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Recurrent Childhood Hodgkin Lymphoma

MedGen UID:
79050
•Concept ID:
C0279918
•
Neoplastic Process
Synonyms: Recurrent Childhood Hodgkin's Disease; Recurrent Childhood Hodgkin's Lymphoma; Recurrent Pediatric Hodgkin's Disease; Recurrent Pediatric Hodgkin's Lymphoma; Relapsed Childhood Hodgkin's Disease; Relapsed Childhood Hodgkin's Lymphoma; Relapsed Pediatric Hodgkin's Disease; Relapsed Pediatric Hodgkin's Lymphoma

Definition

The reemergence of Hodgkin lymphoma after a period of remission during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Hodgkin Lymphoma

Professional guidelines

PubMed

Pharmacotherapeutic Management of Pediatric Lymphoma.
Mauz-Körholz C, Ströter N, Baumann J, Botzen A, Körholz K, Körholz D
Paediatr Drugs 2018 Feb;20(1):43-57. doi: 10.1007/s40272-017-0265-x. PMID: 29127674
Treatment of pediatric lymphoma in Japan: Current status and plans for the future.
Kobayashi R, Sunami S, Mitsui T, Nakazawa A, Koga Y, Mori T, Tanaka F, Ueyama J, Osumi T, Fukano R, Ohki K, Sekimizu M, Mori T; Lymphoma Committee; Japanese Pediatric Leukemia/Lymphoma Study Group
Pediatr Int 2015 Aug;57(4):523-34. doi: 10.1111/ped.12725. PMID: 26096060
Diagnosis and treatment of childhood non-hodgkin lymphoma.
Reiter A
Hematology Am Soc Hematol Educ Program 2007:285-96. doi: 10.1182/asheducation-2007.1.285. PMID: 18024642

Recent clinical studies

Etiology

Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Hodgkin lymphoma in children and adolescents: improving the therapeutic index.
Kelly KM
Hematology Am Soc Hematol Educ Program 2015;2015:514-21. doi: 10.1182/asheducation-2015.1.514. PMID: 26637767
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383
Diagnosis and treatment of childhood non-hodgkin lymphoma.
Reiter A
Hematology Am Soc Hematol Educ Program 2007:285-96. doi: 10.1182/asheducation-2007.1.285. PMID: 18024642
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

Diagnosis

Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.
Miles RR, Shah RK, Frazer JK
Br J Haematol 2016 May;173(4):582-96. Epub 2016 Mar 11 doi: 10.1111/bjh.14011. PMID: 26969846Free PMC Article
Diagnosis and treatment of childhood non-hodgkin lymphoma.
Reiter A
Hematology Am Soc Hematol Educ Program 2007:285-96. doi: 10.1182/asheducation-2007.1.285. PMID: 18024642
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164
Childhood non-Hodgkin's lymphoma involving the testis: clinical features and treatment outcome.
Kellie SJ, Pui CH, Murphy SB
J Clin Oncol 1989 Aug;7(8):1066-70. doi: 10.1200/JCO.1989.7.8.1066. PMID: 2666589

Therapy

Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma (study T2008-002 NECTAR).
Whitlock JA, Malvar J, Dalla-Pozza L, Goldberg JM, Silverman LB, Ziegler DS, Attarbaschi A, Brown PA, Gardner RA, Gaynon PS, Hutchinson R, Huynh VT, Jeha S, Marcus L, Messinger Y, Schultz KR, Cassar J, Locatelli F, Zwaan CM, Wood BL, Sposto R, Gore L
Pediatr Blood Cancer 2022 Nov;69(11):e29901. Epub 2022 Aug 21 doi: 10.1002/pbc.29901. PMID: 35989458
Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial.
Shah NN, Johnson BD, Schneider D, Zhu F, Szabo A, Keever-Taylor CA, Krueger W, Worden AA, Kadan MJ, Yim S, Cunningham A, Hamadani M, Fenske TS, Dropulić B, Orentas R, Hari P
Nat Med 2020 Oct;26(10):1569-1575. Epub 2020 Oct 5 doi: 10.1038/s41591-020-1081-3. PMID: 33020647
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Pharmacotherapeutic Management of Pediatric Lymphoma.
Mauz-Körholz C, Ströter N, Baumann J, Botzen A, Körholz K, Körholz D
Paediatr Drugs 2018 Feb;20(1):43-57. doi: 10.1007/s40272-017-0265-x. PMID: 29127674
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

Prognosis

Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma (study T2008-002 NECTAR).
Whitlock JA, Malvar J, Dalla-Pozza L, Goldberg JM, Silverman LB, Ziegler DS, Attarbaschi A, Brown PA, Gardner RA, Gaynon PS, Hutchinson R, Huynh VT, Jeha S, Marcus L, Messinger Y, Schultz KR, Cassar J, Locatelli F, Zwaan CM, Wood BL, Sposto R, Gore L
Pediatr Blood Cancer 2022 Nov;69(11):e29901. Epub 2022 Aug 21 doi: 10.1002/pbc.29901. PMID: 35989458
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.
Miles RR, Shah RK, Frazer JK
Br J Haematol 2016 May;173(4):582-96. Epub 2016 Mar 11 doi: 10.1111/bjh.14011. PMID: 26969846Free PMC Article
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383
Diagnosis and treatment of childhood non-hodgkin lymphoma.
Reiter A
Hematology Am Soc Hematol Educ Program 2007:285-96. doi: 10.1182/asheducation-2007.1.285. PMID: 18024642

Clinical prediction guides

Outcome and prognostic factors in childhood B non-Hodgkin lymphoma from India: Report by the Indian Pediatric Oncology Group (InPOG-NHL-16-01 study).
Rahiman EA, Bakhshi S, Deepam Pushpam, Ramamoorthy J, Das A, Ghara N, Kalra M, Kapoor G, Meena JP, Siddaigarhi S, Thulkar S, Sharma MC, Srinivasan R, Trehan A
Pediatr Hematol Oncol 2022 Aug;39(5):391-405. Epub 2022 Jan 3 doi: 10.1080/08880018.2021.2002485. PMID: 34978257
Relapse localization in Danish pediatric patients with Hodgkin lymphoma.
Lundgaard AY, Hjalgrim LL, Dejanovic D, Berthelsen AK, Schomerus E, Wendtland P, Specht L, Maraldo MV
Acta Oncol 2021 May;60(5):658-666. Epub 2021 Mar 12 doi: 10.1080/0284186X.2021.1881817. PMID: 33710948
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.
Miles RR, Shah RK, Frazer JK
Br J Haematol 2016 May;173(4):582-96. Epub 2016 Mar 11 doi: 10.1111/bjh.14011. PMID: 26969846Free PMC Article
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

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