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Disseminated peritoneal leiomyomatosis

MedGen UID:
78634
•Concept ID:
C0267785
•
Neoplastic Process
Synonyms: Diffuse Peritoneal Leiomyomatosis; Diffuse peritoneal leiomyomatosis; diffuse peritoneal leiomyomatosis; Disseminated Peritoneal Leiomyomatosis; disseminated peritoneal leiomyomatosis; DPL; Leiomyomatosis Peritonealis Disseminata; Leiomyomatosis peritonealis disseminata; leiomyomatosis peritonealis disseminata; Leiomyomatosis peritonealis disseminate; leiomyomatosis peritonealis disseminate; Leiomyomatosis, peritonealis disseminata; LPD
SNOMED CT: Leiomyomatosis peritonealis disseminata (62557001); Leiomyomatosis, peritonealis disseminata (703634007)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0006183
Orphanet: ORPHA71274

Definition

Disseminated peritoneal leiomyomatosis (DPL) is characterized by the proliferation of multiple benign smooth muscle cell-containing nodules in the peritoneal cavity. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisseminated peritoneal leiomyomatosis

Recent clinical studies

Etiology

Disseminated peritoneal leiomyomatosis and malignant transformation: A case series in a single referral center.
Rosati A, Vargiu V, Angelico G, Zannoni GF, Ciccarone F, Scambia G, Fanfani F
Eur J Obstet Gynecol Reprod Biol 2021 Jul;262:21-27. Epub 2021 May 5 doi: 10.1016/j.ejogrb.2021.05.006. PMID: 33989940
Disseminated peritoneal leiomyomatosis: a devastating sequelae of unconfined laparoscopic morcellation.
Tan HL, Koh YX, Chew MH, Wang J, Lim JSK, Leow WQ, Lee SY
Singapore Med J 2019 Dec;60(12):652-654. doi: 10.11622/smedj.2019159. PMID: 31889207Free PMC Article
Laparoscopic Dissection of Extensive Secondary Disseminated Peritoneal Leiomyomatosis.
Mairaing K, Huang KG
J Minim Invasive Gynecol 2018 May-Jun;25(4):580-581. Epub 2017 Oct 12 doi: 10.1016/j.jmig.2017.10.009. PMID: 29032253
Long-term sequelae of unconfined morcellation during laparoscopic gynecological surgery.
Cohen A, Tulandi T
Maturitas 2017 Mar;97:1-5. Epub 2016 Nov 18 doi: 10.1016/j.maturitas.2016.11.007. PMID: 28159054
Nonmalignant Sequelae of Unconfined Morcellation at Laparoscopic Hysterectomy or Myomectomy.
Tulandi T, Leung A, Jan N
J Minim Invasive Gynecol 2016 Mar-Apr;23(3):331-7. Epub 2016 Jan 21 doi: 10.1016/j.jmig.2016.01.017. PMID: 26802909

Diagnosis

A RARE UTERINE TUMOR: DISSEMINATED PERITONEAL LEIOMYOMATOSIS. CLINICAL OBSERVATIONS.
Svintsitskyi V, Krotevych M, Iegorov M, Trokhymych S, Sendetskyi S
Exp Oncol 2023 Dec 28;45(3):370-378. doi: 10.15407/exp-oncology.2023.03.370. PMID: 38186018
Laparoscopic Management of Disseminated Peritoneal Leiomyomatosis.
Kriplani I, Kriplani A, Sharma S, Sodhi M, Jain N
J Minim Invasive Gynecol 2023 Jun;30(6):443-444. Epub 2023 Mar 17 doi: 10.1016/j.jmig.2023.03.006. PMID: 36934877
Disseminated peritoneal leiomyomatosis: a case report and review of the literature.
Liu X, Hu Y, Chen L, Zhou Q
J Int Med Res 2021 Aug;49(8):3000605211033194. doi: 10.1177/03000605211033194. PMID: 34369191Free PMC Article
Disseminated peritoneal leiomyomatosis and malignant transformation: A case series in a single referral center.
Rosati A, Vargiu V, Angelico G, Zannoni GF, Ciccarone F, Scambia G, Fanfani F
Eur J Obstet Gynecol Reprod Biol 2021 Jul;262:21-27. Epub 2021 May 5 doi: 10.1016/j.ejogrb.2021.05.006. PMID: 33989940
Disseminated peritoneal leiomyomatosis.
Aterman K, Fraser GM, Lea RH
Virchows Arch A Pathol Anat Histol 1977 May 13;374(1):13-26. doi: 10.1007/BF00430567. PMID: 141779

Therapy

Disseminated peritoneal leiomyomatosis: a devastating sequelae of unconfined laparoscopic morcellation.
Tan HL, Koh YX, Chew MH, Wang J, Lim JSK, Leow WQ, Lee SY
Singapore Med J 2019 Dec;60(12):652-654. doi: 10.11622/smedj.2019159. PMID: 31889207Free PMC Article
Ulipristal Acetate for Disseminated Peritoneal Leiomyomatosis.
Benlolo S, Papillon-Smith J, Murji A
Obstet Gynecol 2019 Mar;133(3):434-436. doi: 10.1097/AOG.0000000000003112. PMID: 30741799
Long-term sequelae of unconfined morcellation during laparoscopic gynecological surgery.
Cohen A, Tulandi T
Maturitas 2017 Mar;97:1-5. Epub 2016 Nov 18 doi: 10.1016/j.maturitas.2016.11.007. PMID: 28159054
Disseminated peritoneal leiomyomatosis postmorcellated resection of uterine leiomyomatous tissue.
Sekulic M, Moench L, Movahedi-Lankarani S
APMIS 2016 Dec;124(12):1063-1071. Epub 2016 Sep 20 doi: 10.1111/apm.12601. PMID: 27649643
Nonmalignant Sequelae of Unconfined Morcellation at Laparoscopic Hysterectomy or Myomectomy.
Tulandi T, Leung A, Jan N
J Minim Invasive Gynecol 2016 Mar-Apr;23(3):331-7. Epub 2016 Jan 21 doi: 10.1016/j.jmig.2016.01.017. PMID: 26802909

Prognosis

A RARE UTERINE TUMOR: DISSEMINATED PERITONEAL LEIOMYOMATOSIS. CLINICAL OBSERVATIONS.
Svintsitskyi V, Krotevych M, Iegorov M, Trokhymych S, Sendetskyi S
Exp Oncol 2023 Dec 28;45(3):370-378. doi: 10.15407/exp-oncology.2023.03.370. PMID: 38186018
DISSEMINATED PERITONEAL LEIOMYOMATOSIS - A RARE ENTITY, COMPLICATED BY LATE BLEEDING FROM THE ILEOCOLIC VEIN.
Popivanov G, Ilcheva B, Konakchieva M, Kjossev K, Mutafchiyski V, Tabakov M
Georgian Med News 2022 Nov;(332):118-120. PMID: 36701788
Disseminated peritoneal leiomyomatosis: a case report and review of the literature.
Liu X, Hu Y, Chen L, Zhou Q
J Int Med Res 2021 Aug;49(8):3000605211033194. doi: 10.1177/03000605211033194. PMID: 34369191Free PMC Article
Ulipristal Acetate for Disseminated Peritoneal Leiomyomatosis.
Benlolo S, Papillon-Smith J, Murji A
Obstet Gynecol 2019 Mar;133(3):434-436. doi: 10.1097/AOG.0000000000003112. PMID: 30741799
Disseminated peritoneal leiomyomatosis with endometriosis.
Mueller F, Kuehn K, Neudeck H, Siedentopf N, Ulrich U
J Minim Invasive Gynecol 2012 May-Jun;19(3):380-2. doi: 10.1016/j.jmig.2011.12.016. PMID: 22546423

Clinical prediction guides

A RARE UTERINE TUMOR: DISSEMINATED PERITONEAL LEIOMYOMATOSIS. CLINICAL OBSERVATIONS.
Svintsitskyi V, Krotevych M, Iegorov M, Trokhymych S, Sendetskyi S
Exp Oncol 2023 Dec 28;45(3):370-378. doi: 10.15407/exp-oncology.2023.03.370. PMID: 38186018
Disseminated peritoneal leiomyomatosis: a case report and review of the literature.
Liu X, Hu Y, Chen L, Zhou Q
J Int Med Res 2021 Aug;49(8):3000605211033194. doi: 10.1177/03000605211033194. PMID: 34369191Free PMC Article
A clinicopathological and molecular analysis in uterine leiomyomas and concurrent/metachronous peritoneal nodules: New insights into disseminated peritoneal leiomyomatosis.
Ma Y, Wang S, Liu Q, Lu B
Pathol Res Pract 2020 May;216(5):152938. Epub 2020 Mar 24 doi: 10.1016/j.prp.2020.152938. PMID: 32234244
Disseminated peritoneal leiomyomatosis with malignant change, in a male.
Lausen I, Jensen OJ, Andersen E, Lindahl F
Virchows Arch A Pathol Anat Histopathol 1990;417(2):173-5. doi: 10.1007/BF02190536. PMID: 2114697
Immunohistologic detection of estrogen and progesterone receptors in disseminated peritoneal leiomyomatosis.
Düe W, Pickartz H
Int J Gynecol Pathol 1989;8(1):46-53. doi: 10.1097/00004347-198903000-00006. PMID: 2707953

Recent systematic reviews

The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343
Parasitic leiomyomas: a systematic review.
Lete I, González J, Ugarte L, Barbadillo N, Lapuente O, Álvarez-Sala J
Eur J Obstet Gynecol Reprod Biol 2016 Aug;203:250-9. Epub 2016 Jun 10 doi: 10.1016/j.ejogrb.2016.05.025. PMID: 27359081
Nonmalignant Sequelae of Unconfined Morcellation at Laparoscopic Hysterectomy or Myomectomy.
Tulandi T, Leung A, Jan N
J Minim Invasive Gynecol 2016 Mar-Apr;23(3):331-7. Epub 2016 Jan 21 doi: 10.1016/j.jmig.2016.01.017. PMID: 26802909

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