U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

EEG with generalized spikes

MedGen UID:
777018
Concept ID:
C2206531
Finding
Synonym: EEG with generalised spikes
 
HPO: HP:0012000

Definition

EEG with generalized sharp transient waves of a duration less than 80 msec. [from HPO]

Term Hierarchy

Conditions with this feature

Episodic ataxia type 5
MedGen UID:
356142
Concept ID:
C1866039
Disease or Syndrome
An extremely rare form of hereditary episodic ataxia with characteristics of recurrent episodes of vertigo and ataxia lasting several hours.
Developmental and epileptic encephalopathy 94
MedGen UID:
815608
Concept ID:
C3809278
Disease or Syndrome
CHD2-related neurodevelopmental disorders are characterized by early-onset epileptic encephalopathy (i.e., refractory seizures and cognitive slowing or regression associated with frequent ongoing epileptiform activity). Seizure onset is typically between ages six months and four years. Seizure types typically include drop attacks, myoclonus, and rapid onset of multiple seizure types associated with generalized spike-wave on EEG, atonic-myoclonic-absence seizures, and clinical photosensitivity. Intellectual disability and/or autism spectrum disorders are common.

Professional guidelines

PubMed

Hirsch E, French J, Scheffer IE, Bogacz A, Alsaadi T, Sperling MR, Abdulla F, Zuberi SM, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst JM, Auvin S, Wiebe S, Perucca E, Moshé SL, Tinuper P, Wirrell EC
Epilepsia 2022 Jun;63(6):1475-1499. Epub 2022 May 3 doi: 10.1111/epi.17236. PMID: 35503716
Oguni H
Eur J Paediatr Neurol 2022 Jan;36:37-50. Epub 2021 Dec 1 doi: 10.1016/j.ejpn.2021.11.009. PMID: 34883415
Strzelczyk A, Schubert-Bast S
CNS Drugs 2021 Jan;35(1):61-83. Epub 2021 Jan 21 doi: 10.1007/s40263-020-00784-8. PMID: 33479851Free PMC Article

Recent clinical studies

Etiology

Yayıcı Köken Ö, Şekeroğlu B, Şanlıdağ B, Sarı Yanartaş M, Yılmaz A
Neurol Res 2024 Jul;46(7):626-633. Epub 2024 Apr 21 doi: 10.1080/01616412.2024.2339114. PMID: 38643974
Corona L, Tamilia E, Perry MS, Madsen JR, Bolton J, Stone SSD, Stufflebeam SM, Pearl PL, Papadelis C
Brain 2023 May 2;146(5):1916-1931. doi: 10.1093/brain/awac477. PMID: 36789500Free PMC Article
Nalbantoglu M , Tan OO
Ideggyogy Sz 2019 Mar 30;72(3-4):111-114. doi: 10.18071/isz.72.0111. PMID: 30957465
Blume WT
Brain 1998 Oct;121 ( Pt 10):1937-49. doi: 10.1093/brain/121.10.1937. PMID: 9798748
Doose H
Epilepsy Res Suppl 1992;6:163-8. PMID: 1418479

Diagnosis

Unterberger I, Trinka E, Kaplan PW, Walser G, Luef G, Bauer G
Epilepsia 2018 Mar;59(3):523-529. Epub 2018 Jan 11 doi: 10.1111/epi.13996. PMID: 29327337
Nadler JV, Spencer DD
Adv Exp Med Biol 2014;813:55-62. doi: 10.1007/978-94-017-8914-1_4. PMID: 25012366
Moeller F, Stephani U, Siniatchkin M
Epilepsia 2013 Jun;54(6):971-82. Epub 2013 May 3 doi: 10.1111/epi.12197. PMID: 23647021
Yong T, Chayasirisobhon S, Yoshina JS, Tin SN, Tehrani K, Skinner SE, Markus E, Spurgeon BD, Gurbani S
Clin EEG Neurosci 2008 Jan;39(1):28-32. doi: 10.1177/155005940803900110. PMID: 18318416
Westmoreland BF
Mayo Clin Proc 1996 May;71(5):501-11. doi: 10.4065/71.5.501. PMID: 8628033

Therapy

Besag FMC, Vasey MJ, Chin RFM
Expert Opin Pharmacother 2023 May-Aug;24(11):1249-1268. Epub 2023 Jun 5 doi: 10.1080/14656566.2023.2215924. PMID: 37212330
Strzelczyk A, Schubert-Bast S
CNS Drugs 2021 Jan;35(1):61-83. Epub 2021 Jan 21 doi: 10.1007/s40263-020-00784-8. PMID: 33479851Free PMC Article
Poleon S, Szaflarski JP
Epilepsy Behav 2017 Mar;68:225-233. Epub 2017 Feb 16 doi: 10.1016/j.yebeh.2016.10.040. PMID: 28215998
Yong T, Chayasirisobhon S, Yoshina JS, Tin SN, Tehrani K, Skinner SE, Markus E, Spurgeon BD, Gurbani S
Clin EEG Neurosci 2008 Jan;39(1):28-32. doi: 10.1177/155005940803900110. PMID: 18318416
Dulac O
Epilepsia 2001;42 Suppl 3:23-6. doi: 10.1046/j.1528-1157.2001.042suppl.3023.x. PMID: 11520318

Prognosis

Specchio N, Wirrell EC, Scheffer IE, Nabbout R, Riney K, Samia P, Guerreiro M, Gwer S, Zuberi SM, Wilmshurst JM, Yozawitz E, Pressler R, Hirsch E, Wiebe S, Cross HJ, Perucca E, Moshé SL, Tinuper P, Auvin S
Epilepsia 2022 Jun;63(6):1398-1442. Epub 2022 May 3 doi: 10.1111/epi.17241. PMID: 35503717
Hirsch E, French J, Scheffer IE, Bogacz A, Alsaadi T, Sperling MR, Abdulla F, Zuberi SM, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst JM, Auvin S, Wiebe S, Perucca E, Moshé SL, Tinuper P, Wirrell EC
Epilepsia 2022 Jun;63(6):1475-1499. Epub 2022 May 3 doi: 10.1111/epi.17236. PMID: 35503716
Shibata T, Kobayashi K
Acta Med Okayama 2018 Aug;72(4):325-329. doi: 10.18926/AMO/56166. PMID: 30140078
Blume WT
Brain 1998 Oct;121 ( Pt 10):1937-49. doi: 10.1093/brain/121.10.1937. PMID: 9798748
Doose H
Epilepsy Res Suppl 1992;6:163-8. PMID: 1418479

Clinical prediction guides

Kamitaki BK, Janmohamed M, Kandula P, Elder C, Mani R, Wong S, Perucca P, O'Brien TJ, Lin H, Heiman GA, Choi H
Epilepsia 2022 Jan;63(1):150-161. Epub 2021 Oct 27 doi: 10.1111/epi.17104. PMID: 34705264
Swindale NV, Rowat P, Krause M, Spacek MA, Mitelut C
J Neurophysiol 2021 Apr 1;125(4):1408-1424. Epub 2021 Mar 10 doi: 10.1152/jn.00633.2020. PMID: 33689506
Lagarde S, Bartolomei F
Handb Clin Neurol 2019;161:17-43. doi: 10.1016/B978-0-444-64142-7.00039-4. PMID: 31307599
Unterberger I, Trinka E, Kaplan PW, Walser G, Luef G, Bauer G
Epilepsia 2018 Mar;59(3):523-529. Epub 2018 Jan 11 doi: 10.1111/epi.13996. PMID: 29327337
Sánchez Fernández I, Loddenkemper T
J Clin Neurophysiol 2012 Oct;29(5):425-40. doi: 10.1097/WNP.0b013e31826bd943. PMID: 23027100

Recent systematic reviews

Chapman KE, Haubenberger D, Jen E, Tishchenko A, Nguyen T, McMicken C
Epilepsy Res 2024 Jan;199:107278. Epub 2023 Dec 8 doi: 10.1016/j.eplepsyres.2023.107278. PMID: 38157757
Freibauer AE, RamachandranNair R, Jain P, Jones KC, Whitney R
Seizure 2023 Aug;110:119-125. Epub 2023 Jun 20 doi: 10.1016/j.seizure.2023.06.017. PMID: 37352690
Corniello C, Dono F, Evangelista G, Consoli S, De Angelis S, Cipollone S, Liviello D, Polito G, Melchiorre S, Russo M, Granzotto A, Anzellotti F, Onofrj M, Thomas A, Sensi SL
Seizure 2023 Jul;109:62-67. Epub 2023 May 21 doi: 10.1016/j.seizure.2023.05.017. PMID: 37267668
West S, Nevitt SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2019 Jun 25;6(6):CD010541. doi: 10.1002/14651858.CD010541.pub3. PMID: 31237346Free PMC Article
West S, Nolan SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2015 Jul 1;(7):CD010541. doi: 10.1002/14651858.CD010541.pub2. PMID: 26130264

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...