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Abnormality of acid-base homeostasis

MedGen UID:
7851
Concept ID:
C0001118
Finding; Pathologic Function
Synonyms: Acid Base Imbalance; Acid-Base Imbalance; Acid-Base Imbalances; Imbalance, Acid-Base; Imbalances, Acid-Base
SNOMED CT: Abnormal acid-base balance (704429007)
 
HPO: HP:0004360

Definition

An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Abnormality of acid-base homeostasis

Professional guidelines

PubMed

Glaser N, Fritsch M, Priyambada L, Rewers A, Cherubini V, Estrada S, Wolfsdorf JI, Codner E
Pediatr Diabetes 2022 Nov;23(7):835-856. doi: 10.1111/pedi.13406. PMID: 36250645
Long B, Lentz S, Koyfman A, Gottlieb M
Am J Emerg Med 2021 Jun;44:157-160. Epub 2021 Feb 16 doi: 10.1016/j.ajem.2021.02.015. PMID: 33626481
Fayfman M, Pasquel FJ, Umpierrez GE
Med Clin North Am 2017 May;101(3):587-606. doi: 10.1016/j.mcna.2016.12.011. PMID: 28372715Free PMC Article

Recent clinical studies

Etiology

de-Madaria E, Buxbaum JL, Maisonneuve P, García García de Paredes A, Zapater P, Guilabert L, Vaillo-Rocamora A, Rodríguez-Gandía MÁ, Donate-Ortega J, Lozada-Hernández EE, Collazo Moreno AJR, Lira-Aguilar A, Llovet LP, Mehta R, Tandel R, Navarro P, Sánchez-Pardo AM, Sánchez-Marin C, Cobreros M, Fernández-Cabrera I, Casals-Seoane F, Casas Deza D, Lauret-Braña E, Martí-Marqués E, Camacho-Montaño LM, Ubieto V, Ganuza M, Bolado F; ERICA Consortium
N Engl J Med 2022 Sep 15;387(11):989-1000. doi: 10.1056/NEJMoa2202884. PMID: 36103415
Bagga A, Sinha A
Indian J Pediatr 2020 Sep;87(9):733-744. Epub 2020 Jun 26 doi: 10.1007/s12098-020-03318-8. PMID: 32591997
Dhatariya KK, Glaser NS, Codner E, Umpierrez GE
Nat Rev Dis Primers 2020 May 14;6(1):40. doi: 10.1038/s41572-020-0165-1. PMID: 32409703
Alexander RT, Bitzan M
Pediatr Clin North Am 2019 Feb;66(1):135-157. doi: 10.1016/j.pcl.2018.08.011. PMID: 30454739
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999

Diagnosis

Koirala A, Pourafshar N, Daneshmand A, Wilcox CS, Mannemuddhu SS, Arora N
Adv Kidney Dis Health 2023 Mar;30(2):110-123. doi: 10.1053/j.akdh.2022.12.002. PMID: 36868727
Achanti A, Szerlip HM
Clin J Am Soc Nephrol 2023 Jan 1;18(1):102-112. Epub 2022 Aug 23 doi: 10.2215/CJN.04500422. PMID: 35998977Free PMC Article
Yee J, Frinak S, Mohiuddin N, Uduman J
Kidney360 2022 Aug 25;3(8):1458-1466. Epub 2022 Jun 3 doi: 10.34067/KID.0008102021. PMID: 36176645Free PMC Article
Tucker AM, Johnson TN
Nutr Clin Pract 2022 Oct;37(5):980-989. Epub 2022 Jun 25 doi: 10.1002/ncp.10881. PMID: 35752932
Berend K, de Vries AP, Gans RO
N Engl J Med 2014 Oct 9;371(15):1434-45. doi: 10.1056/NEJMra1003327. PMID: 25295502

Therapy

Achanti A, Szerlip HM
Clin J Am Soc Nephrol 2023 Jan 1;18(1):102-112. Epub 2022 Aug 23 doi: 10.2215/CJN.04500422. PMID: 35998977Free PMC Article
de-Madaria E, Buxbaum JL, Maisonneuve P, García García de Paredes A, Zapater P, Guilabert L, Vaillo-Rocamora A, Rodríguez-Gandía MÁ, Donate-Ortega J, Lozada-Hernández EE, Collazo Moreno AJR, Lira-Aguilar A, Llovet LP, Mehta R, Tandel R, Navarro P, Sánchez-Pardo AM, Sánchez-Marin C, Cobreros M, Fernández-Cabrera I, Casals-Seoane F, Casas Deza D, Lauret-Braña E, Martí-Marqués E, Camacho-Montaño LM, Ubieto V, Ganuza M, Bolado F; ERICA Consortium
N Engl J Med 2022 Sep 15;387(11):989-1000. doi: 10.1056/NEJMoa2202884. PMID: 36103415
Novak JE, Ellison DH
Am J Kidney Dis 2022 Aug;80(2):264-276. Epub 2022 Feb 19 doi: 10.1053/j.ajkd.2021.09.029. PMID: 35190215
Quade BN, Parker MD, Occhipinti R
Biochem Pharmacol 2021 Jan;183:114278. Epub 2020 Oct 9 doi: 10.1016/j.bcp.2020.114278. PMID: 33039418Free PMC Article
Jaber S, Paugam C, Futier E, Lefrant JY, Lasocki S, Lescot T, Pottecher J, Demoule A, Ferrandière M, Asehnoune K, Dellamonica J, Velly L, Abback PS, de Jong A, Brunot V, Belafia F, Roquilly A, Chanques G, Muller L, Constantin JM, Bertet H, Klouche K, Molinari N, Jung B; BICAR-ICU Study Group
Lancet 2018 Jul 7;392(10141):31-40. Epub 2018 Jun 14 doi: 10.1016/S0140-6736(18)31080-8. PMID: 29910040

Prognosis

Wolf MB
Semin Nephrol 2019 Jul;39(4):328-339. doi: 10.1016/j.semnephrol.2019.04.003. PMID: 31300089
Qian Q
Semin Dial 2018 May;31(3):226-235. Epub 2017 Nov 16 doi: 10.1111/sdi.12659. PMID: 29148094
Donn SM, Sinha SK
Semin Fetal Neonatal Med 2017 Aug;22(4):200-205. Epub 2017 Apr 4 doi: 10.1016/j.siny.2017.03.006. PMID: 28389088
Goldenberg RM, Berard LD, Cheng AYY, Gilbert JD, Verma S, Woo VC, Yale JF
Clin Ther 2016 Dec;38(12):2654-2664.e1. doi: 10.1016/j.clinthera.2016.11.002. PMID: 28003053
Nyenwe EA, Kitabchi AE
Metabolism 2016 Apr;65(4):507-21. Epub 2015 Dec 19 doi: 10.1016/j.metabol.2015.12.007. PMID: 26975543

Clinical prediction guides

Uppal NN, Workeneh BT, Rondon-Berrios H, Jhaveri KD
Clin J Am Soc Nephrol 2022 Jun;17(6):922-933. Epub 2022 Jan 21 doi: 10.2215/CJN.14671121. PMID: 35063968Free PMC Article
Wolf MB
Semin Nephrol 2019 Jul;39(4):328-339. doi: 10.1016/j.semnephrol.2019.04.003. PMID: 31300089
Berend K, Duits AJ
Crit Rev Clin Lab Sci 2019 May;56(3):147-169. Epub 2019 Mar 27 doi: 10.1080/10408363.2019.1568965. PMID: 30917291
Chen W, Abramowitz MK
Adv Chronic Kidney Dis 2017 Sep;24(5):280-288. doi: 10.1053/j.ackd.2017.08.003. PMID: 29031354Free PMC Article
Edwards SL
Intensive Crit Care Nurs 2008 Feb;24(1):28-38; quiz 38-40. Epub 2007 Aug 6 doi: 10.1016/j.iccn.2007.05.003. PMID: 17689248

Recent systematic reviews

Nuffield Department of Population Health Renal Studies Group; SGLT2 inhibitor Meta-Analysis Cardio-Renal Trialists' Consortium
Lancet 2022 Nov 19;400(10365):1788-1801. Epub 2022 Nov 6 doi: 10.1016/S0140-6736(22)02074-8. PMID: 36351458Free PMC Article
Rahmati M, Keshvari M, Mirnasuri S, Yon DK, Lee SW, Il Shin J, Smith L
J Med Virol 2022 Nov;94(11):5112-5127. Epub 2022 Jul 22 doi: 10.1002/jmv.27996. PMID: 35831242Free PMC Article
Tinguely D, Gross J, Kosinski C
Curr Diab Rep 2021 Aug 27;21(9):32. doi: 10.1007/s11892-021-01399-z. PMID: 34448957Free PMC Article
Matyukhin I, Patschan S, Ritter O, Patschan D
Kidney Blood Press Res 2020;45(4):523-531. Epub 2020 Jul 14 doi: 10.1159/000507813. PMID: 32663831
Smith ZR, Horng M, Rech MA
Pharmacotherapy 2019 Sep;39(9):946-963. Epub 2019 Aug 29 doi: 10.1002/phar.2316. PMID: 31361914

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