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Adult-onset myasthenia gravis

MedGen UID:
798729
•Concept ID:
CN204979
•
Finding
Synonyms: Adult-onset acquired myasthenia; adult-onset acquired myasthenia; Adult-onset autoimmune myasthenia gravis; adult-onset autoimmune myasthenia gravis; adult-onset myasthenia gravis
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Non-Mendelian inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018324
Orphanet: ORPHA391490

Definition

A rare autoimmune disorder of the neuromuscular junction characterized by fatigable muscle weakness with frequent ocular signs and/or generalized muscle weakness, and occasionally associated with thymoma. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult-onset myasthenia gravis
Follow this link to review classifications for Adult-onset myasthenia gravis in Orphanet.

Professional guidelines

PubMed

Italian recommendations for diagnosis and management of congenital myasthenic syndromes.
Maggi L, Bernasconi P, D'Amico A, Brugnoni R, Fiorillo C, Garibaldi M, Astrea G, Bruno C, Santorelli FM, Liguori R, Antonini G, Evoli A, Bertini E, Rodolico C, Mantegazza R
Neurol Sci 2019 Mar;40(3):457-468. Epub 2018 Dec 15 doi: 10.1007/s10072-018-3682-x. PMID: 30554356

Recent clinical studies

Etiology

Survival and mortality of adult-onset myasthenia gravis in the population of Belgrade, Serbia.
Basta I, PekmezoviĆ T, Peric S, NikoliĆ A, RakoČeviĆ-StojanoviĆ V, SteviĆ Z, LavrniĆ D
Muscle Nerve 2018 Nov;58(5):708-712. Epub 2018 Aug 25 doi: 10.1002/mus.26132. PMID: 29572981
Epidemiological study of adult-onset myasthenia gravis in the area of Belgrade (Serbia) in the period 1979-2008.
Lavrnic D, Basta I, Rakocevic-Stojanovic V, Stevic Z, Peric S, Nikolic A, Marjanovic I, Pekmezovic T
Neuroepidemiology 2013;40(3):190-4. Epub 2013 Jan 24 doi: 10.1159/000342777. PMID: 23363926
Myasthenia gravis and HLA antigens in American blacks and other races.
Christiansen FT, Pollack MS, Garlepp MJ, Dawkins RL
J Neuroimmunol 1984 Dec;7(2-3):121-9. doi: 10.1016/s0165-5728(84)80012-0. PMID: 6334696

Diagnosis

Comparison of anti-acetylcholine receptor profiles between Chinese cases of adult- and juvenile-onset myasthenia gravis using cell-based assays.
Yan C, Zhao R, Song J, Feng X, Xi J, Luo S, Zhong H, Zhou S, Li W, Zhao C
J Neuroimmunol 2020 Dec 15;349:577403. Epub 2020 Sep 22 doi: 10.1016/j.jneuroim.2020.577403. PMID: 32992216
Cell-Based Versus Enzyme-Linked Immunosorbent Assay for the Detection of Acetylcholine Receptor Antibodies in Chinese Juvenile Myasthenia Gravis.
Yan C, Li W, Song J, Feng X, Xi J, Lu J, Zhou S, Zhao C
Pediatr Neurol 2019 Sep;98:74-79. Epub 2019 Jan 30 doi: 10.1016/j.pediatrneurol.2019.01.016. PMID: 31307830
HLA typing using next-generation sequencing for Chinese juvenile- and adult-onset myasthenia gravis patients.
Feng X, Li W, Song J, Liu X, Gu Y, Yan C, Wu H, Xi J, Zhou S, Zhao C
J Clin Neurosci 2019 Jan;59:179-184. Epub 2018 Oct 24 doi: 10.1016/j.jocn.2018.10.077. PMID: 30595166
Epidemiological study of adult-onset myasthenia gravis in the area of Belgrade (Serbia) in the period 1979-2008.
Lavrnic D, Basta I, Rakocevic-Stojanovic V, Stevic Z, Peric S, Nikolic A, Marjanovic I, Pekmezovic T
Neuroepidemiology 2013;40(3):190-4. Epub 2013 Jan 24 doi: 10.1159/000342777. PMID: 23363926
Myasthenia gravis.
Pourmand R
Dis Mon 1997 Feb;43(2):65-109. doi: 10.1016/s0011-5029(97)90033-x. PMID: 9118787

Therapy

Acetylcholine receptor antibody in myasthenia gravis.
Marchiori PE, dos Reis M, Quevedo ME, Scaff M, Cossermelli W, Assis JL, de Oliveira RM
Acta Neurol Scand 1989 Nov;80(5):387-9. doi: 10.1111/j.1600-0404.1989.tb03898.x. PMID: 2589004

Prognosis

Comparison of anti-acetylcholine receptor profiles between Chinese cases of adult- and juvenile-onset myasthenia gravis using cell-based assays.
Yan C, Zhao R, Song J, Feng X, Xi J, Luo S, Zhong H, Zhou S, Li W, Zhao C
J Neuroimmunol 2020 Dec 15;349:577403. Epub 2020 Sep 22 doi: 10.1016/j.jneuroim.2020.577403. PMID: 32992216
Epidemiological study of adult-onset myasthenia gravis in the area of Belgrade (Serbia) in the period 1979-2008.
Lavrnic D, Basta I, Rakocevic-Stojanovic V, Stevic Z, Peric S, Nikolic A, Marjanovic I, Pekmezovic T
Neuroepidemiology 2013;40(3):190-4. Epub 2013 Jan 24 doi: 10.1159/000342777. PMID: 23363926

Clinical prediction guides

Survival and mortality of adult-onset myasthenia gravis in the population of Belgrade, Serbia.
Basta I, PekmezoviĆ T, Peric S, NikoliĆ A, RakoČeviĆ-StojanoviĆ V, SteviĆ Z, LavrniĆ D
Muscle Nerve 2018 Nov;58(5):708-712. Epub 2018 Aug 25 doi: 10.1002/mus.26132. PMID: 29572981

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