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Nicolau Syndrome

MedGen UID:
810780
Concept ID:
C1142083
Disease or Syndrome
Synonyms: Cutis Medicamentosa, Embolia; Dermatitides, Livedo-like; Dermatitis, Livedo-like; Dermatitis, Nicolau Livedoid; Embolia Cutis Medicamentosa; Livedo like Dermatitis; Livedo-like Dermatitides; Livedo-like Dermatitis; Livedoid Dermatitis, Nicolau; Livedoid Syndrome, Nicolau's; Medicamentosa, Embolia Cutis; Nicolau Livedoid Dermatitis; Nicolau Livedoid Syndrome; Nicolau's Livedoid Syndrome; Nicolau's Syndrome; Nicolaus Livedoid Syndrome; Nicolaus Syndrome; Syndrome, Nicolau; Syndrome, Nicolau's; Syndrome, Nicolau's Livedoid

Definition

An uncommon complication of INTRAMUSCULAR INJECTION leading to variable degrees of necrosis of skin and underlying tissue. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNicolau Syndrome

Professional guidelines

PubMed

Santos BC, Correia RM, Kuramoto DAB, Carvalho AAG, Avila RB, Amorim JE, Flumignan RLG, Nakano LCU
Arch Dis Child Fetal Neonatal Ed 2022 Nov;107(6):648. Epub 2021 May 10 doi: 10.1136/archdischild-2021-321637. PMID: 33972262

Recent clinical studies

Etiology

Udawatta M, Mateen FJ
Ann Clin Transl Neurol 2024 Apr;11(4):1080-1085. Epub 2024 Mar 14 doi: 10.1002/acn3.52044. PMID: 38483009Free PMC Article
Andina D, Belloni-Fortina A, Bodemer C, Bonifazi E, Chiriac A, Colmenero I, Diociaiuti A, El-Hachem M, Fertitta L, van Gysel D, Hernández-Martín A, Hubiche T, Luca C, Martos-Cabrera L, Maruani A, Mazzotta F, Akkaya AD, Casals M, Ferrando J, Grimalt R, Grozdev I, Kinsler V, Morren MA, Munisami M, Nanda A, Novoa MP, Ott H, Pasmans S, Salavastru C, Zawar V, Torrelo A; ESPD Group for the Skin Manifestations of COVID-19
Clin Exp Dermatol 2021 Apr;46(3):462-472. Epub 2020 Nov 18 doi: 10.1111/ced.14483. PMID: 33207021Free PMC Article
Marsch WC, Komatsuzaki S, Mueller A, Hagemann M, Lange D, Maemecke L, Villavicencio-Lorini P, Hoffmann K
Eur J Dermatol 2019 Jun 1;29(3):287-293. doi: 10.1684/ejd.2019.3554. PMID: 31389788
Dadaci M, Altuntas Z, Ince B, Bilgen F, Tufekci O, Poyraz N
Bosn J Basic Med Sci 2015 Jan 8;15(1):57-60. doi: 10.17305/bjbms.2015.1.190. PMID: 25725145Free PMC Article
DeLorenzi C
Aesthet Surg J 2014 May 1;34(4):584-600. Epub 2014 Apr 1 doi: 10.1177/1090820X14525035. PMID: 24692598

Diagnosis

Zargarbashi R, Panjavi B, Keshavarz-Fathi M
Int J Low Extrem Wounds 2023 Mar;22(1):113-116. Epub 2020 Aug 17 doi: 10.1177/1534734620948768. PMID: 32806967
Al-Sheeb F, Al Mannai G, Tharupeedikayil S
J Endod 2022 Feb;48(2):269-272. Epub 2021 Oct 31 doi: 10.1016/j.joen.2021.10.006. PMID: 34732322
Esme P, Gahramanov I, Akıncıoglu E, Akoglu G
Indian J Pharmacol 2021 Nov-Dec;53(6):489-492. doi: 10.4103/ijp.ijp_166_21. PMID: 34975138Free PMC Article
Raju B, Ashraf O, Jumah F, Appaji Gowda NM, Gupta G, Sun H, Nanda A
World Neurosurg 2020 Nov;143:51-55. Epub 2020 Jul 15 doi: 10.1016/j.wneu.2020.07.029. PMID: 32679363
Arslan MN, Melez DO, Akcay A, Gur A, Sam B, Guven Apaydın S
J Forensic Sci 2016 Sep;61(5):1369-74. Epub 2016 Jun 20 doi: 10.1111/1556-4029.13126. PMID: 27320825

Therapy

Al-Sheeb F, Al Mannai G, Tharupeedikayil S
J Endod 2022 Feb;48(2):269-272. Epub 2021 Oct 31 doi: 10.1016/j.joen.2021.10.006. PMID: 34732322
Raju B, Ashraf O, Jumah F, Appaji Gowda NM, Gupta G, Sun H, Nanda A
World Neurosurg 2020 Nov;143:51-55. Epub 2020 Jul 15 doi: 10.1016/j.wneu.2020.07.029. PMID: 32679363
Maneshi A, Ravi S, Salehi MR, Hasannezhad M, Khalili H
Arch Iran Med 2017 Jan;20(1):60-64. PMID: 28112534
Srivastava P, Someshwar S, Jerajani H
Indian Pediatr 2015 Apr;52(4):356. PMID: 25929650
DeLorenzi C
Aesthet Surg J 2014 May 1;34(4):584-600. Epub 2014 Apr 1 doi: 10.1177/1090820X14525035. PMID: 24692598

Prognosis

Demircan C, Akdogan N, Elmas L
Int J Low Extrem Wounds 2023 Mar;22(1):149-151. Epub 2020 Dec 1 doi: 10.1177/1534734620973144. PMID: 33258397
Andina D, Belloni-Fortina A, Bodemer C, Bonifazi E, Chiriac A, Colmenero I, Diociaiuti A, El-Hachem M, Fertitta L, van Gysel D, Hernández-Martín A, Hubiche T, Luca C, Martos-Cabrera L, Maruani A, Mazzotta F, Akkaya AD, Casals M, Ferrando J, Grimalt R, Grozdev I, Kinsler V, Morren MA, Munisami M, Nanda A, Novoa MP, Ott H, Pasmans S, Salavastru C, Zawar V, Torrelo A; ESPD Group for the Skin Manifestations of COVID-19
Clin Exp Dermatol 2021 Apr;46(3):462-472. Epub 2020 Nov 18 doi: 10.1111/ced.14483. PMID: 33207021Free PMC Article
Raju B, Ashraf O, Jumah F, Appaji Gowda NM, Gupta G, Sun H, Nanda A
World Neurosurg 2020 Nov;143:51-55. Epub 2020 Jul 15 doi: 10.1016/j.wneu.2020.07.029. PMID: 32679363
Marsch WC, Komatsuzaki S, Mueller A, Hagemann M, Lange D, Maemecke L, Villavicencio-Lorini P, Hoffmann K
Eur J Dermatol 2019 Jun 1;29(3):287-293. doi: 10.1684/ejd.2019.3554. PMID: 31389788
Arslan MN, Melez DO, Akcay A, Gur A, Sam B, Guven Apaydın S
J Forensic Sci 2016 Sep;61(5):1369-74. Epub 2016 Jun 20 doi: 10.1111/1556-4029.13126. PMID: 27320825

Clinical prediction guides

Aktas H, Yılmaz OE, Ertugrul G, Terzi E
Dermatol Ther 2020 May;33(3):e13392. Epub 2020 Apr 30 doi: 10.1111/dth.13392. PMID: 32268452
Marsch WC, Komatsuzaki S, Mueller A, Hagemann M, Lange D, Maemecke L, Villavicencio-Lorini P, Hoffmann K
Eur J Dermatol 2019 Jun 1;29(3):287-293. doi: 10.1684/ejd.2019.3554. PMID: 31389788
Dadaci M, Altuntas Z, Ince B, Bilgen F, Tufekci O, Poyraz N
Bosn J Basic Med Sci 2015 Jan 8;15(1):57-60. doi: 10.17305/bjbms.2015.1.190. PMID: 25725145Free PMC Article
Wilbrand JF, Wilbrand M, Schaaf H, Howaldt HP, Malik CY, Streckbein P
J Endod 2011 Jun;37(6):875-7. Epub 2011 Mar 3 doi: 10.1016/j.joen.2011.01.004. PMID: 21787509
Guarneri C, Polimeni G
Am J Clin Dermatol 2010;11 Suppl 1:51-2. doi: 10.2165/1153426-S0-000000000-00000. PMID: 20586511

Recent systematic reviews

Lardelli PF, Jermini LMM, Milani GP, Peeters GGAM, Ramelli GP, Zgraggen L, Terrani I, Bianchetti MG, Vanoni F, Faré PB, Lava SAG
Int J Clin Pract 2020 Oct;74(10):e13567. Epub 2020 Jun 28 doi: 10.1111/ijcp.13567. PMID: 32479658

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