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Gastric intestinal type adenocarcinoma

MedGen UID:
79017
•Concept ID:
C0279633
•
Neoplastic Process
Synonym: Gastric adenocarcinoma of the intestinal type
 
Monarch Initiative: MONDO:0005037

Definition

An adenocarcinoma of the stomach arising on a background of intestinal metaplasia. Microscopically, it is characterized by a glandular pattern and it closely resembles a colonic adenocarcinoma. Grossly, it tends to be nodular, polypoid or ulcerated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric intestinal type adenocarcinoma

Professional guidelines

PubMed

Inverse association of Helicobacter pylori cagPAI genotypes with risk of cardia and non-cardia gastric adenocarcinoma.
Bakhti SZ, Latifi-Navid S, Zahri S, Yazdanbod A
Cancer Med 2019 Aug;8(10):4928-4937. Epub 2019 Jul 5 doi: 10.1002/cam4.2390. PMID: 31273955Free PMC Article
Update on the Diagnosis and Management of Gastric Intestinal Metaplasia in the USA.
Trieu JA, Bilal M, Saraireh H, Wang AY
Dig Dis Sci 2019 May;64(5):1079-1088. doi: 10.1007/s10620-019-05526-5. PMID: 30771043
Are Helicobacter pylori highly cytotoxic genotypes and cardia gastric adenocarcinoma linked? Lessons from Iran.
Bakhti SZ, Latifi-Navid S, Zahri S, Bakhti FS, Hajavi N, Yazdanbod A
Cancer Biomark 2017 Dec 12;21(1):235-246. doi: 10.3233/CBM-170701. PMID: 29036792

Recent clinical studies

Etiology

a-Methylacyl coenzyme A racemase is highly expressed in the intestinal-type adenocarcinoma and high-grade dysplasia lesions of the stomach.
Huang W, Zhao J, Li L, Huang Y, Yang X, Wang J, Zhang T
Histol Histopathol 2008 Nov;23(11):1315-20. doi: 10.14670/HH-23.1315. PMID: 18785113
Pathological disorders of the gastric mucosa surrounding carcinomas and primary lymphomas.
Arista-Nasr J, Jiménez-Rosas F, Uribe-Uribe N, Herrera-Goepfert R, Lazos-Ochoa M
Am J Gastroenterol 2001 Jun;96(6):1746-50. doi: 10.1111/j.1572-0241.2001.03868.x. PMID: 11419824

Diagnosis

L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression.
Cheng J, Sha Z, Zhang R, Ge J, Chen P, Kuang X, Chang J, Ren K, Luo X, Chen S, Gou X
Bioengineered 2022 Mar;13(3):6650-6664. doi: 10.1080/21655979.2022.2045842. PMID: 35230214Free PMC Article

Therapy

A BAP31 intrabody induces gastric cancer cell death by inhibiting p27(kip1) proteasome degradation.
Chen J, Guo H, Jiang H, Namusamba M, Wang C, Lan T, Wang T, Wang B
Int J Cancer 2019 Apr 15;144(8):2051-2062. Epub 2019 Jan 17 doi: 10.1002/ijc.31930. PMID: 30338855

Prognosis

L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression.
Cheng J, Sha Z, Zhang R, Ge J, Chen P, Kuang X, Chang J, Ren K, Luo X, Chen S, Gou X
Bioengineered 2022 Mar;13(3):6650-6664. doi: 10.1080/21655979.2022.2045842. PMID: 35230214Free PMC Article
Mining topoisomerase isoforms in gastric cancer.
Hou G, Deng J, You X, Chen J, Jiang Y, Qian T, Bi Y, Song B, Xu Y, Yang X
Gene 2020 Sep 5;754:144859. Epub 2020 Jun 11 doi: 10.1016/j.gene.2020.144859. PMID: 32535049
Outcomes of endoscopic submucosal dissection for intestinal-type adenocarcinoma with anastomosing glands of the stomach.
Kim TS, Kim B, Min BH, Min YW, Lee H, Lee JH, Rhee PL, Kim JJ, Kushima R, Kim KM
J Gastroenterol Hepatol 2020 Jan;35(1):50-55. Epub 2019 Jul 29 doi: 10.1111/jgh.14756. PMID: 31242325
Tumor budding as a standardized parameter in gastrointestinal carcinomas: more than just the colon.
Berg KB, Schaeffer DF
Mod Pathol 2018 Jun;31(6):862-872. Epub 2018 Feb 6 doi: 10.1038/s41379-018-0028-4. PMID: 29403085
Distinct prognostic values of YAP1 in gastric cancer.
Yu L, Gao C, Feng B, Wang L, Tian X, Wang H, Ma D
Tumour Biol 2017 Apr;39(4):1010428317695926. doi: 10.1177/1010428317695926. PMID: 28381174

Clinical prediction guides

L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression.
Cheng J, Sha Z, Zhang R, Ge J, Chen P, Kuang X, Chang J, Ren K, Luo X, Chen S, Gou X
Bioengineered 2022 Mar;13(3):6650-6664. doi: 10.1080/21655979.2022.2045842. PMID: 35230214Free PMC Article
Outcomes of endoscopic submucosal dissection for intestinal-type adenocarcinoma with anastomosing glands of the stomach.
Kim TS, Kim B, Min BH, Min YW, Lee H, Lee JH, Rhee PL, Kim JJ, Kushima R, Kim KM
J Gastroenterol Hepatol 2020 Jan;35(1):50-55. Epub 2019 Jul 29 doi: 10.1111/jgh.14756. PMID: 31242325
Distinct prognostic values of YAP1 in gastric cancer.
Yu L, Gao C, Feng B, Wang L, Tian X, Wang H, Ma D
Tumour Biol 2017 Apr;39(4):1010428317695926. doi: 10.1177/1010428317695926. PMID: 28381174
Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer.
Shen JX, Liu J, Li GW, Huang YT, Wu HT
Oncotarget 2016 May 3;7(18):25340-9. doi: 10.18632/oncotarget.8294. PMID: 27015121Free PMC Article
Comparison of HER2 status between surgically resected specimens and matched biopsy specimens of gastric intestinal-type adenocarcinoma.
Yoshida H, Yamamoto N, Taniguchi H, Oda I, Katai H, Kushima R, Tsuda H
Virchows Arch 2014 Aug;465(2):145-54. Epub 2014 Jun 3 doi: 10.1007/s00428-014-1597-3. PMID: 24889042

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