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Metastatic Ovarian Carcinoma

MedGen UID:
78864
•Concept ID:
C0278688
•
Neoplastic Process

Definition

A carcinoma that arises from the ovary and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Therapeutic effect of haploidentical peripheral blood stem cell treatment on relapsed/refractory ovarian cancer.
Li R, Zhang D, Ren B, Cao S, Zhou L, Xiong Y, Sun Q, Ren X
Bull Cancer 2023 Mar;110(3):285-292. Epub 2023 Feb 2 doi: 10.1016/j.bulcan.2022.11.013. PMID: 36739242
Increased circulating tumor DNA as a noninvasive biomarker of early treatment response in patients with metastatic ovarian carcinoma: A pilot study.
Alves MC, Fonseca FLA, Yamada AMTD, Barros LADR, Lopes A, Silva LCFF, Luz AS, Melo Cruz FJS, Del Giglio A
Tumour Biol 2020 May;42(5):1010428320919198. doi: 10.1177/1010428320919198. PMID: 32364828
Recent advances with topotecan in the treatment of lung cancer.
O'Brien M, Eckardt J, Ramlau R
Oncologist 2007 Oct;12(10):1194-204. doi: 10.1634/theoncologist.12-10-1194. PMID: 17962613

Recent clinical studies

Etiology

Epidemiological overview of metastatic ovarian carcinoma: long-term experience of TOTSG database.
Kajiyama H, Suzuki S, Utsumi F, Nishino K, Niimi K, Mizuno M, Yoshikawa N, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Shibata K, Nagasaka T, Kikkawa F
Nagoya J Med Sci 2019 May;81(2):193-198. doi: 10.18999/nagjms.81.2.193. PMID: 31239587Free PMC Article
Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma.
Kajiyama H, Suzuki S, Utsumi F, Yoshikawa N, Nishino K, Ikeda Y, Niimi K, Yamamoto E, Kawai M, Shibata K, Nagasaka T, Kikkawa F
Int J Clin Oncol 2019 Aug;24(8):950-956. Epub 2019 Apr 2 doi: 10.1007/s10147-019-01438-6. PMID: 30941534
Metastatic ovarian tumors: a clinicopathologic study of 150 cases.
Alvarado-Cabrero I, Rodríguez-Gómez A, Castelan-Pedraza J, Valencia-Cedillo R
Anal Quant Cytopathol Histpathol 2013 Oct;35(5):241-8. PMID: 24282903
Recent advances with topotecan in the treatment of lung cancer.
O'Brien M, Eckardt J, Ramlau R
Oncologist 2007 Oct;12(10):1194-204. doi: 10.1634/theoncologist.12-10-1194. PMID: 17962613
Adhesion molecules.
Skubitz AP
Cancer Treat Res 2002;107:305-29. doi: 10.1007/978-1-4757-3587-1_15. PMID: 11775459

Diagnosis

Integrated analysis of DNA methylome and transcriptome reveals SFRP1 and LIPG as potential drivers of ovarian cancer metastasis.
Yi J, Wu M, Zheng Z, Zhou Q, Li X, Lu Y, Liu P
J Gynecol Oncol 2023 Nov;34(6):e71. Epub 2023 Jun 27 doi: 10.3802/jgo.2023.34.e71. PMID: 37417299Free PMC Article
Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma.
Sallinen H, Janhonen S, Pölönen P, Niskanen H, Liu OH, Kivelä A, Hartikainen JM, Anttila M, Heinäniemi M, Ylä-Herttuala S, Kaikkonen MU
BMC Cancer 2019 Nov 19;19(1):1121. doi: 10.1186/s12885-019-6339-0. PMID: 31744494Free PMC Article
Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma.
Jiang RT, Yemelyanova A, Xing D, Anchoori RK, Hamazaki J, Murata S, Seidman JD, Wang TL, Roden RBS
J Ovarian Res 2017 Aug 7;10(1):53. doi: 10.1186/s13048-017-0347-y. PMID: 28784174Free PMC Article
New determinates of disease progression and outcome in metastatic ovarian carcinoma.
Davidson B, Reich R, Trope CG, Wang TL, Shih IeM
Histol Histopathol 2010 Dec;25(12):1591-609. doi: 10.14670/HH-25.1591. PMID: 20886439
A review of the cutaneous paraneoplastic associations and metastatic presentations of ovarian carcinoma.
Scheinfeld N
Clin Exp Dermatol 2008 Jan;33(1):10-5. Epub 2007 Nov 3 doi: 10.1111/j.1365-2230.2007.02560.x. PMID: 17983453

Therapy

Tunneling Nanotubular Expressways for Ultrafast and Accurate M1 Macrophage Delivery of Anticancer Drugs to Metastatic Ovarian Carcinoma.
Guo L, Zhang Y, Yang Z, Peng H, Wei R, Wang C, Feng M
ACS Nano 2019 Feb 26;13(2):1078-1096. Epub 2019 Jan 4 doi: 10.1021/acsnano.8b08872. PMID: 30608136
Fibroblast recruitment as a tool for ovarian cancer detection and targeted therapy.
Oren R, Addadi Y, Narunsky Haziza L, Dafni H, Rotkopf R, Meir G, Fishman A, Neeman M
Int J Cancer 2016 Oct 15;139(8):1788-98. Epub 2016 Jun 20 doi: 10.1002/ijc.30209. PMID: 27242346Free PMC Article
Recent advances with topotecan in the treatment of lung cancer.
O'Brien M, Eckardt J, Ramlau R
Oncologist 2007 Oct;12(10):1194-204. doi: 10.1634/theoncologist.12-10-1194. PMID: 17962613
Intraperitoneal immunotherapy for metastatic ovarian carcinoma: Resistance of intratumoral collagen to antibody penetration.
Choi J, Credit K, Henderson K, Deverkadra R, He Z, Wiig H, Vanpelt H, Flessner MF
Clin Cancer Res 2006 Mar 15;12(6):1906-12. doi: 10.1158/1078-0432.CCR-05-2141. PMID: 16551876
Expression of xeroderma pigmentosum A protein predicts improved outcome in metastatic ovarian carcinoma.
Stevens EV, Raffeld M, Espina V, Kristensen GB, Trope' CG, Kohn EC, Davidson B
Cancer 2005 Jun 1;103(11):2313-9. doi: 10.1002/cncr.21031. PMID: 15844177

Prognosis

Integrated analysis of DNA methylome and transcriptome reveals SFRP1 and LIPG as potential drivers of ovarian cancer metastasis.
Yi J, Wu M, Zheng Z, Zhou Q, Li X, Lu Y, Liu P
J Gynecol Oncol 2023 Nov;34(6):e71. Epub 2023 Jun 27 doi: 10.3802/jgo.2023.34.e71. PMID: 37417299Free PMC Article
Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma.
Sallinen H, Janhonen S, Pölönen P, Niskanen H, Liu OH, Kivelä A, Hartikainen JM, Anttila M, Heinäniemi M, Ylä-Herttuala S, Kaikkonen MU
BMC Cancer 2019 Nov 19;19(1):1121. doi: 10.1186/s12885-019-6339-0. PMID: 31744494Free PMC Article
Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma.
Kajiyama H, Suzuki S, Utsumi F, Yoshikawa N, Nishino K, Ikeda Y, Niimi K, Yamamoto E, Kawai M, Shibata K, Nagasaka T, Kikkawa F
Int J Clin Oncol 2019 Aug;24(8):950-956. Epub 2019 Apr 2 doi: 10.1007/s10147-019-01438-6. PMID: 30941534
A review of the cutaneous paraneoplastic associations and metastatic presentations of ovarian carcinoma.
Scheinfeld N
Clin Exp Dermatol 2008 Jan;33(1):10-5. Epub 2007 Nov 3 doi: 10.1111/j.1365-2230.2007.02560.x. PMID: 17983453
Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast.
Raptis S, Kanbour AI, Dusenbery D, Kanbour-Shakir A
Diagn Cytopathol 1996 Jul;15(1):1-6. doi: 10.1002/(SICI)1097-0339(199607)15:1<1::AID-DC2>3.0.CO;2-N. PMID: 8807244

Clinical prediction guides

Toll-like receptor 8 agonists improve NK-cell function primarily targeting CD56(bright)CD16(-) subset.
Veneziani I, Alicata C, Pelosi A, Landolina N, Ricci B, D'Oria V, Fagotti A, Scambia G, Moretta L, Maggi E
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003385. PMID: 35091452Free PMC Article
Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma.
Sallinen H, Janhonen S, Pölönen P, Niskanen H, Liu OH, Kivelä A, Hartikainen JM, Anttila M, Heinäniemi M, Ylä-Herttuala S, Kaikkonen MU
BMC Cancer 2019 Nov 19;19(1):1121. doi: 10.1186/s12885-019-6339-0. PMID: 31744494Free PMC Article
Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma.
Kajiyama H, Suzuki S, Utsumi F, Yoshikawa N, Nishino K, Ikeda Y, Niimi K, Yamamoto E, Kawai M, Shibata K, Nagasaka T, Kikkawa F
Int J Clin Oncol 2019 Aug;24(8):950-956. Epub 2019 Apr 2 doi: 10.1007/s10147-019-01438-6. PMID: 30941534
New determinates of disease progression and outcome in metastatic ovarian carcinoma.
Davidson B, Reich R, Trope CG, Wang TL, Shih IeM
Histol Histopathol 2010 Dec;25(12):1591-609. doi: 10.14670/HH-25.1591. PMID: 20886439
Heparanase expression correlates with poor survival in metastatic ovarian carcinoma.
Davidson B, Shafat I, Risberg B, Ilan N, Trope' CG, Vlodavsky I, Reich R
Gynecol Oncol 2007 Feb;104(2):311-9. Epub 2006 Oct 9 doi: 10.1016/j.ygyno.2006.08.045. PMID: 17030350

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