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Abnormality of acid-base homeostasis

MedGen UID:
7851
•Concept ID:
C0001118
•
Finding; Pathologic Function
Synonyms: Acid Base Imbalance; Acid-Base Imbalance; Acid-Base Imbalances; Imbalance, Acid-Base; Imbalances, Acid-Base
SNOMED CT: Abnormal acid-base balance (704429007)
 
HPO: HP:0004360

Definition

An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Abnormality of acid-base homeostasis

Professional guidelines

PubMed

Euglycemic diabetic ketoacidosis: Etiologies, evaluation, and management.
Long B, Lentz S, Koyfman A, Gottlieb M
Am J Emerg Med 2021 Jun;44:157-160. Epub 2021 Feb 16 doi: 10.1016/j.ajem.2021.02.015. PMID: 33626481
Management of Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State.
Fayfman M, Pasquel FJ, Umpierrez GE
Med Clin North Am 2017 May;101(3):587-606. doi: 10.1016/j.mcna.2016.12.011. PMID: 28372715Free PMC Article
Metabolic acidosis: pathophysiology, diagnosis and management.
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999

Recent clinical studies

Etiology

Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis.
de-Madaria E, Buxbaum JL, Maisonneuve P, García García de Paredes A, Zapater P, Guilabert L, Vaillo-Rocamora A, Rodríguez-Gandía MÁ, Donate-Ortega J, Lozada-Hernández EE, Collazo Moreno AJR, Lira-Aguilar A, Llovet LP, Mehta R, Tandel R, Navarro P, Sánchez-Pardo AM, Sánchez-Marin C, Cobreros M, Fernández-Cabrera I, Casals-Seoane F, Casas Deza D, Lauret-Braña E, Martí-Marqués E, Camacho-Montaño LM, Ubieto V, Ganuza M, Bolado F; ERICA Consortium
N Engl J Med 2022 Sep 15;387(11):989-1000. doi: 10.1056/NEJMoa2202884. PMID: 36103415
Renal Tubular Acidosis.
Bagga A, Sinha A
Indian J Pediatr 2020 Sep;87(9):733-744. Epub 2020 Jun 26 doi: 10.1007/s12098-020-03318-8. PMID: 32591997
Diabetic ketoacidosis.
Dhatariya KK, Glaser NS, Codner E, Umpierrez GE
Nat Rev Dis Primers 2020 May 14;6(1):40. doi: 10.1038/s41572-020-0165-1. PMID: 32409703
Renal Tubular Acidosis.
Alexander RT, Bitzan M
Pediatr Clin North Am 2019 Feb;66(1):135-157. doi: 10.1016/j.pcl.2018.08.011. PMID: 30454739
Metabolic acidosis: pathophysiology, diagnosis and management.
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999

Diagnosis

Fundamentals of Arterial Blood Gas Interpretation.
Yee J, Frinak S, Mohiuddin N, Uduman J
Kidney360 2022 Aug 25;3(8):1458-1466. Epub 2022 Jun 3 doi: 10.34067/KID.0008102021. PMID: 36176645Free PMC Article
Acid-base disorders: A primer for clinicians.
Tucker AM, Johnson TN
Nutr Clin Pract 2022 Oct;37(5):980-989. Epub 2022 Jun 25 doi: 10.1002/ncp.10881. PMID: 35752932
The arterial blood gas algorithm: Proposal of a systematic approach to analysis of acid-base disorders.
Rodríguez-Villar S, Do Vale BM, Fletcher HM
Rev Esp Anestesiol Reanim (Engl Ed) 2020 Jan;67(1):20-34. Epub 2019 Dec 9 doi: 10.1016/j.redar.2019.04.001. PMID: 31826801
Integration of acid-base and electrolyte disorders.
Seifter JL
N Engl J Med 2014 Nov 6;371(19):1821-31. doi: 10.1056/NEJMra1215672. PMID: 25372090
Physiological approach to assessment of acid-base disturbances.
Berend K, de Vries AP, Gans RO
N Engl J Med 2014 Oct 9;371(15):1434-45. doi: 10.1056/NEJMra1003327. PMID: 25295502

Therapy

Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis.
de-Madaria E, Buxbaum JL, Maisonneuve P, García García de Paredes A, Zapater P, Guilabert L, Vaillo-Rocamora A, Rodríguez-Gandía MÁ, Donate-Ortega J, Lozada-Hernández EE, Collazo Moreno AJR, Lira-Aguilar A, Llovet LP, Mehta R, Tandel R, Navarro P, Sánchez-Pardo AM, Sánchez-Marin C, Cobreros M, Fernández-Cabrera I, Casals-Seoane F, Casas Deza D, Lauret-Braña E, Martí-Marqués E, Camacho-Montaño LM, Ubieto V, Ganuza M, Bolado F; ERICA Consortium
N Engl J Med 2022 Sep 15;387(11):989-1000. doi: 10.1056/NEJMoa2202884. PMID: 36103415
Diuretics in States of Volume Overload: Core Curriculum 2022.
Novak JE, Ellison DH
Am J Kidney Dis 2022 Aug;80(2):264-276. Epub 2022 Feb 19 doi: 10.1053/j.ajkd.2021.09.029. PMID: 35190215
Electrolyte and Acid-Base Disorders Associated with Cancer Immunotherapy.
Uppal NN, Workeneh BT, Rondon-Berrios H, Jhaveri KD
Clin J Am Soc Nephrol 2022 Jun;17(6):922-933. Epub 2022 Jan 21 doi: 10.2215/CJN.14671121. PMID: 35063968Free PMC Article
The therapeutic importance of acid-base balance.
Quade BN, Parker MD, Occhipinti R
Biochem Pharmacol 2021 Jan;183:114278. Epub 2020 Oct 9 doi: 10.1016/j.bcp.2020.114278. PMID: 33039418Free PMC Article
Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial.
Jaber S, Paugam C, Futier E, Lefrant JY, Lasocki S, Lescot T, Pottecher J, Demoule A, Ferrandière M, Asehnoune K, Dellamonica J, Velly L, Abback PS, de Jong A, Brunot V, Belafia F, Roquilly A, Chanques G, Muller L, Constantin JM, Bertet H, Klouche K, Molinari N, Jung B; BICAR-ICU Study Group
Lancet 2018 Jul 7;392(10141):31-40. Epub 2018 Jun 14 doi: 10.1016/S0140-6736(18)31080-8. PMID: 29910040

Prognosis

Physicochemical Models of Acid-Base.
Wolf MB
Semin Nephrol 2019 Jul;39(4):328-339. doi: 10.1016/j.semnephrol.2019.04.003. PMID: 31300089
Epidemiology of Acid-Base Derangements in CKD.
Chen W, Abramowitz MK
Adv Chronic Kidney Dis 2017 Sep;24(5):280-288. doi: 10.1053/j.ackd.2017.08.003. PMID: 29031354Free PMC Article
Pulmonary diagnostics.
Donn SM, Sinha SK
Semin Fetal Neonatal Med 2017 Aug;22(4):200-205. Epub 2017 Apr 4 doi: 10.1016/j.siny.2017.03.006. PMID: 28389088
SGLT2 Inhibitor-associated Diabetic Ketoacidosis: Clinical Review and Recommendations for Prevention and Diagnosis.
Goldenberg RM, Berard LD, Cheng AYY, Gilbert JD, Verma S, Woo VC, Yale JF
Clin Ther 2016 Dec;38(12):2654-2664.e1. doi: 10.1016/j.clinthera.2016.11.002. PMID: 28003053
The evolution of diabetic ketoacidosis: An update of its etiology, pathogenesis and management.
Nyenwe EA, Kitabchi AE
Metabolism 2016 Apr;65(4):507-21. Epub 2015 Dec 19 doi: 10.1016/j.metabol.2015.12.007. PMID: 26975543

Clinical prediction guides

Electrolyte and Acid-Base Disorders Associated with Cancer Immunotherapy.
Uppal NN, Workeneh BT, Rondon-Berrios H, Jhaveri KD
Clin J Am Soc Nephrol 2022 Jun;17(6):922-933. Epub 2022 Jan 21 doi: 10.2215/CJN.14671121. PMID: 35063968Free PMC Article
The Urine Anion Gap: Common Misconceptions.
Uribarri J, Oh MS
J Am Soc Nephrol 2021 May 3;32(5):1025-1028. Epub 2021 Mar 5 doi: 10.1681/ASN.2020101509. PMID: 33769949Free PMC Article
Physicochemical Models of Acid-Base.
Wolf MB
Semin Nephrol 2019 Jul;39(4):328-339. doi: 10.1016/j.semnephrol.2019.04.003. PMID: 31300089
Dialysis Prescription and Sudden Death.
Rhee CM, Chou JA, Kalantar-Zadeh K
Semin Nephrol 2018 Nov;38(6):570-581. doi: 10.1016/j.semnephrol.2018.08.003. PMID: 30413252Free PMC Article
Epidemiology of Acid-Base Derangements in CKD.
Chen W, Abramowitz MK
Adv Chronic Kidney Dis 2017 Sep;24(5):280-288. doi: 10.1053/j.ackd.2017.08.003. PMID: 29031354Free PMC Article

Recent systematic reviews

Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials.
Nuffield Department of Population Health Renal Studies Group; SGLT2 inhibitor Meta-Analysis Cardio-Renal Trialists' Consortium
Lancet 2022 Nov 19;400(10365):1788-1801. Epub 2022 Nov 6 doi: 10.1016/S0140-6736(22)02074-8. PMID: 36351458Free PMC Article
The global impact of COVID-19 pandemic on the incidence of pediatric new-onset type 1 diabetes and ketoacidosis: A systematic review and meta-analysis.
Rahmati M, Keshvari M, Mirnasuri S, Yon DK, Lee SW, Il Shin J, Smith L
J Med Virol 2022 Nov;94(11):5112-5127. Epub 2022 Jul 22 doi: 10.1002/jmv.27996. PMID: 35831242Free PMC Article
Efficacy of Ketogenic Diets on Type 2 Diabetes: a Systematic Review.
Tinguely D, Gross J, Kosinski C
Curr Diab Rep 2021 Aug 27;21(9):32. doi: 10.1007/s11892-021-01399-z. PMID: 34448957Free PMC Article
Etiology and Management of Acute Metabolic Acidosis: An Update.
Matyukhin I, Patschan S, Ritter O, Patschan D
Kidney Blood Press Res 2020;45(4):523-531. Epub 2020 Jul 14 doi: 10.1159/000507813. PMID: 32663831
Medication-Induced Hyperlactatemia and Lactic Acidosis: A Systematic Review of the Literature.
Smith ZR, Horng M, Rech MA
Pharmacotherapy 2019 Sep;39(9):946-963. Epub 2019 Aug 29 doi: 10.1002/phar.2316. PMID: 31361914

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