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Adult Immunoblastic Lymphoma

MedGen UID:
78883
Concept ID:
C0278763
Neoplastic Process
Synonym: Adult Immunoblastic Large Cell Lymphoma

Definition

A morphologic variant of diffuse large B-cell lymphoma occurring in adults. It is characterized by the presence of large lymphoid cells with abundant cytoplasm and prominent nucleoli. [from NCI]

Professional guidelines

PubMed

Zhang C, Mi L, Wu M, Liu W, Ma H, Ren J, Zhao L, Wang X, Song Y, Zhu J
Leuk Lymphoma 2022 May;63(5):1152-1159. Epub 2021 Dec 27 doi: 10.1080/10428194.2021.2015586. PMID: 34957894
Tari G, Lemonnier F, Morschhauser F
Curr Opin Oncol 2021 Sep 1;33(5):400-405. doi: 10.1097/CCO.0000000000000773. PMID: 34230442
Crickx E, Poullot E, Moulis G, Goulabchand R, Fieschi C, Galicier L, Meignin V, Coppo P, Delarue R, Casasnovas O, Roos-Weil D, de Leval L, Parrens M, Michel M, Dupuis J, Le Bras F, Fataccioli V, Martin-Garcia N, Godeau B, Haïoun C, Gaulard P, Mahévas M
Eur J Haematol 2019 Jul;103(1):35-42. Epub 2019 May 30 doi: 10.1111/ejh.13239. PMID: 30985955

Recent clinical studies

Etiology

Donzel M, Trecourt A, Balme B, Harou O, Mauduit C, Bachy E, Guesquières H, Fontaine J, Ortonne N, Perier-Muzet M, Dalle S, Traverse-Glehen A
Sci Rep 2023 Apr 20;13(1):6500. doi: 10.1038/s41598-023-33031-3. PMID: 37081015Free PMC Article
El Hussein S, Medeiros LJ, Lyapichev KA, Fang H, Jelloul FZ, Fiskus W, Chen J, Wei P, Schlette E, Xu J, Li S, Kanagal-Shamanna R, Yang H, Tang Z, Thakral B, Loghavi S, Jain N, Thompson PA, Ferrajoli A, Wierda WG, Jabbour E, Patel KP, Dabaja BS, Bhalla KN, Khoury JD
Pathology 2023 Jun;55(4):514-524. Epub 2023 Feb 25 doi: 10.1016/j.pathol.2022.12.354. PMID: 36933995
Kameda K, Kako S, Kim SW, Usui Y, Kato K, Fukuda T, Uchida N, Kobayashi H, Wakayama T, Sakaida E, Yano S, Imada K, Nara M, Ikeda T, Fuchida SI, Ishikawa J, Sugahara H, Kanda J, Kimura T, Ichinohe T, Atsuta Y, Kondo E
Leukemia 2022 May;36(5):1361-1370. Epub 2022 Mar 28 doi: 10.1038/s41375-022-01545-w. PMID: 35347237
Advani RH, Skrypets T, Civallero M, Spinner MA, Manni M, Kim WS, Shustov AR, Horwitz SM, Hitz F, Cabrera ME, Dlouhy I, Vassallo J, Pileri SA, Inghirami G, Montoto S, Vitolo U, Radford J, Vose JM, Federico M
Blood 2021 Jul 22;138(3):213-220. doi: 10.1182/blood.2020010387. PMID: 34292324Free PMC Article
Greiner TC, Medeiros LJ, Jaffe ES
Cancer 1995 Jan 1;75(1 Suppl):370-80. doi: 10.1002/1097-0142(19950101)75:1+<370::aid-cncr2820751319>3.0.co;2-q. PMID: 8001008

Diagnosis

Chen HC, Wang RC, Tsai HP, Medeiros LJ, Chang KC
Arch Pathol Lab Med 2022 Sep 1;146(9):1084-1093. doi: 10.5858/arpa.2021-0087-OA. PMID: 34902854
Advani RH, Skrypets T, Civallero M, Spinner MA, Manni M, Kim WS, Shustov AR, Horwitz SM, Hitz F, Cabrera ME, Dlouhy I, Vassallo J, Pileri SA, Inghirami G, Montoto S, Vitolo U, Radford J, Vose JM, Federico M
Blood 2021 Jul 22;138(3):213-220. doi: 10.1182/blood.2020010387. PMID: 34292324Free PMC Article
Zeppa P, Cozzolino I
Monogr Clin Cytol 2018;23:34-51. Epub 2017 Nov 13 doi: 10.1159/000478880. PMID: 29131043
Magrath IT
Oncology (Williston Park) 1998 Oct;12(10 Suppl 8):40-8. PMID: 9830632
Harris GJ, Tio FO, Von Hoff DD
Cancer 1989 Feb 15;63(4):799-803. doi: 10.1002/1097-0142(19890215)63:4<799::aid-cncr2820630432>3.0.co;2-5. PMID: 2644013

Therapy

Advani RH, Skrypets T, Civallero M, Spinner MA, Manni M, Kim WS, Shustov AR, Horwitz SM, Hitz F, Cabrera ME, Dlouhy I, Vassallo J, Pileri SA, Inghirami G, Montoto S, Vitolo U, Radford J, Vose JM, Federico M
Blood 2021 Jul 22;138(3):213-220. doi: 10.1182/blood.2020010387. PMID: 34292324Free PMC Article
Saba NS, Dang D, Saba J, Cao C, Janbain M, Maalouf B, Safah H
Onkologie 2013;36(5):287-91. Epub 2013 Apr 5 doi: 10.1159/000350325. PMID: 23689224
Magrath IT
Oncology (Williston Park) 1998 Oct;12(10 Suppl 8):40-8. PMID: 9830632
Nakano A, Hatta K, Kobashi Y, Goto M, Imanaka T
Intern Med 1996 Nov;35(11):894-7. doi: 10.2169/internalmedicine.35.894. PMID: 8968805
Shimoyama M, Oyama A, Tajima K, Tobinai K, Minato K, Takenaka T, Konda C, Takeyama K, Kohno A, Narabayashi M
Leuk Lymphoma 1993 Jul;10(4-5):335-42. doi: 10.3109/10428199309148557. PMID: 8220132

Prognosis

El Hussein S, Medeiros LJ, Lyapichev KA, Fang H, Jelloul FZ, Fiskus W, Chen J, Wei P, Schlette E, Xu J, Li S, Kanagal-Shamanna R, Yang H, Tang Z, Thakral B, Loghavi S, Jain N, Thompson PA, Ferrajoli A, Wierda WG, Jabbour E, Patel KP, Dabaja BS, Bhalla KN, Khoury JD
Pathology 2023 Jun;55(4):514-524. Epub 2023 Feb 25 doi: 10.1016/j.pathol.2022.12.354. PMID: 36933995
Mohammed Saleh MF, Kotb A, Abdallah GEM, Muhsen IN, El Fakih R, Aljurf M
Curr Oncol 2021 Dec 20;28(6):5480-5498. doi: 10.3390/curroncol28060456. PMID: 34940095Free PMC Article
Advani RH, Skrypets T, Civallero M, Spinner MA, Manni M, Kim WS, Shustov AR, Horwitz SM, Hitz F, Cabrera ME, Dlouhy I, Vassallo J, Pileri SA, Inghirami G, Montoto S, Vitolo U, Radford J, Vose JM, Federico M
Blood 2021 Jul 22;138(3):213-220. doi: 10.1182/blood.2020010387. PMID: 34292324Free PMC Article
Tari G, Lemonnier F, Morschhauser F
Curr Opin Oncol 2021 Sep 1;33(5):400-405. doi: 10.1097/CCO.0000000000000773. PMID: 34230442
Greiner TC, Medeiros LJ, Jaffe ES
Cancer 1995 Jan 1;75(1 Suppl):370-80. doi: 10.1002/1097-0142(19950101)75:1+<370::aid-cncr2820751319>3.0.co;2-q. PMID: 8001008

Clinical prediction guides

Donzel M, Trecourt A, Balme B, Harou O, Mauduit C, Bachy E, Guesquières H, Fontaine J, Ortonne N, Perier-Muzet M, Dalle S, Traverse-Glehen A
Sci Rep 2023 Apr 20;13(1):6500. doi: 10.1038/s41598-023-33031-3. PMID: 37081015Free PMC Article
Kameda K, Kako S, Kim SW, Usui Y, Kato K, Fukuda T, Uchida N, Kobayashi H, Wakayama T, Sakaida E, Yano S, Imada K, Nara M, Ikeda T, Fuchida SI, Ishikawa J, Sugahara H, Kanda J, Kimura T, Ichinohe T, Atsuta Y, Kondo E
Leukemia 2022 May;36(5):1361-1370. Epub 2022 Mar 28 doi: 10.1038/s41375-022-01545-w. PMID: 35347237
Advani RH, Skrypets T, Civallero M, Spinner MA, Manni M, Kim WS, Shustov AR, Horwitz SM, Hitz F, Cabrera ME, Dlouhy I, Vassallo J, Pileri SA, Inghirami G, Montoto S, Vitolo U, Radford J, Vose JM, Federico M
Blood 2021 Jul 22;138(3):213-220. doi: 10.1182/blood.2020010387. PMID: 34292324Free PMC Article
Tari G, Lemonnier F, Morschhauser F
Curr Opin Oncol 2021 Sep 1;33(5):400-405. doi: 10.1097/CCO.0000000000000773. PMID: 34230442
Greiner TC, Medeiros LJ, Jaffe ES
Cancer 1995 Jan 1;75(1 Suppl):370-80. doi: 10.1002/1097-0142(19950101)75:1+<370::aid-cncr2820751319>3.0.co;2-q. PMID: 8001008

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