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Squamous cell carcinoma of the vulva

MedGen UID:
79201
Concept ID:
C0280856
Neoplastic Process
Synonyms: CA - Squamous cell carcinoma of vulva; Epidermoid Carcinoma of the Vulva; epidermoid carcinoma of the vulva; Epidermoid Carcinoma of Vulva; epidermoid carcinoma of vulva; Epidermoid Cell Carcinoma of the Vulva; epidermoid cell carcinoma of the vulva; Epidermoid Cell Carcinoma of Vulva; epidermoid cell carcinoma of vulva; Epithelioma of vulva; mammalian vulva squamous cell carcinoma; SCC - Squamous cell carcinoma of vulva; Squamous Cell Carcinoma of the Vulva; squamous cell carcinoma of the vulva; Squamous cell carcinoma of vulva; Squamous Cell Carcinoma of Vulva; squamous cell carcinoma of vulva; Vulva Epidermoid Carcinoma; vulva epidermoid carcinoma; Vulva Epidermoid Cell Carcinoma; vulva epidermoid cell carcinoma; Vulva Squamous Cell Carcinoma; vulva squamous cell carcinoma; Vulval squamous cell carcinoma; Vulvar Epidermoid Carcinoma; vulvar epidermoid carcinoma; Vulvar Epidermoid Cell Carcinoma; vulvar epidermoid cell carcinoma; vulvar squamous cell cancer; Vulvar Squamous Cell Carcinoma; vulvar squamous cell carcinoma; Vulvar squamous cell carcinoma
SNOMED CT: Epithelioma of vulva (254895003); SCC - Squamous cell carcinoma of vulva (254895003); CA - Squamous cell carcinoma of vulva (254895003); Squamous cell carcinoma of vulva (254895003)
 
HPO: HP:0030417
Monarch Initiative: MONDO:0024609
Orphanet: ORPHA494448

Definition

A cancer that originates in the squamous cells that line the surface of the vulva. [from HPO]

Professional guidelines

PubMed

Buchanan T, Mutch D
Expert Rev Anticancer Ther 2019 Jan;19(1):43-50. Epub 2018 Oct 26 doi: 10.1080/14737140.2019.1538797. PMID: 30336700
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Moore DH
Gynecol Oncol 2009 Jun;113(3):379-83. Epub 2009 Feb 20 doi: 10.1016/j.ygyno.2009.01.004. PMID: 19232700

Recent clinical studies

Etiology

Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Dellinger TH, Hakim AA, Lee SJ, Wakabayashi MT, Morgan RJ, Han ES
J Natl Compr Canc Netw 2017 Jan;15(1):121-128. doi: 10.6004/jnccn.2017.0009. PMID: 28040722
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Ansink AC, Heintz AP
Eur J Obstet Gynecol Reprod Biol 1993 Feb;48(2):111-5. doi: 10.1016/0028-2243(93)90250-g. PMID: 8387937

Diagnosis

Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Gadducci A, Aletti GD
Gynecol Oncol 2020 Jul;158(1):208-217. Epub 2020 May 25 doi: 10.1016/j.ygyno.2020.05.021. PMID: 32460996
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Dellinger TH, Hakim AA, Lee SJ, Wakabayashi MT, Morgan RJ, Han ES
J Natl Compr Canc Netw 2017 Jan;15(1):121-128. doi: 10.6004/jnccn.2017.0009. PMID: 28040722
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Therapy

Assi T, Kattan J, Othman A, Farhat F
Future Oncol 2021 Aug;17(24):3133-3135. Epub 2021 Jul 2 doi: 10.2217/fon-2021-0610. PMID: 34213372
Faber MT, Sand FL, Albieri V, Norrild B, Kjaer SK, Verdoodt F
Int J Cancer 2017 Sep 15;141(6):1161-1169. Epub 2017 Jun 21 doi: 10.1002/ijc.30821. PMID: 28577297
Deppe G, Mert I, Belotte J, Winer IS
Wien Klin Wochenschr 2013 Mar;125(5-6):119-28. Epub 2013 Mar 22 doi: 10.1007/s00508-013-0338-y. PMID: 23519539
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Moore DH
Gynecol Oncol 2009 Jun;113(3):379-83. Epub 2009 Feb 20 doi: 10.1016/j.ygyno.2009.01.004. PMID: 19232700

Prognosis

Gadducci A, Aletti GD
Gynecol Oncol 2020 Jul;158(1):208-217. Epub 2020 May 25 doi: 10.1016/j.ygyno.2020.05.021. PMID: 32460996
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Dellinger TH, Hakim AA, Lee SJ, Wakabayashi MT, Morgan RJ, Han ES
J Natl Compr Canc Netw 2017 Jan;15(1):121-128. doi: 10.6004/jnccn.2017.0009. PMID: 28040722
Moore DH
Gynecol Oncol 2009 Jun;113(3):379-83. Epub 2009 Feb 20 doi: 10.1016/j.ygyno.2009.01.004. PMID: 19232700
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Clinical prediction guides

Çelik ZE, Akar S, Fındık S, Aytekin E, Çelik Ç
J Obstet Gynaecol 2022 Aug;42(6):2325-2330. Epub 2022 May 2 doi: 10.1080/01443615.2022.2049722. PMID: 35499473
Faber MT, Sand FL, Albieri V, Norrild B, Kjaer SK, Verdoodt F
Int J Cancer 2017 Sep 15;141(6):1161-1169. Epub 2017 Jun 21 doi: 10.1002/ijc.30821. PMID: 28577297
Gadducci A, Tana R, Barsotti C, Guerrieri ME, Genazzani AR
Crit Rev Oncol Hematol 2012 Jul;83(1):71-83. Epub 2011 Oct 19 doi: 10.1016/j.critrevonc.2011.09.003. PMID: 22015047
Ansink A, van der Velden J
Cochrane Database Syst Rev 2000;2000(2):CD002036. doi: 10.1002/14651858.CD002036. PMID: 10796849Free PMC Article
Piura B, Masotina A, Murdoch J, Lopes A, Morgan P, Monaghan J
Gynecol Oncol 1993 Feb;48(2):189-95. doi: 10.1006/gyno.1993.1032. PMID: 8428690

Recent systematic reviews

Te Grootenhuis NC, Pouwer AW, de Bock GH, Hollema H, Bulten J, van der Zee AGJ, de Hullu JA, Oonk MHM
Gynecol Oncol 2018 Mar;148(3):622-631. Epub 2017 Nov 12 doi: 10.1016/j.ygyno.2017.11.006. PMID: 29137809
Faber MT, Sand FL, Albieri V, Norrild B, Kjaer SK, Verdoodt F
Int J Cancer 2017 Sep 15;141(6):1161-1169. Epub 2017 Jun 21 doi: 10.1002/ijc.30821. PMID: 28577297
Luchini C, Nottegar A, Solmi M, Sergi G, Manzato E, Capelli P, Scarpa A, Veronese N
Surg Oncol 2016 Mar;25(1):60-5. Epub 2015 Sep 14 doi: 10.1016/j.suronc.2015.09.005. PMID: 26394825
Hassanzade M, Attaran M, Treglia G, Yousefi Z, Sadeghi R
Gynecol Oncol 2013 Jul;130(1):237-45. Epub 2013 Apr 20 doi: 10.1016/j.ygyno.2013.04.023. PMID: 23612317
Ansink A, van der Velden J
Cochrane Database Syst Rev 2000;2000(2):CD002036. doi: 10.1002/14651858.CD002036. PMID: 10796849Free PMC Article

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