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Anaplasmosis

MedGen UID:
8053
•Concept ID:
C0002797
•
Disease or Syndrome
Synonyms: Anaplasma Infection; Anaplasma Infections; Anaplasma phagocytophilum Infection; Anaplasma phagocytophilum Infections; Anaplasmoses; Infection, Anaplasma; Infections, Anaplasma
SNOMED CT: Anaplasmosis (13906002); Gallsickness (13906002)
 
Monarch Initiative: MONDO:0025303

Definition

An infection that is caused by Anaplasma phagocytophilum, which is transmitted to humans by infected ticks; it is characterized by fever, headache, chills, and myalgia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplasmosis

Professional guidelines

PubMed

Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis.
Figoni J, Chirouze C, Hansmann Y, Lemogne C, Hentgen V, Saunier A, Bouiller K, Gehanno JF, Rabaud C, Perrot S, Caumes E, Eldin C, de Broucker T, Jaulhac B, Roblot F, Toubiana J, Sellal F, Vuillemet F, Sordet C, Fantin B, Lina G, Gocko X, Dieudonné M, Picone O, Bodaghi B, Gangneux JP, Degeilh B, Partouche H, Lenormand C, Sotto A, Raffetin A, Monsuez JJ, Michel C, Boulanger N, Cathebras P, Tattevin P; endorsed by scientific societies
Med Mal Infect 2019 Aug;49(5):318-334. Epub 2019 May 13 doi: 10.1016/j.medmal.2019.04.381. PMID: 31097370
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article

Recent clinical studies

Etiology

Human Granulocytic Anaplasmosis.
MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States.
Mowla SJ, Drexler NA, Cherry CC, Annambholta PD, Kracalik IT, Basavaraju SV
Emerg Infect Dis 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127. PMID: 34670661Free PMC Article
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Control of Lyme borreliosis and other Ixodes ricinus-borne diseases.
Sprong H, Azagi T, Hoornstra D, Nijhof AM, Knorr S, Baarsma ME, Hovius JW
Parasit Vectors 2018 Mar 6;11(1):145. doi: 10.1186/s13071-018-2744-5. PMID: 29510749Free PMC Article
Human granulocytic anaplasmosis.
Bakken JS, Dumler JS
Infect Dis Clin North Am 2015 Jun;29(2):341-55. doi: 10.1016/j.idc.2015.02.007. PMID: 25999228Free PMC Article

Diagnosis

Human Granulocytic Anaplasmosis.
MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis.
Figoni J, Chirouze C, Hansmann Y, Lemogne C, Hentgen V, Saunier A, Bouiller K, Gehanno JF, Rabaud C, Perrot S, Caumes E, Eldin C, de Broucker T, Jaulhac B, Roblot F, Toubiana J, Sellal F, Vuillemet F, Sordet C, Fantin B, Lina G, Gocko X, Dieudonné M, Picone O, Bodaghi B, Gangneux JP, Degeilh B, Partouche H, Lenormand C, Sotto A, Raffetin A, Monsuez JJ, Michel C, Boulanger N, Cathebras P, Tattevin P; endorsed by scientific societies
Med Mal Infect 2019 Aug;49(5):318-334. Epub 2019 May 13 doi: 10.1016/j.medmal.2019.04.381. PMID: 31097370
Tick borne illness-Lyme disease.
Bush LM, Vazquez-Pertejo MT
Dis Mon 2018 May;64(5):195-212. doi: 10.1016/j.disamonth.2018.01.007. PMID: 29402399
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article

Therapy

Human Granulocytic Anaplasmosis.
MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States.
Mowla SJ, Drexler NA, Cherry CC, Annambholta PD, Kracalik IT, Basavaraju SV
Emerg Infect Dis 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127. PMID: 34670661Free PMC Article
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Tick borne illness-Lyme disease.
Bush LM, Vazquez-Pertejo MT
Dis Mon 2018 May;64(5):195-212. doi: 10.1016/j.disamonth.2018.01.007. PMID: 29402399
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article

Prognosis

Zoonotic Babesia: A scoping review of the global evidence.
Young KM, Corrin T, Wilhelm B, Uhland C, Greig J, Mascarenhas M, Waddell LA
PLoS One 2019;14(12):e0226781. Epub 2019 Dec 30 doi: 10.1371/journal.pone.0226781. PMID: 31887120Free PMC Article
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
The Blacklegged Tick, Ixodes scapularis: An Increasing Public Health Concern.
Eisen RJ, Eisen L
Trends Parasitol 2018 Apr;34(4):295-309. Epub 2018 Jan 11 doi: 10.1016/j.pt.2017.12.006. PMID: 29336985Free PMC Article
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article
Vector-borne diseases in humans and animals: activities of the Swiss Tropical Institute and risks for Switzerland.
Zinsstag J, Schelling E
Schweiz Arch Tierheilkd 2003 Dec;145(12):559-66, 568-9. doi: 10.1024/0036-7281.145.12.559. PMID: 14725182

Clinical prediction guides

Zoonotic Babesia: A scoping review of the global evidence.
Young KM, Corrin T, Wilhelm B, Uhland C, Greig J, Mascarenhas M, Waddell LA
PLoS One 2019;14(12):e0226781. Epub 2019 Dec 30 doi: 10.1371/journal.pone.0226781. PMID: 31887120Free PMC Article
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
Distribution of tick-borne diseases in China.
Wu XB, Na RH, Wei SS, Zhu JS, Peng HJ
Parasit Vectors 2013 Apr 23;6:119. doi: 10.1186/1756-3305-6-119. PMID: 23617899Free PMC Article
Clinical diagnosis and treatment of human granulocytotropic anaplasmosis.
Bakken JS, Dumler JS
Ann N Y Acad Sci 2006 Oct;1078:236-47. doi: 10.1196/annals.1374.042. PMID: 17114714
Coinfections acquired from ixodes ticks.
Swanson SJ, Neitzel D, Reed KD, Belongia EA
Clin Microbiol Rev 2006 Oct;19(4):708-27. doi: 10.1128/CMR.00011-06. PMID: 17041141Free PMC Article

Recent systematic reviews

Laboratory Methods for Detection of Infectious Agents and Serological Response in Humans With Tick-Borne Infections: A Systematic Review of Evaluations Based on Clinical Patient Samples.
Henningsson AJ, Aase A, Bavelaar H, Flottorp S, Forsberg P, Kirkehei I, Lövmar M, Nilsson K, Nyman D, Ornstein K, Sjöwall J, Skogman BH, Tjernberg I, Aaberge I
Front Public Health 2021;9:580102. Epub 2021 Sep 20 doi: 10.3389/fpubh.2021.580102. PMID: 34616701Free PMC Article
Systematic review and meta-analysis of tick-borne disease risk factors in residential yards, neighborhoods, and beyond.
Fischhoff IR, Bowden SE, Keesing F, Ostfeld RS
BMC Infect Dis 2019 Oct 17;19(1):861. doi: 10.1186/s12879-019-4484-3. PMID: 31623574Free PMC Article
Repellence of essential oils and selected compounds against ticks-A systematic review.
Benelli G, Pavela R
Acta Trop 2018 Mar;179:47-54. Epub 2017 Dec 26 doi: 10.1016/j.actatropica.2017.12.025. PMID: 29287758
Chronic coinfections in patients diagnosed with chronic lyme disease: a systematic review.
Lantos PM, Wormser GP
Am J Med 2014 Nov;127(11):1105-1110. Epub 2014 Jun 12 doi: 10.1016/j.amjmed.2014.05.036. PMID: 24929022Free PMC Article
Epidemiology and control of human granulocytic anaplasmosis: a systematic review.
Jin H, Wei F, Liu Q, Qian J
Vector Borne Zoonotic Dis 2012 Apr;12(4):269-74. Epub 2012 Jan 4 doi: 10.1089/vbz.2011.0753. PMID: 22217177

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