U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Carcinoma of liver and intrahepatic biliary tract

MedGen UID:
78921
Concept ID:
C0279000
Neoplastic Process
Synonyms: Cancer of Liver; Cancer of Liver and Intrahepatic Biliary Tract; Cancer of the Liver; Cancer of the Liver and Intrahepatic Biliary Tract; Carcinoma of liver and IBT; carcinoma of liver and IBT; carcinoma of liver and intrahepatic biliary tract; hepatocellular carcinoma plus intrahepatic cholangiocarcinoma; Liver and Intrahepatic Bile Duct Cancer; Liver and Intrahepatic Bile Duct Carcinoma; liver and intrahepatic bile duct carcinoma; Liver and Intrahepatic Biliary Tract Cancer; liver and intrahepatic biliary tract cancer; Liver and Intrahepatic Biliary Tract Carcinoma; liver and intrahepatic biliary tract carcinoma; Liver Cancer; Liver Carcinoma; Primary Liver Carcinoma; primary liver carcinoma
 
Monarch Initiative: MONDO:0018531
Orphanet: ORPHA424936

Definition

A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma of liver and intrahepatic biliary tract

Professional guidelines

PubMed

European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Jul;79(1):181-208. Epub 2023 Apr 20 doi: 10.1016/j.jhep.2023.03.010. PMID: 37084797
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

Lapitz A, Azkargorta M, Milkiewicz P, Olaizola P, Zhuravleva E, Grimsrud MM, Schramm C, Arbelaiz A, O'Rourke CJ, La Casta A, Milkiewicz M, Pastor T, Vesterhus M, Jimenez-Agüero R, Dill MT, Lamarca A, Valle JW, Macias RIR, Izquierdo-Sanchez L, Pérez Castaño Y, Caballero-Camino FJ, Riaño I, Krawczyk M, Ibarra C, Bustamante J, Nova-Camacho LM, Falcon-Perez JM, Elortza F, Perugorria MJ, Andersen JB, Bujanda L, Karlsen TH, Folseraas T, Rodrigues PM, Banales JM
J Hepatol 2023 Jul;79(1):93-108. Epub 2023 Mar 1 doi: 10.1016/j.jhep.2023.02.027. PMID: 36868481Free PMC Article
Ma J, Li J, Jin C, Yang J, Zheng C, Chen K, Xie Y, Yang Y, Bo Z, Wang J, Su Q, Wang J, Chen G, Wang Y
Liver Int 2023 Jan;43(1):221-233. Epub 2022 Nov 8 doi: 10.1111/liv.15466. PMID: 36300678
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Sarcognato S, Sacchi D, Fassan M, Fabris L, Cadamuro M, Zanus G, Cataldo I, Capelli P, Baciorri F, Cacciatore M, Guido M
Pathologica 2021 Jun;113(3):158-169. doi: 10.32074/1591-951X-252. PMID: 34294934Free PMC Article
Sia D, Villanueva A, Friedman SL, Llovet JM
Gastroenterology 2017 Mar;152(4):745-761. Epub 2016 Dec 30 doi: 10.1053/j.gastro.2016.11.048. PMID: 28043904

Diagnosis

Benson AB, D'Angelica MI, Abrams T, Abbott DE, Ahmed A, Anaya DA, Anders R, Are C, Bachini M, Binder D, Borad M, Bowlus C, Brown D, Burgoyne A, Castellanos J, Chahal P, Cloyd J, Covey AM, Glazer ES, Hawkins WG, Iyer R, Jacob R, Jennings L, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Ronnekleiv-Kelly S, Sahai V, Singh G, Stein S, Turk A, Vauthey JN, Venook AP, Yopp A, McMillian N, Schonfeld R, Hochstetler C
J Natl Compr Canc Netw 2023 Jul;21(7):694-704. doi: 10.6004/jnccn.2023.0035. PMID: 37433432
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Jul;79(1):181-208. Epub 2023 Apr 20 doi: 10.1016/j.jhep.2023.03.010. PMID: 37084797
Lapitz A, Azkargorta M, Milkiewicz P, Olaizola P, Zhuravleva E, Grimsrud MM, Schramm C, Arbelaiz A, O'Rourke CJ, La Casta A, Milkiewicz M, Pastor T, Vesterhus M, Jimenez-Agüero R, Dill MT, Lamarca A, Valle JW, Macias RIR, Izquierdo-Sanchez L, Pérez Castaño Y, Caballero-Camino FJ, Riaño I, Krawczyk M, Ibarra C, Bustamante J, Nova-Camacho LM, Falcon-Perez JM, Elortza F, Perugorria MJ, Andersen JB, Bujanda L, Karlsen TH, Folseraas T, Rodrigues PM, Banales JM
J Hepatol 2023 Jul;79(1):93-108. Epub 2023 Mar 1 doi: 10.1016/j.jhep.2023.02.027. PMID: 36868481Free PMC Article
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Sarcognato S, Sacchi D, Fassan M, Fabris L, Cadamuro M, Zanus G, Cataldo I, Capelli P, Baciorri F, Cacciatore M, Guido M
Pathologica 2021 Jun;113(3):158-169. doi: 10.32074/1591-951X-252. PMID: 34294934Free PMC Article

Therapy

Pinter M, Scheiner B, Pinato DJ
Lancet Gastroenterol Hepatol 2023 Aug;8(8):760-770. Epub 2023 Jun 14 doi: 10.1016/S2468-1253(23)00147-4. PMID: 37327807
Ma J, Li J, Jin C, Yang J, Zheng C, Chen K, Xie Y, Yang Y, Bo Z, Wang J, Su Q, Wang J, Chen G, Wang Y
Liver Int 2023 Jan;43(1):221-233. Epub 2022 Nov 8 doi: 10.1111/liv.15466. PMID: 36300678
Vogel A, Segatto O, Stenzinger A, Saborowski A
Annu Rev Med 2023 Jan 27;74:293-306. Epub 2022 Sep 28 doi: 10.1146/annurev-med-042921-024707. PMID: 36170665
Weber M, Lam M, Chiesa C, Konijnenberg M, Cremonesi M, Flamen P, Gnesin S, Bodei L, Kracmerova T, Luster M, Garin E, Herrmann K
Eur J Nucl Med Mol Imaging 2022 Apr;49(5):1682-1699. Epub 2022 Feb 11 doi: 10.1007/s00259-021-05600-z. PMID: 35146577Free PMC Article
Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, Kleiner DE, Hewitt SM, Ylaya K, Wood BJ, Greten TF, Wang XW
Cancer Cell 2019 Oct 14;36(4):418-430.e6. Epub 2019 Oct 3 doi: 10.1016/j.ccell.2019.08.007. PMID: 31588021Free PMC Article

Prognosis

Cheng K, Cai N, Zhu J, Yang X, Liang H, Zhang W
Cancer Commun (Lond) 2022 Nov;42(11):1112-1140. Epub 2022 Sep 7 doi: 10.1002/cac2.12345. PMID: 36069342Free PMC Article
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, Kleiner DE, Hewitt SM, Ylaya K, Wood BJ, Greten TF, Wang XW
Cancer Cell 2019 Oct 14;36(4):418-430.e6. Epub 2019 Oct 3 doi: 10.1016/j.ccell.2019.08.007. PMID: 31588021Free PMC Article
Sia D, Villanueva A, Friedman SL, Llovet JM
Gastroenterology 2017 Mar;152(4):745-761. Epub 2016 Dec 30 doi: 10.1053/j.gastro.2016.11.048. PMID: 28043904
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Clinical prediction guides

Calderaro J, Ghaffari Laleh N, Zeng Q, Maille P, Favre L, Pujals A, Klein C, Bazille C, Heij LR, Uguen A, Luedde T, Di Tommaso L, Beaufrère A, Chatain A, Gastineau D, Nguyen CT, Nguyen-Canh H, Thi KN, Gnemmi V, Graham RP, Charlotte F, Wendum D, Vij M, Allende DS, Aucejo F, Diaz A, Rivière B, Herrero A, Evert K, Calvisi DF, Augustin J, Leow WQ, Leung HHW, Boleslawski E, Rela M, François A, Cha AW, Forner A, Reig M, Allaire M, Scatton O, Chatelain D, Boulagnon-Rombi C, Sturm N, Menahem B, Frouin E, Tougeron D, Tournigand C, Kempf E, Kim H, Ningarhari M, Michalak-Provost S, Gopal P, Brustia R, Vibert E, Schulze K, Rüther DF, Weidemann SA, Rhaiem R, Pawlotsky JM, Zhang X, Luciani A, Mulé S, Laurent A, Amaddeo G, Regnault H, De Martin E, Sempoux C, Navale P, Westerhoff M, Lo RC, Bednarsch J, Gouw A, Guettier C, Lequoy M, Harada K, Sripongpun P, Wetwittayaklang P, Loménie N, Tantipisit J, Kaewdech A, Shen J, Paradis V, Caruso S, Kather JN
Nat Commun 2023 Dec 14;14(1):8290. doi: 10.1038/s41467-023-43749-3. PMID: 38092727Free PMC Article
Yang X, Wang J, Wang H
Eur J Clin Invest 2023 Aug;53(8):e14002. Epub 2023 Apr 17 doi: 10.1111/eci.14002. PMID: 37029746
Lapitz A, Azkargorta M, Milkiewicz P, Olaizola P, Zhuravleva E, Grimsrud MM, Schramm C, Arbelaiz A, O'Rourke CJ, La Casta A, Milkiewicz M, Pastor T, Vesterhus M, Jimenez-Agüero R, Dill MT, Lamarca A, Valle JW, Macias RIR, Izquierdo-Sanchez L, Pérez Castaño Y, Caballero-Camino FJ, Riaño I, Krawczyk M, Ibarra C, Bustamante J, Nova-Camacho LM, Falcon-Perez JM, Elortza F, Perugorria MJ, Andersen JB, Bujanda L, Karlsen TH, Folseraas T, Rodrigues PM, Banales JM
J Hepatol 2023 Jul;79(1):93-108. Epub 2023 Mar 1 doi: 10.1016/j.jhep.2023.02.027. PMID: 36868481Free PMC Article
Ma J, Li J, Jin C, Yang J, Zheng C, Chen K, Xie Y, Yang Y, Bo Z, Wang J, Su Q, Wang J, Chen G, Wang Y
Liver Int 2023 Jan;43(1):221-233. Epub 2022 Nov 8 doi: 10.1111/liv.15466. PMID: 36300678
Weber M, Lam M, Chiesa C, Konijnenberg M, Cremonesi M, Flamen P, Gnesin S, Bodei L, Kracmerova T, Luster M, Garin E, Herrmann K
Eur J Nucl Med Mol Imaging 2022 Apr;49(5):1682-1699. Epub 2022 Feb 11 doi: 10.1007/s00259-021-05600-z. PMID: 35146577Free PMC Article

Recent systematic reviews

Fahrner R, Dennler SG, Inderbitzin D
World J Gastroenterol 2020 Aug 21;26(31):4718-4728. doi: 10.3748/wjg.v26.i31.4718. PMID: 32884228Free PMC Article
Gao YX, Yang TW, Yin JM, Yang PX, Kou BX, Chai MY, Liu XN, Chen DX
Int J Oncol 2020 Jul;57(1):54-66. Epub 2020 Apr 1 doi: 10.3892/ijo.2020.5035. PMID: 32236573
Miyazaki Y, Kokudo T, Amikura K, Kageyama Y, Takahashi A, Ohkohchi N, Sakamoto H
Jpn J Clin Oncol 2017 Mar 1;47(3):206-212. doi: 10.1093/jjco/hyw182. PMID: 27940488
Zhimin G, Noor H, Jian-Bo Z, Lin W, Jha RK
Med Sci Monit 2013 Aug 7;19:648-56. doi: 10.12659/MSM.889379. PMID: 23921971Free PMC Article
Lau SH, Lau WY
Hepatobiliary Pancreat Dis Int 2012 Feb;11(1):12-7. doi: 10.1016/s1499-3872(11)60119-7. PMID: 22251465

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...