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EEG with generalized spikes

MedGen UID:
777018
Concept ID:
C2206531
Finding
Synonym: EEG with generalised spikes
 
HPO: HP:0012000

Definition

EEG with generalized sharp transient waves of a duration less than 80 msec. [from HPO]

Term Hierarchy

Conditions with this feature

Episodic ataxia type 5
MedGen UID:
356142
Concept ID:
C1866039
Disease or Syndrome
An extremely rare form of hereditary episodic ataxia with characteristics of recurrent episodes of vertigo and ataxia lasting several hours.
Developmental and epileptic encephalopathy 94
MedGen UID:
815608
Concept ID:
C3809278
Disease or Syndrome
CHD2-related neurodevelopmental disorders are characterized by early-onset epileptic encephalopathy (i.e., refractory seizures and cognitive slowing or regression associated with frequent ongoing epileptiform activity). Seizure onset is typically between ages six months and four years. Seizure types typically include drop attacks, myoclonus, and rapid onset of multiple seizure types associated with generalized spike-wave on EEG, atonic-myoclonic-absence seizures, and clinical photosensitivity. Intellectual disability and/or autism spectrum disorders are common.

Professional guidelines

PubMed

Hirsch E, French J, Scheffer IE, Bogacz A, Alsaadi T, Sperling MR, Abdulla F, Zuberi SM, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst JM, Auvin S, Wiebe S, Perucca E, Moshé SL, Tinuper P, Wirrell EC
Epilepsia 2022 Jun;63(6):1475-1499. Epub 2022 May 3 doi: 10.1111/epi.17236. PMID: 35503716
Strzelczyk A, Schubert-Bast S
CNS Drugs 2021 Jan;35(1):61-83. Epub 2021 Jan 21 doi: 10.1007/s40263-020-00784-8. PMID: 33479851Free PMC Article
Al-Banji MH, Zahr DK, Jan MM
Neurosciences (Riyadh) 2015 Jul;20(3):207-12. doi: 10.17712/nsj.2015.3.20140677. PMID: 26166587Free PMC Article

Recent clinical studies

Etiology

Macdonald M, Crawford J, Datta AN
J Child Neurol 2021 Oct;36(11):1027-1033. Epub 2021 Jul 27 doi: 10.1177/08830738211026072. PMID: 34315269
Nalbantoglu M , Tan OO
Ideggyogy Sz 2019 Mar 30;72(3-4):111-114. doi: 10.18071/isz.72.0111. PMID: 30957465
Verrotti A, D'Alonzo R, Rinaldi VE, Casciato S, D'Aniello A, Di Gennaro G
World J Pediatr 2017 Apr;13(2):106-111. Epub 2017 Jan 15 doi: 10.1007/s12519-017-0006-9. PMID: 28101769
Blume WT
Brain 1998 Oct;121 ( Pt 10):1937-49. doi: 10.1093/brain/121.10.1937. PMID: 9798748
Doose H
Epilepsy Res Suppl 1992;6:163-8. PMID: 1418479

Diagnosis

Andrade-Machado R, Benjumea Cuartas V, Muhammad IK
Epilepsy Behav 2021 Apr;117:107830. Epub 2021 Feb 25 doi: 10.1016/j.yebeh.2021.107830. PMID: 33639439
Unterberger I, Trinka E, Kaplan PW, Walser G, Luef G, Bauer G
Epilepsia 2018 Mar;59(3):523-529. Epub 2018 Jan 11 doi: 10.1111/epi.13996. PMID: 29327337
Nadler JV, Spencer DD
Adv Exp Med Biol 2014;813:55-62. doi: 10.1007/978-94-017-8914-1_4. PMID: 25012366
Rodin E, Constantino T, Rampp S, Wong PK
Clin EEG Neurosci 2009 Oct;40(4):288-99. doi: 10.1177/155005940904000411. PMID: 19780350
Yong T, Chayasirisobhon S, Yoshina JS, Tin SN, Tehrani K, Skinner SE, Markus E, Spurgeon BD, Gurbani S
Clin EEG Neurosci 2008 Jan;39(1):28-32. doi: 10.1177/155005940803900110. PMID: 18318416

Therapy

Strzelczyk A, Schubert-Bast S
CNS Drugs 2021 Jan;35(1):61-83. Epub 2021 Jan 21 doi: 10.1007/s40263-020-00784-8. PMID: 33479851Free PMC Article
Pollack SF, Grocott OR, Parkin KA, Larson AM, Thibert RL
Epilepsy Behav 2018 May;82:170-174. Epub 2018 Mar 17 doi: 10.1016/j.yebeh.2018.02.006. PMID: 29555100
Poleon S, Szaflarski JP
Epilepsy Behav 2017 Mar;68:225-233. Epub 2017 Feb 16 doi: 10.1016/j.yebeh.2016.10.040. PMID: 28215998
Dulac O
Epilepsia 2001;42 Suppl 3:23-6. doi: 10.1046/j.1528-1157.2001.042suppl.3023.x. PMID: 11520318
Clement MJ, Wallace SJ
Arch Dis Child 1988 Sep;63(9):1049-53. doi: 10.1136/adc.63.9.1049. PMID: 3140737Free PMC Article

Prognosis

Specchio N, Wirrell EC, Scheffer IE, Nabbout R, Riney K, Samia P, Guerreiro M, Gwer S, Zuberi SM, Wilmshurst JM, Yozawitz E, Pressler R, Hirsch E, Wiebe S, Cross HJ, Perucca E, Moshé SL, Tinuper P, Auvin S
Epilepsia 2022 Jun;63(6):1398-1442. Epub 2022 May 3 doi: 10.1111/epi.17241. PMID: 35503717
Steinhoff BJ, Staack AM
Epilepsy Behav 2019 Feb;91:4-8. Epub 2018 Jun 28 doi: 10.1016/j.yebeh.2018.05.025. PMID: 29960857
Shibata T, Kobayashi K
Acta Med Okayama 2018 Aug;72(4):325-329. doi: 10.18926/AMO/56166. PMID: 30140078
Rodin E, Constantino T, Rampp S, Wong PK
Clin EEG Neurosci 2009 Oct;40(4):288-99. doi: 10.1177/155005940904000411. PMID: 19780350
Doose H
Epilepsy Res Suppl 1992;6:163-8. PMID: 1418479

Clinical prediction guides

Kamitaki BK, Janmohamed M, Kandula P, Elder C, Mani R, Wong S, Perucca P, O'Brien TJ, Lin H, Heiman GA, Choi H
Epilepsia 2022 Jan;63(1):150-161. Epub 2021 Oct 27 doi: 10.1111/epi.17104. PMID: 34705264
Lagarde S, Bartolomei F
Handb Clin Neurol 2019;161:17-43. doi: 10.1016/B978-0-444-64142-7.00039-4. PMID: 31307599
Unterberger I, Trinka E, Kaplan PW, Walser G, Luef G, Bauer G
Epilepsia 2018 Mar;59(3):523-529. Epub 2018 Jan 11 doi: 10.1111/epi.13996. PMID: 29327337
Lévesque M, Shiri Z, Chen LY, Avoli M
Neurosci Lett 2018 Feb 22;667:66-74. Epub 2017 Jan 20 doi: 10.1016/j.neulet.2017.01.047. PMID: 28115239
Sánchez Fernández I, Loddenkemper T
J Clin Neurophysiol 2012 Oct;29(5):425-40. doi: 10.1097/WNP.0b013e31826bd943. PMID: 23027100

Recent systematic reviews

Freibauer AE, RamachandranNair R, Jain P, Jones KC, Whitney R
Seizure 2023 Aug;110:119-125. Epub 2023 Jun 20 doi: 10.1016/j.seizure.2023.06.017. PMID: 37352690
Corniello C, Dono F, Evangelista G, Consoli S, De Angelis S, Cipollone S, Liviello D, Polito G, Melchiorre S, Russo M, Granzotto A, Anzellotti F, Onofrj M, Thomas A, Sensi SL
Seizure 2023 Jul;109:62-67. Epub 2023 May 21 doi: 10.1016/j.seizure.2023.05.017. PMID: 37267668
West S, Nevitt SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2019 Jun 25;6(6):CD010541. doi: 10.1002/14651858.CD010541.pub3. PMID: 31237346Free PMC Article
Brigo F, Igwe SC
Cochrane Database Syst Rev 2017 Feb 14;2(2):CD003032. doi: 10.1002/14651858.CD003032.pub3. PMID: 28195639Free PMC Article
West S, Nolan SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R
Cochrane Database Syst Rev 2015 Jul 1;(7):CD010541. doi: 10.1002/14651858.CD010541.pub2. PMID: 26130264

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