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Pediatric supratentorial ependymoma

MedGen UID:
78854
Concept ID:
C0278650
Neoplastic Process
Synonyms: childhood supratentorial ependymoma; Childhood Supratentorial Ependymoma, NOS; Childhood Supratentorial Ependymoma, Not Otherwise Specified; paediatric cerebral ependymoma; paediatric supratentorial ependymoblastoma; pediatric cerebral ependymoma; pediatric supratentorial ependymoblastoma; pediatric supratentorial ependymoma
 
Monarch Initiative: MONDO:0004249

Definition

An ependymoma, not otherwise specified that arises from the supratentorial region of the brain and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPediatric supratentorial ependymoma

Professional guidelines

PubMed

Fangusaro J, Bandopadhayay P
Curr Opin Pediatr 2021 Feb 1;33(1):26-32. doi: 10.1097/MOP.0000000000000975. PMID: 33278109
Khatua S, Mangum R, Bertrand KC, Zaky W, McCall D, Mack SC
Future Oncol 2018 Dec;14(30):3175-3186. Epub 2018 Nov 12 doi: 10.2217/fon-2018-0502. PMID: 30418040
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article

Recent clinical studies

Etiology

Okonechnikov K, Camgöz A, Chapman O, Wani S, Park DE, Hübner JM, Chakraborty A, Pagadala M, Bump R, Chandran S, Kraft K, Acuna-Hidalgo R, Reid D, Sikkink K, Mauermann M, Juarez EF, Jenseit A, Robinson JT, Pajtler KW, Milde T, Jäger N, Fiesel P, Morgan L, Sridhar S, Coufal NG, Levy M, Malicki D, Hobbs C, Kingsmore S, Nahas S, Snuderl M, Crawford J, Wechsler-Reya RJ, Davidson TB, Cotter J, Michaiel G, Fleischhack G, Mundlos S, Schmitt A, Carter H, Michealraj KA, Kumar SA, Taylor MD, Rich J, Buchholz F, Mesirov JP, Pfister SM, Ay F, Dixon JR, Kool M, Chavez L
Nat Commun 2023 Apr 21;14(1):2300. doi: 10.1038/s41467-023-38044-0. PMID: 37085539Free PMC Article
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Santi M, Viaene AN, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):59-67. doi: 10.1177/10935266211018928. PMID: 35168420
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz HJ, Ryzhova M, Mack S, Ramaswamy V, Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Toledano H, Avigad S, Hoffman LM, Donson AM, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong TS, Gupta N, Allen JC, Karajannis MA, Zagzag D, Hasselblatt M, Kulozik AE, Witt O, Collins VP, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo ML, von Deimling A, Lichter P, Taylor MD, Gilbertson R, Ellison DW, Aldape K, Korshunov A, Kool M, Pfister SM
Cancer Cell 2015 May 11;27(5):728-43. doi: 10.1016/j.ccell.2015.04.002. PMID: 25965575Free PMC Article

Diagnosis

Santi M, Viaene AN, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):59-67. doi: 10.1177/10935266211018928. PMID: 35168420
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Khatua S, Mangum R, Bertrand KC, Zaky W, McCall D, Mack SC
Future Oncol 2018 Dec;14(30):3175-3186. Epub 2018 Nov 12 doi: 10.2217/fon-2018-0502. PMID: 30418040
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article
Zamora C, Huisman TA, Izbudak I
Neuroimaging Clin N Am 2017 Feb;27(1):39-67. doi: 10.1016/j.nic.2016.08.003. PMID: 27889023

Therapy

Zhang M, Tam L, Wright J, Mohammadzadeh M, Han M, Chen E, Wagner M, Nemalka J, Lai H, Eghbal A, Ho CY, Lober RM, Cheshier SH, Vitanza NA, Grant GA, Prolo LM, Yeom KW, Jaju A
AJNR Am J Neuroradiol 2022 Apr;43(4):603-610. Epub 2022 Mar 31 doi: 10.3174/ajnr.A7481. PMID: 35361575Free PMC Article
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Khatua S, Mangum R, Bertrand KC, Zaky W, McCall D, Mack SC
Future Oncol 2018 Dec;14(30):3175-3186. Epub 2018 Nov 12 doi: 10.2217/fon-2018-0502. PMID: 30418040
Khatua S, Ramaswamy V, Bouffet E
Eur J Cancer 2017 Jan;70:34-41. Epub 2016 Nov 18 doi: 10.1016/j.ejca.2016.10.013. PMID: 27866097
Cohen KJ, Broniscer A, Glod J
Curr Treat Options Oncol 2001 Dec;2(6):529-36. doi: 10.1007/s11864-001-0074-9. PMID: 12057098

Prognosis

Träger M, Schweizer L, Pérez E, Schmid S, Hain EG, Dittmayer C, Onken J, Fukuoka K, Ichimura K, Schüller U, Dührsen L, Müther M, Paulus W, Thomas C, Gutt-Will M, Schucht P, Maragkou T, Schittenhelm J, Eckert F, Niyazi M, Fleischmann DF, Dorostkar MM, Feyer P, May SA, Moskopp D, Badakhshi H, Radke C, Walter J, Ehret F, Capper D, Kaul D
Neuro Oncol 2023 Jul 6;25(7):1286-1298. doi: 10.1093/neuonc/noad030. PMID: 36734226Free PMC Article
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Santi M, Viaene AN, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):59-67. doi: 10.1177/10935266211018928. PMID: 35168420
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article
Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz HJ, Ryzhova M, Mack S, Ramaswamy V, Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Toledano H, Avigad S, Hoffman LM, Donson AM, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong TS, Gupta N, Allen JC, Karajannis MA, Zagzag D, Hasselblatt M, Kulozik AE, Witt O, Collins VP, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo ML, von Deimling A, Lichter P, Taylor MD, Gilbertson R, Ellison DW, Aldape K, Korshunov A, Kool M, Pfister SM
Cancer Cell 2015 May 11;27(5):728-43. doi: 10.1016/j.ccell.2015.04.002. PMID: 25965575Free PMC Article

Clinical prediction guides

Okonechnikov K, Camgöz A, Chapman O, Wani S, Park DE, Hübner JM, Chakraborty A, Pagadala M, Bump R, Chandran S, Kraft K, Acuna-Hidalgo R, Reid D, Sikkink K, Mauermann M, Juarez EF, Jenseit A, Robinson JT, Pajtler KW, Milde T, Jäger N, Fiesel P, Morgan L, Sridhar S, Coufal NG, Levy M, Malicki D, Hobbs C, Kingsmore S, Nahas S, Snuderl M, Crawford J, Wechsler-Reya RJ, Davidson TB, Cotter J, Michaiel G, Fleischhack G, Mundlos S, Schmitt A, Carter H, Michealraj KA, Kumar SA, Taylor MD, Rich J, Buchholz F, Mesirov JP, Pfister SM, Ay F, Dixon JR, Kool M, Chavez L
Nat Commun 2023 Apr 21;14(1):2300. doi: 10.1038/s41467-023-38044-0. PMID: 37085539Free PMC Article
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Zschernack V, Jünger ST, Mynarek M, Rutkowski S, Garre ML, Ebinger M, Neu M, Faber J, Erdlenbruch B, Claviez A, Bielack S, Brozou T, Frühwald MC, Dörner E, Dreschmann V, Stock A, Solymosi L, Hench J, Frank S, Vokuhl C, Waha A, Andreiuolo F, Pietsch T
Acta Neuropathol 2021 Mar;141(3):455-466. Epub 2021 Jan 22 doi: 10.1007/s00401-020-02260-5. PMID: 33481105Free PMC Article
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz HJ, Ryzhova M, Mack S, Ramaswamy V, Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Toledano H, Avigad S, Hoffman LM, Donson AM, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong TS, Gupta N, Allen JC, Karajannis MA, Zagzag D, Hasselblatt M, Kulozik AE, Witt O, Collins VP, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo ML, von Deimling A, Lichter P, Taylor MD, Gilbertson R, Ellison DW, Aldape K, Korshunov A, Kool M, Pfister SM
Cancer Cell 2015 May 11;27(5):728-43. doi: 10.1016/j.ccell.2015.04.002. PMID: 25965575Free PMC Article

Recent systematic reviews

Ajithkumar T, Avanzo M, Yorke E, Tsang DS, Milano MT, Olch AJ, Merchant TE, Dieckmann K, Mahajan A, Fuji H, Paulino AC, Timmermann B, Marks LB, Bentzen SM, Jackson A, Constine LS
Int J Radiat Oncol Biol Phys 2024 Jun 1;119(2):655-668. Epub 2024 Feb 1 doi: 10.1016/j.ijrobp.2023.12.043. PMID: 38300187
Byer L, Kline CN, Coleman C, Allen IE, Whitaker E, Mueller S
J Neurooncol 2019 Sep;144(3):445-452. Epub 2019 Sep 9 doi: 10.1007/s11060-019-03255-3. PMID: 31502040
Cage TA, Clark AJ, Aranda D, Gupta N, Sun PP, Parsa AT, Auguste KI
J Neurosurg Pediatr 2013 Jun;11(6):673-81. Epub 2013 Mar 29 doi: 10.3171/2013.2.PEDS12345. PMID: 23540528
Au Yong KJ, Jaremko JL, Jans L, Bhargava R, Coleman LT, Mehta V, Ditchfield MR
Pediatr Radiol 2013 Mar;43(3):347-54. Epub 2012 Nov 10 doi: 10.1007/s00247-012-2530-z. PMID: 23143401

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