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Recurrent Childhood Hodgkin Lymphoma

MedGen UID:: 79050
•Concept ID:: C0279918
•: Neoplastic Process

Synonyms:

Recurrent Childhood Hodgkin's Lymphoma; Recurrent Pediatric Hodgkin's Lymphoma; Relapsed Childhood Hodgkin's Lymphoma; Relapsed Pediatric Hodgkin's Lymphoma

Definition

The reemergence of Hodgkin lymphoma after a period of remission during childhood. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRecurrent Childhood Hodgkin Lymphoma

Neoplasm by Special Category
- Neoplasm by Obsolete Classification
  - Hematopoietic and Lymphoid Neoplasm (Antiquated)
    - Hodgkin Lymphoma (Antiquated)
      - Classic Hodgkin lymphoma
        Childhood Hodgkin Lymphoma
        Recurrent Childhood Hodgkin Lymphoma

Professional guidelines

PubMed

Pharmacotherapeutic Management of Pediatric Lymphoma.

Mauz-Körholz C, Ströter N, Baumann J, Botzen A, Körholz K, Körholz D
Paediatr Drugs 2018 Feb;20(1):43-57. doi: 10.1007/s40272-017-0265-x. PMID: 29127674

Treatment of pediatric lymphoma in Japan: Current status and plans for the future.

Kobayashi R, Sunami S, Mitsui T, Nakazawa A, Koga Y, Mori T, Tanaka F, Ueyama J, Osumi T, Fukano R, Ohki K, Sekimizu M, Mori T; Lymphoma Committee; Japanese Pediatric Leukemia/Lymphoma Study Group
Pediatr Int 2015 Aug;57(4):523-34. doi: 10.1111/ped.12725. PMID: 26096060

Management of pediatric non-Hodgkin's lymphoma.

Blay JY, Louis D, Bouffet E, Thiesse P, Biron P, Favrot MC, Brunat-Mentigny M, Philip T
Blood Rev 1991 Jun;5(2):90-7. doi: 10.1016/0268-960x(91)90040-j. PMID: 1912759

See all (27)

Recent clinical studies

Etiology

Hydroa vacciniforme-like lymphoproliferative disorder in Korea.

Han B, Hur K, Ohn J, Kim TM, Jeon YK, Kim YC, Mun JH
Sci Rep 2020 Nov 9;10(1):19294. doi: 10.1038/s41598-020-76345-2. PMID: 33168864 Free PMC Article

Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.

Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573 Free PMC Article

Hodgkin lymphoma in children and adolescents: improving the therapeutic index.

Kelly KM
Hematology Am Soc Hematol Educ Program 2015;2015:514-21. doi: 10.1182/asheducation-2015.1.514. PMID: 26637767

The epidemiology of osteosarcoma.

Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383

Chlorambucil-induced seizures.

Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

See all (137)

Diagnosis

Hydroa vacciniforme-like lymphoproliferative disorder in Korea.

Han B, Hur K, Ohn J, Kim TM, Jeon YK, Kim YC, Mun JH
Sci Rep 2020 Nov 9;10(1):19294. doi: 10.1038/s41598-020-76345-2. PMID: 33168864 Free PMC Article

Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.

Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797

Rituximab in steroid-sensitive nephrotic syndrome: lessons from clinical trials.

Iijima K, Sako M, Kamei K, Nozu K
Pediatr Nephrol 2018 Sep;33(9):1449-1455. Epub 2017 Jul 17 doi: 10.1007/s00467-017-3746-9. PMID: 28717938 Free PMC Article

Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.

Miles RR, Shah RK, Frazer JK
Br J Haematol 2016 May;173(4):582-96. Epub 2016 Mar 11 doi: 10.1111/bjh.14011. PMID: 26969846 Free PMC Article

Chlorambucil-induced seizures.

Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

See all (119)

Therapy

Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma (study T2008-002 NECTAR).

Whitlock JA, Malvar J, Dalla-Pozza L, Goldberg JM, Silverman LB, Ziegler DS, Attarbaschi A, Brown PA, Gardner RA, Gaynon PS, Hutchinson R, Huynh VT, Jeha S, Marcus L, Messinger Y, Schultz KR, Cassar J, Locatelli F, Zwaan CM, Wood BL, Sposto R, Gore L
Pediatr Blood Cancer 2022 Nov;69(11):e29901. Epub 2022 Aug 21 doi: 10.1002/pbc.29901. PMID: 35989458

Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial.

Shah NN, Johnson BD, Schneider D, Zhu F, Szabo A, Keever-Taylor CA, Krueger W, Worden AA, Kadan MJ, Yim S, Cunningham A, Hamadani M, Fenske TS, Dropulić B, Orentas R, Hari P
Nat Med 2020 Oct;26(10):1569-1575. Epub 2020 Oct 5 doi: 10.1038/s41591-020-1081-3. PMID: 33020647

Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.

Pharmacotherapeutic Management of Pediatric Lymphoma.

Mauz-Körholz C, Ströter N, Baumann J, Botzen A, Körholz K, Körholz D
Paediatr Drugs 2018 Feb;20(1):43-57. doi: 10.1007/s40272-017-0265-x. PMID: 29127674

Chlorambucil-induced seizures.

Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

See all (125)

Prognosis

Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma (study T2008-002 NECTAR).

Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.

Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797

Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.

Miles RR, Shah RK, Frazer JK
Br J Haematol 2016 May;173(4):582-96. Epub 2016 Mar 11 doi: 10.1111/bjh.14011. PMID: 26969846 Free PMC Article

Hodgkin lymphoma in children and adolescents: improving the therapeutic index.

Kelly KM
Hematology Am Soc Hematol Educ Program 2015;2015:514-21. doi: 10.1182/asheducation-2015.1.514. PMID: 26637767

The epidemiology of osteosarcoma.

Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383

See all (113)

Clinical prediction guides

Outcome and prognostic factors in childhood B non-Hodgkin lymphoma from India: Report by the Indian Pediatric Oncology Group (InPOG-NHL-16-01 study).

Rahiman EA, Bakhshi S, Deepam Pushpam, Ramamoorthy J, Das A, Ghara N, Kalra M, Kapoor G, Meena JP, Siddaigarhi S, Thulkar S, Sharma MC, Srinivasan R, Trehan A
Pediatr Hematol Oncol 2022 Aug;39(5):391-405. Epub 2022 Jan 3 doi: 10.1080/08880018.2021.2002485. PMID: 34978257

Relapse localization in Danish pediatric patients with Hodgkin lymphoma.

Lundgaard AY, Hjalgrim LL, Dejanovic D, Berthelsen AK, Schomerus E, Wendtland P, Specht L, Maraldo MV
Acta Oncol 2021 May;60(5):658-666. Epub 2021 Mar 12 doi: 10.1080/0284186X.2021.1881817. PMID: 33710948

Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.

Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.

Miles RR, Shah RK, Frazer JK
Br J Haematol 2016 May;173(4):582-96. Epub 2016 Mar 11 doi: 10.1111/bjh.14011. PMID: 26969846 Free PMC Article

Chlorambucil-induced seizures.

Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

See all (48)