U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Salivary gland large cell carcinoma

MedGen UID:
810975
Concept ID:
C2111671
Neoplastic Process
Synonyms: Large Cell Salivary Gland Carcinoma; large cell salivary gland carcinoma; Large Cell Undifferentiated Salivary Gland Carcinoma; large cell undifferentiated salivary gland carcinoma; saliva-secreting gland large cell carcinoma; Salivary Gland Large Cell Carcinoma; salivary gland large cell carcinoma
 
Monarch Initiative: MONDO:0006404

Definition

A rare, highly aggressive carcinoma that arises from the salivary gland, predominantly the parotid gland. It is characterized by the presence of large pleomorphic malignant cells with or without neuroendocrine differentiation. Patients usually present with a rapidly growing mass. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary gland large cell carcinoma

Professional guidelines

PubMed

Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Li Q, Zhang XR, Liu XK, Liu ZM, Liu WW, Li H, Guo ZM
Oral Oncol 2012 May;48(5):456-62. Epub 2012 Jan 16 doi: 10.1016/j.oraloncology.2011.12.005. PMID: 22248739

Recent clinical studies

Etiology

Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Kshirsagar RS, Eide JG, Brant JA, Palmer JN, Adappa ND
Am J Rhinol Allergy 2022 Nov;36(6):741-746. Epub 2022 Jun 14 doi: 10.1177/19458924221107206. PMID: 35702005
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Saunders MI, Dische S, Grosch EJ, Fermont DC, Ashford RF, Maher EJ, Makepeace AR
Int J Radiat Oncol Biol Phys 1991 Aug;21(3):871-8. doi: 10.1016/0360-3016(91)90722-g. PMID: 1651312

Diagnosis

Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Mete O, Wenig BM
Head Neck Pathol 2022 Mar;16(1):123-142. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01435-8. PMID: 35312985Free PMC Article
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Kusafuka K, Ferlito A, Lewis JS Jr, Woolgar JA, Rinaldo A, Slootweg PJ, Gnepp DR, Devaney KO, Travis WD, Barnes L
Oral Oncol 2012 Mar;48(3):211-5. Epub 2011 Oct 22 doi: 10.1016/j.oraloncology.2011.09.016. PMID: 22024350

Therapy

Zarinshenas R, Campbell P, Sun K, Molitoris JK, Patel AN, Witek ME, Cullen KJ, Mehra R, Hatten KM, Moyer KF, Taylor RJ, Vakharia KT, Wolf JS, Ferris MJ
Radiother Oncol 2024 Apr;193:110112. Epub 2024 Feb 1 doi: 10.1016/j.radonc.2024.110112. PMID: 38309587
Ishida M, Iwai M, Yoshida K, Kagotani A, Kohzaki H, Arikata M, Shimizu T, Okabe H
Int J Clin Exp Pathol 2013;6(9):1929-34. Epub 2013 Aug 15 PMID: 24040460Free PMC Article
Bell D, Hanna EY
Curr Oncol Rep 2012 Apr;14(2):166-74. doi: 10.1007/s11912-012-0220-5. PMID: 22246609
Chandana SR, Conley BA
Expert Rev Anticancer Ther 2008 Apr;8(4):645-52. doi: 10.1586/14737140.8.4.645. PMID: 18402531
Saunders MI, Dische S, Grosch EJ, Fermont DC, Ashford RF, Maher EJ, Makepeace AR
Int J Radiat Oncol Biol Phys 1991 Aug;21(3):871-8. doi: 10.1016/0360-3016(91)90722-g. PMID: 1651312

Prognosis

Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Ward BJH, Schaal DL, Nkadi EH, Scott RS
Viruses 2022 Dec 1;14(12) doi: 10.3390/v14122700. PMID: 36560704Free PMC Article
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Kusafuka K, Ferlito A, Lewis JS Jr, Woolgar JA, Rinaldo A, Slootweg PJ, Gnepp DR, Devaney KO, Travis WD, Barnes L
Oral Oncol 2012 Mar;48(3):211-5. Epub 2011 Oct 22 doi: 10.1016/j.oraloncology.2011.09.016. PMID: 22024350

Clinical prediction guides

Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Ward BJH, Schaal DL, Nkadi EH, Scott RS
Viruses 2022 Dec 1;14(12) doi: 10.3390/v14122700. PMID: 36560704Free PMC Article
Wang B, Gan J, Liu Z, Hui Z, Wei J, Gu X, Mu Y, Zang G
J Exp Clin Cancer Res 2022 Dec 17;41(1):350. doi: 10.1186/s13046-022-02561-5. PMID: 36527158Free PMC Article
Schrank TP, Zhan KY, Lentsch EJ
Laryngoscope 2017 Feb;127(2):372-376. Epub 2016 Aug 22 doi: 10.1002/lary.26136. PMID: 27545825
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

Wu L, Jiang C, Zhu Z, Sun Y, Zhang T
PLoS One 2022;17(7):e0272080. Epub 2022 Jul 26 doi: 10.1371/journal.pone.0272080. PMID: 35881656Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...