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Salivary Gland Adenocarcinoma

MedGen UID:
79033
•Concept ID:
C0279746
•
Neoplastic Process
Synonyms: Adenocarcinoma of Salivary Gland; Adenocarcinoma of the Salivary Gland

Definition

An adenocarcinoma arising from the salivary gland. It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland oncocytic carcinoma, salivary gland mucinous adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, salivary gland cystadenocarcinoma, salivary gland basal cell adenocarcinoma, salivary gland acinic cell carcinoma, salivary duct carcinoma, and salivary gland adenocarcinoma not otherwise specified. [from NCI]

Professional guidelines

PubMed

Macrocystic (Mammary Analogue) Secretory Carcinoma: An Unusual Variant and a Pitfall in the Differential Diagnosis of Cystic Lesions in the Head and Neck.
Hernandez-Prera JC, Holmes BJ, Valentino A, Harshan M, Bacchi CE, Petersson F, Liu KK, Najfeld V, Wenig BM
Am J Surg Pathol 2019 Nov;43(11):1483-1492. doi: 10.1097/PAS.0000000000001309. PMID: 31464708

Recent clinical studies

Etiology

Distant metastases and synchronous malignancies on FDG-PET/CT in patients with head and neck cancer: a retrospective study.
Flygare L, Al-Ubaedi A, Öhman W, Mo SJ
Acta Radiol 2020 Sep;61(9):1196-1204. Epub 2020 Jan 5 doi: 10.1177/0284185119896344. PMID: 31902218Free PMC Article
Macrocystic (Mammary Analogue) Secretory Carcinoma: An Unusual Variant and a Pitfall in the Differential Diagnosis of Cystic Lesions in the Head and Neck.
Hernandez-Prera JC, Holmes BJ, Valentino A, Harshan M, Bacchi CE, Petersson F, Liu KK, Najfeld V, Wenig BM
Am J Surg Pathol 2019 Nov;43(11):1483-1492. doi: 10.1097/PAS.0000000000001309. PMID: 31464708
Microsecretory Adenocarcinoma: A Novel Salivary Gland Tumor Characterized by a Recurrent MEF2C-SS18 Fusion.
Bishop JA, Weinreb I, Swanson D, Westra WH, Qureshi HS, Sciubba J, MacMillan C, Rooper LM, Dickson BC
Am J Surg Pathol 2019 Aug;43(8):1023-1032. doi: 10.1097/PAS.0000000000001273. PMID: 31094920
Upper aerodigestive tract cancers.
Muir C, Weiland L
Cancer 1995 Jan 1;75(1 Suppl):147-53. doi: 10.1002/1097-0142(19950101)75:1+<147::aid-cncr2820751304>3.0.co;2-u. PMID: 8000993
Nonsalivary sinonasal adenocarcinoma.
Alessi DM, Trapp TK, Fu YS, Calcaterra TC
Arch Otolaryngol Head Neck Surg 1988 Sep;114(9):996-9. doi: 10.1001/archotol.1988.01860210062016. PMID: 3408582

Diagnosis

Evaluation of cervical lymph nodes using multispectral optoacoustic tomography: a proof-of-concept study.
Becker C, Hardarson J, Hoelzer A, Geisler A, Schulz T, Reichl C, Burton NC, Schuler T, Kohl P, Zgierski-Johnston C
Eur Arch Otorhinolaryngol 2023 Oct;280(10):4657-4664. Epub 2023 Jun 24 doi: 10.1007/s00405-023-08073-y. PMID: 37354339Free PMC Article
Misleading Morphologic and Phenotypic Features (Transdifferentiation) in Solitary Fibrous Tumor of the Head and Neck: Report of 3 Cases and Review of the Literature.
Baněčková M, Michal M, Hájkova V, Haller F, Mosaieby E, Salajka P, Arolt C, Nachtsheim L, Michal M, Agaimy A, Skálová A
Am J Surg Pathol 2022 Aug 1;46(8):1084-1094. Epub 2022 Feb 24 doi: 10.1097/PAS.0000000000001875. PMID: 35195577
SalvGlandDx - a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets.
Freiberger SN, Brada M, Fritz C, Höller S, Vogetseder A, Horcic M, Bihl M, Michal M, Lanzer M, Wartenberg M, Borner U, Bode PK, Broglie MA, Rordorf T, Morand GB, Rupp NJ
Neoplasia 2021 May;23(5):473-487. Epub 2021 Apr 18 doi: 10.1016/j.neo.2021.03.008. PMID: 33878706Free PMC Article
Microsecretory Adenocarcinoma: A Novel Salivary Gland Tumor Characterized by a Recurrent MEF2C-SS18 Fusion.
Bishop JA, Weinreb I, Swanson D, Westra WH, Qureshi HS, Sciubba J, MacMillan C, Rooper LM, Dickson BC
Am J Surg Pathol 2019 Aug;43(8):1023-1032. doi: 10.1097/PAS.0000000000001273. PMID: 31094920
A salivary gland adenocarcinoma mimicking a microcystic adnexal carcinoma.
Basile JR, Lin YL
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Apr;109(4):e28-33. doi: 10.1016/j.tripleo.2009.12.030. PMID: 20303043

Therapy

Complete Response to Nivolumab of Resected Adenocarcinoma NOS With Parotid Gland Origin and Lung Metastasis.
Negishi Y, Okamoto I, Ueda Y, Sato H, Tanigawa M, Nagao T, Tsukahara K
In Vivo 2022 Nov-Dec;36(6):2840-2843. doi: 10.21873/invivo.13023. PMID: 36309400Free PMC Article
Marked responses to pemetrexed chemotherapy for metastatic adenocarcinoma of the parotid gland: Case series.
Viscuse PV, Price K
Head Neck 2019 Jun;41(6):E99-E103. Epub 2019 Feb 1 doi: 10.1002/hed.25658. PMID: 30706564
Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells.
Park JH, Moon YH, Kim DJ, Kim SA, Lee JB, Ahn SG, Yoon JH
Oncol Rep 2010 Jul;24(1):177-81. PMID: 20514459
Monoclonal antibody to a human salivary gland adenocarcinoma cell line: augmentation of antibody-dependent cell-mediated cytotoxicity activity by streptococcal preparation OK-432 in human salivary gland adenocarcinoma-bearing nude mice given the antibody.
Kaji R, Yoshida H, Yanagawa T, Sato M
J Biol Response Mod 1989 Oct;8(5):488-500. PMID: 2552025
Effects of 5-fluorouracil and the combination of 5-fluorouracil and human leukocyte interferon on human salivary gland adenocarcinoma cell line in culture.
Sato M, Yoshida H, Urata M, Yanagawa T, Yura Y, Nitta T, Kobayashi S, Hayashi Y
Int J Oral Surg 1984 Feb;13(1):35-44. doi: 10.1016/s0300-9785(84)80054-x. PMID: 6429067

Prognosis

Evaluation of cervical lymph nodes using multispectral optoacoustic tomography: a proof-of-concept study.
Becker C, Hardarson J, Hoelzer A, Geisler A, Schulz T, Reichl C, Burton NC, Schuler T, Kohl P, Zgierski-Johnston C
Eur Arch Otorhinolaryngol 2023 Oct;280(10):4657-4664. Epub 2023 Jun 24 doi: 10.1007/s00405-023-08073-y. PMID: 37354339Free PMC Article
Cytoplasmic expression of survivin is an independent predictor of poor prognosis in patients with salivary gland cancer.
Stenner M, Weinell A, Ponert T, Hardt A, Hahn M, Preuss SF, Guntinas-Lichius O, Klussmann JP
Histopathology 2010 Nov;57(5):699-706. doi: 10.1111/j.1365-2559.2010.03693.x. PMID: 21083600
Upper aerodigestive tract cancers.
Muir C, Weiland L
Cancer 1995 Jan 1;75(1 Suppl):147-53. doi: 10.1002/1097-0142(19950101)75:1+<147::aid-cncr2820751304>3.0.co;2-u. PMID: 8000993
Simultaneous multifocal polymorphous low-grade adenocarcinoma. Report of two cases.
Clayton JR, Pogrel MA, Regezi JA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Jul;80(1):71-7. doi: 10.1016/s1079-2104(95)80019-0. PMID: 7552866
Nonsalivary sinonasal adenocarcinoma.
Alessi DM, Trapp TK, Fu YS, Calcaterra TC
Arch Otolaryngol Head Neck Surg 1988 Sep;114(9):996-9. doi: 10.1001/archotol.1988.01860210062016. PMID: 3408582

Clinical prediction guides

Evaluation of cervical lymph nodes using multispectral optoacoustic tomography: a proof-of-concept study.
Becker C, Hardarson J, Hoelzer A, Geisler A, Schulz T, Reichl C, Burton NC, Schuler T, Kohl P, Zgierski-Johnston C
Eur Arch Otorhinolaryngol 2023 Oct;280(10):4657-4664. Epub 2023 Jun 24 doi: 10.1007/s00405-023-08073-y. PMID: 37354339Free PMC Article
5'-Nitro-indirubinoxime induces G1 cell cycle arrest and apoptosis in salivary gland adenocarcinoma cells through the inhibition of Notch-1 signaling.
Yoon JH, Kim SA, Kwon SM, Park JH, Park HS, Kim YC, Yoon JH, Ahn SG
Biochim Biophys Acta 2010 Mar;1800(3):352-8. Epub 2009 Nov 13 doi: 10.1016/j.bbagen.2009.11.007. PMID: 19914349
Biological role of estrogen receptor beta in salivary gland adenocarcinoma cells.
Ohshiro K, Rayala SK, Williams MD, Kumar R, El-Naggar AK
Clin Cancer Res 2006 Oct 15;12(20 Pt 1):5994-9. doi: 10.1158/1078-0432.CCR-06-1251. PMID: 17062671
Nonsalivary sinonasal adenocarcinoma.
Alessi DM, Trapp TK, Fu YS, Calcaterra TC
Arch Otolaryngol Head Neck Surg 1988 Sep;114(9):996-9. doi: 10.1001/archotol.1988.01860210062016. PMID: 3408582
Intermediate-sized filaments and specific markers in a human salivary gland adenocarcinoma cell line and its nude mouse tumors.
Sato M, Hayashi Y, Yanagawa T, Yoshida H, Yura Y, Azuma M, Ueno A
Cancer Res 1985 Aug;45(8):3878-90. PMID: 2410104

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