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Gastric dysplasia

MedGen UID:
78625
Concept ID:
C0267111
Disease or Syndrome
Synonyms: Gastric Dysplasia; Gastric Glandular Intraepithelial Dysplasia; Gastric Glandular Intraepithelial Neoplasia; Gastric Intraepithelial Neoplasia; Gastric Intraepithelial Neoplasia (Dysplasia); Intraepithelial Neoplasia (Dysplasia) of Stomach; Intraepithelial Neoplasia (Dysplasia) of the Stomach; Stomach dysplasia; Stomach Intraepithelial Neoplasia (Dysplasia)
SNOMED CT: Stomach dysplasia (20915006); Gastric dysplasia (20915006)

Definition

A morphologic finding indicating the presence of dysplastic changes within the gastric mucosal epithelial cells. [from NCI]

Professional guidelines

PubMed

Young E, Philpott H, Singh R
World J Gastroenterol 2021 Aug 21;27(31):5126-5151. doi: 10.3748/wjg.v27.i31.5126. PMID: 34497440Free PMC Article
Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro M
Gut 2019 Sep;68(9):1545-1575. Epub 2019 Jul 5 doi: 10.1136/gutjnl-2018-318126. PMID: 31278206Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article

Recent clinical studies

Etiology

Niknam N, Obanor S, Lee LA
Curr Opin Gastroenterol 2022 Sep 1;38(5):436-442. Epub 2022 Jul 15 doi: 10.1097/MOG.0000000000000867. PMID: 35881962
Zhang X, Soutto M, Chen Z, Bhat N, Zhu S, Eissmann MF, Ernst M, Lu H, Peng D, Xu Z, El-Rifai W
Gastroenterology 2022 Sep;163(3):620-636.e9. Epub 2022 May 17 doi: 10.1053/j.gastro.2022.05.016. PMID: 35588797Free PMC Article
Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro M
Gut 2019 Sep;68(9):1545-1575. Epub 2019 Jul 5 doi: 10.1136/gutjnl-2018-318126. PMID: 31278206Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Misdraji J, Lauwers GY
Semin Diagn Pathol 2002 Feb;19(1):20-30. PMID: 11936263

Diagnosis

Sugano K, Moss SF, Kuipers EJ
Gastroenterology 2023 Dec;165(6):1352-1366.e1. Epub 2023 Aug 29 doi: 10.1053/j.gastro.2023.08.028. PMID: 37652306
Young E, Philpott H, Singh R
World J Gastroenterol 2021 Aug 21;27(31):5126-5151. doi: 10.3748/wjg.v27.i31.5126. PMID: 34497440Free PMC Article
Battista S, Ambrosio MR, Limarzi F, Gallo G, Saragoni L
Int J Mol Sci 2021 Jun 22;22(13) doi: 10.3390/ijms22136652. PMID: 34206291Free PMC Article
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro M
Gut 2019 Sep;68(9):1545-1575. Epub 2019 Jul 5 doi: 10.1136/gutjnl-2018-318126. PMID: 31278206Free PMC Article

Therapy

Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
Nelson A, Bi Y, Harris D
Rom J Intern Med 2021 Jun 1;59(2):112-118. Epub 2021 May 8 doi: 10.2478/rjim-2020-0043. PMID: 33565305
Akbari M, Tabrizi R, Kardeh S, Lankarani KB
PLoS One 2019;14(7):e0219865. Epub 2019 Jul 26 doi: 10.1371/journal.pone.0219865. PMID: 31348819Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Ko Y, Tang J, Sanagapalli S, Kim BS, Leong RW
Expert Opin Drug Saf 2016 Jan;15(1):53-63. Epub 2015 Dec 14 doi: 10.1517/14740338.2016.1118050. PMID: 26560097

Prognosis

Battista S, Ambrosio MR, Limarzi F, Gallo G, Saragoni L
Int J Mol Sci 2021 Jun 22;22(13) doi: 10.3390/ijms22136652. PMID: 34206291Free PMC Article
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro M
Gut 2019 Sep;68(9):1545-1575. Epub 2019 Jul 5 doi: 10.1136/gutjnl-2018-318126. PMID: 31278206Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Sipponen P
Curr Top Pathol 1990;81:61-76. doi: 10.1007/978-3-642-74662-8_3. PMID: 2407446

Clinical prediction guides

Ushiku T, Lauwers GY
Gastroenterol Clin North Am 2024 Mar;53(1):39-55. doi: 10.1016/j.gtc.2023.11.003. PMID: 38280750
Xiao S, Lu H, Xue Y, Cui R, Meng L, Jin Z, Yin Z, Zhou L
Clin Gastroenterol Hepatol 2022 Jun;20(6):1259-1268.e7. Epub 2021 Oct 28 doi: 10.1016/j.cgh.2021.10.032. PMID: 34718170
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Sipponen P
Curr Top Pathol 1990;81:61-76. doi: 10.1007/978-3-642-74662-8_3. PMID: 2407446

Recent systematic reviews

Akbari M, Kardeh B, Tabrizi R, Ahmadizar F, Lankarani KB
J Clin Gastroenterol 2019 Nov/Dec;53(10):703-710. doi: 10.1097/MCG.0000000000001257. PMID: 31415022
Akbari M, Tabrizi R, Kardeh S, Lankarani KB
PLoS One 2019;14(7):e0219865. Epub 2019 Jul 26 doi: 10.1371/journal.pone.0219865. PMID: 31348819Free PMC Article

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