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Cervical adenocarcinoma

MedGen UID:
79024
•Concept ID:
C0279672
•
Neoplastic Process
Synonym: Adenocarcinoma of cervix uteri
SNOMED CT: Adenocarcinoma of cervix (254887002); Adenocarcinoma cervix uteri (254887002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005153
Orphanet: ORPHA213772

Definition

An adenocarcinoma arising from the endocervical glandular epithelium. It is classified as either human papillomavirus-related or human papillomavirus-independent adenocarcinoma. Histologic variants include usual-type, mucinous, mesonephric, serous, clear cell, and endometrioid adenocarcinoma. [from NCI]

Professional guidelines

PubMed

Prevalence and genotype distribution of human papillomavirus in cervical adenocarcinoma (usual type and variants): A systematic review and meta-analysis.
Reynders C, Lerho T, Goebel EA, Crum CP, Vandenput S, Beaudart C, Herfs M
J Med Virol 2023 Oct;95(10):e29190. doi: 10.1002/jmv.29190. PMID: 37861377
Menopause hormone treatment after cancer.
Gompel A
Climacteric 2023 Jun;26(3):240-247. Epub 2023 Apr 3 doi: 10.1080/13697137.2023.2176216. PMID: 37011657
Diagnosis and Management of Adenocarcinoma in Situ: A Society of Gynecologic Oncology Evidence-Based Review and Recommendations.
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article

Recent clinical studies

Etiology

Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype.
Cohen CM, Wentzensen N, Castle PE, Schiffman M, Zuna R, Arend RC, Clarke MA
J Clin Oncol 2023 Feb 10;41(5):1059-1068. Epub 2022 Dec 1 doi: 10.1200/JCO.22.01424. PMID: 36455190Free PMC Article
Diagnosis and Management of Adenocarcinoma in Situ: A Society of Gynecologic Oncology Evidence-Based Review and Recommendations.
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Cervical cancer.
Lea JS, Lin KY
Obstet Gynecol Clin North Am 2012 Jun;39(2):233-53. Epub 2012 Apr 24 doi: 10.1016/j.ogc.2012.02.008. PMID: 22640713

Diagnosis

Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype.
Cohen CM, Wentzensen N, Castle PE, Schiffman M, Zuna R, Arend RC, Clarke MA
J Clin Oncol 2023 Feb 10;41(5):1059-1068. Epub 2022 Dec 1 doi: 10.1200/JCO.22.01424. PMID: 36455190Free PMC Article
HPV-Negative Adenocarcinomas of the Uterine Cervix: From Molecular Characterization to Clinical Implications.
Giannella L, Di Giuseppe J, Delli Carpini G, Grelloni C, Fichera M, Sartini G, Caimmi S, Natalini L, Ciavattini A
Int J Mol Sci 2022 Nov 30;23(23) doi: 10.3390/ijms232315022. PMID: 36499345Free PMC Article
Diagnosis and Management of Adenocarcinoma in Situ: A Society of Gynecologic Oncology Evidence-Based Review and Recommendations.
Teoh D, Musa F, Salani R, Huh W, Jimenez E
Obstet Gynecol 2020 Apr;135(4):869-878. doi: 10.1097/AOG.0000000000003761. PMID: 32168211Free PMC Article
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686

Therapy

Prevalence and genotype distribution of human papillomavirus in cervical adenocarcinoma (usual type and variants): A systematic review and meta-analysis.
Reynders C, Lerho T, Goebel EA, Crum CP, Vandenput S, Beaudart C, Herfs M
J Med Virol 2023 Oct;95(10):e29190. doi: 10.1002/jmv.29190. PMID: 37861377
Menopause hormone treatment after cancer.
Gompel A
Climacteric 2023 Jun;26(3):240-247. Epub 2023 Apr 3 doi: 10.1080/13697137.2023.2176216. PMID: 37011657
CALLA: Efficacy and safety of concurrent and adjuvant durvalumab with chemoradiotherapy versus chemoradiotherapy alone in women with locally advanced cervical cancer: a phase III, randomized, double-blind, multicenter study.
Mayadev J, Nunes AT, Li M, Marcovitz M, Lanasa MC, Monk BJ
Int J Gynecol Cancer 2020 Jul;30(7):1065-1070. Epub 2020 May 23 doi: 10.1136/ijgc-2019-001135. PMID: 32447296Free PMC Article
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Cervical cancer.
Lea JS, Lin KY
Obstet Gynecol Clin North Am 2012 Jun;39(2):233-53. Epub 2012 Apr 24 doi: 10.1016/j.ogc.2012.02.008. PMID: 22640713

Prognosis

Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype.
Cohen CM, Wentzensen N, Castle PE, Schiffman M, Zuna R, Arend RC, Clarke MA
J Clin Oncol 2023 Feb 10;41(5):1059-1068. Epub 2022 Dec 1 doi: 10.1200/JCO.22.01424. PMID: 36455190Free PMC Article
HPV-Negative Adenocarcinomas of the Uterine Cervix: From Molecular Characterization to Clinical Implications.
Giannella L, Di Giuseppe J, Delli Carpini G, Grelloni C, Fichera M, Sartini G, Caimmi S, Natalini L, Ciavattini A
Int J Mol Sci 2022 Nov 30;23(23) doi: 10.3390/ijms232315022. PMID: 36499345Free PMC Article
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
Cervical Glandular Neoplasia: Classification and Staging.
Turashvili G, Park KJ
Surg Pathol Clin 2019 Jun;12(2):281-313. doi: 10.1016/j.path.2019.01.002. PMID: 31097105
Cervical cancer.
Lea JS, Lin KY
Obstet Gynecol Clin North Am 2012 Jun;39(2):233-53. Epub 2012 Apr 24 doi: 10.1016/j.ogc.2012.02.008. PMID: 22640713

Clinical prediction guides

Characteristics of HPV integration in cervical adenocarcinoma and squamous carcinoma.
Bi Y, Hu J, Zeng L, Chen G, Cai H, Cao H, Ma Q, Wu X
J Cancer Res Clin Oncol 2023 Dec;149(20):17973-17986. Epub 2023 Nov 15 doi: 10.1007/s00432-023-05494-4. PMID: 37966613Free PMC Article
A novel human papillomavirus and host DNA methylation score and detection of cervical adenocarcinoma.
Gradissimo A, Clarke MA, Xue X, Castle PE, Raine-Bennett TR, Schiffman M, Wentzensen N, Strickler HD, Burk RD
J Natl Cancer Inst 2023 Dec 6;115(12):1535-1543. doi: 10.1093/jnci/djad134. PMID: 37467068Free PMC Article
The combined finding of HPV 16, 18, or 45 and cytologic Atypical Glandular Cells (AGC) indicates a greatly elevated risk of in situ and invasive cervical adenocarcinoma.
Schiffman M, Mirabello L, Egemen D, Befano B, Xiao Y, Wentzensen N, Raine-Bennett T, Nayar R, Cheung LC, Rositch A, Beaty T, Perkins RB, de Sanjose S, Lorey T, Castle PE, Burk RD
Gynecol Oncol 2023 Jul;174:253-261. Epub 2023 May 25 doi: 10.1016/j.ygyno.2023.05.011. PMID: 37243996
Development and validation of a deep learning survival model for cervical adenocarcinoma patients.
Li R, Qu W, Liu Q, Tan Y, Zhang W, Hao Y, Jiang N, Mao Z, Ye J, Jiao J, Gao Q, Cui B, Dong T
BMC Bioinformatics 2023 Apr 13;24(1):146. doi: 10.1186/s12859-023-05239-7. PMID: 37055729Free PMC Article
Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype.
Cohen CM, Wentzensen N, Castle PE, Schiffman M, Zuna R, Arend RC, Clarke MA
J Clin Oncol 2023 Feb 10;41(5):1059-1068. Epub 2022 Dec 1 doi: 10.1200/JCO.22.01424. PMID: 36455190Free PMC Article

Recent systematic reviews

Prevalence and genotype distribution of human papillomavirus in cervical adenocarcinoma (usual type and variants): A systematic review and meta-analysis.
Reynders C, Lerho T, Goebel EA, Crum CP, Vandenput S, Beaudart C, Herfs M
J Med Virol 2023 Oct;95(10):e29190. doi: 10.1002/jmv.29190. PMID: 37861377
Infection status and survival impact of high-risk human papillomavirus in cervical adenocarcinomas: A systematic review and meta-analysis.
Chen H, Xiong W, Dong X, Liu Y, Tan X
Gynecol Oncol 2022 Oct;167(1):129-136. Epub 2022 Aug 13 doi: 10.1016/j.ygyno.2022.08.007. PMID: 35973872
Villoglandular adenocarcinoma of the uterine cervix: a systematic review and meta-analysis.
Dietl AK, Beckmann MW, Aumann K
Arch Gynecol Obstet 2021 Aug;304(2):317-327. Epub 2021 May 25 doi: 10.1007/s00404-021-06077-9. PMID: 34036437Free PMC Article
Comparison of Cold-Knife Conization versus Loop Electrosurgical Excision for Cervical Adenocarcinoma In Situ (ACIS): A Systematic Review and Meta-Analysis.
Jiang Y, Chen C, Li L
PLoS One 2017;12(1):e0170587. Epub 2017 Jan 26 doi: 10.1371/journal.pone.0170587. PMID: 28125627Free PMC Article
Mutations of the TP53 gene in adenocarcinoma and squamous cell carcinoma of the cervix: a systematic review.
Tornesello ML, Buonaguro L, Buonaguro FM
Gynecol Oncol 2013 Mar;128(3):442-8. Epub 2012 Nov 17 doi: 10.1016/j.ygyno.2012.11.017. PMID: 23168175

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