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Multiple chronic diseases

MedGen UID:
781391
•Concept ID:
C3266262
•
Disease or Syndrome
Synonyms: Chronic Conditions, Multiple; Chronic Illnesses, Multiple; Multiple Chronic Conditions; Multiple Chronic Health Conditions; Multiple Chronic Illnesses; Multiple Chronic Medical Conditions
SNOMED CT: Multiple chronic diseases (2081000124103)

Definition

Two or more concurrent chronic physical, mental, or behavioral health problems in an individual. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultiple chronic diseases

Professional guidelines

PubMed

Evaluation of the Effectiveness of Telehealth Chronic Disease Management System: Systematic Review and Meta-analysis.
Xiao Z, Han X
J Med Internet Res 2023 Apr 27;25:e44256. doi: 10.2196/44256. PMID: 37103993Free PMC Article
Assessment and Management Tools for Advancing Disease.
Stober MJ, Hager K, Rinker G
Home Healthc Now 2022 May-Jun 01;40(3):159-166. doi: 10.1097/NHH.0000000000001076. PMID: 35510971
Dietary Strategies for Management of Metabolic Syndrome: Role of Gut Microbiota Metabolites.
Croci S, D'Apolito LI, Gasperi V, Catani MV, Savini I
Nutrients 2021 Apr 21;13(5) doi: 10.3390/nu13051389. PMID: 33919016Free PMC Article

Recent clinical studies

Etiology

Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.
Liu D, Meng X, Tian Q, Cao W, Fan X, Wu L, Song M, Meng Q, Wang W, Wang Y
Adv Nutr 2022 Aug 1;13(4):1044-1062. doi: 10.1093/advances/nmab142. PMID: 34999745Free PMC Article
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
Adverse Childhood Experiences.
Hustedde C
Prim Care 2021 Sep;48(3):493-504. Epub 2021 Jul 10 doi: 10.1016/j.pop.2021.05.005. PMID: 34311853
An overview of co-morbidities and the development of pressure ulcers among older adults.
Jaul E, Barron J, Rosenzweig JP, Menczel J
BMC Geriatr 2018 Dec 11;18(1):305. doi: 10.1186/s12877-018-0997-7. PMID: 30537947Free PMC Article
Soybean Bioactive Peptides and Their Functional Properties.
Chatterjee C, Gleddie S, Xiao CW
Nutrients 2018 Sep 1;10(9) doi: 10.3390/nu10091211. PMID: 30200502Free PMC Article

Diagnosis

New horizons in Parkinson's disease in older populations.
Chhetri JK, Mei S, Wang C, Chan P
Age Ageing 2023 Oct 2;52(10) doi: 10.1093/ageing/afad186. PMID: 37847793
Frailty and polypharmacy in the community-dwelling elderly with multiple chronic diseases.
Chuang YN, Chen CC, Wang CJ, Chang YS, Liu YH
Psychogeriatrics 2023 Mar;23(2):337-344. Epub 2023 Jan 30 doi: 10.1111/psyg.12936. PMID: 36717278
Adverse Childhood Experiences.
Hustedde C
Prim Care 2021 Sep;48(3):493-504. Epub 2021 Jul 10 doi: 10.1016/j.pop.2021.05.005. PMID: 34311853
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL
EBioMedicine 2019 Sep;47:446-456. Epub 2019 Sep 18 doi: 10.1016/j.ebiom.2019.08.069. PMID: 31542391Free PMC Article
An overview of co-morbidities and the development of pressure ulcers among older adults.
Jaul E, Barron J, Rosenzweig JP, Menczel J
BMC Geriatr 2018 Dec 11;18(1):305. doi: 10.1186/s12877-018-0997-7. PMID: 30537947Free PMC Article

Therapy

Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.
Liu D, Meng X, Tian Q, Cao W, Fan X, Wu L, Song M, Meng Q, Wang W, Wang Y
Adv Nutr 2022 Aug 1;13(4):1044-1062. doi: 10.1093/advances/nmab142. PMID: 34999745Free PMC Article
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
Anesthetic management of geriatric patients.
Lim BG, Lee IO
Korean J Anesthesiol 2020 Feb;73(1):8-29. Epub 2019 Oct 22 doi: 10.4097/kja.19391. PMID: 31636241Free PMC Article
Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms.
Tosti V, Bertozzi B, Fontana L
J Gerontol A Biol Sci Med Sci 2018 Mar 2;73(3):318-326. doi: 10.1093/gerona/glx227. PMID: 29244059Free PMC Article
Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.
Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB
Br J Pharmacol 2017 Jun;174(11):1325-1348. Epub 2016 Oct 21 doi: 10.1111/bph.13621. PMID: 27638428Free PMC Article

Prognosis

Hydration Status in Older Adults: Current Knowledge and Future Challenges.
Li S, Xiao X, Zhang X
Nutrients 2023 Jun 2;15(11) doi: 10.3390/nu15112609. PMID: 37299572Free PMC Article
Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention.
Watanabe K, Wilmanski T, Diener C, Earls JC, Zimmer A, Lincoln B, Hadlock JJ, Lovejoy JC, Gibbons SM, Magis AT, Hood L, Price ND, Rappaport N
Nat Med 2023 Apr;29(4):996-1008. Epub 2023 Mar 20 doi: 10.1038/s41591-023-02248-0. PMID: 36941332Free PMC Article
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
Endogenous testosterone and mortality risk.
Meyer EJ, Wittert G
Asian J Androl 2018 Mar-Apr;20(2):115-119. doi: 10.4103/aja.aja_70_17. PMID: 29384142Free PMC Article
Sedentary death syndrome.
Lees SJ, Booth FW
Can J Appl Physiol 2004 Aug;29(4):447-60; discussion 444-6. doi: 10.1139/h04-029. PMID: 15317985

Clinical prediction guides

Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention.
Watanabe K, Wilmanski T, Diener C, Earls JC, Zimmer A, Lincoln B, Hadlock JJ, Lovejoy JC, Gibbons SM, Magis AT, Hood L, Price ND, Rappaport N
Nat Med 2023 Apr;29(4):996-1008. Epub 2023 Mar 20 doi: 10.1038/s41591-023-02248-0. PMID: 36941332Free PMC Article
Systemic chronic diseases coexist with and affect locomotive syndrome: The Nagahama Study.
Morita Y, Ito H, Kawaguchi S, Nishitani K, Nakamura S, Kuriyama S, Ikezoe T, Tsuboyama T, Ichihashi N, Tabara Y, Matsuda F, Matsuda S
Mod Rheumatol 2023 Apr 13;33(3):608-616. doi: 10.1093/mr/roac039. PMID: 35554562
Prevalence and impact of polypharmacy in older patients with type 2 diabetes.
Remelli F, Ceresini MG, Trevisan C, Noale M, Volpato S
Aging Clin Exp Res 2022 Sep;34(9):1969-1983. Epub 2022 Jun 20 doi: 10.1007/s40520-022-02165-1. PMID: 35723858Free PMC Article
Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.
Liu D, Meng X, Tian Q, Cao W, Fan X, Wu L, Song M, Meng Q, Wang W, Wang Y
Adv Nutr 2022 Aug 1;13(4):1044-1062. doi: 10.1093/advances/nmab142. PMID: 34999745Free PMC Article
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article

Recent systematic reviews

Risk factors for multimorbidity in adulthood: A systematic review.
Tazzeo C, Zucchelli A, Vetrano DL, Demurtas J, Smith L, Schoene D, Sanchez-Rodriguez D, Onder G, Balci C, Bonetti S, Grande G, Torbahn G, Veronese N, Marengoni A
Ageing Res Rev 2023 Nov;91:102039. Epub 2023 Aug 28 doi: 10.1016/j.arr.2023.102039. PMID: 37647994
Menstrual Dysfunction in Adolescents with Chronic Illness: A Systematic Review.
Hobbs AK, Cheng HL, Tee EYF, Steinbeck KS
J Pediatr Adolesc Gynecol 2023 Aug;36(4):338-348. Epub 2023 May 14 doi: 10.1016/j.jpag.2023.05.005. PMID: 37192680
Prevalence and impact of polypharmacy in older patients with type 2 diabetes.
Remelli F, Ceresini MG, Trevisan C, Noale M, Volpato S
Aging Clin Exp Res 2022 Sep;34(9):1969-1983. Epub 2022 Jun 20 doi: 10.1007/s40520-022-02165-1. PMID: 35723858Free PMC Article
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
Aging with multimorbidity: a systematic review of the literature.
Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, Meinow B, Fratiglioni L
Ageing Res Rev 2011 Sep;10(4):430-9. Epub 2011 Mar 23 doi: 10.1016/j.arr.2011.03.003. PMID: 21402176

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