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Multiple system atrophy, parkinsonian type

MedGen UID:
798017
•Concept ID:
CN207200
•
Disease or Syndrome
Synonyms: MSA, parkinsonian type; MSA-p; multiple system atrophy, parkinsonian type
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0020352
Orphanet: ORPHA98933

Definition

Multiple system atrophy, parkinsonian type (MSA-p) is a form of multiple system atrophy (MSA; see this term) with predominant parkinsonian features (bradykinesia, rigidity, irregular jerky postural tremor, and postural instability). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Multiple system atrophy, parkinsonian type in Orphanet.

Professional guidelines

PubMed

Neuroimaging in Parkinsonism: a study with magnetic resonance and spectroscopy as tools in the differential diagnosis.
Vasconcellos LF, Novis SA, Moreira DM, Rosso AL, Leite AC
Arq Neuropsiquiatr 2009 Mar;67(1):1-6. doi: 10.1590/s0004-282x2009000100002. PMID: 19330200

Recent clinical studies

Etiology

Functional connectome automatically differentiates multiple system atrophy (parkinsonian type) from idiopathic Parkinson's disease at early stages.
Chen B, Cui W, Wang S, Sun A, Yu H, Liu Y, He J, Fan G
Hum Brain Mapp 2023 Apr 15;44(6):2176-2190. Epub 2023 Jan 20 doi: 10.1002/hbm.26201. PMID: 36661217Free PMC Article
Postganglionic Sudomotor Assessment in Early Stage of Multiple System Atrophy and Parkinson Disease: A Morpho-functional Study.
Provitera V, Iodice V, Manganelli F, Mozzillo S, Caporaso G, Stancanelli A, Borreca I, Esposito M, Dubbioso R, Iodice R, Vitale F, Koay S, Vichayanrat E, Valerio F, Santoro L, Nolano M
Neurology 2022 Mar 22;98(12):e1282-e1291. Epub 2022 Jan 11 doi: 10.1212/WNL.0000000000013300. PMID: 35017309Free PMC Article
Diagnostic performance of T2* gradient echo, susceptibility-weighted imaging, and quantitative susceptibility mapping for patients with multiple system atrophy-parkinsonian type: a systematic review and meta-analysis.
Lim SJ, Suh CH, Shim WH, Kim SJ
Eur Radiol 2022 Jan;32(1):308-318. Epub 2021 Jul 16 doi: 10.1007/s00330-021-08174-4. PMID: 34272590
3-Hz postural tremor in multiple system atrophy cerebellar type (MSA-C)-a static posturography study.
Li X, Wang Y, Wang Z, Xu Y, Zheng W
Neurol Sci 2018 Jan;39(1):71-77. Epub 2017 Oct 12 doi: 10.1007/s10072-017-3130-3. PMID: 29027029
White matter differences between multiple system atrophy (parkinsonian type) and Parkinson's disease: A diffusion tensor image study.
Ji L, Wang Y, Zhu D, Liu W, Shi J
Neuroscience 2015 Oct 1;305:109-16. Epub 2015 Jul 26 doi: 10.1016/j.neuroscience.2015.07.060. PMID: 26215920

Diagnosis

Functional connectome automatically differentiates multiple system atrophy (parkinsonian type) from idiopathic Parkinson's disease at early stages.
Chen B, Cui W, Wang S, Sun A, Yu H, Liu Y, He J, Fan G
Hum Brain Mapp 2023 Apr 15;44(6):2176-2190. Epub 2023 Jan 20 doi: 10.1002/hbm.26201. PMID: 36661217Free PMC Article
Postganglionic Sudomotor Assessment in Early Stage of Multiple System Atrophy and Parkinson Disease: A Morpho-functional Study.
Provitera V, Iodice V, Manganelli F, Mozzillo S, Caporaso G, Stancanelli A, Borreca I, Esposito M, Dubbioso R, Iodice R, Vitale F, Koay S, Vichayanrat E, Valerio F, Santoro L, Nolano M
Neurology 2022 Mar 22;98(12):e1282-e1291. Epub 2022 Jan 11 doi: 10.1212/WNL.0000000000013300. PMID: 35017309Free PMC Article
Diagnostic performance of T2* gradient echo, susceptibility-weighted imaging, and quantitative susceptibility mapping for patients with multiple system atrophy-parkinsonian type: a systematic review and meta-analysis.
Lim SJ, Suh CH, Shim WH, Kim SJ
Eur Radiol 2022 Jan;32(1):308-318. Epub 2021 Jul 16 doi: 10.1007/s00330-021-08174-4. PMID: 34272590
3-Hz postural tremor in multiple system atrophy cerebellar type (MSA-C)-a static posturography study.
Li X, Wang Y, Wang Z, Xu Y, Zheng W
Neurol Sci 2018 Jan;39(1):71-77. Epub 2017 Oct 12 doi: 10.1007/s10072-017-3130-3. PMID: 29027029
White matter differences between multiple system atrophy (parkinsonian type) and Parkinson's disease: A diffusion tensor image study.
Ji L, Wang Y, Zhu D, Liu W, Shi J
Neuroscience 2015 Oct 1;305:109-16. Epub 2015 Jul 26 doi: 10.1016/j.neuroscience.2015.07.060. PMID: 26215920

Therapy

Functional connectome automatically differentiates multiple system atrophy (parkinsonian type) from idiopathic Parkinson's disease at early stages.
Chen B, Cui W, Wang S, Sun A, Yu H, Liu Y, He J, Fan G
Hum Brain Mapp 2023 Apr 15;44(6):2176-2190. Epub 2023 Jan 20 doi: 10.1002/hbm.26201. PMID: 36661217Free PMC Article
Stacked Model-Based Classification of Parkinson's Disease Patients Using Imaging Biomarker Data.
Hathaliya J, Modi H, Gupta R, Tanwar S, Alqahtani F, Elghatwary M, Neagu BC, Raboaca MS
Biosensors (Basel) 2022 Jul 29;12(8) doi: 10.3390/bios12080579. PMID: 36004975Free PMC Article
Diagnostic performance of T2* gradient echo, susceptibility-weighted imaging, and quantitative susceptibility mapping for patients with multiple system atrophy-parkinsonian type: a systematic review and meta-analysis.
Lim SJ, Suh CH, Shim WH, Kim SJ
Eur Radiol 2022 Jan;32(1):308-318. Epub 2021 Jul 16 doi: 10.1007/s00330-021-08174-4. PMID: 34272590
Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies.
Bartus RT, Kordower JH, Johnson EM Jr, Brown L, Kruegel BR, Chu Y, Baumann TL, Lang AE, Olanow CW, Herzog CD
Neurobiol Dis 2015 Jun;78:162-71. Epub 2015 Apr 2 doi: 10.1016/j.nbd.2015.03.023. PMID: 25841760
Non-ergot dopamine agonist rotigotine as a promising therapeutic tool in atypical parkinsonism syndromes: a 24 months pilot observational open-label study.
Moretti DV, Binetti G, Zanetti O, Frisoni GB
Neuropharmacology 2014 Oct;85:284-9. Epub 2014 Jun 7 doi: 10.1016/j.neuropharm.2014.05.028. PMID: 24915072

Prognosis

Additional Role of Midbrain F-18 FP-CIT Uptake on PET in Evaluation of Essential Tremor and Parkinsonism.
Lee H, Sung YH, Hwang KH
Curr Med Imaging 2023;19(9):1041-1051. doi: 10.2174/1573405619666230124142725. PMID: 36734891
Stacked Model-Based Classification of Parkinson's Disease Patients Using Imaging Biomarker Data.
Hathaliya J, Modi H, Gupta R, Tanwar S, Alqahtani F, Elghatwary M, Neagu BC, Raboaca MS
Biosensors (Basel) 2022 Jul 29;12(8) doi: 10.3390/bios12080579. PMID: 36004975Free PMC Article
Postganglionic Sudomotor Assessment in Early Stage of Multiple System Atrophy and Parkinson Disease: A Morpho-functional Study.
Provitera V, Iodice V, Manganelli F, Mozzillo S, Caporaso G, Stancanelli A, Borreca I, Esposito M, Dubbioso R, Iodice R, Vitale F, Koay S, Vichayanrat E, Valerio F, Santoro L, Nolano M
Neurology 2022 Mar 22;98(12):e1282-e1291. Epub 2022 Jan 11 doi: 10.1212/WNL.0000000000013300. PMID: 35017309Free PMC Article
Non-ergot dopamine agonist rotigotine as a promising therapeutic tool in atypical parkinsonism syndromes: a 24 months pilot observational open-label study.
Moretti DV, Binetti G, Zanetti O, Frisoni GB
Neuropharmacology 2014 Oct;85:284-9. Epub 2014 Jun 7 doi: 10.1016/j.neuropharm.2014.05.028. PMID: 24915072
Comparison of cerebral glucose metabolism between multiple system atrophy Parkinsonian type and Parkinson's disease.
Feng T, Wang Y, Ouyang Q, Duan Z, Li W, Lu L, Xiang W
Neurol Res 2008 May;30(4):377-82. doi: 10.1179/174313208X300396. PMID: 18544255

Clinical prediction guides

Stacked Model-Based Classification of Parkinson's Disease Patients Using Imaging Biomarker Data.
Hathaliya J, Modi H, Gupta R, Tanwar S, Alqahtani F, Elghatwary M, Neagu BC, Raboaca MS
Biosensors (Basel) 2022 Jul 29;12(8) doi: 10.3390/bios12080579. PMID: 36004975Free PMC Article
Thalamic and cerebellar hypoperfusion in single photon emission computed tomography may differentiate multiple system atrophy and progressive supranuclear palsy.
Alster P, Nieciecki M, Koziorowski DM, Cacko A, Charzyńska I, Królicki L, Friedman A
Medicine (Baltimore) 2019 Jul;98(30):e16603. doi: 10.1097/MD.0000000000016603. PMID: 31348305Free PMC Article
Classification of degenerative parkinsonism subtypes by support-vector-machine analysis and striatal (123)I-FP-CIT indices.
Nicastro N, Wegrzyk J, Preti MG, Fleury V, Van de Ville D, Garibotto V, Burkhard PR
J Neurol 2019 Jul;266(7):1771-1781. Epub 2019 Apr 29 doi: 10.1007/s00415-019-09330-z. PMID: 31037416Free PMC Article
3-Hz postural tremor in multiple system atrophy cerebellar type (MSA-C)-a static posturography study.
Li X, Wang Y, Wang Z, Xu Y, Zheng W
Neurol Sci 2018 Jan;39(1):71-77. Epub 2017 Oct 12 doi: 10.1007/s10072-017-3130-3. PMID: 29027029
Comparison of cerebral glucose metabolism between multiple system atrophy Parkinsonian type and Parkinson's disease.
Feng T, Wang Y, Ouyang Q, Duan Z, Li W, Lu L, Xiang W
Neurol Res 2008 May;30(4):377-82. doi: 10.1179/174313208X300396. PMID: 18544255

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