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Chronic acquired lymphedema

MedGen UID:
78533
•Concept ID:
C0265191
•
Disease or Syndrome
Synonyms: Secondary Lymphedema; Secondary lymphedema
SNOMED CT: Chronic acquired lymphedema (28590005); Secondary lymphedema (28590005)

Definition

A condition that is caused by trauma to the lymph system, which disrupts the normal flow of lymph fluid. This is most often due to surgery that requires lymph node removal or a large amount of lymph tissue. This disruption is especially apparent if the lymph nodes under the arm and arm and around the breast are compromised due to breast cancer surgery, diagnostic dissection, mastectomy, or radiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic acquired lymphedema

Professional guidelines

PubMed

Advances in the prevention and treatment of breast cancer-related lymphedema.
Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Breast Cancer Res Treat 2023 Jul;200(1):1-14. Epub 2023 Apr 27 doi: 10.1007/s10549-023-06947-7. PMID: 37103598Free PMC Article
Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Edema: diagnosis and management.
Trayes KP, Studdiford JS, Pickle S, Tully AS
Am Fam Physician 2013 Jul 15;88(2):102-10. PMID: 23939641

Recent clinical studies

Etiology

Advances in the prevention and treatment of breast cancer-related lymphedema.
Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Breast Cancer Res Treat 2023 Jul;200(1):1-14. Epub 2023 Apr 27 doi: 10.1007/s10549-023-06947-7. PMID: 37103598Free PMC Article
The American Venous Forum, American Vein and Lymphatic Society and the Society for Vascular Medicine expert opinion consensus on lymphedema diagnosis and treatment.
Lurie F, Malgor RD, Carman T, Dean SM, Iafrati MD, Khilnani NM, Labropoulos N, Maldonado TS, Mortimer P, O'Donnell TF Jr, Raffetto JD, Rockson SG, Gasparis AP
Phlebology 2022 May;37(4):252-266. Epub 2022 Mar 8 doi: 10.1177/02683555211053532. PMID: 35258350Free PMC Article
Prospective Surveillance for Breast Cancer-Related Arm Lymphedema: A Systematic Review and Meta-Analysis.
Rafn BS, Christensen J, Larsen A, Bloomquist K
J Clin Oncol 2022 Mar 20;40(9):1009-1026. Epub 2022 Jan 25 doi: 10.1200/JCO.21.01681. PMID: 35077194
Lower extremity lymphedema in patients with gynecologic malignancies.
Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136Free PMC Article
Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable.
Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, Zucker DS, Matthews CE, Ligibel JA, Gerber LH, Morris GS, Patel AV, Hue TF, Perna FM, Schmitz KH
Med Sci Sports Exerc 2019 Nov;51(11):2375-2390. doi: 10.1249/MSS.0000000000002116. PMID: 31626055Free PMC Article

Diagnosis

Advances in the prevention and treatment of breast cancer-related lymphedema.
Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Breast Cancer Res Treat 2023 Jul;200(1):1-14. Epub 2023 Apr 27 doi: 10.1007/s10549-023-06947-7. PMID: 37103598Free PMC Article
Primary lymphoedema.
Brouillard P, Witte MH, Erickson RP, Damstra RJ, Becker C, Quéré I, Vikkula M
Nat Rev Dis Primers 2021 Oct 21;7(1):77. doi: 10.1038/s41572-021-00309-7. PMID: 34675250
Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Lymphedema: Pathophysiology and clinical manifestations.
Grada AA, Phillips TJ
J Am Acad Dermatol 2017 Dec;77(6):1009-1020. doi: 10.1016/j.jaad.2017.03.022. PMID: 29132848
Edema: diagnosis and management.
Trayes KP, Studdiford JS, Pickle S, Tully AS
Am Fam Physician 2013 Jul 15;88(2):102-10. PMID: 23939641

Therapy

Advances in the prevention and treatment of breast cancer-related lymphedema.
Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Breast Cancer Res Treat 2023 Jul;200(1):1-14. Epub 2023 Apr 27 doi: 10.1007/s10549-023-06947-7. PMID: 37103598Free PMC Article
Surgical Treatment and Rehabilitation Strategies for Upper and Lower Extremity Lymphedema: A Comprehensive Review.
de Sire A, Losco L, Lippi L, Spadoni D, Kaciulyte J, Sert G, Ciamarra P, Marcasciano M, Cuomo R, Bolletta A, Invernizzi M, Cigna E
Medicina (Kaunas) 2022 Jul 19;58(7) doi: 10.3390/medicina58070954. PMID: 35888673Free PMC Article
Update in the management of lipedema.
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable.
Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, Zucker DS, Matthews CE, Ligibel JA, Gerber LH, Morris GS, Patel AV, Hue TF, Perna FM, Schmitz KH
Med Sci Sports Exerc 2019 Nov;51(11):2375-2390. doi: 10.1249/MSS.0000000000002116. PMID: 31626055Free PMC Article
Persistent Post-Mastectomy Pain: Risk Factors and Current Approaches to Treatment.
Tait RC, Zoberi K, Ferguson M, Levenhagen K, Luebbert RA, Rowland K, Salsich GB, Herndon C
J Pain 2018 Dec;19(12):1367-1383. Epub 2018 Jun 30 doi: 10.1016/j.jpain.2018.06.002. PMID: 29966772Free PMC Article

Prognosis

Lymphedema and Kaposi sarcoma: A narrative review.
Dauguet M, Lebbé C, Vignes S
J Med Vasc 2023 Nov-Dec;48(5-6):181-187. Epub 2023 Nov 8 doi: 10.1016/j.jdmv.2023.10.007. PMID: 38035924
Dietary supplements in lymphedema.
Bonetti G, Dhuli K, Michelini S, Michelini S, Michelini S, Ricci M, Cestari M, Bertelli M
J Prev Med Hyg 2022 Jun;63(2 Suppl 3):E200-E205. Epub 2022 Oct 17 doi: 10.15167/2421-4248/jpmh2022.63.2S3.2761. PMID: 36479479Free PMC Article
Primary lymphoedema.
Brouillard P, Witte MH, Erickson RP, Damstra RJ, Becker C, Quéré I, Vikkula M
Nat Rev Dis Primers 2021 Oct 21;7(1):77. doi: 10.1038/s41572-021-00309-7. PMID: 34675250
Radiation-induced angiosarcoma of the breast: A review.
Bonito FJP, de Almeida Cerejeira D, Dahlstedt-Ferreira C, Oliveira Coelho H, Rosas R
Breast J 2020 Mar;26(3):458-463. Epub 2019 Aug 25 doi: 10.1111/tbj.13504. PMID: 31448482
Clinical and diagnostic aspects of lymphedema.
Keo HH, Gretener SB, Staub D
Vasa 2017 Jul;46(4):255-261. Epub 2017 Mar 10 doi: 10.1024/0301-1526/a000622. PMID: 28281399

Clinical prediction guides

Peripheral Edema: Evaluation and Management in Primary Care.
Patel H, Skok C, DeMarco A
Am Fam Physician 2022 Nov;106(5):557-564. PMID: 36379502
The American Venous Forum, American Vein and Lymphatic Society and the Society for Vascular Medicine expert opinion consensus on lymphedema diagnosis and treatment.
Lurie F, Malgor RD, Carman T, Dean SM, Iafrati MD, Khilnani NM, Labropoulos N, Maldonado TS, Mortimer P, O'Donnell TF Jr, Raffetto JD, Rockson SG, Gasparis AP
Phlebology 2022 May;37(4):252-266. Epub 2022 Mar 8 doi: 10.1177/02683555211053532. PMID: 35258350Free PMC Article
Prospective Surveillance for Breast Cancer-Related Arm Lymphedema: A Systematic Review and Meta-Analysis.
Rafn BS, Christensen J, Larsen A, Bloomquist K
J Clin Oncol 2022 Mar 20;40(9):1009-1026. Epub 2022 Jan 25 doi: 10.1200/JCO.21.01681. PMID: 35077194
Compression therapy for leg oedema in patients with heart failure.
Urbanek T, Juśko M, Kuczmik WB
ESC Heart Fail 2020 Oct;7(5):2012-2020. Epub 2020 Jul 25 doi: 10.1002/ehf2.12848. PMID: 32710511Free PMC Article
Clinical and diagnostic aspects of lymphedema.
Keo HH, Gretener SB, Staub D
Vasa 2017 Jul;46(4):255-261. Epub 2017 Mar 10 doi: 10.1024/0301-1526/a000622. PMID: 28281399

Recent systematic reviews

Guidelines Relevant to Diagnosis, Assessment, and Management of Lymphedema: A Systematic Review.
Torgbenu E, Luckett T, Buhagiar MA, Phillips JL
Adv Wound Care (New Rochelle) 2023 Jan;12(1):15-27. Epub 2022 Apr 6 doi: 10.1089/wound.2021.0149. PMID: 35196892
Prospective Surveillance for Breast Cancer-Related Arm Lymphedema: A Systematic Review and Meta-Analysis.
Rafn BS, Christensen J, Larsen A, Bloomquist K
J Clin Oncol 2022 Mar 20;40(9):1009-1026. Epub 2022 Jan 25 doi: 10.1200/JCO.21.01681. PMID: 35077194
A systematic review of pharmacologic and cell-based therapies for treatment of lymphedema (2010-2021).
Walker J, Tanna S, Roake J, Lyons O
J Vasc Surg Venous Lymphat Disord 2022 Jul;10(4):966-975.e1. Epub 2021 Sep 26 doi: 10.1016/j.jvsv.2021.09.004. PMID: 34587525
Current Advancements in Animal Models of Postsurgical Lymphedema: A Systematic Review.
Hsu JF, Yu RP, Stanton EW, Wang J, Wong AK
Adv Wound Care (New Rochelle) 2022 Aug;11(8):399-418. Epub 2021 Aug 27 doi: 10.1089/wound.2021.0033. PMID: 34128396Free PMC Article
Patient-Reported Outcome Measures in Lymphedema: A Systematic Review and COSMIN Analysis.
Beelen LM, van Dishoeck AM, Tsangaris E, Coriddi M, Dayan JH, Pusic AL, Klassen A, Vasilic D
Ann Surg Oncol 2021 Mar;28(3):1656-1668. Epub 2020 Nov 28 doi: 10.1245/s10434-020-09346-0. PMID: 33249519Free PMC Article

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