U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Diabetic Fetopathy

MedGen UID:
810783
•Concept ID:
C1167662
•
Disease or Syndrome

Definition

A constellation of features seen in the hyperinsulinemic fetus of a diabetic mother that include macrosomia, postnatal hypoglycemia and polycythemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiabetic Fetopathy

Professional guidelines

PubMed

Etiology, detection, and management of fetal macrosomia in pregnancies complicated by diabetes mellitus.
Sacks DA
Clin Obstet Gynecol 2007 Dec;50(4):980-9. doi: 10.1097/GRF.0b013e31815a6242. PMID: 17982341
Diagnosis and treatment of gestational diabetes according to amniotic fluid insulin levels.
Weiss PA, Hofmann HM, Winter RR, Lichtenegger W, Pürstner P, Haas J
Arch Gynecol 1986;239(2):81-91. doi: 10.1007/BF02133967. PMID: 3535694

Recent clinical studies

Etiology

Severe types of fetopathy are associated with changes in the serological proteome of diabetic mothers.
Kopylov AT, Papysheva O, Gribova I, Kaysheva AL, Kotaysch G, Kharitonova L, Mayatskaya T, Nurbekov MK, Schipkova E, Terekhina O, Morozov SG
Medicine (Baltimore) 2021 Nov 12;100(45):e27829. doi: 10.1097/MD.0000000000027829. PMID: 34766598Free PMC Article
Association of Proteins Modulating Immune Response and Insulin Clearance During Gestation with Antenatal Complications in Patients with Gestational or Type 2 Diabetes Mellitus.
Kopylov AT, Kaysheva AL, Papysheva O, Gribova I, Kotaysch G, Kharitonova L, Mayatskaya T, Krasheninnikova A, Morozov SG
Cells 2020 Apr 21;9(4) doi: 10.3390/cells9041032. PMID: 32326243Free PMC Article
Gestational diabetes, obesity, and metabolic syndrome diagnosed during pregnancy.
Baliutavičienė D, Buinauskienė JB, Petrenko V, Danytė E, Žalinkevičius R
Metab Syndr Relat Disord 2012 Jun;10(3):214-7. Epub 2012 Feb 7 doi: 10.1089/met.2011.0067. PMID: 22313156
The use of pharmacotherapy in pregnancies with suspected diabetic fetopathy.
Sacks DA
J Matern Fetal Neonatal Med 2012 Jan;25(1):45-9. Epub 2011 Dec 7 doi: 10.3109/14767058.2012.626929. PMID: 22046973
Metabolic interactions of diabetes and pregnancy.
Buchanan TA, Kitzmiller JL
Annu Rev Med 1994;45:245-60. doi: 10.1146/annurev.med.45.1.245. PMID: 8198381

Diagnosis

Severe types of fetopathy are associated with changes in the serological proteome of diabetic mothers.
Kopylov AT, Papysheva O, Gribova I, Kaysheva AL, Kotaysch G, Kharitonova L, Mayatskaya T, Nurbekov MK, Schipkova E, Terekhina O, Morozov SG
Medicine (Baltimore) 2021 Nov 12;100(45):e27829. doi: 10.1097/MD.0000000000027829. PMID: 34766598Free PMC Article
Newborns from women infected with COVID-19: somatic and metabolic status.
Borodina IA, Gil'miyarova FN, Gusyakova OA, Selezneva IA, Borisova OV, Potyakina EE, Kolot'eva NA, Kozlov AV, Gorbacheva IV, Kuznecova OY, Baldina OA, Vinogradova LN, Emel'yanova NG, Koroteeva YA
Klin Lab Diagn 2021 Aug 13;66(8):453-458. doi: 10.51620/0869-2084-2021-66-8-453-458. PMID: 34388314
Association of Proteins Modulating Immune Response and Insulin Clearance During Gestation with Antenatal Complications in Patients with Gestational or Type 2 Diabetes Mellitus.
Kopylov AT, Kaysheva AL, Papysheva O, Gribova I, Kotaysch G, Kharitonova L, Mayatskaya T, Krasheninnikova A, Morozov SG
Cells 2020 Apr 21;9(4) doi: 10.3390/cells9041032. PMID: 32326243Free PMC Article
Weight-related and analytical maternal factors in gestational diabetes to predict birth weight and cord markers of diabetic fetopathy.
Garcia-Flores J, Cruceyra M, Cañamares M, Garicano A, Nieto O, Espada M, Lopez A, Tamarit I, Sainz De La Cuesta R
Gynecol Endocrinol 2016 Jul;32(7):548-52. Epub 2016 Feb 1 doi: 10.3109/09513590.2016.1138461. PMID: 26829514
Etiology, detection, and management of fetal macrosomia in pregnancies complicated by diabetes mellitus.
Sacks DA
Clin Obstet Gynecol 2007 Dec;50(4):980-9. doi: 10.1097/GRF.0b013e31815a6242. PMID: 17982341

Therapy

Gestational diabetes, obesity, and metabolic syndrome diagnosed during pregnancy.
Baliutavičienė D, Buinauskienė JB, Petrenko V, Danytė E, Žalinkevičius R
Metab Syndr Relat Disord 2012 Jun;10(3):214-7. Epub 2012 Feb 7 doi: 10.1089/met.2011.0067. PMID: 22313156
The use of pharmacotherapy in pregnancies with suspected diabetic fetopathy.
Sacks DA
J Matern Fetal Neonatal Med 2012 Jan;25(1):45-9. Epub 2011 Dec 7 doi: 10.3109/14767058.2012.626929. PMID: 22046973
Etiology, detection, and management of fetal macrosomia in pregnancies complicated by diabetes mellitus.
Sacks DA
Clin Obstet Gynecol 2007 Dec;50(4):980-9. doi: 10.1097/GRF.0b013e31815a6242. PMID: 17982341
Possible mechanisms of diabetic fetopathy.
Poletaev AB, Gnedenko BB, Makarova AA, Krasnopolsky VI, Budykina TS, Petrukhin VA, Morozov SG
Hum Antibodies 2000;9(4):189-97. PMID: 11341172
Indication and results of insulin therapy for gestational diabetes mellitus.
Hopp H, Vollert W, Ragosch V, Novak A, Weitzel HK, Glöckner E, Besch W
J Perinat Med 1996;24(5):521-30. doi: 10.1515/jpme.1996.24.5.521. PMID: 8950733

Prognosis

Weight-related and analytical maternal factors in gestational diabetes to predict birth weight and cord markers of diabetic fetopathy.
Garcia-Flores J, Cruceyra M, Cañamares M, Garicano A, Nieto O, Espada M, Lopez A, Tamarit I, Sainz De La Cuesta R
Gynecol Endocrinol 2016 Jul;32(7):548-52. Epub 2016 Feb 1 doi: 10.3109/09513590.2016.1138461. PMID: 26829514
Gestational diabetes, obesity, and metabolic syndrome diagnosed during pregnancy.
Baliutavičienė D, Buinauskienė JB, Petrenko V, Danytė E, Žalinkevičius R
Metab Syndr Relat Disord 2012 Jun;10(3):214-7. Epub 2012 Feb 7 doi: 10.1089/met.2011.0067. PMID: 22313156
Relationship between sonographically estimated fetal subcutaneous adipose tissue measurements and neonatal skinfold measurements.
Buhling KJ, Doll I, Siebert G, Catalano PM
Ultrasound Obstet Gynecol 2012 May;39(5):558-62. doi: 10.1002/uog.10092. PMID: 21898636
Pregnancy in a woman suffering from type 1 diabetes associated with Addison's disease and Hashimoto's thyroiditis (fully developed Autoimmune Polyglandular Syndrome Type 2).
Stechova K, Bartaskova D, Mrstinova M, Cerny M, Snajderova M, Cinek O, Sumnik Z, Vavrinec J
Exp Clin Endocrinol Diabetes 2004 Jun;112(6):333-7. doi: 10.1055/s-2004-820912. PMID: 15216452
Amniotic fluid insulin levels identify the fetus at risk of neonatal hypoglycaemia.
Fraser RB, Bruce C
Diabet Med 1999 Jul;16(7):568-72. doi: 10.1046/j.1464-5491.1999.00104.x. PMID: 10445832

Clinical prediction guides

Severe types of fetopathy are associated with changes in the serological proteome of diabetic mothers.
Kopylov AT, Papysheva O, Gribova I, Kaysheva AL, Kotaysch G, Kharitonova L, Mayatskaya T, Nurbekov MK, Schipkova E, Terekhina O, Morozov SG
Medicine (Baltimore) 2021 Nov 12;100(45):e27829. doi: 10.1097/MD.0000000000027829. PMID: 34766598Free PMC Article
Newborns from women infected with COVID-19: somatic and metabolic status.
Borodina IA, Gil'miyarova FN, Gusyakova OA, Selezneva IA, Borisova OV, Potyakina EE, Kolot'eva NA, Kozlov AV, Gorbacheva IV, Kuznecova OY, Baldina OA, Vinogradova LN, Emel'yanova NG, Koroteeva YA
Klin Lab Diagn 2021 Aug 13;66(8):453-458. doi: 10.51620/0869-2084-2021-66-8-453-458. PMID: 34388314
Weight-related and analytical maternal factors in gestational diabetes to predict birth weight and cord markers of diabetic fetopathy.
Garcia-Flores J, Cruceyra M, Cañamares M, Garicano A, Nieto O, Espada M, Lopez A, Tamarit I, Sainz De La Cuesta R
Gynecol Endocrinol 2016 Jul;32(7):548-52. Epub 2016 Feb 1 doi: 10.3109/09513590.2016.1138461. PMID: 26829514
Gestational diabetes, obesity, and metabolic syndrome diagnosed during pregnancy.
Baliutavičienė D, Buinauskienė JB, Petrenko V, Danytė E, Žalinkevičius R
Metab Syndr Relat Disord 2012 Jun;10(3):214-7. Epub 2012 Feb 7 doi: 10.1089/met.2011.0067. PMID: 22313156
Alcohol embryopathy and diabetic fetopathy in the same newborn.
Majewski F, Nothjunge J, Bierich JR
Helv Paediatr Acta 1979 May;34(2):135-9. PMID: 457429

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...