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Alpha granule disease

MedGen UID:
798010
•Concept ID:
CN207009
•
Disease or Syndrome
Synonym: alpha granule disease
 
Monarch Initiative: MONDO:0020117
Orphanet: ORPHA98455

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlpha granule disease
Follow this link to review classifications for Alpha granule disease in Orphanet.

Professional guidelines

PubMed

Laboratory testing for platelet factor 4 antibodies: differential utility for diagnosis/exclusion of heparin induced thrombocytopenia versus suspected vaccine induced thrombotic thrombocytopenia.
Favaloro EJ, Pasalic L, Henry B, Lippi G
Pathology 2022 Apr;54(3):254-261. Epub 2022 Feb 4 doi: 10.1016/j.pathol.2021.10.008. PMID: 35125202
Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders.
Bath PM, May J, Heptinstall S
Platelets 2018 Jul;29(5):425-430. Epub 2018 Apr 18 doi: 10.1080/09537104.2018.1445839. PMID: 29667460
Quebec platelet disorder: update on pathogenesis, diagnosis, and treatment.
Blavignac J, Bunimov N, Rivard GE, Hayward CP
Semin Thromb Hemost 2011 Sep;37(6):713-20. Epub 2011 Nov 18 doi: 10.1055/s-0031-1291382. PMID: 22102275

Recent clinical studies

Etiology

Circadian nuclear receptor Rev-erbα is expressed by platelets and potentiates platelet activation and thrombus formation.
Shi J, Tong R, Zhou M, Gao Y, Zhao Y, Chen Y, Liu W, Li G, Lu D, Meng G, Hu L, Yuan A, Lu X, Pu J
Eur Heart J 2022 Jun 21;43(24):2317-2334. doi: 10.1093/eurheartj/ehac109. PMID: 35267019Free PMC Article
Release of α-granule contents during platelet activation.
Smith CW
Platelets 2022 May 19;33(4):491-502. Epub 2021 Sep 25 doi: 10.1080/09537104.2021.1913576. PMID: 34569425
AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance.
Benito-Cuesta I, Ordóñez-Gutiérrez L, Wandosell F
Autophagy 2021 Mar;17(3):656-671. Epub 2020 Feb 20 doi: 10.1080/15548627.2020.1728095. PMID: 32075509Free PMC Article
Autophagy-dependent secretion: mechanism, factors secreted, and disease implications.
New J, Thomas SM
Autophagy 2019 Oct;15(10):1682-1693. Epub 2019 Apr 14 doi: 10.1080/15548627.2019.1596479. PMID: 30894055Free PMC Article
Platelet-cancer interactions.
Goubran HA, Stakiw J, Radosevic M, Burnouf T
Semin Thromb Hemost 2014 Apr;40(3):296-305. Epub 2014 Mar 3 doi: 10.1055/s-0034-1370767. PMID: 24590421

Diagnosis

α-granule biogenesis: from disease to discovery.
Chen CH, Lo RW, Urban D, Pluthero FG, Kahr WH
Platelets 2017 Mar;28(2):147-154. Epub 2017 Feb 22 doi: 10.1080/09537104.2017.1280599. PMID: 28277061
Chromogranin A as biomarker in diabetes.
Broedbaek K, Hilsted L
Biomark Med 2016 Nov;10(11):1181-1189. Epub 2016 Sep 9 doi: 10.2217/bmm-2016-0091. PMID: 27611656
Hepatobiliary pathology.
Lefkowitch JH
Curr Opin Gastroenterol 2006 May;22(3):198-208. doi: 10.1097/01.mog.0000218955.55688.af. PMID: 16550033
Autoantibodies in vasculitis.
Wiik A
Arthritis Res Ther 2003;5(3):147-52. Epub 2003 Apr 9 doi: 10.1186/ar758. PMID: 12723981Free PMC Article
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

Therapy

The immunology of PF4 polyanion interactions.
Ngo ATP, Bochenek V, Gollomp K
Curr Opin Hematol 2023 Nov 1;30(6):219-229. Epub 2023 Aug 28 doi: 10.1097/MOH.0000000000000782. PMID: 37603711
PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36.
Qi Z, Hu L, Zhang J, Yang W, Liu X, Jia D, Yao Z, Chang L, Pan G, Zhong H, Luo X, Yao K, Sun A, Qian J, Ding Z, Ge J
Circulation 2021 Jan 5;143(1):45-61. Epub 2020 Sep 29 doi: 10.1161/CIRCULATIONAHA.120.046290. PMID: 32988222
Regulation of PCSK9 by nutraceuticals.
Momtazi AA, Banach M, Pirro M, Katsiki N, Sahebkar A
Pharmacol Res 2017 Jun;120:157-169. Epub 2017 Mar 29 doi: 10.1016/j.phrs.2017.03.023. PMID: 28363723
Subcutaneous panniculitis-like T-cell lymphoma.
Tomasini D, Berti E
G Ital Dermatol Venereol 2013 Aug;148(4):395-411. PMID: 23900161
Drug-induced ocular disorders.
Li J, Tripathi RC, Tripathi BJ
Drug Saf 2008;31(2):127-41. doi: 10.2165/00002018-200831020-00003. PMID: 18217789

Prognosis

Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.
Zhang X, Chao P, Zhang L, Xu L, Cui X, Wang S, Wusiman M, Jiang H, Lu C
Front Immunol 2023;14:1030198. Epub 2023 Mar 29 doi: 10.3389/fimmu.2023.1030198. PMID: 37063851Free PMC Article
Platelets in the NETworks interweaving inflammation and thrombosis.
Wienkamp AK, Erpenbeck L, Rossaint J
Front Immunol 2022;13:953129. Epub 2022 Aug 1 doi: 10.3389/fimmu.2022.953129. PMID: 35979369Free PMC Article
Release of α-granule contents during platelet activation.
Smith CW
Platelets 2022 May 19;33(4):491-502. Epub 2021 Sep 25 doi: 10.1080/09537104.2021.1913576. PMID: 34569425
Subcutaneous panniculitis-like T-cell lymphoma.
Tomasini D, Berti E
G Ital Dermatol Venereol 2013 Aug;148(4):395-411. PMID: 23900161
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

Clinical prediction guides

Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.
Zhang X, Chao P, Zhang L, Xu L, Cui X, Wang S, Wusiman M, Jiang H, Lu C
Front Immunol 2023;14:1030198. Epub 2023 Mar 29 doi: 10.3389/fimmu.2023.1030198. PMID: 37063851Free PMC Article
Alpha-Synuclein and Its Role in Melanocytes.
Rachinger N, Mittag N, Böhme-Schäfer I, Xiang W, Kuphal S, Bosserhoff AK
Cells 2022 Jun 30;11(13) doi: 10.3390/cells11132087. PMID: 35805172Free PMC Article
Release of α-granule contents during platelet activation.
Smith CW
Platelets 2022 May 19;33(4):491-502. Epub 2021 Sep 25 doi: 10.1080/09537104.2021.1913576. PMID: 34569425
The early history of the eosinophil.
Kay AB
Clin Exp Allergy 2015 Mar;45(3):575-82. doi: 10.1111/cea.12480. PMID: 25544991
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

Recent systematic reviews

Adverse reactions of Niaoduqing granules: A systematic review and meta-analysis.
Fu B, Shang Z, Song S, Xu Y, Wei L, Li G, Yang H
Phytomedicine 2023 Jan;109:154535. Epub 2022 Nov 9 doi: 10.1016/j.phymed.2022.154535. PMID: 36610168
Effects of Uremic Clearance Granules in Uremic Pruritus: A Meta-Analysis.
Lu PH, Wang JY, Chuo HE, Lu PH
Toxins (Basel) 2021 Oct 4;13(10) doi: 10.3390/toxins13100702. PMID: 34678995Free PMC Article
Effect of resistant starch type 2 on inflammatory mediators: A systematic review and meta-analysis of randomized controlled trials.
Haghighatdoost F, Gholami A, Hariri M
Complement Ther Med 2021 Jan;56:102597. Epub 2020 Oct 24 doi: 10.1016/j.ctim.2020.102597. PMID: 33197672
What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence.
Nogueira BCF, Campos AK, Alves RS, Sarandy MM, Novaes RD, Esposito D, Gonçalves RV
Oxid Med Cell Longev 2020;2020:8862953. Epub 2020 Dec 7 doi: 10.1155/2020/8862953. PMID: 33488938Free PMC Article
Platelet rich plasma: a valid augmentation for cartilage scaffolds? A systematic review.
Perdisa F, Filardo G, Di Matteo B, Marcacci M, Kon E
Histol Histopathol 2014 Jul;29(7):805-14. Epub 2014 Jan 24 doi: 10.14670/HH-29.805. PMID: 24458849

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