin Neurol 2023;196:443-455. doi: 10.1016/B978-0-323-98817-9.00008-9. PMID: 37620084
Lees AJ
Pract Neurol 2019 Oct;19(5):427-430. Epub 2019 Apr 4 doi: 10.1136/practneurol-2018-002176. PMID: 30948556
Kelley RE, El-Khoury R
Neurol Clin 2016 Feb;34(1):171-81. doi: 10.1016/j.ncl.2015.08.007. PMID: 26613998Free PMC Article
Ghoshal S, Gokhale S, Rebovich G, Caplan LR
Rev Neurol Dis 2011;8(3-4):e55-67. PMID: 22249571
Marin RS, Wilkosz PA
J Head Trauma Rehabil 2005 Jul-Aug;20(4):377-88. doi: 10.1097/00001199-200507000-00009. PMID: 16030444

Therapy

Baller EB, Hogan CS, Fusunyan MA, Ivkovic A, Luccarelli JW, Madva E, Nisavic M, Praschan N, Quijije NV, Beach SR, Smith FA
Psychosomatics 2020 Nov-Dec;61(6):585-596. Epub 2020 May 21 doi: 10.1016/j.psym.2020.05.013. PMID: 32828569Free PMC Article
Shabbir SH, Nadeem F, Labovitz D
BMJ Case Rep 2018 May 2;2018 doi: 10.1136/bcr-2017-223404. PMID: 29724871Free PMC Article
Thome J, Foley P
J Neural Transm (Vienna) 2015 Aug;122 Suppl 1:S3-7. Epub 2013 Dec 6 doi: 10.1007/s00702-013-1126-6. PMID: 24311062
Jorge RE, Starkstein SE, Robinson RG
Can J Psychiatry 2010 Jun;55(6):350-4. doi: 10.1177/070674371005500603. PMID: 20540829
Marin RS, Wilkosz PA
J Head Trauma Rehabil 2005 Jul-Aug;20(4):377-88. doi: 10.1097/00001199-200507000-00009. PMID: 16030444

Prognosis

Jorge RE, Starkstein SE, Robinson RG
Can J Psychiatry 2010 Jun;55(6):350-4. doi: 10.1177/070674371005500603. PMID: 20540829
Ferro JM, Canhâo P
Front Neurol Neurosci 2008;23:161-71. doi: 10.1159/000111377. PMID: 18004061
Moretti R, Torre P, Antonello RM, Cazzato G
Neurologist 2006 Jan;12(1):43-7. doi: 10.1097/01.nrl.0000186806.54314.e8. PMID: 16547446
Herrero MT, Barcia C, Navarro JM
Childs Nerv Syst 2002 Aug;18(8):386-404. Epub 2002 Jul 26 doi: 10.1007/s00381-002-0604-1. PMID: 12192499
Ferro JM
J Neurol 2001 Oct;248(10):841-9. doi: 10.1007/s004150170067. PMID: 11697519

Clinical prediction guides

Thompson AE, Thompson PD
Handb Clin Neurol 2023;196:443-455. doi: 10.1016/B978-0-323-98817-9.00008-9. PMID: 37620084
Ślosarczyk M, Ślosarczyk K, Furgał M
Psychiatr Pol 2022 Apr 30;56(2):229-244. doi: 10.12740/PP/125937. PMID: 35988071
Lees AJ
Pract Neurol 2019 Oct;19(5):427-430. Epub 2019 Apr 4 doi: 10.1136/practneurol-2018-002176. PMID: 30948556
Herrero MT, Barcia C, Navarro JM
Childs Nerv Syst 2002 Aug;18(8):386-404. Epub 2002 Jul 26 doi: 10.1007/s00381-002-0604-1. PMID: 12192499
Fisher CM
Clin Neurosurg 1983;31:9-31. doi: 10.1093/neurosurgery/31.cn_suppl_1.9. PMID: 6149834

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